{"id":"https://openalex.org/W1985196861","doi":"https://doi.org/10.1039/c3lc50980j","title":"Lab-on-a-chip technology: impacting non-invasive prenatal diagnostics (NIPD) through miniaturisation","display_name":"Lab-on-a-chip technology: impacting non-invasive prenatal diagnostics (NIPD) through miniaturisation","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W1985196861","doi":"https://doi.org/10.1039/c3lc50980j","mag":"1985196861","pmid":"https://pubmed.ncbi.nlm.nih.gov/24452749"},"language":"en","primary_location":{"id":"doi:10.1039/c3lc50980j","doi":"https://doi.org/10.1039/c3lc50980j","is_oa":false,"landing_page_url":"https://doi.org/10.1039/c3lc50980j","pdf_url":null,"source":{"id":"https://openalex.org/S116836101","display_name":"Lab on a Chip","issn_l":"1473-0189","issn":["1473-0189","1473-0197"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lab on a Chip","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085432019","display_name":"Chaitanya Kantak","orcid":"https://orcid.org/0000-0003-1620-7084","observed_orcids":["https://orcid.org/0000-0003-1620-7084"]},"institutions":[{"id":"https://openalex.org/I115228651","display_name":"Agency for Science, Technology and Research","ror":"https://ror.org/036wvzt09","country_code":"SG","type":"government","lineage":["https://openalex.org/I115228651"]},{"id":"https://openalex.org/I2799413724","display_name":"Singapore Science Park","ror":"https://ror.org/0023asr12","country_code":"SG","type":"archive","lineage":["https://openalex.org/I2799413724"]},{"id":"https://openalex.org/I4210090209","display_name":"Institute of Microelectronics","ror":"https://ror.org/009rw8n36","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I4210090209","https://openalex.org/I91275662"]}],"countries":["SG"],"is_corresponding":true,"raw_author_name":"Chaitanya Kantak","raw_affiliation_strings":["Institute of Microelectronics, Agency for Science Technology and Research, 11 Science Park Road, Singapore Science Park 2, Singapore 117685, Singapore. kantakcs@ime.a-star.edu.sg","Institute of Microelectronics, Agency for Science Technology and Research, 11 Science Park Road, Singapore Science Park 2,Singapore 117685,Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Microelectronics, Agency for Science Technology and Research, 11 Science Park Road, Singapore Science Park 2, Singapore 117685, Singapore. kantakcs@ime.a-star.edu.sg","institution_ids":["https://openalex.org/I115228651","https://openalex.org/I2799413724","https://openalex.org/I4210090209"]},{"raw_affiliation_string":"Institute of Microelectronics, Agency for Science Technology and Research, 11 Science Park Road, Singapore Science Park 2,Singapore 117685,Singapore","institution_ids":["https://openalex.org/I115228651","https://openalex.org/I2799413724","https://openalex.org/I4210090209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074783959","display_name":"Chia-Pin Chang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I115228651","display_name":"Agency for Science, Technology and Research","ror":"https://ror.org/036wvzt09","country_code":"SG","type":"government","lineage":["https://openalex.org/I115228651"]},{"id":"https://openalex.org/I2799413724","display_name":"Singapore Science Park","ror":"https://ror.org/0023asr12","country_code":"SG","type":"archive","lineage":["https://openalex.org/I2799413724"]},{"id":"https://openalex.org/I4210090209","display_name":"Institute of Microelectronics","ror":"https://ror.org/009rw8n36","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I4210090209","https://openalex.org/I91275662"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Chia-Pin Chang","raw_affiliation_strings":["Institute of Microelectronics, Agency for Science Technology and Research, 11 Science Park Road, Singapore Science Park 2, Singapore 117685, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Microelectronics, Agency for Science Technology and Research, 11 Science Park Road, Singapore Science Park 2, Singapore 117685, Singapore","institution_ids":["https://openalex.org/I115228651","https://openalex.org/I2799413724","https://openalex.org/I4210090209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113908776","display_name":"Chee Chung Wong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I115228651","display_name":"Agency