{"id":"https://openalex.org/W1985187934","doi":"https://doi.org/10.1007/s40262-013-0090-5","title":"Development of a Paediatric Population-Based Model of the Pharmacokinetics of Rivaroxaban","display_name":"Development of a Paediatric Population-Based Model of the Pharmacokinetics of Rivaroxaban","publication_year":2013,"publication_date":"2013-08-02","ids":{"openalex":"https://openalex.org/W1985187934","doi":"https://doi.org/10.1007/s40262-013-0090-5","mag":"1985187934","pmid":"https://pubmed.ncbi.nlm.nih.gov/23912563","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3889826"},"language":"en","primary_location":{"id":"doi:10.1007/s40262-013-0090-5","doi":"https://doi.org/10.1007/s40262-013-0090-5","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s40262-013-0090-5","pdf_url":"https://link.springer.com/content/pdf/10.1007/s40262-013-0090-5.pdf","source":{"id":"https://openalex.org/S69290020","display_name":"Clinical Pharmacokinetics","issn_l":"0312-5963","issn":["0312-5963","1179-1926"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320330","host_organization_name":"Adis, Springer Healthcare","host_organization_lineage":["https://openalex.org/P4310320330","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Adis, Springer Healthcare","Springer Nature"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Pharmacokinetics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://link.springer.com/content/pdf/10.1007/s40262-013-0090-5.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044550530","display_name":"Stefan Willmann","orcid":"https://orcid.org/0000-0001-8322-965X","observed_orcids":["https://orcid.org/0000-0001-8322-965X"]},"institutions":[{"id":"https://openalex.org/I67348948","display_name":"Bayer (Germany)","ror":"https://ror.org/04hmn8g73","country_code":"DE","type":"company","lineage":["https://openalex.org/I67348948"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Stefan Willmann","raw_affiliation_strings":["Bayer Technology Services GmbH, Leverkusen, Germany, stefan.willmann@bayer.com","Bayer Technology Services GmbH; Leverkusen Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bayer Technology Services GmbH, Leverkusen, Germany, stefan.willmann@bayer.com","institution_ids":["https://openalex.org/I67348948"]},{"raw_affiliation_string":"Bayer Technology Services GmbH; Leverkusen Germany","institution_ids":["https://openalex.org/I67348948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025972354","display_name":"Corina Becker","orcid":"https://orcid.org/0000-0003-4715-6726","observed_orcids":["https://orcid.org/0000-0003-4715-6726"]},"institutions":[{"id":"https://openalex.org/I67348948","display_name":"Bayer (Germany)","ror":"https://ror.org/04hmn8g73","country_code":"DE","type":"company","lineage":["https://openalex.org/I67348948"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Corina Becker","raw_affiliation_strings":["Bayer HealthCare AG, Wuppertal, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bayer HealthCare AG, Wuppertal, Germany","institution_ids":["https://openalex.org/I67348948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022371964","display_name":"Rolf Burghaus","orcid":"https://orcid.org/0000-0001-7843-427X","observed_orcids":["https://orcid.org/0000-0001-7843-427X"]},"institutions":[{"id":"https://openalex.org/I67348948","display_name":"Bayer (Germany)","ror":"https://ror.org/04hmn8g73","country_code":"DE","type":"company","lineage":["https://openalex.org/I67348948"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Rolf Burghaus","raw_affiliation_strings":["Bayer HealthCare AG, Wuppertal, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bayer HealthCare AG, Wuppertal, Germany","institution_ids":["https://openalex.org/I67348948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020917627","display_name":"Katrin Coboeken","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I67348948","display_name":"Bayer (Germany)","ror":"https://ror.org/04hmn8g73","country_code":"DE","type":"company","lineage":["https://openalex.org/I67348948"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Katrin Coboeken","raw_affiliation_strings":["Bayer Technology Services GmbH, Leverkusen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bayer Technology Services GmbH, Leverkusen, Germany","institution_ids":["https://openalex.org/I67348948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019411028","display_name":"Andrea N. Edginton","orcid":"https://orcid.org/0000-0002-9014-1653","observed_orcids":["https://orcid.org/0000-0002-9014-1653"]},"institutions":[{"id":"https://openalex.org/I151746483","display_name":"University of