{"id":"https://openalex.org/W1985233531","doi":"https://doi.org/10.1002/cncr.21986","title":"Review of capecitabine as oral treatment of gastric, gastroesophageal, and esophageal cancers","display_name":"Review of capecitabine as oral treatment of gastric, gastroesophageal, and esophageal cancers","publication_year":2006,"publication_date":"2006-06-12","ids":{"openalex":"https://openalex.org/W1985233531","doi":"https://doi.org/10.1002/cncr.21986","mag":"1985233531","pmid":"https://pubmed.ncbi.nlm.nih.gov/16770784"},"language":"en","primary_location":{"id":"doi:10.1002/cncr.21986","doi":"https://doi.org/10.1002/cncr.21986","is_oa":false,"landing_page_url":"https://doi.org/10.1002/cncr.21986","pdf_url":null,"source":{"id":"https://openalex.org/S126033908","display_name":"Cancer","issn_l":"0008-543X","issn":["0008-543X","1045-7410","1097-0142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044064524","display_name":"Jaffer A. Ajani","orcid":"https://orcid.org/0000-0001-9946-0629","observed_orcids":["https://orcid.org/0000-0001-9946-0629"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jaffer Ajani","raw_affiliation_strings":["Department of Gastrointestinal Medical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030-4009, USA. jajani@mdanderson.org","Department of Gastrointestinal Medical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastrointestinal Medical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030-4009, USA. jajani@mdanderson.org","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"Department of Gastrointestinal Medical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas","institution_ids":["https://openalex.org/I1343551460"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5044064524"],"corresponding_institution_ids":["https://openalex.org/I1343551460"],"apc_list":{"value":4790,"currency":"USD","value_usd":4790},"apc_paid":null,"fwci":1.3377,"has_fulltext":false,"cited_by_count":59,"citation_normalized_percentile":{"value":0.77164009,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"107","issue":"2","first_page":"221","last_page":"231"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10696","display_name":"Gastric Cancer Management and Outcomes","score":0.9765999913215637,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10696","display_name":"Gastric Cancer Management and Outcomes","score":0.9765999913215637,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10619","display_name":"Esophageal Cancer Research and Treatment","score":0.008899999782443047,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.0071000000461936,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/capecitabine","display_name":"capecitabine","score":1.0},{"id":"https://openalex.org/keywords/gastric-cancer","display_name":"gastric cancer","score":0.9369999766349792},{"id":"https://openalex.org/keywords/gastroesophageal-cancer","display_name":"gastroesophageal cancer","score":0.9980000257492065},{"id":"https://openalex.org/keywords/esophageal-cancer","display_name":"esophageal cancer","score":1.0},{"id":"https://openalex.org/keywords/oral-fluoropyrimidine","display_name":"oral fluoropyrimidine","score":0.7889999747276306},{"id":"https://openalex.org/keywords/metastatic-cancer","display_name":"metastatic cancer","score":0.6480000019073486},{"id":"https://openalex.org/keywords/adjuvant-therapy","display_name":"adjuvant therapy","score":0.7289999723434448},{"id":"https://openalex.org/keywords/combination-chemotherapy","display_name":"combination chemotherapy","score":0.6570000052452087},{"id":"https://openalex.org/keywords/docetaxel","display_name":"docetaxel","score":0.9649999737739563},{"id":"https://openalex.org/keywords/paclitaxel","display_name":"paclitaxel","score":0.875},{"id":"https://openalex.org/keywords/cisplatin","display_name":"cisplatin","score":0.9409999847412109},{"id":"https://openalex.org/keywords/oxaliplatin","display_name":"oxaliplatin","score":0.9980000257492065},{"id":"https://openalex.org/keywords/irinotecan","display_name":"irinotecan","score":1.0},{"id":"https://openalex.org/keywords/5-fluorouracil","display_name":"5-fluorouracil","score":0.968999981880188}],"concepts":[{"id":"https://openalex.org/C2777909004","wikidata":"https