for Science, Technology and Research","ror":"https://ror.org/036wvzt09","country_code":"SG","type":"government","lineage":["https://openalex.org/I115228651"]},{"id":"https://openalex.org/I2799413724","display_name":"Singapore Science Park","ror":"https://ror.org/0023asr12","country_code":"SG","type":"archive","lineage":["https://openalex.org/I2799413724"]},{"id":"https://openalex.org/I4210090209","display_name":"Institute of Microelectronics","ror":"https://ror.org/009rw8n36","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I4210090209","https://openalex.org/I91275662"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Chee Chung Wong","raw_affiliation_strings":["Institute of Microelectronics, Agency for Science Technology and Research, 11 Science Park Road, Singapore Science Park 2, Singapore 117685, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Microelectronics, Agency for Science Technology and Research, 11 Science Park Road, Singapore Science Park 2, Singapore 117685, Singapore","institution_ids":["https://openalex.org/I115228651","https://openalex.org/I2799413724","https://openalex.org/I4210090209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070710421","display_name":"Aniza Puteri Mahyuddin","orcid":"https://orcid.org/0000-0001-8570-8427","observed_orcids":["https://orcid.org/0000-0001-8570-8427"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Aniza Mahyuddin","raw_affiliation_strings":["YLL School of Medicine, National University of Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"YLL School of Medicine, National University of Singapore, Singapore","institution_ids":["https://openalex.org/I165932596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075249092","display_name":"Mahesh Arjandas Choolani","orcid":"https://orcid.org/0000-0001-8336-0973","observed_orcids":["https://orcid.org/0000-0001-8336-0973"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Mahesh Choolani","raw_affiliation_strings":["YLL School of Medicine, National University of Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"YLL School of Medicine, National University of Singapore, Singapore","institution_ids":["https://openalex.org/I165932596"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110232075","display_name":"Abdur Rahman","orcid":"https://orcid.org/0009-0006-6302-6269","observed_orcids":["https://orcid.org/0009-0006-6302-6269"]},"institutions":[{"id":"https://openalex.org/I115228651","display_name":"Agency for Science, Technology and Research","ror":"https://ror.org/036wvzt09","country_code":"SG","type":"government","lineage":["https://openalex.org/I115228651"]},{"id":"https://openalex.org/I2799413724","display_name":"Singapore Science Park","ror":"https://ror.org/0023asr12","country_code":"SG","type":"archive","lineage":["https://openalex.org/I2799413724"]},{"id":"https://openalex.org/I4210090209","display_name":"Institute of Microelectronics","ror":"https://ror.org/009rw8n36","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I4210090209","https://openalex.org/I91275662"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Abdur Rahman","raw_affiliation_strings":["Institute of Microelectronics, Agency for Science Technology and Research, 11 Science Park Road, Singapore Science Park 2, Singapore 117685, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Microelectronics, Agency for Science Technology and Research, 11 Science Park Road, Singapore Science Park 2, Singapore 117685, Singapore","institution_ids":["https://openalex.org/I115228651","https://openalex.org/I2799413724","https://openalex.org/I4210090209"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5085432019"],"corresponding_institution_ids":["https://openalex.org/I115228651","https://openalex.org/I2799413724","https://openalex.org/I4210090209"],"apc_list":null,"apc_paid":null,"fwci":0.5387,"has_fulltext":false,"cited_by_count":28,"citation_normalized_percentile":{"value":0.46673597,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"14","issue":"5","first_page":"841","last_page":"841"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10978","display_name":"Prenatal Screening and Diagnostics","score":0.8095999956130981,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10978","display_name":"Prenatal