Waterloo","ror":"https://ror.org/01aff2v68","country_code":"CA","type":"education","lineage":["https://openalex.org/I151746483"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Andrea Edginton","raw_affiliation_strings":["University of Waterloo, Waterloo, ON, Canada","University of Waterloo, Waterloo, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Waterloo, Waterloo, ON, Canada","institution_ids":["https://openalex.org/I151746483"]},{"raw_affiliation_string":"University of Waterloo, Waterloo, Canada","institution_ids":["https://openalex.org/I151746483"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082230029","display_name":"J\u00f6rg Lippert","orcid":"https://orcid.org/0000-0002-0683-2874","observed_orcids":["https://orcid.org/0000-0002-0683-2874"]},"institutions":[{"id":"https://openalex.org/I67348948","display_name":"Bayer (Germany)","ror":"https://ror.org/04hmn8g73","country_code":"DE","type":"company","lineage":["https://openalex.org/I67348948"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"J\u00f6rg Lippert","raw_affiliation_strings":["Bayer Technology Services GmbH, Leverkusen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bayer Technology Services GmbH, Leverkusen, Germany","institution_ids":["https://openalex.org/I67348948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001068025","display_name":"Hans\u2010Ulrich Siegmund","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I67348948","display_name":"Bayer (Germany)","ror":"https://ror.org/04hmn8g73","country_code":"DE","type":"company","lineage":["https://openalex.org/I67348948"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Hans-Ulrich Siegmund","raw_affiliation_strings":["Bayer Technology Services GmbH, Leverkusen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bayer Technology Services GmbH, Leverkusen, Germany","institution_ids":["https://openalex.org/I67348948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087606354","display_name":"Kirstin Thelen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I67348948","display_name":"Bayer (Germany)","ror":"https://ror.org/04hmn8g73","country_code":"DE","type":"company","lineage":["https://openalex.org/I67348948"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Kirstin Thelen","raw_affiliation_strings":["Bayer Technology Services GmbH, Leverkusen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bayer Technology Services GmbH, Leverkusen, Germany","institution_ids":["https://openalex.org/I67348948"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111697742","display_name":"Wolfgang M. M\u00fcck","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I67348948","display_name":"Bayer (Germany)","ror":"https://ror.org/04hmn8g73","country_code":"DE","type":"company","lineage":["https://openalex.org/I67348948"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Wolfgang M\u00fcck","raw_affiliation_strings":["Bayer HealthCare AG, Wuppertal, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bayer HealthCare AG, Wuppertal, Germany","institution_ids":["https://openalex.org/I67348948"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5044550530"],"corresponding_institution_ids":["https://openalex.org/I67348948"],"apc_list":{"value":4990,"currency":"USD","value_usd":4990},"apc_paid":{"value":4990,"currency":"USD","value_usd":4990},"fwci":4.9598,"has_fulltext":true,"cited_by_count":87,"citation_normalized_percentile":{"value":0.94738852,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"53","issue":"1","first_page":"89","last_page":"102"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12547","display_name":"Pharmaceutical studies and practices","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12547","display_name":"Pharmaceutical studies and practices","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10285","display_name":"Venous Thromboembolism Diagnosis and Management","score":0.01080000028014183,"subfield":{"id":"https://openalex.org/subfields/2724","display_name":"Internal Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11235","display_name":"Statistical Methods in Clinical Trials","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rivaroxaban","display_name":"rivaroxaban","score":0.9679999947547913},{"id":"https://openalex.org/keywords/pediatric-pharmacokinetics","display_name":"pediatric pharmacokinetics","score":0.8949999809265137},{"id":"https://openalex.org/keywords/physiologically-based-pharmacokinetic-model","display_name":"physiologically based pharmacokinetic modeling","score":0.9710000157356262},{"id":"https://openalex.org/keywords/model-scaling","display_name":"model scaling","score":0.5649999976158142},{"id":"https://openalex.org/keywords/venous-thromboembolism","display_name":"venous