://www.wikidata.org/wiki/Q420207","display_name":"Capecitabine","level":4,"score":0.9691653251647949},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9228674173355103},{"id":"https://openalex.org/C2781190966","wikidata":"https://www.wikidata.org/wiki/Q420436","display_name":"Docetaxel","level":3,"score":0.7979207038879395},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7320605516433716},{"id":"https://openalex.org/C2780259306","wikidata":"https://www.wikidata.org/wiki/Q412197","display_name":"Irinotecan","level":4,"score":0.6337485313415527},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.6330618262290955},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.4938271939754486},{"id":"https://openalex.org/C2775930923","wikidata":"https://www.wikidata.org/wiki/Q12859063","display_name":"Metastatic breast cancer","level":4,"score":0.464163601398468},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.46400371193885803},{"id":"https://openalex.org/C2777292972","wikidata":"https://www.wikidata.org/wiki/Q423762","display_name":"Paclitaxel","level":3,"score":0.43225905299186707},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.42629849910736084},{"id":"https://openalex.org/C2780456651","wikidata":"https://www.wikidata.org/wiki/Q238512","display_name":"Fluorouracil","level":3,"score":0.410995215177536},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.33540019392967224}],"mesh":[{"descriptor_ui":"D000069287","descriptor_name":"Capecitabine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000964","descriptor_name":"Antimetabolites, Antineoplastic","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000964","descriptor_name":"Antimetabolites, Antineoplastic","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D003841","descriptor_name":"Deoxycytidine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D003841","descriptor_name":"Deoxycytidine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D003841","descriptor_name":"Deoxycytidine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D004935","descriptor_name":"Esophageal Diseases","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D004938","descriptor_name":"Esophageal Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D005472","descriptor_name":"Fluorouracil","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013274","descriptor_name":"Stomach Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D017326","descriptor_name":"Clinical Trials, Phase III as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/cncr.21986","doi":"https://doi.org/10.1002/cncr.21986","is_oa":false,"landing_page_url":"https://doi.org/10.1002/cncr.21986","pdf_url":null,"source":{"id":"https://openalex.org/S126033908","display_name":"Cancer","issn_l":"0008-543X","issn":["0008-543X","1045-7410","1097-0142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"journal-article"},{"id":"pmid:16770784","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16770784","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":64,"referenced_works":["https://openalex.org/W7246245","https://openalex.org/W611873600","https://openalex.org/W1483592745","https://openalex.org/W1848862702","https://openalex.org/W1875994730","https://openalex.org/W1940613095","https://openalex.org/W1954264896","https://openalex.org/W1958115519","https://openalex.org/W1965806699","https://openalex.org/W1969037111","https://openalex.org/W1974449546","https://openalex.org/W1978026907","https://openalex.org/W1981480220","https://openalex.org/W1993389431","https://openalex.org/W2001333832","https://openalex.org/W2008575122","https://openalex.org/W2012007322","https://openalex.org/W2018619890","https://openalex.org/W2018643571","https://openalex.org/W2020830322","https://openalex.org/W2028593808","https://openalex.org/W2029730331","https://openalex.org/W2035874162","https://openalex.org/W2044970916","https://openalex.org/W2056634859","https://openalex.org/W2057965951","https://openalex.org/W2058105025","https://openalex.org/W2064636208","https://openalex.org/W2068225833","https://openalex.org/W2087234093","https://openalex.org/W2090941375","https://openalex.org/W2092888371","https://openalex.org/W2106719016","https://openalex.org/W2106787323","https://openalex.