Screening and Diagnostics","score":0.8095999956130981,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10412","display_name":"Microfluidic and Capillary Electrophoresis Applications","score":0.18039999902248383,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11255","display_name":"Microfluidic and Bio-sensing Technologies","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/microfluidics","display_name":"microfluidics","score":0.9950000047683716},{"id":"https://openalex.org/keywords/cell-free-fetal-dna","display_name":"cell-free fetal DNA","score":0.9229999780654907},{"id":"https://openalex.org/keywords/fetal-cells","display_name":"fetal cells","score":0.824999988079071},{"id":"https://openalex.org/keywords/invasive-prenatal-diagnosis","display_name":"invasive prenatal diagnosis","score":0.6510000228881836},{"id":"https://openalex.org/keywords/ethical-issues","display_name":"ethical considerations","score":0.7760000228881836}],"concepts":[{"id":"https://openalex.org/C8673954","wikidata":"https://www.wikidata.org/wiki/Q138845","display_name":"Microfluidics","level":2,"score":0.7423715591430664},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.4910006821155548},{"id":"https://openalex.org/C2988198817","wikidata":"https://www.wikidata.org/wiki/Q633261","display_name":"Microfluidic chip","level":3,"score":0.44536250829696655},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4330088496208191},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.40108492970466614},{"id":"https://openalex.org/C183696295","wikidata":"https://www.wikidata.org/wiki/Q2487696","display_name":"Biochemical engineering","level":1,"score":0.39848828315734863},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.3922247588634491},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.10265618562698364}],"mesh":[{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005333","descriptor_name":"Fetus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008904","descriptor_name":"Miniaturization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011296","descriptor_name":"Prenatal Diagnosis","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":true},{"descriptor_ui":"D011296","descriptor_name":"Prenatal Diagnosis","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":true},{"descriptor_ui":"D046210","descriptor_name":"Microfluidic Analytical Techniques","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D056656","descriptor_name":"Lab-On-A-Chip Devices","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1039/c3lc50980j","doi":"https://doi.org/10.1039/c3lc50980j","is_oa":false,"landing_page_url":"https://doi.org/10.1039/c3lc50980j","pdf_url":null,"source":{"id":"https://openalex.org/S116836101","display_name":"Lab on a Chip","issn_l":"1473-0189","issn":["1473-0189","1473-0197"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lab on a Chip","raw_type":"journal-article"},{"id":"pmid:24452749","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24452749","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lab on a chip","raw_type":"Journal Article"},{"id":"pmh:oai:scholarbank.nus.edu.sg:10635/128965","doi":null,"is_oa":false,"landing_page_url":"http://scholarbank.nus.edu.sg/handle/10635/128965","pdf_url":null,"source":{"id":"https://openalex.org/S7407052290","display_name":"National University of Singapore","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scopus","raw_type":"Review"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":95,"referenced_works":["https://openalex.org/W1513662956","https://openalex.org/W1604324416","https://openalex.org/W1720911209","https://openalex.org/W1852879029","https://openalex.org/W1951185821","https://openalex.org/W1965090465","https://openalex.org/W1972867200","https://openalex.org/W1974966585","https://openalex.org/W1975994865","https://openalex.org/W1976540048","https://openalex.org/W1984290204","https://openalex.org/W1984444241","https://openalex.org/W1986190893","https://openalex.org/W1986430780","https://openalex.org/W1987425282","https://openalex.org/W1994046752","https://openalex.org/W2003282289","https://openalex.org/W2007373720","https://openalex.org/W2010162458","https://openalex.org/W2014720310","https://openalex.org