thromboembolism","score":0.9120000004768372},{"id":"https://openalex.org/keywords/direct-factor-xa-inhibitors","display_name":"direct factor Xa inhibitors","score":0.765999972820282},{"id":"https://openalex.org/keywords/weight-based-dosing","display_name":"weight-based dosing","score":0.8510000109672546},{"id":"https://openalex.org/keywords/virtual-population","display_name":"virtual population","score":0.44699999690055847},{"id":"https://openalex.org/keywords/dosing-regimen","display_name":"dosing regimen","score":0.38499999046325684},{"id":"https://openalex.org/keywords/infants-and-preschool-children","display_name":"infants and preschool children","score":0.6480000019073486},{"id":"https://openalex.org/keywords/adolescents","display_name":"adolescents","score":0.8859999775886536},{"id":"https://openalex.org/keywords/visual-predictive-check","display_name":"visual predictive check","score":0.6840000152587891},{"id":"https://openalex.org/keywords/antithrombotic-therapy","display_name":"antithrombotic therapy","score":0.7120000123977661}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.836552619934082},{"id":"https://openalex.org/C2778661090","wikidata":"https://www.wikidata.org/wiki/Q420262","display_name":"Rivaroxaban","level":4,"score":0.773059606552124},{"id":"https://openalex.org/C185867374","wikidata":"https://www.wikidata.org/wiki/Q2562769","display_name":"Physiologically based pharmacokinetic modelling","level":3,"score":0.7525739669799805},{"id":"https://openalex.org/C2777288759","wikidata":"https://www.wikidata.org/wiki/Q4164182","display_name":"Dosing","level":2,"score":0.7387701272964478},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5934208631515503},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.5825448632240295},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.5063141584396362},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.42551174759864807},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3781284987926483},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.27525776624679565},{"id":"https://openalex.org/C2776301958","wikidata":"https://www.wikidata.org/wiki/Q407431","display_name":"Warfarin","level":3,"score":0.08965778350830078},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C2779161974","wikidata":"https://www.wikidata.org/wiki/Q815819","display_name":"Atrial fibrillation","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000069552","descriptor_name":"Rivaroxaban","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000925","descriptor_name":"Anticoagulants","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000925","descriptor_name":"Anticoagulants","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007231","descriptor_name":"Infant, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009025","descriptor_name":"Morpholines","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D009025","descriptor_name":"Morpholines","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D013876","descriptor_name":"Thiophenes","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D013876","descriptor_name":"Thiophenes","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1007/s40262-013-0090-5","doi":"https://doi.org/10.1007/s40262-013-0090-5","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s40262-013-0090-5","pdf_url":"https://link.springer.com/content/pdf/10.1007/s40262-013-0090-5.pdf","source":{"id":"https://openalex.org/S69290020","display_name":"Clinical Pharmacokinetics","issn_l":"0312-5963","issn":["0312-5963","1179-1926"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320330","host_organization_name":"Adis, Springer Healthcare","host_organization_lineage":["https://openalex.org/P4310320330","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Adis, Springer Healthcare","Springer Nature"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Pharmacokinetics","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2877017","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3889826","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3889826","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3889826","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clin Pharmacokinet","raw_type":"Text"},{"id":"pmid:23912563","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23912563","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical pharmacokinetics","raw_type":"Clinical Trial, Phase I"}],"best_oa_location":{"id":"doi:10.1007/s40262-013-0090-5","doi":"https://doi.org/10.1007/s40262-013-0090-5","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s40262-013-0090-5","pdf_url":"https://link.springer.com/content/pdf/10.1007/s40262-013-0090-5.pdf","source":{"id":"https://openalex.org/S69290020","display_name":"Clinical