{"id":"https://openalex.org/W1985197868","doi":"https://doi.org/10.3390/genes3040686","title":"Using Multiple Phenotype Assays and Epistasis Testing to Enhance the Reliability of RNAi Screening and Identify Regulators of Muscle Protein Degradation","display_name":"Using Multiple Phenotype Assays and Epistasis Testing to Enhance the Reliability of RNAi Screening and Identify Regulators of Muscle Protein Degradation","publication_year":2012,"publication_date":"2012-11-02","ids":{"openalex":"https://openalex.org/W1985197868","doi":"https://doi.org/10.3390/genes3040686","mag":"1985197868","pmid":"https://pubmed.ncbi.nlm.nih.gov/23152949","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3495584"},"language":"en","primary_location":{"id":"doi:10.3390/genes3040686","doi":"https://doi.org/10.3390/genes3040686","is_oa":true,"landing_page_url":"https://doi.org/10.3390/genes3040686","pdf_url":"https://www.mdpi.com/2073-4425/3/4/686/pdf?version=1352129776","source":{"id":"https://openalex.org/S194631498","display_name":"Genes","issn_l":"2073-4425","issn":["2073-4425"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genes","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2073-4425/3/4/686/pdf?version=1352129776","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007474952","display_name":"Susann Lehmann","orcid":"https://orcid.org/0000-0001-9041-3383","observed_orcids":["https://orcid.org/0000-0001-9041-3383","https://orcid.org/0009-0001-0580-4580"]},"institutions":[{"id":"https://openalex.org/I142263535","display_name":"University of Nottingham","ror":"https://ror.org/01ee9ar58","country_code":"GB","type":"education","lineage":["https://openalex.org/I142263535"]},{"id":"https://openalex.org/I2799342194","display_name":"Royal Derby Hospital","ror":"https://ror.org/005r9p256","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2799342194","https://openalex.org/I4210149821"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Susann Lehmann","raw_affiliation_strings":["Medical Resarch Council/Arthritis Research UK Centre for Musculoskeletal Ageing Research, University of Nottingham, Royal Derby Hospital, Derby, DE22 3DT, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Resarch Council/Arthritis Research UK Centre for Musculoskeletal Ageing Research, University of Nottingham, Royal Derby Hospital, Derby, DE22 3DT, UK","institution_ids":["https://openalex.org/I142263535","https://openalex.org/I2799342194"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044284922","display_name":"Freya Shephard","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142263535","display_name":"University of Nottingham","ror":"https://ror.org/01ee9ar58","country_code":"GB","type":"education","lineage":["https://openalex.org/I142263535"]},{"id":"https://openalex.org/I4387156334","display_name":"Arthritis Research UK","ror":"https://ror.org/03phf2w66","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I4210117448","https://openalex.org/I4387156334"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Freya Shephard","raw_affiliation_strings":["Medical Resarch Council/Arthritis Research UK Centre for Musculoskeletal Ageing Research, University of Nottingham, School of Veterinary Medicine & Science, Sutton Bonington, LE12 5RD, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Resarch Council/Arthritis Research UK Centre for Musculoskeletal Ageing Research, University of Nottingham, School of Veterinary Medicine & Science, Sutton Bonington, LE12 5RD, UK","institution_ids":["https://openalex.org/I142263535","https://openalex.org/I4387156334"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091449127","display_name":"Lewis A. Jacobson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lewis A. Jacobson","raw_affiliation_strings":["Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA 15260, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA 15260, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059648760","display_name":"Nathaniel J. Szewczyk","orcid":"https://orcid.org/0000-0003-4425-9746","observed_orcids":["https://orcid.org/0000-0003-4425-9746"]},"institutions":[{"id":"https://openalex.org/I142263535","display_name":"University of Nottingham","ror":"https://ror.org/01ee9ar58","country_code":"GB","type":"education","lineage":["https://openalex.org/I142263535"]},{"id":"https://openalex.org/I2799342194","display_name":"Royal Derby Hospital","ror":"https://ror.org/005r9p256","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2799342194","https://openalex.org/I4210149821"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Nathaniel J. Szewczyk","raw_affiliation_strings":["Medical Resarch Council/Arthritis Research UK Centre for Musculoskeletal Ageing Research, University of Nottingham, Royal Derby Hospital, Derby, DE22 3DT, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Resarch Council/Arthritis