/W2021680265","https://openalex.org/W2023879574","https://openalex.org/W2023885786","https://openalex.org/W2025233635","https://openalex.org/W2028115197","https://openalex.org/W2030166892","https://openalex.org/W2030753111","https://openalex.org/W2031754870","https://openalex.org/W2033845019","https://openalex.org/W2034619892","https://openalex.org/W2038762365","https://openalex.org/W2040616737","https://openalex.org/W2043686152","https://openalex.org/W2045356522","https://openalex.org/W2047108361","https://openalex.org/W2049706382","https://openalex.org/W2050329279","https://openalex.org/W2056205515","https://openalex.org/W2057297160","https://openalex.org/W2060051478","https://openalex.org/W2060246168","https://openalex.org/W2063250806","https://openalex.org/W2064464143","https://openalex.org/W2065323400","https://openalex.org/W2072721747","https://openalex.org/W2073027248","https://openalex.org/W2075769784","https://openalex.org/W2076538875","https://openalex.org/W2076743789","https://openalex.org/W2077539313","https://openalex.org/W2077851458","https://openalex.org/W2079726850","https://openalex.org/W2087538577","https://openalex.org/W2095218580","https://openalex.org/W2096206246","https://openalex.org/W2097491292","https://openalex.org/W2098017568","https://openalex.org/W2098453953","https://openalex.org/W2100977485","https://openalex.org/W2107670801","https://openalex.org/W2108480917","https://openalex.org/W2111696692","https://openalex.org/W2112304461","https://openalex.org/W2112331560","https://openalex.org/W2114755369","https://openalex.org/W2115865929","https://openalex.org/W2117819507","https://openalex.org/W2123370218","https://openalex.org/W2125249373","https://openalex.org/W2129125677","https://openalex.org/W2130035498","https://openalex.org/W2132238722","https://openalex.org/W2132617642","https://openalex.org/W2134164600","https://openalex.org/W2134433349","https://openalex.org/W2137895072","https://openalex.org/W2143065917","https://openalex.org/W2144067971","https://openalex.org/W2147719694","https://openalex.org/W2150204651","https://openalex.org/W2151056739","https://openalex.org/W2155214157","https://openalex.org/W2155296215","https://openalex.org/W2155553535","https://openalex.org/W2161987212","https://openalex.org/W2163604529","https://openalex.org/W2164099436","https://openalex.org/W2170881225","https://openalex.org/W2172268282","https://openalex.org/W2339267517","https://openalex.org/W3187434984","https://openalex.org/W4239536861","https://openalex.org/W4246449377","https://openalex.org/W4247413620","https://openalex.org/W4295334948"],"related_works":["https://openalex.org/W4313575318","https://openalex.org/W2771351246","https://openalex.org/W4321441590","https://openalex.org/W1959077821","https://openalex.org/W2100291412","https://openalex.org/W4405421456","https://openalex.org/W4411836716","https://openalex.org/W2887554272","https://openalex.org/W3162080958","https://openalex.org/W3029454322"],"abstract_inverted_index":{"This":[0,88],"paper":[1],"aims":[2],"to":[3,13,27,70,78],"provide":[4],"a":[5,20,30,44],"concise":[6],"review":[7,89],"of":[8,22,32,47,97],"non-invasive":[9,56],"prenatal":[10],"diagnostics":[11],"(NIPD)":[12],"the":[14,72,98],"lab-on-a-chip":[15],"and":[16,29,59,74,94],"microfluidics":[17,39],"community.":[18],"Having":[19],"market":[21],"over":[23],"one":[24],"billion":[25],"dollars":[26],"explore":[28],"plethora":[31],"applications,":[33],"NIPD":[34],"requires":[35],"greater":[36],"attention":[37],"from":[38],"researchers.":[40],"In":[41],"this":[42],"review,":[43],"complete":[45],"overview":[46],"conventional":[48],"diagnostic":[49],"procedures":[50],"including":[51],"invasive":[52],"as":[53,55,80,82],"well":[54,81],"(fetal":[57],"cells":[58],"cell-free":[60],"fetal":[61],"DNA)":[62],"types":[63],"are":[64],"discussed.":[65],"Special":[66],"focus":[67],"is":[68],"given":[69],"reviewing":[71],"recent":[73],"past":[75],"microfluidic":[76],"approaches":[77],"NIPD,":[79],"various":[83],"commercial":[84],"entities":[85],"in":[86],"NIPD.":[87],"concludes":[90],"with":[91],"future":[92],"challenges":[93],"ethical":[95],"considerations":[96],"field.":[99]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":6}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}