Pharmacokinetics","issn_l":"0312-5963","issn":["0312-5963","1179-1926"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320330","host_organization_name":"Adis, Springer Healthcare","host_organization_lineage":["https://openalex.org/P4310320330","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Adis, Springer Healthcare","Springer Nature"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Pharmacokinetics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320307771","display_name":"Bayer","ror":"https://ror.org/04hmn8g73"},{"id":"https://openalex.org/F4320320303","display_name":"Bayer HealthCare","ror":"https://ror.org/04hmn8g73"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1985187934.pdf","grobid_xml":"https://content.openalex.org/works/W1985187934.grobid-xml"},"referenced_works_count":98,"referenced_works":["https://openalex.org/W2447587","https://openalex.org/W110402639","https://openalex.org/W181091954","https://openalex.org/W198418484","https://openalex.org/W200020947","https://openalex.org/W601386163","https://openalex.org/W1480212256","https://openalex.org/W1482978529","https://openalex.org/W1485772655","https://openalex.org/W1509358020","https://openalex.org/W1521727979","https://openalex.org/W1965029547","https://openalex.org/W1967142434","https://openalex.org/W1968295431","https://openalex.org/W1969218311","https://openalex.org/W1978867369","https://openalex.org/W1979930569","https://openalex.org/W1980519120","https://openalex.org/W1981328065","https://openalex.org/W1981366327","https://openalex.org/W1984231572","https://openalex.org/W1984381869","https://openalex.org/W1984452104","https://openalex.org/W1984935828","https://openalex.org/W1988463445","https://openalex.org/W1989452277","https://openalex.org/W1991510925","https://openalex.org/W1992489935","https://openalex.org/W1999456783","https://openalex.org/W1999944262","https://openalex.org/W2006267648","https://openalex.org/W2009500776","https://openalex.org/W2014491911","https://openalex.org/W2015249654","https://openalex.org/W2017223238","https://openalex.org/W2018220913","https://openalex.org/W2022934702","https://openalex.org/W2028162842","https://openalex.org/W2028165836","https://openalex.org/W2030189926","https://openalex.org/W2031390211","https://openalex.org/W2031742675","https://openalex.org/W2032738310","https://openalex.org/W2036506340","https://openalex.org/W2040233060","https://openalex.org/W2042446520","https://openalex.org/W2042553471","https://openalex.org/W2045987573","https://openalex.org/W2049110362","https://openalex.org/W2054998869","https://openalex.org/W2056455169","https://openalex.org/W2058972718","https://openalex.org/W2060578439","https://openalex.org/W2061963307","https://openalex.org/W2062088407","https://openalex.org/W2062486643","https://openalex.org/W2062989158","https://openalex.org/W2064313355","https://openalex.org/W2064627639","https://openalex.org/W2066739129","https://openalex.org/W2069707383","https://openalex.org/W2075341962","https://openalex.org/W2083713858","https://openalex.org/W2084005362","https://openalex.org/W2085980610","https://openalex.org/W2088996598","https://openalex.org/W2097854437","https://openalex.org/W2106459062","https://openalex.org/W2113753061","https://openalex.org/W2113830209","https://openalex.org/W2115571073","https://openalex.org/W2115787552","https://openalex.org/W2117677020","https://openalex.org/W2123448465","https://openalex.org/W2130199362","https://openalex.org/W2132158620","https://openalex.org/W2137477398","https://openalex.org/W2139716972","https://openalex.org/W2143907400","https://openalex.org/W2144462910","https://openalex.org/W2148085455","https://openalex.org/W2148583353","https://openalex.org/W2149868433","https://openalex.org/W2150567120","https://openalex.org/W2151252098","https://openalex.org/W2151667908","https://openalex.org/W2153438515","https://openalex.org/W2155916653","https://openalex.org/W2157940292","https://openalex.org/W2161183750","https://openalex.org/W2162099840","https://openalex.org/W2165334931","https://openalex.org/W2167182965","https://openalex.org/W2170707127","https://openalex.org/W2332475927","https://openalex.org/W2385746387","https://openalex.org/W2410315922","https://openalex.org/W2415619104"],"related_works":["https://openalex.org/W3186812241","https://openalex.org/W2901338299","https://openalex.org/W4281711657","https://openalex.org/W3145555452","https://openalex.org/W3201455773","https://openalex.org/W2900559090","https://openalex.org/W4390603144","https://openalex.org/W3014334390","https://openalex.org/W2968662162","