{"id":"https://openalex.org/W1985207474","doi":"https://doi.org/10.1016/j.brainres.2007.07.100","title":"Corticotropin-releasing hormone receptors in the medial prefrontal cortex regulate hypothalamic\u2013pituitary\u2013adrenal activity and anxiety-related behavior regardless of prior stress experience","display_name":"Corticotropin-releasing hormone receptors in the medial prefrontal cortex regulate hypothalamic\u2013pituitary\u2013adrenal activity and anxiety-related behavior regardless of prior stress experience","publication_year":2007,"publication_date":"2007-09-20","ids":{"openalex":"https://openalex.org/W1985207474","doi":"https://doi.org/10.1016/j.brainres.2007.07.100","mag":"1985207474","pmid":"https://pubmed.ncbi.nlm.nih.gov/18001698","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2175080"},"language":"en","primary_location":{"id":"doi:10.1016/j.brainres.2007.07.100","doi":"https://doi.org/10.1016/j.brainres.2007.07.100","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.brainres.2007.07.100","pdf_url":null,"source":{"id":"https://openalex.org/S96638545","display_name":"Brain Research","issn_l":"0006-8993","issn":["0006-8993","1872-6240"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2175080","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010639458","display_name":"Azra Jaferi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Azra Jaferi","raw_affiliation_strings":["Department of Psychology, University of Michigan, MI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychology, University of Michigan, MI, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005944709","display_name":"Seema Bhatnagar","orcid":"https://orcid.org/0000-0003-4371-0910","observed_orcids":["https://orcid.org/0000-0003-4371-0910"]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Seema Bhatnagar","raw_affiliation_strings":["Department of Anesthesiology, School of Medicine, Children's Hospital of Philadelphia, PA 19104, USA","University of Pennsylvania, Philadelphia, PA 19104, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, School of Medicine, Children's Hospital of Philadelphia, PA 19104, USA","institution_ids":["https://openalex.org/I1335321130"]},{"raw_affiliation_string":"University of Pennsylvania, Philadelphia, PA 19104, USA","institution_ids":["https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5005944709"],"corresponding_institution_ids":["https://openalex.org/I1335321130","https://openalex.org/I79576946"],"apc_list":{"value":3360,"currency":"USD","value_usd":3360},"apc_paid":null,"fwci":1.8012,"has_fulltext":false,"cited_by_count":84,"citation_normalized_percentile":{"value":0.81569474,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"1186","issue":null,"first_page":"212","last_page":"223"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11541","display_name":"Neuroendocrine regulation and behavior","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/3207","display_name":"Social Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/corticotropin-releasing-factor","display_name":"corticotropin-releasing factor","score":0.9330000281333923},{"id":"https://openalex.org/keywords/crh-receptors","display_name":"CRH receptors","score":0.6660000085830688},{"id":"https://openalex.org/keywords/medial-prefrontal-cortex","display_name":"medial prefrontal cortex","score":0.9919999837875366},{"id":"https://openalex.org/keywords/hypothalamic-pituitary-adrenal-axis","display_name":"hypothalamic-pituitary-adrenal axis","score":0.9929999709129333},{"id":"https://openalex.org/keywords/anxiety-like-behavior","display_name":"anxiety-like behavior","score":0.7609999775886536},{"id":"https://openalex.org/keywords/repeated-stress","display_name":"repeated stress","score":0.5490000247955322},{"id":"https://openalex.org/keywords/restraint-stress","display_name":"restraint stress","score":0.8389999866485596},{"id":"https://openalex.org/keywords/elevated-plus-maze","display_name":"elevated plus maze","score":0.8270000219345093},{"id":"https://openalex.org/keywords/stress-response-regulation","display_name":"stress response regulation","score":0.5139999985694885}],"concepts":[{"id":"https://openalex.org/C2781195155","wikidata":"https://www.wikidata.org/wiki/Q18680","display_name":"Prefrontal cortex","level":3,"score":0.7016831040382385},{"id":"https://openalex.org/C558461103","wikidata":"https://www.wikidata.org/wiki/Q154430","display_name":"Anxiety","level":2,"score":0.574838399887085},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.5374956727027893},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5265766978263855},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5128786563873291},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5084359049797058},{"id":"https://openalex.org/C2777003273","wikidata":"https://www.wikidata.org/wiki/Q164386","display_name":"Hypothalamus","level":2,"score":0.4967270493507385},{"id":"https://openalex.org/C2780546910","wikidata":"https://www.wikidata.org/wiki/Q185690","display_name":"Adrenocorticotropic hormone","level":3,"score":0.4939289689064026},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.48290181159973145},{"id":"https://openalex.org/C2779558481","wikidata":"https://www.wikidata.org/wiki/Q2355954","display_name":"Stress hormone","level":3,"score":0.4536038637161255},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.44008830189704895},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3265261948108673},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.11724638938903809},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.0565316379070282}],"mesh":[{"descriptor_ui":"D000222","descriptor_name":"Adaptation, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000324","descriptor_name":"Adrenocorticotropic Hormone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001007","descriptor_name":"Anxiety","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001245","descriptor_name":"Association Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003345","descriptor_name":"Corticosterone","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003346","descriptor_name":"Corticotropin-Releasing Hormone","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D003346","descriptor_name":"Corticotropin-Releasing Hormone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006185","descriptor_name":"Habituation, Psychophysiologic","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D007030","descriptor_name":"Hypothalamo-Hypophyseal