{"id":"https://openalex.org/W1985223777","doi":"https://doi.org/10.1177/154405910308200905","title":"Effects of Echistatin and an RGD Peptide on Orthodontic Tooth Movement","display_name":"Effects of Echistatin and an RGD Peptide on Orthodontic Tooth Movement","publication_year":2003,"publication_date":"2003-09-01","ids":{"openalex":"https://openalex.org/W1985223777","doi":"https://doi.org/10.1177/154405910308200905","mag":"1985223777","pmid":"https://pubmed.ncbi.nlm.nih.gov/12939350"},"language":"en","primary_location":{"id":"doi:10.1177/154405910308200905","doi":"https://doi.org/10.1177/154405910308200905","is_oa":false,"landing_page_url":"https://doi.org/10.1177/154405910308200905","pdf_url":null,"source":{"id":"https://openalex.org/S62865007","display_name":"Journal of Dental Research","issn_l":"0022-0345","issn":["0022-0345","1544-0591"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Dental Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079550929","display_name":"Calogero Dolce","orcid":"https://orcid.org/0000-0002-9634-3854","observed_orcids":["https://orcid.org/0000-0002-9634-3854"]},"institutions":[{"id":"https://openalex.org/I2800717037","display_name":"University of Florida Health","ror":"https://ror.org/04tk2gy88","country_code":"US","type":"education","lineage":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]},{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C. Dolce","raw_affiliation_strings":["Department of Orthodontics, College of Dentistry, University of Florida, Box 100444, JHMHC, Gainesville, FL 32610-0444;","Department of Orthodontics, College of Dentistry, University of Florida, Box 100444, JHMHC, Gainesville, FL 32610-0444, USA. cdolce@dental.ufl.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthodontics, College of Dentistry, University of Florida, Box 100444, JHMHC, Gainesville, FL 32610-0444;","institution_ids":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]},{"raw_affiliation_string":"Department of Orthodontics, College of Dentistry, University of Florida, Box 100444, JHMHC, Gainesville, FL 32610-0444, USA. cdolce@dental.ufl.edu","institution_ids":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073025705","display_name":"A. Vakani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800717037","display_name":"University of Florida Health","ror":"https://ror.org/04tk2gy88","country_code":"US","type":"education","lineage":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]},{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. Vakani","raw_affiliation_strings":["Department of Orthodontics, College of Dentistry, University of Florida, Box 100444, JHMHC, Gainesville, FL 32610-0444;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthodontics, College of Dentistry, University of Florida, Box 100444, JHMHC, Gainesville, FL 32610-0444;","institution_ids":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":null,"display_name":"L. Archer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800717037","display_name":"University of Florida Health","ror":"https://ror.org/04tk2gy88","country_code":"US","type":"education","lineage":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]},{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L. Archer","raw_affiliation_strings":["Department of Orthodontics, College of Dentistry, University of Florida, Box 100444, JHMHC, Gainesville, FL 32610-0444;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthodontics, College of Dentistry, University of Florida, Box 100444, JHMHC, Gainesville, FL 32610-0444;","institution_ids":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008872979","display_name":"Joyce A Morris-Wiman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800717037","display_name":"University of Florida Health","ror":"https://ror.org/04tk2gy88","country_code":"US","type":"education","lineage":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]},{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J.A. Morris-Wiman","raw_affiliation_strings":["Department of Orthodontics, College of Dentistry, University of Florida, Box 100444, JHMHC, Gainesville, FL 32610-0444;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthodontics, College of Dentistry, University of Florida, Box 100444, JHMHC, Gainesville, FL 32610-0444;","institution_ids":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084245350","display_name":"Lexie Shannon Holliday","orcid":"https://orcid.org/0000-0002-0844-1965","observed_orcids":["https://orcid.org/0000-0002-0844-1965"]},"institutions":[{"id":"https://openalex.org/I2800717037","display_name":"University of Florida