https://openalex.org/W3087018691"],"abstract_inverted_index":{"BACKGROUND:":[0],"Venous":[1],"thromboembolism":[2],"has":[3,51],"been":[4,52],"increasingly":[5],"recognised":[6],"as":[7,334],"a":[8,96,129,216,460],"clinical":[9,30,39,130,461],"problem":[10],"in":[11,20,41,54,73,81,110,134,183,204,241,278,292,320,335,362,452,463],"the":[12,35,82,118,125,146,163,209,224,227,251,265,275,279,304,311,330,359,363,387,403,409,415,448,456],"paediatric":[13,21,42,83,119,135,164,221,438,464],"population.":[14,84],"Guideline":[15],"recommendations":[16],"for":[17,57,102,128,190,257,274,283,420,459],"antithrombotic":[18],"therapy":[19],"patients":[22,56,422],"are":[23],"based":[24,98],"mainly":[25],"on":[26],"extrapolation":[27],"from":[28,141],"adult":[29,55,152,156,252,280,312,365,410,428],"trial":[31],"data,":[32],"owing":[33,413],"to":[34,92,113,117,123,162,197,325,328,414,454],"limited":[36],"number":[37],"of":[38,78,88,105,132,150,181,186,208,215,223,310,382,394,408,431,447,450],"trials":[40],"populations.":[43],"The":[44,86,178,206,437],"oral,":[45],"direct":[46],"Factor":[47],"Xa":[48],"inhibitor":[49],"rivaroxaban":[50,103,133,182,423,451],"approved":[53],"several":[58],"thromboembolic":[59],"disorders,":[60],"and":[61,65,68,70,94,107,112,148,169,174,199,239,261,294,344,355,378,396,433],"its":[62],"well-defined":[63],"pharmacokinetic":[64,99,179,290,349],"pharmacodynamic":[66],"characteristics":[67],"efficacy":[69],"safety":[71],"profiles":[72],"adults":[74,111],"warrant":[75],"further":[76],"investigation":[77],"this":[79,89,115],"agent":[80],"OBJECTIVE:":[85],"objective":[87],"study":[90,131,462],"was":[91,159,211,373],"develop":[93],"qualify":[95],"physiologically":[97],"(PBPK)":[100],"model":[101,116,158,210,314,440],"doses":[104,319,430],"10":[106,198,432],"20":[108,200,434],"mg":[109,201],"scale":[114],"population":[120,165],"(0-18":[121],"years)":[122],"inform":[124,455],"dosing":[126,194,287,457],"regimen":[127,458],"patients.":[136,465],"METHODS:":[137],"Experimental":[138],"data":[139],"sets":[140],"phase":[142],"I":[143],"studies":[144],"supported":[145],"development":[147],"qualification":[149],"an":[151,444],"PBPK":[153,157,439],"model.":[154],"This":[155],"then":[160],"scaled":[161],"by":[166,213],"including":[167],"anthropometric":[168],"physiological":[170],"information,":[171],"age-dependent":[172,175],"clearance":[173],"protein":[176],"binding.":[177],"properties":[180],"virtual":[184],"populations":[185],"children":[187,296,338,377,453],"were":[188,248,301,399],"simulated":[189,347,388],"two":[191],"body":[192,285,340,370,385],"weight-related":[193,286,371],"regimens":[195],"equivalent":[196],"once":[202],"daily":[203],"adults.":[205,336,379],"quality":[207],"judged":[212],"means":[214],"visual":[217],"predictive":[218],"check.":[219],"Subsequently,":[220],"simulations":[222],"area":[225],"under":[226],"plasma":[228,234,242,332,348],"concentration-time":[229],"curve":[230],"(AUC),":[231],"maximum":[232],"(peak)":[233],"drug":[235],"concentration":[236,240],"(C":[237,246,351],"max)":[238],"after":[243],"24":[244],"h":[245],"24h)":[247],"compared":[249],"with":[250,271,339,358],"reference":[253,281,313,366,411],"simulations.":[254],"RESULTS:":[255],"Simulations":[256],"AUC,":[258],"C":[259,262,353,397],"max":[260],"24h":[263,354,398],"throughout":[264],"investigated":[266],"age":[267],"range":[268],"largely":[269],"overlapped":[270,357],"values":[272,291,360,393],"obtained":[273,361],"corresponding":[276,364],"dose":[277],"simulation":[282,417],"both":[284],"regimens.":[288],"However,":[289],"infants":[293],"preschool":[295],"(body":[297],"weight":[298,341],"<40":[299],"kg)":[300],"lower":[302],"than":[303,402],"90":[305,389,404],"%":[306,390,405],"confidence":[307,406],"interval":[308,392,407],"threshold":[309],"and,":[315],"therefore,":[316],"indicated":[317],"that":[318,369],"these":[321,376,421],"groups":[322],"may":[323],"need":[324],"be":[326,425],"increased":[327],"achieve":[329],"same":[331],"levels":[333],"For":[337],"between":[342,375],"40":[343],"70":[345],"kg,":[346],"parameters":[350],"max,":[352],"AUC)":[356],"simulation,":[367],"indicating":[368],"exposure":[372],"similar":[374],"In":[380],"adolescents":[381],">70":[383],"kg":[384],"weight,":[386],"prediction":[391],"AUC":[395],"much":[400],"higher":[401],"population,":[412],"weight-based":[416],"approach,":[418],"but":[419],"would":[424],"administered":[426],"at":[427],"fixed":[429],"mg.":[435],"CONCLUSION:":[436],"developed":[441],"here":[442],"allowed":[443],"exploratory":[445],"analysis":[446],"pharmacokinetics":[449]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":12},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