Research UK Centre for Musculoskeletal Ageing Research, University of Nottingham, Royal Derby Hospital, Derby, DE22 3DT, UK","institution_ids":["https://openalex.org/I142263535","https://openalex.org/I2799342194"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5007474952","https://openalex.org/A5059648760"],"corresponding_institution_ids":["https://openalex.org/I142263535","https://openalex.org/I2799342194"],"apc_list":{"value":2600,"currency":"CHF","value_usd":3137},"apc_paid":{"value":2600,"currency":"CHF","value_usd":3137},"fwci":0.386,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.57198967,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"3","issue":"4","first_page":"686","last_page":"701"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.510699987411499,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.510699987411499,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.186599999666214,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.1160999983549118,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rnai-screening","display_name":"RNAi screening","score":0.9629999995231628},{"id":"https://openalex.org/keywords/muscle-protein-degradation","display_name":"muscle protein degradation","score":0.9150000214576721},{"id":"https://openalex.org/keywords/caenorhabditis-elegans","display_name":"Caenorhabditis elegans","score":0.9559999704360962},{"id":"https://openalex.org/keywords/false-positives-and-false-negatives","display_name":"false positives and false negatives","score":0.5130000114440918},{"id":"https://openalex.org/keywords/multiplexed-screening","display_name":"multiplexed screening","score":0.5720000267028809},{"id":"https://openalex.org/keywords/phenotypic-assays","display_name":"phenotypic assays","score":0.5809999704360962},{"id":"https://openalex.org/keywords/proteasome-inhibitors","display_name":"proteasome inhibitors","score":0.6240000128746033},{"id":"https://openalex.org/keywords/gene-knockdown","display_name":"gene knockdown","score":0.48399999737739563}],"concepts":[{"id":"https://openalex.org/C166703698","wikidata":"https://www.wikidata.org/wiki/Q201993","display_name":"RNA interference","level":4,"score":0.8119312524795532},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.6370735764503479},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.613558828830719},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.607912540435791},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6004114151000977},{"id":"https://openalex.org/C64869954","wikidata":"https://www.wikidata.org/wiki/Q1859747","display_name":"False positive paradox","level":2,"score":0.5301728248596191},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4640324115753174},{"id":"https://openalex.org/C2992195973","wikidata":"https://www.wikidata.org/wiki/Q33123","display_name":"Protein degradation","level":2,"score":0.4561876058578491},{"id":"https://openalex.org/C6555983","wikidata":"https://www.wikidata.org/wiki/Q7181398","display_name":"Phenotypic screening","level":4,"score":0.41227617859840393},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.36345070600509644},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3442744314670563},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2695080637931824},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.17067289352416992},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.12675127387046814},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[],"locations_count":6,"locations":[{"id":"doi:10.3390/genes3040686","doi":"https://doi.org/10.3390/genes3040686","is_oa":true,"landing_page_url":"https://doi.org/10.3390/genes3040686","pdf_url":"https://www.mdpi.com/2073-4425/3/4/686/pdf?version=1352129776","source":{"id":"https://openalex.org/S194631498","display_name":"Genes","issn_l":"2073-4425","issn":["2073-4425"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genes","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2493375","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3495584","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3495584","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3495584","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genes (Basel)","raw_type":"Text"},{"id":"pmid:23152949","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23152949","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genes","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.397.171","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.397.171","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.mdpi.com/2073-4425/3/4/686/pdf/","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:1d8ec3295b614f73bb7e2ded9a55d7d8","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/1d8ec3295b614f73bb7e2ded9a55d7d8","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Genes, Vol 3, Iss 4, Pp 686-701 (2012)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/genes3040686","doi":"https://doi.org/10.3390/genes3040686","is_oa":true,"landing_page_url":"https://doi.org/10.3390/genes3040686","pdf_url":"https://www.mdpi.com/2073-4425/3/4/686/pdf?version=1352129776","source":{"id":"https://openalex.org/S194631498","display_name":"Genes","issn_l":"2073-4425","issn":["2073-4425"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genes","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3724397141","display_name":"Gene Networks Regulating Muscle Protein Degradation","funder_award_id":"R01AR054342","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G7593207116","display_name":null,"funder_award_id":"G0801271","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1985197868.pdf","grobid_xml":"https://content.openalex.org/works/W1985197868.grobid-xml"},"referenced_works_count":54,"referenced_works":["https://openalex.org/W1581485762","https://openalex.org/W1647075334","https://openalex.org/W1944127002","https://openalex.org/W1979428788","https://openalex.org/W1985213868","https://openalex.org/W1986330164","https://openalex.org/W1990478935","https://openalex.org/W1991159765","https://openalex.org/W1996646269","https://openalex.org/W1998653602","https://openalex.org/W2000396646","https://openalex.org/W2018840791","https://openalex.org/W2025406638","https://openalex.org/W2028727571","https://openalex.org/W2035077771","https://openalex.org/W2038492783","https://openalex.org/W2047205406","https://openalex.org/W2047221065","https://openalex.org/W2050956010","https://openalex.org/W2058809066","https://openalex.org/W2060965926","https://openalex.org/W2068228035","https://openalex.org/W2069150012","https://openalex.org/W2074005945","https://openalex.org/W2078249988","https://openalex.org/W2091591117","https://openalex.org/W2095127655","https://openalex.org/W2099305058","https://openalex.org/W2099698491","https://openalex.org/W2100581989","https://openalex.org/W2103017472","https://openalex.org/W2104455432","https://openalex.org/W2107575096","https://openalex.org/W2107728988","https://openalex.org/W2112264994","https://openalex.org/W2115803302","https://openalex.org/W2117132491","https://openalex.org/W2124649441","https://openalex.org/W2126624770","https://openalex.org/W2128491398","https://openalex.org/W2135281682","https://openalex.org/W2141729174","https://openalex.org/W2147893071","https://openalex.org/W2152350957","https://openalex.org/W2158217645","https://openalex.org/W2159675211","https://openalex.org/W2165970635","https://openalex.org/W2166542841","https://openalex.org/W2171545955","https://openalex.org/W2471154810","https://openalex.org/W4200119855","https://openalex.org/W4205472914","https://openalex.org/W4237330088","https://openalex.org/W4247523613"],"related_works":["https://openalex.org/W1990478935","https://openalex.org/W2898513678","https://openalex.org/W4254321736","https://openalex.org/W2056798289","https://openalex.org/W369848682","https://openalex.org/W6991830045","https://openalex.org/W2096387803","https://openalex.org/W2068707689","https://openalex.org/W2061245947","https://openalex.org/W2400198141"],"abstract_inverted_index":{"RNAi":[0,50,110,142],"is":[1],"a":[2],"convenient,":[3],"widely":[4],"used":[5,16,47],"tool":[6],"for":[7,9,28],"screening":[8],"genes":[10],"of":[11,79,82,87,114,120,128],"interest.":[12],"We":[13,74],"have":[14,45,53,64,75],"recently":[15],"this":[17],"technology":[18],"to":[19,95],"screen":[20],"roughly":[21],"750":[22],"candidate":[23],"genes,":[24],"in":[25,31,36,69,72,84],"C.":[26],"elegans,":[27],"potential":[29,129],"roles":[30],"regulating":[32],"muscle":[33],"protein":[34,97],"degradation":[35,83,98],"vivo.":[37],"To":[38,59],"maximize":[39,60],"confidence":[40],"and":[41,52,57,116,118,132],"assess":[42],"reproducibility,":[43],"we":[44,63,103],"only":[46],"previously":[48,93],"validated":[49],"constructs":[51],"included":[54],"time":[55],"courses":[56],"replicates.":[58],"mechanistic":[61,138],"understanding,":[62],"examined":[65],"multiple":[66,70,107],"sub-cellular":[67],"phenotypes":[68],"compartments":[71],"muscle.":[73],"also":[76],"tested":[77],"knockdowns":[78],"putative":[80],"regulators":[81],"the":[85],"context":[86],"mutations":[88,115],"or":[89],"drugs":[90],"that":[91],"were":[92],"shown":[94],"inhibit":[96],"by":[99],"diverse":[100],"mechanisms.":[101],"Here":[102],"discuss":[104],"how":[105],"assaying":[106],"phenotypes,":[108],"multiplexing":[109],"screens":[111],"with":[112],"use":[113,119],"drugs,":[117],"bioinformatics":[121],"can":[122],"provide":[123],"more":[124,137],"data":[125],"on":[126],"rates":[127],"false":[130],"positives":[131],"negatives":[133],"as":[134,136],"well":[135],"insight":[139],"than":[140],"simple":[141],"screening.":[143]},"counts_by_year":[{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2016-06-24T00:00:00"}