{"id":"https://openalex.org/W198522820","doi":null,"title":"[Glucagon-like peptide-1 regulates lipometabolism by down-regulating adipose triglyceride lipase in 3T3-L1 adipocytes].","display_name":"[Glucagon-like peptide-1 regulates lipometabolism by down-regulating adipose triglyceride lipase in 3T3-L1 adipocytes].","publication_year":2013,"publication_date":"2013-10-01","ids":{"openalex":"https://openalex.org/W198522820","mag":"198522820","pmid":"https://pubmed.ncbi.nlm.nih.gov/24144755"},"language":"zh","primary_location":{"id":"pmid:24144755","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24144755","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nan fang yi ke da xue xue bao = Journal of Southern Medical University","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102012640","display_name":"Huili Zhu","orcid":"https://orcid.org/0000-0003-2369-0123","observed_orcids":["https://orcid.org/0000-0003-2369-0123"]},"institutions":[{"id":"https://openalex.org/I4210162753","display_name":"First Affiliated Hospital of Jinan University","ror":"https://ror.org/05d5vvz89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210162753"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huili Zhu","raw_affiliation_strings":["First Affiliated Hospital of Jinan University, Guangzhou 510630, China. E-mail: zhlffff@163.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Affiliated Hospital of Jinan University, Guangzhou 510630, China. E-mail: zhlffff@163.com","institution_ids":["https://openalex.org/I4210162753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009439498","display_name":"Zeping Weng","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zeping Weng","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101768796","display_name":"Chenli Lin","orcid":"https://orcid.org/0000-0001-6901-7896","observed_orcids":["https://orcid.org/0000-0001-6901-7896"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chenli Lin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100935362","display_name":"Jiwei Ma","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jiwei Ma","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5003931980","display_name":"Xueyun Zhong","orcid":"https://orcid.org/0000-0001-9242-2291","observed_orcids":["https://orcid.org/0000-0001-9242-2291"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xueyun Zhong","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.02726002,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"33","issue":"10","first_page":"1499","last_page":"503"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11457","display_name":"Adipose Tissue and Metabolism","score":0.33739998936653137,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11457","display_name":"Adipose Tissue and Metabolism","score":0.33739998936653137,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":0.2831999957561493,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.07819999754428864,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glucagon-like-peptide-1","display_name":"glucagon-like peptide-1","score":1.0},{"id":"https://openalex.org/keywords/adipose-triglyceride-lipase","display_name":"adipose triglyceride lipase","score":0.9950000047683716},{"id":"https://openalex.org/keywords/3t3-l1-adipocytes","display_name":"3T3-L1 adipocytes","score":0.949999988079071},{"id":"https://openalex.org/keywords/lipolysis","display_name":"lipolysis","score":0.8769999742507935},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.671999990940094},{"id":"https://openalex.org/keywords/glut4-translocation","display_name":"GLUT4 translocation","score":0.8920000195503235},{"id":"https://openalex.org/keywords/akt1","display_name":"AKT1","score":0.7789999842643738},{"id":"https://openalex.org/keywords/akt2","display_name":"AKT2","score":0.996999979019165},{"id":"https://openalex.org/keywords/insulin-signaling","display_name":"insulin signaling","score":0.6570000052452087},{"id":"https://openalex.org/keywords/glucose-transporters","display_name":"glucose transporters","score":0.3930000066757202},{"id":"https://openalex.org/keywords/lipid-metabolism","display_name":"lipid metabolism","score":0.6489999890327454}],"concepts":[{"id":"https://openalex.org/C2776188179","wikidata":"https://www.wikidata.org/wiki/Q24768727","display_name":"GLUT4","level":4,"score":0.9050867557525635},{"id":"https://openalex.org/C2777062983","wikidata":"https://www.wikidata.org/wiki/Q21126841","display_name":"Adipose triglyceride lipase","level":4,"score":0.8952161073684692},{"id":"https://openalex.org/C142536801","wikidata":"https://www.wikidata.org/wiki/Q4636414","display_name":"3T3-L1","level":4,"score":0.8785600662231445},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6610496044158936},{"id":"https://openalex.org/C140985366","wikidata":"https://www.wikidata.org/wiki/Q898489","display_name":"Lipolysis","level":3,"score":0.6175495386123657},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6020549535751343},{"id":"https://openalex.org/C88216763","wikidata":"https://www.wikidata.org/wiki/Q4652205","display_name":"AKT2","level":5,"score":0.5856710076332092},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5802410244941711},{"id":"https://openalex.org/C161573976","wikidata":"https://www.wikidata.org/wiki/Q420277","display_name":"Glucose