{"id":"https://openalex.org/W1985201730","doi":"https://doi.org/10.1371/journal.pone.0000106","title":"An NF-\u03baB and Slug Regulatory Loop Active in Early Vertebrate Mesoderm","display_name":"An NF-\u03baB and Slug Regulatory Loop Active in Early Vertebrate Mesoderm","publication_year":2006,"publication_date":"2006-12-27","ids":{"openalex":"https://openalex.org/W1985201730","doi":"https://doi.org/10.1371/journal.pone.0000106","mag":"1985201730","pmid":"https://pubmed.ncbi.nlm.nih.gov/17205110","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1762408"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0000106","doi":"https://doi.org/10.1371/journal.pone.0000106","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0000106","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0000106&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0000106&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100458214","display_name":"Chi Zhang","orcid":"https://orcid.org/0000-0002-9297-0690","observed_orcids":["https://orcid.org/0000-0002-9297-0690"]},"institutions":[{"id":"https://openalex.org/I188538660","display_name":"University of Colorado Boulder","ror":"https://ror.org/02ttsq026","country_code":"US","type":"education","lineage":["https://openalex.org/I188538660"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chi Zhang","raw_affiliation_strings":["Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, Colorado, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, Colorado, United States of America","institution_ids":["https://openalex.org/I188538660"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108403064","display_name":"Timothy F. Carl","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I188538660","display_name":"University of Colorado Boulder","ror":"https://ror.org/02ttsq026","country_code":"US","type":"education","lineage":["https://openalex.org/I188538660"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Timothy F. Carl","raw_affiliation_strings":["Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, Colorado, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, Colorado, United States of America","institution_ids":["https://openalex.org/I188538660"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001691043","display_name":"Evan D. Trudeau","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I188538660","display_name":"University of Colorado Boulder","ror":"https://ror.org/02ttsq026","country_code":"US","type":"education","lineage":["https://openalex.org/I188538660"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Evan D. Trudeau","raw_affiliation_strings":["Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, Colorado, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, Colorado, United States of America","institution_ids":["https://openalex.org/I188538660"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105416609","display_name":"Thomas Simmet","orcid":"https://orcid.org/0000-0002-8027-2617","observed_orcids":["https://orcid.org/0000-0002-8027-2617"]},"institutions":[{"id":"https://openalex.org/I196349391","display_name":"Universit\u00e4t Ulm","ror":"https://ror.org/032000t02","country_code":"DE","type":"education","lineage":["https://openalex.org/I196349391"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Thomas Simmet","raw_affiliation_strings":["Institute of Pharmacology of Natural Products and Clinical Pharmacology, University of Ulm, Ulm, Germany","Institute of Pharmacology of Natural Products & Clinical Pharmacology, University of Ulm, Ulm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pharmacology of Natural Products and Clinical Pharmacology, University of Ulm, Ulm, Germany","institution_ids":["https://openalex.org/I196349391"]},{"raw_affiliation_string":"Institute of Pharmacology of Natural Products & Clinical Pharmacology, University of Ulm, Ulm, Germany","institution_ids":["https://openalex.org/I196349391"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055780182","display_name":"Michael W. Klymkowsky","orcid":"https://orcid.org/0000-0001-5816-9771","observed_orcids":["https://orcid.org/0000-0001-5816-9771"]},"institutions":[{"id":"https://openalex.org/I188538660","display_name":"University of Colorado Boulder","ror":"https://ror.org/02ttsq026","country_code":"US","type":"education","lineage":["https://openalex.org/I188538660"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Michael W. Klymkowsky","raw_affiliation_strings":["Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, Colorado, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, Colorado, United States of