{"id":"https://openalex.org/W1985228059","doi":"https://doi.org/10.1002/jcb.240501120","title":"Transforming growth factors and related peptides in gastrointestinal neoplasia","display_name":"Transforming growth factors and related peptides in gastrointestinal neoplasia","publication_year":1992,"publication_date":"1992-01-01","ids":{"openalex":"https://openalex.org/W1985228059","doi":"https://doi.org/10.1002/jcb.240501120","mag":"1985228059","pmid":"https://pubmed.ncbi.nlm.nih.gov/1335097"},"language":"en","primary_location":{"id":"doi:10.1002/jcb.240501120","doi":"https://doi.org/10.1002/jcb.240501120","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jcb.240501120","pdf_url":null,"source":{"id":"https://openalex.org/S53807158","display_name":"Journal of Cellular Biochemistry","issn_l":"0730-2312","issn":["0730-2312","1097-4644"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cellular Biochemistry","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046249010","display_name":"Robert J. Coffey","orcid":"https://orcid.org/0000-0002-2180-3844","observed_orcids":["https://orcid.org/0000-0002-2180-3844"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert J. Coffey","raw_affiliation_strings":["Department of Medicine (Gastroenterology) and Cell Biology, Vanderbilt University, Nashville, Tennessee 37232"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine (Gastroenterology) and Cell Biology, Vanderbilt University, Nashville, Tennessee 37232","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041139090","display_name":"Carol M. McCutchen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carol M. McCutchen","raw_affiliation_strings":["Department of Medicine (Gastroenterology ) and Cell Biology, Vanderbilt University, Nashville, Tennessee 37232"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine (Gastroenterology ) and Cell Biology, Vanderbilt University, Nashville, Tennessee 37232","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036988988","display_name":"Ramona Graves\u2010Deal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ramona Graves-Deal","raw_affiliation_strings":["Department of Medicine (Gastroenterology ) and Cell Biology, Vanderbilt University, Nashville, Tennessee 37232","Department of Medicine, Gastroenterology Division, MCN/C\u20102104, Vanderbilt University, Nashvilfe TN 37232\u20102279"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine (Gastroenterology ) and Cell Biology, Vanderbilt University, Nashville, Tennessee 37232","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"Department of Medicine, Gastroenterology Division, MCN/C\u20102104, Vanderbilt University, Nashvilfe TN 37232\u20102279","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090332721","display_name":"William H. Polk","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William H. Polk","raw_affiliation_strings":["Department of Surgery, Vanderbilt University, Nashville, Tennessee 37232"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Vanderbilt University, Nashville, Tennessee 37232","institution_ids":["https://openalex.org/I200719446"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5036988988"],"corresponding_institution_ids":["https://openalex.org/I200719446"],"apc_list":{"value":5110,"currency":"USD","value_usd":5110},"apc_paid":null,"fwci":0.1452,"has_fulltext":false,"cited_by_count":32,"citation_normalized_percentile":{"value":0.17557932,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"50","issue":"S16G","first_page":"111","last_page":"118"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/transforming-growth-factor-alpha","display_name":"transforming growth factor-alpha","score":0.9950000047683716},{"id":"https://openalex.org/keywords/tgf-beta1","display_name":"TGF-\u03b21","score":0.9800000190734863},{"id":"https://openalex.org/keywords/gastrointestinal-cancer","display_name":"gastrointestinal cancer","score":0.9259999990463257},{"id":"https://openalex.org/keywords/colon-cancer","display_name":"colon cancer","score":0.9860000014305115},{"id":"https://openalex.org/keywords/growth-factor-receptors","display_name":"growth factor receptors","score":0.7279999852180481},{"id":"https://openalex.org/keywords/mrna-expression","display_name":"mRNA expression","score":0.8500000238418579},{"id":"https://openalex.org/keywords/epithelial-cell-proliferation","display_name":"epithelial cell proliferation","score":0.7329999804496765},{"id":"https://openalex.org/keywords/tumor-promotion","display_name":"tumor promotion","score":0.8820000290870667},{"id":"https://openalex.org/keywords/transgenic-mice","display_name":"transgenic mice","score":0.8840000033378601},{"id":"https://openalex.org/keywords/cell-transformation","display_name":"cell transformation","score":0.4050000011920929}],"concepts":[{"id":"https://openalex.org/C118131993","wikidata":"https://www.wikidata.org/wiki/Q423671","display_name":"Transforming growth factor","level":2,"score":0.7953853607177734},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5760753154754639},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5639786720275879},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.5482504963874817},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.5175080299377441},{"id":"https://openalex.org/C141035611","wikidata":"https://www.wikidata.org/wiki/Q5532934","display_name":"Genetically modified mouse","level":4,"score":0.5126160979270935},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.46794360876083374},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4555373191833496},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4400304853916168},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3810083568096161},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.32936203479766846},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.21713367104530334}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002471","descriptor_name":"Cell