Health","ror":"https://ror.org/04tk2gy88","country_code":"US","type":"education","lineage":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]},{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L.S. Holliday","raw_affiliation_strings":["Department of Orthodontics, College of Dentistry, University of Florida, Box 100444, JHMHC, Gainesville, FL 32610-0444;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthodontics, College of Dentistry, University of Florida, Box 100444, JHMHC, Gainesville, FL 32610-0444;","institution_ids":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4400,"currency":"USD","value_usd":4400},"apc_paid":null,"fwci":3.0546,"has_fulltext":false,"cited_by_count":38,"citation_normalized_percentile":{"value":0.88520527,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"82","issue":"9","first_page":"682","last_page":"686"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10356","display_name":"Orthodontics and Dentofacial Orthopedics","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/3505","display_name":"Orthodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10356","display_name":"Orthodontics and Dentofacial Orthopedics","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/3505","display_name":"Orthodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11919","display_name":"dental development and anomalies","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/orthodontic-tooth-movement","display_name":"orthodontic tooth movement","score":0.9070000052452087},{"id":"https://openalex.org/keywords/echistatin","display_name":"echistatin","score":0.9980000257492065},{"id":"https://openalex.org/keywords/rgd-peptide","display_name":"RGD peptide","score":0.972000002861023},{"id":"https://openalex.org/keywords/integrin-inhibitors","display_name":"integrin inhibitors","score":0.8529999852180481},{"id":"https://openalex.org/keywords/bone-remodeling","display_name":"bone remodeling","score":0.6850000023841858},{"id":"https://openalex.org/keywords/osteoclasts","display_name":"osteoclasts","score":0.8849999904632568},{"id":"https://openalex.org/keywords/sustained-release","display_name":"sustained drug release","score":0.7770000100135803},{"id":"https://openalex.org/keywords/ethylene-vinyl-acetate","display_name":"ethylene vinyl acetate","score":0.9240000247955322},{"id":"https://openalex.org/keywords/periodontal-ligament","display_name":"periodontal ligament","score":0.8410000205039978},{"id":"https://openalex.org/keywords/local-drug-administration","display_name":"local drug administration","score":0.42800000309944153}],"concepts":[{"id":"https://openalex.org/C202271784","wikidata":"https://www.wikidata.org/wiki/Q189218","display_name":"Molar","level":2,"score":0.754278838634491},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.6636478900909424},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5681628584861755},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.4676973819732666},{"id":"https://openalex.org/C2777756961","wikidata":"https://www.wikidata.org/wiki/Q620730","display_name":"Glycine","level":3,"score":0.4459741413593292},{"id":"https://openalex.org/C199343813","wikidata":"https://www.wikidata.org/wiki/Q12128","display_name":"Dentistry","level":1,"score":0.3801816999912262},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.3139182925224304},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.22736376523971558},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2090013325214386}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000704","descriptor_name":"Analysis of Variance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002508","descriptor_name":"Cephalometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003692","descriptor_name":"Delayed-Action Preparations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005240","descriptor_name":"Feasibility Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008437","descriptor_name":"Maxilla","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008963","descriptor_name":"Molar","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009842","descriptor_name":"Oligopeptides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010010","descriptor_name":"Osteoclasts","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011145","descriptor_name":"Polyvinyls","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011971","descriptor_name":"Receptors, Immunologic","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D014087","descriptor_name":"Tooth Movement Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014757","descriptor_name":"Viper