America","institution_ids":["https://openalex.org/I188538660"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5055780182"],"corresponding_institution_ids":["https://openalex.org/I188538660"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":2.0376,"has_fulltext":true,"cited_by_count":49,"citation_normalized_percentile":{"value":0.84707232,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"1","issue":"1","first_page":"e106","last_page":"e106"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.00419999985024333,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/slug","display_name":"Slug","score":0.843999981880188},{"id":"https://openalex.org/keywords/snails","display_name":"snails","score":0.8349999785423279},{"id":"https://openalex.org/keywords/nf-kappab","display_name":"NF-\u03baB","score":0.8859999775886536},{"id":"https://openalex.org/keywords/mesoderm-formation","display_name":"mesoderm formation","score":0.824999988079071},{"id":"https://openalex.org/keywords/neural-crest-formation","display_name":"neural crest formation","score":0.7870000004768372},{"id":"https://openalex.org/keywords/epithelial-mesenchymal-transition","display_name":"epithelial-mesenchymal transition","score":0.949999988079071},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8769999742507935},{"id":"https://openalex.org/keywords/bcl-xl","display_name":"Bcl-xL","score":0.9850000143051147},{"id":"https://openalex.org/keywords/ikappab-kinase","display_name":"I\u03baB kinase","score":0.9369999766349792},{"id":"https://openalex.org/keywords/rela","display_name":"RelA","score":0.6259999871253967},{"id":"https://openalex.org/keywords/rel2","display_name":"REL2","score":0.8659999966621399},{"id":"https://openalex.org/keywords/caspase-9","display_name":"caspase-9","score":0.9409999847412109},{"id":"https://openalex.org/keywords/xenopus-laevis","display_name":"Xenopus laevis","score":0.8410000205039978},{"id":"https://openalex.org/keywords/morpholino-knockdown","display_name":"morpholino knockdown","score":0.8240000009536743}],"concepts":[{"id":"https://openalex.org/C2781381752","wikidata":"https://www.wikidata.org/wiki/Q1953597","display_name":"Slug","level":2,"score":0.9289708137512207},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8251622915267944},{"id":"https://openalex.org/C2780915607","wikidata":"https://www.wikidata.org/wiki/Q323438","display_name":"Mesoderm","level":4,"score":0.8142989873886108},{"id":"https://openalex.org/C2779535977","wikidata":"https://www.wikidata.org/wiki/Q1342298","display_name":"Xenopus","level":3,"score":0.6743366122245789},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6724148988723755},{"id":"https://openalex.org/C2777124376","wikidata":"https://www.wikidata.org/wiki/Q8072277","display_name":"Zinc finger transcription factor","level":5,"score":0.5887974500656128},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.5716872215270996},{"id":"https://openalex.org/C136571751","wikidata":"https://www.wikidata.org/wiki/Q424607","display_name":"Morpholino","level":4,"score":0.5406152606010437},{"id":"https://openalex.org/C24284526","wikidata":"https://www.wikidata.org/wiki/Q204785","display_name":"Zinc finger","level":4,"score":0.4828510880470276},{"id":"https://openalex.org/C126749454","wikidata":"https://www.wikidata.org/wiki/Q1348455","display_name":"Neural crest","level":3,"score":0.4558710753917694},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2787696123123169},{"id":"https://openalex.org/C2776878037","wikidata":"https://www.wikidata.org/wiki/Q169444","display_name":"Zebrafish","level":3,"score":0.24834096431732178},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.2011207938194275},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.19732388854026794},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.17893177270889282},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.13505396246910095}],"mesh":[{"descriptor_ui":"D000071250","descriptor_name":"Snail Family Transcription Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008648","descriptor_name":"Mesoderm","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":true},{"descriptor_ui":"D008648","descriptor_name":"Mesoderm","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014982","descriptor_name":"Xenopus laevis","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":true},{"descriptor_ui":"D014982","descriptor_name":"Xenopus laevis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014982","descriptor_name":"Xenopus laevis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017931","descriptor_name":"DNA Primers","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018507","descriptor_name":"Gene Expression Regulation, Developmental","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019253","descriptor_name":"Proto-Oncogene Proteins c-bcl-2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020319","descriptor_name":"Oligodeoxyribonucleotides, Antisense","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029867","descriptor_name":"Xenopus Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D029867","descriptor_name":"Xenopus Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D029867","descriptor_name":"Xenopus Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D030801","descriptor_name":"Animals, Genetically