Transformation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003106","descriptor_name":"Colon","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005770","descriptor_name":"Gastrointestinal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005770","descriptor_name":"Gastrointestinal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005810","descriptor_name":"Multigene Family","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011519","descriptor_name":"Proto-Oncogenes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016211","descriptor_name":"Transforming Growth Factor alpha","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D016211","descriptor_name":"Transforming Growth Factor alpha","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016211","descriptor_name":"Transforming Growth Factor alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016212","descriptor_name":"Transforming Growth Factor beta","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D016212","descriptor_name":"Transforming Growth Factor beta","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016212","descriptor_name":"Transforming Growth Factor beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018125","descriptor_name":"Receptors, Transforming Growth Factor beta","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/jcb.240501120","doi":"https://doi.org/10.1002/jcb.240501120","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jcb.240501120","pdf_url":null,"source":{"id":"https://openalex.org/S53807158","display_name":"Journal of Cellular Biochemistry","issn_l":"0730-2312","issn":["0730-2312","1097-4644"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cellular Biochemistry","raw_type":"journal-article"},{"id":"pmid:1335097","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1335097","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cellular biochemistry. Supplement","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2924300808","display_name":null,"funder_award_id":"CA46413","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8868505193","display_name":"Role of EGFR Ligands in Neoplasia","funder_award_id":"R01CA046413","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":50,"referenced_works":["https://openalex.org/W8347340","https://openalex.org/W44741267","https://openalex.org/W55784314","https://openalex.org/W151446319","https://openalex.org/W1587325941","https://openalex.org/W1852725426","https://openalex.org/W1924000143","https://openalex.org/W1932528123","https://openalex.org/W1965084403","https://openalex.org/W1973033337","https://openalex.org/W1973557583","https://openalex.org/W1974449627","https://openalex.org/W1974466807","https://openalex.org/W1979040485","https://openalex.org/W1980561309","https://openalex.org/W1980755859","https://openalex.org/W1982738011","https://openalex.org/W1982882974","https://openalex.org/W1991195167","https://openalex.org/W2008465346","https://openalex.org/W2011334059","https://openalex.org/W2018911817","https://openalex.org/W2023423199","https://openalex.org/W2024507604","https://openalex.org/W2036033314","https://openalex.org/W2037722366","https://openalex.org/W2038086562","https://openalex.org/W2046756969","https://openalex.org/W2048905477","https://openalex.org/W2054012934","https://openalex.org/W2055149726","https://openalex.org/W2071607446","https://openalex.org/W2071972670","https://openalex.org/W2085899645","https://openalex.org/W2092429540","https://openalex.org/W2113992548","https://openalex.org/W2118299100","https://openalex.org/W2124806986","https://openalex.org/W2128891019","https://openalex.org/W2129414194","https://openalex.org/W2133009685","https://openalex.org/W2144910592","https://openalex.org/W2161271976","https://openalex.org/W2166277258","https://openalex.org/W2167490614","https://openalex.org/W2337783739","https://openalex.org/W2412183380","https://openalex.org/W2415032506","https://openalex.org/W2764885353","https://openalex.org/W3151144641"],"related_works":["https://openalex.org/W2398405755","https://openalex.org/W2097725160","https://openalex.org/W7043605591","https://openalex.org/W2273538832","https://openalex.org/W1982882974","https://openalex.org/W2070617849","https://openalex.org/W2463427090","https://openalex.org/W1976035032","https://openalex.org/W2163575930","https://openalex.org/W2165183041"],"abstract_inverted_index":{"Transforming":[0],"growth":[1,24,60],"factor":[2],"alpha":[3,8,27,89,102],"and":[4,9,19,62,72],"beta":[5,11,35],"1":[6,36],"(TGF":[7],"TGF":[10,26,34,88,101],"1)":[12],"are":[13],"representative":[14],"members":[15],"of":[16,22,43,68,110],"two":[17],"distinct":[18],"expanding":[20],"families":[21],"polypeptide":[23],"factors.":[25],"is":[28,52,76,90,112],"an":[29],"epithelial":[30,38],"cell":[31,39],"mitogen,":[32],"whereas":[33],"inhibits":[37],"growth;":[40],"the":[41,49,94,108],"role":[42,99],"these":[44,59],"factors":[45,61],"in":[46,65,79,86,93,107],"contributing":[47],"to":[48],"transformed":[50],"phenotype":[51],"uncertain.":[53],"Steady":[54],"state":[55],"mRNA":[56],"expression":[57],"for":[58,100],"their":[63],"receptors":[64],"a":[66,97,104],"panel":[67],"human":[69],"colon":[70],"cancers":[71],"adjacent":[73],"normal":[74],"mucosa":[75],"presented.":[77],"Based":[78],"part":[80],"on":[81],"results":[82],"from":[83],"transgenic":[84],"mice":[85],"which":[87],"selectively":[91],"overproduced":[92],"mammary":[95],"gland,":[96],"possible":[98],"as":[103],"tumor":[105],"promoter":[106],"process":[109],"transformation":[111],"discussed.":[113]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}