org/W2116419063","https://openalex.org/W2118247947","https://openalex.org/W2122879222","https://openalex.org/W2131463911","https://openalex.org/W2137194656","https://openalex.org/W2142751306","https://openalex.org/W2143870027","https://openalex.org/W2147338520","https://openalex.org/W2156645058","https://openalex.org/W2157308207","https://openalex.org/W2169106066","https://openalex.org/W2171531063","https://openalex.org/W2224575593","https://openalex.org/W2229673777","https://openalex.org/W2240638428","https://openalex.org/W2260976961","https://openalex.org/W2263155398","https://openalex.org/W2268444908","https://openalex.org/W2270709789","https://openalex.org/W2272809506","https://openalex.org/W2299383865","https://openalex.org/W2328684596","https://openalex.org/W2336779220","https://openalex.org/W2344564639","https://openalex.org/W2395101107","https://openalex.org/W2411001292","https://openalex.org/W2589531825","https://openalex.org/W2591148839","https://openalex.org/W4211070159","https://openalex.org/W4233130113"],"related_works":["https://openalex.org/W1912470641","https://openalex.org/W2170864036","https://openalex.org/W2112605615","https://openalex.org/W2059972659","https://openalex.org/W2250097951","https://openalex.org/W2033136737","https://openalex.org/W3158992533","https://openalex.org/W2080852612","https://openalex.org/W4281949988","https://openalex.org/W2150046939"],"abstract_inverted_index":{"Capecitabine":[0,54],"is":[1,55,212],"a":[2,32,195,207,213],"novel,":[3],"orally":[4],"administered":[5],"fluoropyrimidine":[6],"carbamate":[7],"that":[8,95,107,159,233],"has":[9,148],"been":[10,149],"approved":[11],"for":[12,64,91],"adjuvant":[13,83,248],"treatment":[14,66],"in":[15,45,58,74,81,172,186,194,216,243],"patients":[16,36],"with":[17,47,104,139,151,162,239],"Stage":[18],"III":[19,166,222,228],"colon":[20],"cancer,":[21,25,29],"first-line":[22,76,174,245],"metastatic":[23,27,77,175,246],"colorectal":[24],"and":[26,42,44,61,70,117,125,145,177,237,247],"breast":[28],"both":[30,244],"as":[31,206],"single":[33],"agent":[34,215],"(for":[35],"who":[37],"are":[38,180,224],"resistant":[39],"to":[40],"paclitaxel":[41],"anthracyclines)":[43],"combination":[46],"docetaxel":[48],"(after":[49],"failure":[50],"on":[51],"anthracycline-based":[52],"therapy).":[53],"being":[56],"investigated":[57,135],"Phase":[59,165,221,227],"I":[60],"II":[62],"trials":[63,94,167,223,229],"the":[65,75,82,111,121,126,173],"of":[67,114,120,129,168,198,209,230],"gastric,":[68],"gastroesophageal,":[69],"esophageal":[71],"cancers,":[72],"primarily":[73],"setting":[78],"but":[79],"also":[80,147],"setting.":[84],"The":[85,132],"MEDLINE":[86],"data":[87,158,163],"base":[88],"was":[89],"searched":[90],"English-language":[92],"clinical":[93],"were":[96,108,137],"published":[97],"from":[98,164],"1996":[99],"through":[100],"October":[101],"2005":[102],"along":[103],"relevant":[105],"abstracts":[106],"presented":[109],"at":[110,118],"American":[112],"Society":[113,128],"Clinical":[115],"Oncology":[116],"meetings":[119],"European":[122,127],"Cancer":[123],"Conference":[124],"Medical":[130],"Oncology.":[131],"most":[133],"frequently":[134],"combinations":[136,232],"capecitabine":[138,146],"docetaxel,":[140],"paclitaxel,":[141],"cisplatin,":[142],"or":[143,201],"oxaliplatin,":[144],"combined":[150,185],"irinotecan.":[152],"These":[153],"therapies":[154],"have":[155],"yielded":[156],"efficacy":[157,236],"compare":[160,234],"favorably":[161],"parenteral":[169,240],"5-fluorouracil":[170],"(5-FU)":[171],"setting,":[176],"they":[178],"mostly":[179],"well":[181],"tolerated.":[182],"Capecitabine,":[183,205],"when":[184],"doses":[187],"<1250":[188],"mg/m(2)":[189],"twice":[190],"daily,":[191],"consistently":[192],"resulted":[193],"lower":[196],"frequency":[197],"Grade":[199],"3":[200],"4":[202],"toxic":[203],"effects.":[204],"representative":[208],"oral":[210],"fluoropymidine,":[211],"promising":[214],"gastroesophageal":[217],"cancers.":[218],"Although":[219],"some":[220],"completed,":[225],"additional":[226],"capecitabine-based":[231],"its":[235],"safety":[238],"5-FU-based":[241],"combinations,":[242],"settings,":[249],"would":[250],"be":[251],"important.":[252]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