Modified","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051020","descriptor_name":"bcl-X Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1371/journal.pone.0000106","doi":"https://doi.org/10.1371/journal.pone.0000106","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0000106","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0000106&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmid:17205110","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17205110","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:632399255af846da9df2e1529c79c686","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/632399255af846da9df2e1529c79c686","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 1, p e106 (2006)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0000106","doi":"https://doi.org/10.1371/journal.pone.0000106","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0000106","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0000106&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8048999905586243,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2924281905","display_name":null,"funder_award_id":"GM54001","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G8994402681","display_name":"CATENINS, EPITHELIAL BEHAVIOR AND GENE EXPRESSION","funder_award_id":"R01GM054001","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320306182","display_name":"March of Dimes Foundation","ror":"https://ror.org/04bd5p711"},{"id":"https://openalex.org/F4320306230","display_name":"American Heart Association","ror":"https://ror.org/013kjyp64"},{"id":"https://openalex.org/F4320323556","display_name":"Deutsche Krebshilfe","ror":"https://ror.org/01wxdd722"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1985201730.pdf","grobid_xml":"https://content.openalex.org/works/W1985201730.grobid-xml"},"referenced_works_count":149,"referenced_works":["https://openalex.org/W35473498","https://openalex.org/W74337203","https://openalex.org/W1525178559","https://openalex.org/W1565712144","https://openalex.org/W1607382116","https://openalex.org/W1658652867","https://openalex.org/W1778245127","https://openalex.org/W1790685184","https://openalex.org/W1809702767","https://openalex.org/W1874287342","https://openalex.org/W1890923531","https://openalex.org/W1911954838","https://openalex.org/W1912873449","https://openalex.org/W1915074145","https://openalex.org/W1939615246","https://openalex.org/W1948956899","https://openalex.org/W1949487746","https://openalex.org/W1965822047","https://openalex.org/W1970140424","https://openalex.org/W1970596089","https://openalex.org/W1970798233","https://openalex.org/W1973170858","https://openalex.org/W1973862406","https://openalex.org/W1974109645","https://openalex.org/W1976820032","https://openalex.org/W1977346307","https://openalex.org/W1980401861","https://openalex.org/W1983828713","https://openalex.org/W1984634814","https://openalex.org/W1986683530","https://openalex.org/W1988798314","https://openalex.org/W1990201193","https://openalex.org/W1990903306","https://openalex.org/W1993075625","https://openalex.org/W1994015824","https://openalex.org/W1994242450","https://openalex.org/W1995168697","https://openalex.org/W1995644262","https://openalex.org/W1997094245","https://openalex.org/W2003149480","https://openalex.org/W2005051338","https://openalex.org/W2006417453","https://openalex.org/W2010523714","https://openalex.org/W2010854221","https://openalex.org/W2011496352","https://openalex.org/W2013589301","https://openalex.org/W2013746488","https://openalex.org/W2016414500","https://openalex.org/W2021863302","https://openalex.org/W2025853097","https://openalex.org/W2025914311","https://openalex.org/W2027059131","https://openalex.org/W2030714994","https://openalex.org/W2031019010","https://openalex.org/W2033342703","https://openalex.org/W2033458380","https://openalex.org/W2033509429","https://openalex.org/W2033624366","https://openalex.org/W2033762793","https://openalex.org/W2037397876","https://openalex.org/W2039410291","https://openalex.org/W2039748798","https://openalex.org/W2041559240","https://openalex.org/W2041728327","https://openalex.org/W2045324074","https://openalex.org/W2046037771","https://openalex.org/W2046056065","https://openalex.org/W2047063509","https://openalex.org/W2052408181","https://openalex.org/W2055304598","https://openalex.org/W2057967850","https://openalex.org/W2059572507","https://openalex.org/W2060308517","https://openalex.org/W2062654253","https://openalex.org/W2065832539","https://openalex.org/W2068279595","https://openalex.org/W2069312900","https://openalex.org/W2069603887","https://openalex.org/W2071018297","https://openalex.org/W2072001338","https://openalex.org/W2073554410","https://openalex.org/W2074933818","https://openalex.org/W2075093