Venoms","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D016023","descriptor_name":"Integrins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D016723","descriptor_name":"Bone Remodeling","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019030","descriptor_name":"Receptors, Vitronectin","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D036341","descriptor_name":"Intercellular Signaling Peptides and Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1177/154405910308200905","doi":"https://doi.org/10.1177/154405910308200905","is_oa":false,"landing_page_url":"https://doi.org/10.1177/154405910308200905","pdf_url":null,"source":{"id":"https://openalex.org/S62865007","display_name":"Journal of Dental Research","issn_l":"0022-0345","issn":["0022-0345","1544-0591"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Dental Research","raw_type":"journal-article"},{"id":"pmid:12939350","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12939350","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of dental research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G6052271337","display_name":"Integrins and Orthodontic Tooth Movement","funder_award_id":"5r03de013857-02","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6268705949","display_name":null,"funder_award_id":"DE13857","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"},{"id":"https://openalex.org/G7587627229","display_name":"Osteoclast activation in uremic bone disease","funder_award_id":"R01AR047959","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G991245020","display_name":null,"funder_award_id":"AR47959","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"},{"id":"https://openalex.org/F4320337365","display_name":"National Institute of Dental and Craniofacial Research","ror":"https://ror.org/004a2wv92"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W17029058","https://openalex.org/W88187846","https://openalex.org/W1967268115","https://openalex.org/W1967502057","https://openalex.org/W1967654423","https://openalex.org/W1975730039","https://openalex.org/W1982267750","https://openalex.org/W1993346651","https://openalex.org/W1994659764","https://openalex.org/W1995866466","https://openalex.org/W2006725651","https://openalex.org/W2015877034","https://openalex.org/W2022811527","https://openalex.org/W2025137697","https://openalex.org/W2052580681","https://openalex.org/W2060429863","https://openalex.org/W2068015571","https://openalex.org/W2068063049","https://openalex.org/W2070316095","https://openalex.org/W2091693164","https://openalex.org/W2112136254","https://openalex.org/W2137022580","https://openalex.org/W2156287729","https://openalex.org/W2160873496","https://openalex.org/W2417438168","https://openalex.org/W2437290885"],"related_works":["https://openalex.org/W7096587452","https://openalex.org/W2049603363","https://openalex.org/W2021471228","https://openalex.org/W2132289554","https://openalex.org/W2953984184","https://openalex.org/W2385483961","https://openalex.org/W2906506419","https://openalex.org/W2377779008","https://openalex.org/W4306678314","https://openalex.org/W2151188291"],"abstract_inverted_index":{"We":[0],"tested":[1],"whether":[2],"orthodontic":[3,98,137],"tooth":[4,99,132],"movement":[5,100,133],"(OTM)":[6],"could":[7],"be":[8],"blocked":[9],"by":[10],"local":[11,131],"administration":[12],"of":[13,119],"echistatin":[14,51,88],"or":[15,87],"an":[16],"arginine-glycine-aspartic":[17],"acid":[18],"(RGD)":[19],"peptide,":[20],"agents":[21],"known":[22],"to":[23,28,65,93,122,127,129,136],"perturb":[24],"bone":[25],"remodeling,":[26],"adjacent":[27,126],"maxillary":[29,95],"molars":[30,96],"in":[31,59,134],"rats.":[32],"These":[33],"molecules":[34],"were":[35,55],"incorporated":[36],"into":[37,75],"ethylene-vinyl":[38],"acetate":[39],"(ELVAX),":[40],"a":[41],"non-biodegradable,":[42],"sustained-release":[43],"polymer.":[44],"In":[45],"vitro":[46],"experiments":[47],"showed":[48],"that":[49],"the":[50,76,94,117],"and":[52,89],"RGD":[53,69,85,105],"peptide":[54,70,86,106],"released":[56,72],"from":[57,73],"ELVAX":[58,74,81,121],"active":[60],"forms":[61],"at":[62],"levels":[63],"sufficient":[64],"disrupt":[66],"osteoclasts.":[67],"Biotinylated":[68],"was":[71],"PDL":[77],"after":[78],"surgical":[79],"implantation.":[80],"loaded":[82],"with":[83],"either":[84],"surgically":[90],"implanted":[91],"next":[92],"inhibited":[97],"(p":[101,111],"<":[102,112],"0.01).":[103],"The":[104],"also":[107],"reduced":[108],"molar":[109],"drift":[110],"0.05).":[113],"This":[114],"study":[115],"shows":[116],"feasibility":[118],"using":[120],"deliver":[123],"integrin":[124],"inhibitors":[125],"teeth":[128],"limit":[130],"response":[135],"forces.":[138]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