System","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010913","descriptor_name":"Pituitary-Adrenal System","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013315","descriptor_name":"Stress, Psychological","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017397","descriptor_name":"Prefrontal Cortex","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018019","descriptor_name":"Receptors, Corticotropin-Releasing Hormone","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D018019","descriptor_name":"Receptors, Corticotropin-Releasing Hormone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.brainres.2007.07.100","doi":"https://doi.org/10.1016/j.brainres.2007.07.100","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.brainres.2007.07.100","pdf_url":null,"source":{"id":"https://openalex.org/S96638545","display_name":"Brain Research","issn_l":"0006-8993","issn":["0006-8993","1872-6240"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain Research","raw_type":"journal-article"},{"id":"pmid:18001698","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18001698","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain research","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:1379252","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2175080","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:2175080","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2175080","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Brain Res","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:1379252","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2175080","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8999999761581421,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.7300000190734863,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1886354186","display_name":"Role of central CRF systems in chronic stress responses","funder_award_id":"5f31mh069071-03","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G560785378","display_name":null,"funder_award_id":"5F31MH069071","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G6004425557","display_name":null,"funder_award_id":"F31 MH069071","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G6815679293","display_name":"Neural Circuitry Underlying Chronic Stress Effects","funder_award_id":"R01MH067651","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"}],"funders":[{"id":"https://openalex.org/F4320309652","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":101,"referenced_works":["https://openalex.org/W14396242","https://openalex.org/W280469932","https://openalex.org/W1518117902","https://openalex.org/W1521382255","https://openalex.org/W1535894955","https://openalex.org/W1547358456","https://openalex.org/W1617973807","https://openalex.org/W1659705459","https://openalex.org/W1877857226","https://openalex.org/W1920823193","https://openalex.org/W1927719697","https://openalex.org/W1951492130","https://openalex.org/W1965045797","https://openalex.org/W1967827729","https://openalex.org/W1969601654","https://openalex.org/W1975218744","https://openalex.org/W1975889182","https://openalex.org/W1976131491","https://openalex.org/W1976727298","https://openalex.org/W1978509199","https://openalex.org/W1979567195","https://openalex.org/W1981304815","https://openalex.org/W1985304419","https://openalex.org/W1990400180","https://openalex.org/W1995308981","https://openalex.org/W1995892920","https://openalex.org/W1999076203","https://openalex.org/W2000081665","https://openalex.org/W2001628402","https://openalex.org/W2002731382","https://openalex.org/W2003983445","https://openalex.org/W2004159545","https://openalex.org/W2004744978","https://openalex.org/W2008860212","https://openalex.org/W2012416101","https://openalex.org/W2012483271","https://openalex.org/W2012958393","https://openalex.org/W2013398667","https://openalex.org/W2015780545","https://openalex.org/W2016120721","https://openalex.org/W2018782871","https://openalex.org/W2020159446","https://openalex.org/W2024512909","https://openalex.org/W2026988768","https://openalex.org/W2027907042","https://openalex.org/W2029677928","https://openalex.org/W2031513328","https://openalex.org/W2038990782","https://openalex.org/W2039560714","https://openalex.org/W2041561931","https://openalex.org/W2041736210","https://openalex.org/W2044246448","https://openalex.org/W2044823814","https://openalex.org/W2047723877","https://openalex.org/W2048417345","https://openalex.org/W2055620693","https://openalex.org/W2056301492","https://openalex.org/W2057969028","https://openalex.org/W2061478482","https://openalex.org/W2062408214","https://openalex.org/W2063494264","https://openalex.org/W2066491784","https://openalex.org/W2069637786","https://openalex.org/W2070524299","https://openalex.org/W2071371666","https://openalex.org/W2078830390","https://openalex.org/W2079342919","https://openalex.org/W2079570643","https://openalex.org/W2089759334","https://openalex.org/W2090421493","https://openalex.org/W2091824230","https://openalex.org/W2092953670","https://openalex.org/W2093475197","https://openalex.org/W2095057322","https://openalex.org/W2095491277","https://openalex.org/W2098925242","https://openalex.org/W2107858261","https://openalex.org/W2114770633","https://openalex.org/W2115215262","https://openalex.org/W2118238128","https://openalex.org/W2126401900","https://openalex.org/W2129340317","https://openalex.org/W2137983860","https://openalex.org/W2140159910","https://openalex.org/W2146132701","https://openalex.org/W2146415593","https://openalex.org/W2149878393","https://openalex.org/W2156873270","https://openalex.org/W2158052449","https://openalex.org/W2158128209","https://openalex.org/W2159594385","https://openalex.org/W2160425673","https://openalex.org/W2163815564","https://openalex.org/W2164313237","https://openalex.org/W2165949694","https://openalex.org/W2166271275","https://openalex.org/W2167326675","https://openalex.org/W2171420106","https://openalex.org/W2171934036","https://openalex.org/W3114739857","https://openalex.org/W4321429266"],"related_works":["https://openalex.org/W2031492177","https://openalex.org/W2021464806","https://openalex.org/W2095905991","https://openalex.org/W6987089542","https://openalex.org/W1547358456","https://openalex.org/W7099869650","https://openalex.org/W2048654839","https://openalex.org/W3110269534","https://openalex.org/W2025899369","https://openalex.org/W2146132701"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":8}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}