{"id":"https://openalex.org/W1985235876","doi":"https://doi.org/10.1007/bf02303787","title":"Flow cytometric measurement of mitochondrial mass and function: A novel method for assessing chemoresistance","display_name":"Flow cytometric measurement of mitochondrial mass and function: A novel method for assessing chemoresistance","publication_year":1998,"publication_date":"1998-04-01","ids":{"openalex":"https://openalex.org/W1985235876","doi":"https://doi.org/10.1007/bf02303787","mag":"1985235876","pmid":"https://pubmed.ncbi.nlm.nih.gov/9607633"},"language":"en","primary_location":{"id":"doi:10.1007/bf02303787","doi":"https://doi.org/10.1007/bf02303787","is_oa":false,"landing_page_url":"https://doi.org/10.1007/bf02303787","pdf_url":null,"source":{"id":"https://openalex.org/S177486402","display_name":"Annals of Surgical Oncology","issn_l":"1068-9265","issn":["1068-9265","1534-4681"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Surgical Oncology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082465791","display_name":"Mariangela Mancini","orcid":"https://orcid.org/0000-0001-6766-8767","observed_orcids":["https://orcid.org/0000-0001-6766-8767"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mariangela Mancini","raw_affiliation_strings":["Department of Surgery, University of Washington, Seattle 98195, USA","the Divisions of Clinical Research and Molecular Medicine, Fred Hutchinson Cancer Research Center, Seattle, Washington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, University of Washington, Seattle 98195, USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"the Divisions of Clinical Research and Molecular Medicine, Fred Hutchinson Cancer Research Center, Seattle, Washington","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004374290","display_name":"Monireh Sedghinasab","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Monireh Sedghinasab","raw_affiliation_strings":["Dept. of Surgery, University of Washington, Box 356410, 98195, Seattle, WA","the Divisions of Clinical Research and Molecular Medicine, Fred Hutchinson Cancer Research Center, Seattle, Washington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Surgery, University of Washington, Box 356410, 98195, Seattle, WA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"the Divisions of Clinical Research and Molecular Medicine, Fred Hutchinson Cancer Research Center, Seattle, Washington","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084519559","display_name":"Katya Knowlton","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katya Knowlton","raw_affiliation_strings":["Dept. of Surgery, University of Washington, Box 356410, 98195, Seattle, WA","the Divisions of Clinical Research and Molecular Medicine, Fred Hutchinson Cancer Research Center, Seattle, Washington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Surgery, University of Washington, Box 356410, 98195, Seattle, WA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"the Divisions of Clinical Research and Molecular Medicine, Fred Hutchinson Cancer Research Center, Seattle, Washington","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Amy Tam","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amy Tam","raw_affiliation_strings":["the Divisions of Clinical Research and Molecular Medicine, Fred Hutchinson Cancer Research Center, Seattle, Washington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the Divisions of Clinical Research and Molecular Medicine, Fred Hutchinson Cancer Research Center, Seattle, Washington","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5097664014","display_name":"David Hockenberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Hockenberg","raw_affiliation_strings":["the Divisions of Clinical Research and Molecular Medicine, Fred Hutchinson Cancer Research Center, Seattle, Washington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the Divisions of Clinical Research and Molecular Medicine, Fred Hutchinson Cancer Research Center, Seattle, Washington","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063822600","display_name":"Benjamin O. Anderson","orcid":"https://orcid.org/0000-0001-7217-7428","observed_orcids":["https://orcid.org/0000-0001-7217-7428"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Benjamin O. Anderson","raw_affiliation_strings":["Dept. of Surgery, University of Washington, Box 356410, 98195, Seattle, WA","the Divisions of Clinical Research and Molecular Medicine, Fred Hutchinson Cancer Research Center, Seattle, Washington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Surgery, University of Washington, Box 356410, 98195, Seattle, WA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"the Divisions of Clinical Research and Molecular Medicine, Fred Hutchinson Cancer Research Center, Seattle, Washington","institution_ids":["https://openalex.org/I4210089486"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4590,"currency":"USD","value_usd":4590},"apc_paid":null,"fwci":1.046,"has_fulltext":false,"cited_by_count":36,"citation_normalized_percentile":{"value":0.74396941,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"5","issue":"3","first_page":"287","last_page":"295"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.006599999964237213,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chemoresistance","display_name":"chemoresistance","score":0.9610000252723694},{"id":"https://openalex.org/keywords/mitochondrial-mass","display_name":"mitochondrial