transporter","level":3,"score":0.559840738773346},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.5293980836868286},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.4923497438430786},{"id":"https://openalex.org/C2777866211","wikidata":"https://www.wikidata.org/wiki/Q5572349","display_name":"Glucose uptake","level":3,"score":0.4153299927711487},{"id":"https://openalex.org/C2776175234","wikidata":"https://www.wikidata.org/wiki/Q357519","display_name":"Adipocyte","level":3,"score":0.4142516851425171},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.41085532307624817},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.400826096534729},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.3814324140548706},{"id":"https://openalex.org/C154137905","wikidata":"https://www.wikidata.org/wiki/Q17816452","display_name":"AKT1","level":4,"score":0.3184501528739929},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24854737520217896},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20186439156532288},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.07527673244476318}],"mesh":[{"descriptor_ui":"D000217","descriptor_name":"Acyltransferases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004357","descriptor_name":"Drug Synergism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007333","descriptor_name":"Insulin Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007425","descriptor_name":"Intracellular Membranes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008049","descriptor_name":"Lipase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017667","descriptor_name":"Adipocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D017667","descriptor_name":"Adipocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D021381","descriptor_name":"Protein Transport","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D041721","descriptor_name":"3T3-L1 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051057","descriptor_name":"Proto-Oncogene Proteins c-akt","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051275","descriptor_name":"Glucose Transporter Type 4","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052216","descriptor_name":"Glucagon-Like Peptide 1","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"pmid:24144755","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24144755","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nan fang yi ke da xue xue bao = Journal of Southern Medical University","raw_type":"Journal Article"},{"id":"mag:198522820","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24144755","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null},{"id":"mag:2284228735","doi":null,"is_oa":false,"landing_page_url":"http://www.cqvip.com/QK/91170A/201310/47448347.html","pdf_url":null,"source":{"id":"https://openalex.org/S4306545097","display_name":"\u5357\u65b9\u533b\u79d1\u5927\u5b66\u5b66\u62a5","issn_l":"1000-2588","issn":["1000-2588","1673-4254"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["ki-jl-1","medline","poland-20","russia-white-list-3"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"\u5357\u65b9\u533b\u79d1\u5927\u5b66\u5b66\u62a5","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2284228735","https://openalex.org/W2103052169","https://openalex.org/W2149528363","https://openalex.org/W2345270412","https://openalex.org/W4304620044","https://openalex.org/W2389735898","https://openalex.org/W6990629071","https://openalex.org/W2079889142","https://openalex.org/W2020604155","https://openalex.org/W3153018936"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"investigate":[2],"the":[3,17,39,58,91,97,102,114,128,138],"effect":[4,116],"of":[5,42,93,99,117,130,140],"glucagon-like":[6],"peptide-1":[7],"(GLP-1)":[8],"on":[9],"glycolipid":[10],"metabolism":[11],"in":[12,57,67,80,119,142],"3T3-L1":[13,20,68,81,120,143],"adipocytes":[14,21],"and":[15,32,54,72,95,132],"explore":[16],"mechanism.":[18],"METHODS:":[19],"were":[22,74,110],"treated":[23],"with":[24],"GLP-1,":[25],"insulin,":[26],"or":[27],"both":[28],"for":[29],"24":[30],"h,":[31],"Western":[33],"blotting":[34],"was":[35,61,84],"used":[36,62],"to":[37,63,105],"analyze":[38],"expression":[40,92,129],"levels":[41],"adipose":[43],"triglyceride":[44],"lipase":[45],"(ATGL),":[46],"glucose":[47],"transporter":[48],"type":[49],"4":[50],"(GLUT4),":[51],"Akt1,":[52],"Akt2":[53,73],"phosphorylated":[55,85],"Akt":[56,83],"cells.":[59],"Immunofluorescence":[60],"observe":[64],"lipid":[65],"content":[66],"adipocytes.":[69,82,121,144],"RESULTS:":[70],"Akt1":[71],"not":[75],"activated":[76],"by":[77,86,126,136],"insulin":[78,118,134],"stimulation":[79],"GLP-1":[87,123],"stimulation,":[88],"which":[89],"inhibited":[90],"ATGL":[94,131],"increased":[96],"translocation":[98,139],"GLUT4":[100,141],"from":[101],"intracellular":[103],"membranes":[104],"plasma":[106],"membranes.":[107],"These":[108],"changes":[109],"more":[111],"obvious":[112],"under":[113],"synergistic":[115],"CONCLUSION:":[122],"decreases":[124],"lipolysis":[125],"inhibiting":[127],"improves":[133],"resistance":[135],"increasing":[137]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