878","https://openalex.org/W2075386924","https://openalex.org/W2075721098","https://openalex.org/W2075759604","https://openalex.org/W2076038104","https://openalex.org/W2077720819","https://openalex.org/W2079181843","https://openalex.org/W2079762169","https://openalex.org/W2083271514","https://openalex.org/W2084448229","https://openalex.org/W2085618630","https://openalex.org/W2086519742","https://openalex.org/W2086533520","https://openalex.org/W2087367170","https://openalex.org/W2088354566","https://openalex.org/W2091154399","https://openalex.org/W2092715066","https://openalex.org/W2095202492","https://openalex.org/W2102514614","https://openalex.org/W2103780536","https://openalex.org/W2104312647","https://openalex.org/W2105296759","https://openalex.org/W2107495315","https://openalex.org/W2108186158","https://openalex.org/W2109998353","https://openalex.org/W2112286579","https://openalex.org/W2112482541","https://openalex.org/W2113558048","https://openalex.org/W2115861317","https://openalex.org/W2116026731","https://openalex.org/W2116842204","https://openalex.org/W2125917793","https://openalex.org/W2133378734","https://openalex.org/W2134203671","https://openalex.org/W2134542375","https://openalex.org/W2137280750","https://openalex.org/W2139328195","https://openalex.org/W2139928557","https://openalex.org/W2140551998","https://openalex.org/W2141290206","https://openalex.org/W2146410026","https://openalex.org/W2148524869","https://openalex.org/W2151812223","https://openalex.org/W2154633327","https://openalex.org/W2154918211","https://openalex.org/W2155482231","https://openalex.org/W2155516654","https://openalex.org/W2155554726","https://openalex.org/W2156273277","https://openalex.org/W2158370511","https://openalex.org/W2159526033","https://openalex.org/W2161537000","https://openalex.org/W2165901622","https://openalex.org/W2165987163","https://openalex.org/W2170773649","https://openalex.org/W2171180591","https://openalex.org/W2185450900","https://openalex.org/W2288623603","https://openalex.org/W2299653895","https://openalex.org/W2315613727","https://openalex.org/W2328269288","https://openalex.org/W2335925695","https://openalex.org/W2340443225","https://openalex.org/W2417292153","https://openalex.org/W2439819887","https://openalex.org/W4300790656","https://openalex.org/W6701979062"],"related_works":["https://openalex.org/W7095898769","https://openalex.org/W1971703943","https://openalex.org/W2096171314","https://openalex.org/W7099037912","https://openalex.org/W2088568448","https://openalex.org/W2091056599","https://openalex.org/W7098610002","https://openalex.org/W2151812223","https://openalex.org/W16179074","https://openalex.org/W2158905542"],"abstract_inverted_index":{"BACKGROUND:":[0],"In":[1],"both":[2,75,176],"Drosophila":[3,161],"and":[4,34,42,52,77,119,135,137,179,185],"the":[5,7,32,35,71,93,106,129,142,159,181],"mouse,":[6],"zinc":[8],"finger":[9],"transcription":[10,108],"factor":[11,109],"Snail":[12,43,120],"is":[13,68,170],"required":[14,26,69],"for":[15,27,70],"mesoderm":[16],"formation;":[17],"its":[18],"vertebrate":[19],"paralog":[20],"Slug":[21,41,67,118,122],"(Snai2)":[22],"appears":[23],"to":[24,45,48,53,155],"be":[25],"neural":[28,78],"crest":[29,79],"formation":[30,166],"in":[31,81,112,158,167,177,180],"chick":[33],"clawed":[36],"frog":[37],"Xenopus":[38],"laevis.":[39,83],"Both":[40,84],"act":[44],"induce":[46],"epithelial":[47],"mesenchymal":[49],"transition":[50],"(EMT)":[51],"suppress":[54],"apoptosis.":[55],"METHODOLOGY":[56],"&":[57],"PRINCIPLE":[58],"FINDINGS:":[59],"Morpholino-based":[60],"loss":[61],"of":[62,74,90,105,117,126,141,174,183],"function":[63],"studies":[64,148],"indicate":[65],"that":[66,156],"normal":[72],"expression":[73],"mesodermal":[76,165],"markers":[80],"X.":[82],"phenotypes":[85],"are":[86,99],"rescued":[87],"by":[88],"injection":[89],"RNA":[91],"encoding":[92,128],"anti-apoptotic":[94],"protein":[95],"Bcl-xL;":[96],"Bcl-xL's":[97],"effects":[98],"dependent":[100],"upon":[101],"IkappaB":[102],"kinase-mediated":[103],"activation":[104],"bipartite":[107],"NF-kappaB.":[110],"NF-kappaB,":[111],"turn,":[113],"directly":[114,138],"up-regulates":[115,124],"levels":[116,125,140],"RNAs.":[121],"indirectly":[123],"RNAs":[127],"NF-kappaB":[130],"subunit":[131],"proteins":[132],"RelA,":[133],"Rel2,":[134],"Rel3,":[136],"down-regulates":[139],"pro-apopotic":[143],"Caspase-9":[144],"RNA.":[145],"CONCLUSIONS/SIGNIFICANCE:":[146],"These":[147],"reveal":[149],"a":[150,171],"Slug/Snail-NF-kappaB":[151],"regulatory":[152,172],"circuit,":[153],"analogous":[154],"present":[157],"early":[160],"embryo,":[162],"active":[163],"during":[164],"Xenopus.":[168],"This":[169],"interaction":[173],"significance":[175],"development":[178],"course":[182],"inflammatory":[184],"metastatic":[186],"disease.":[187]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":6}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}