mass","score":0.9139999747276306},{"id":"https://openalex.org/keywords/mitochondrial-membrane-potential","display_name":"mitochondrial membrane potential","score":0.8970000147819519},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.8709999918937683},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.722000002861023},{"id":"https://openalex.org/keywords/bcl-2","display_name":"Bcl-2","score":0.9940000176429749},{"id":"https://openalex.org/keywords/herbimycin-a","display_name":"herbimycin A","score":0.8180000185966492},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.8109999895095825},{"id":"https://openalex.org/keywords/skbr-3-cells","display_name":"SK-BR-3 cells","score":0.9509999752044678},{"id":"https://openalex.org/keywords/cell-cycle-arrest","display_name":"cell cycle arrest","score":0.7820000052452087}],"concepts":[{"id":"https://openalex.org/C2780140570","wikidata":"https://www.wikidata.org/wiki/Q3545481","display_name":"Surgical oncology","level":2,"score":0.8150007724761963},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.668550431728363},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.5152666568756104},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3349502682685852},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.30656495690345764},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.19303834438323975},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.16709133982658386}],"mesh":[{"descriptor_ui":"D000903","descriptor_name":"Antibiotics, Antineoplastic","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D004354","descriptor_name":"Drug Screening Assays, Antitumor","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":true},{"descriptor_ui":"D011809","descriptor_name":"Quinones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016196","descriptor_name":"S Phase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016227","descriptor_name":"Benzoquinones","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017828","descriptor_name":"Rifabutin","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019253","descriptor_name":"Proto-Oncogene Proteins c-bcl-2","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D047029","descriptor_name":"Lactams, Macrocyclic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/bf02303787","doi":"https://doi.org/10.1007/bf02303787","is_oa":false,"landing_page_url":"https://doi.org/10.1007/bf02303787","pdf_url":null,"source":{"id":"https://openalex.org/S177486402","display_name":"Annals of Surgical Oncology","issn_l":"1068-9265","issn":["1068-9265","1534-4681"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Surgical Oncology","raw_type":"journal-article"},{"id":"pmid:9607633","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9607633","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of surgical oncology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":46,"referenced_works":["https://openalex.org/W88692221","https://openalex.org/W303936545","https://openalex.org/W1512984914","https://openalex.org/W1871768557","https://openalex.org/W1906197854","https://openalex.org/W1934775191","https://openalex.org/W1967986995","https://openalex.org/W1976570855","https://openalex.org/W1980608195","https://openalex.org/W1980923728","https://openalex.org/W1981883990","https://openalex.org/W1988075901","https://openalex.org/W1988353980","https://openalex.org/W1992689843","https://openalex.org/W1997208169","https://openalex.org/W2001731569","https://openalex.org/W2028625808","https://openalex.org/W2030528472","https://openalex.org/W2031475867","https://openalex.org/W2037473273","https://openalex.org/W2039445898","https://openalex.org/W2043066069","https://openalex.org/W2052607700","https://openalex.org/W2057257609","https://openalex.org/W2057509964","https://openalex.org/W2078003307","https://openalex.org/W2089883223","https://openalex.org/W2093842124","https://openalex.org/W2098712005","https://openalex.org/W2100092765","https://openalex.org/W2101575450","https://openalex.org/W2115727783","https://openalex.org/W2126258908","https://openalex.org/W2127122957","https://openalex.org/W2128070857","https://openalex.org/W2128231283","https://openalex.org/W2134738490","https://openalex.org/W2138302361","https://openalex.org/W2144634347","https://openalex.org/W2146820712","https://openalex.org/W2149429457","https://openalex.org/W2154346380","https://openalex.org/W2188526507","https://openalex.org/W2314225431","https://openalex.org/W2328452031","https://openalex.org/W2403259871"],"related_works":["https://openalex.org/W2121770588","https://openalex.org/W1982410119","https://openalex.org/W1651860280","https://openalex.org/W2556296997","https://openalex.org/W2031472508","https://openalex.org/W1638082120","https://openalex.org/W1988353980","https://openalex.org/W7096498455","https://openalex.org/W2071421573","https://openalex.org/W2326288480"],"abstract_inverted_index":null,"counts_by_year":[{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}