{"id":"https://openalex.org/W1985185407","doi":"https://doi.org/10.1089/08828240260066305","title":"BHV-1-Specific CD4 + , CD8 + , and \u03b3\u03b4 T Cells in Calves Vaccinated with One Dose of a Modified Live BHV-1 Vaccine","display_name":"BHV-1-Specific CD4 + , CD8 + , and \u03b3\u03b4 T Cells in Calves Vaccinated with One Dose of a Modified Live BHV-1 Vaccine","publication_year":2002,"publication_date":"2002-06-01","ids":{"openalex":"https://openalex.org/W1985185407","doi":"https://doi.org/10.1089/08828240260066305","mag":"1985185407","pmid":"https://pubmed.ncbi.nlm.nih.gov/12081020"},"language":"en","primary_location":{"id":"doi:10.1089/08828240260066305","doi":"https://doi.org/10.1089/08828240260066305","is_oa":false,"landing_page_url":"https://doi.org/10.1089/08828240260066305","pdf_url":null,"source":{"id":"https://openalex.org/S203476268","display_name":"Viral Immunology","issn_l":"0882-8245","issn":["0882-8245","1557-8976"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Viral Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021838709","display_name":"Janice Jones Endsley","orcid":"https://orcid.org/0000-0002-3883-8250","observed_orcids":["https://orcid.org/0000-0002-3883-8250"]},"institutions":[{"id":"https://openalex.org/I173911158","display_name":"Iowa State University","ror":"https://ror.org/04rswrd78","country_code":"US","type":"education","lineage":["https://openalex.org/I173911158"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Janice J. Endsley","raw_affiliation_strings":["Department of Veterinary Microbiology and Preventative Medicine, College of Veterinary Medicine, Iowa State University, Ames, Iowa","Department of Veterinary Microbiology and Preventative Medicine, College of Veterinary Medicine, Iowa State University, Ames 50011, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Microbiology and Preventative Medicine, College of Veterinary Medicine, Iowa State University, Ames, Iowa","institution_ids":["https://openalex.org/I173911158"]},{"raw_affiliation_string":"Department of Veterinary Microbiology and Preventative Medicine, College of Veterinary Medicine, Iowa State University, Ames 50011, USA","institution_ids":["https://openalex.org/I173911158"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017086997","display_name":"Mark John Quade","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I173911158","display_name":"Iowa State University","ror":"https://ror.org/04rswrd78","country_code":"US","type":"education","lineage":["https://openalex.org/I173911158"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark J. Quade","raw_affiliation_strings":["Department of Veterinary Microbiology and Preventative Medicine, College of Veterinary Medicine, Iowa State University, Ames, Iowa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Microbiology and Preventative Medicine, College of Veterinary Medicine, Iowa State University, Ames, Iowa","institution_ids":["https://openalex.org/I173911158"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077949610","display_name":"Brett L. Terhaar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I173911158","display_name":"Iowa State University","ror":"https://ror.org/04rswrd78","country_code":"US","type":"education","lineage":["https://openalex.org/I173911158"]},{"id":"https://openalex.org/I4210117146","display_name":"St. Joseph's University New York","ror":"https://ror.org/02fs6en72","country_code":"US","type":"education","lineage":["https://openalex.org/I4210117146"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brett Terhaar","raw_affiliation_strings":["Agri Laboratories Ltd., St. Joseph, Missouri","Iowa State University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Agri Laboratories Ltd., St. Joseph, Missouri","institution_ids":["https://openalex.org/I4210117146"]},{"raw_affiliation_string":"Iowa State University","institution_ids":["https://openalex.org/I173911158"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043298435","display_name":"James A. Roth","orcid":"https://orcid.org/0000-0003-3562-668X","observed_orcids":["https://orcid.org/0000-0003-3562-668X"]},"institutions":[{"id":"https://openalex.org/I173911158","display_name":"Iowa State University","ror":"https://ror.org/04rswrd78","country_code":"US","type":"education","lineage":["https://openalex.org/I173911158"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James A. Roth","raw_affiliation_strings":["Department of Veterinary Microbiology and Preventative Medicine, College of Veterinary Medicine, Iowa State University, Ames, Iowa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Microbiology and Preventative Medicine, College of Veterinary Medicine, Iowa State University, Ames, Iowa","institution_ids":["https://openalex.org/I173911158"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.4149,"has_fulltext":false,"cited_by_count":24,"citation_normalized_percentile":{"value":0.89683991,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"15","issue":"2","first_page":"385","last_page":"393"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11495","display_name":"Animal Virus Infections Studies","score":0.5425000190734863,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11495","display_name":"Animal Virus Infections Studies","score":0.5425000190734863,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10625","display_name":"Herpesvirus Infections and Treatments","score":0.3610999882221222,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.025499999523162842,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bovine-herpesvirus-1","display_name":"bovine herpesvirus 1","score":0.9769999980926514},{"id":"https://openalex.org/keywords/live-attenuated-vaccine","display_name":"live attenuated vaccine","score":0.9440000057220459},{"id":"https://openalex.org/keywords/calves","display_name":"calves","score":0.6190000176429749},{"id":"https://openalex.org/keywords/cd4-t-cells","display_name":"CD4+ T cells","score":0.8640000224113464},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":1.0},{"id":"https://openalex.org/keywords/gamma-delta-t-cells","display_name":"\u03b3\u03b4 T cells","score":0.9279999732971191},{"id":"https://openalex.org/keywords/cd25-expression","display_name":"CD25 expression","score":0.9049999713897705},{"id":"https://openalex.org/keywords/antigen-specific-t-cell-activation","display_name":"antigen-specific T cell activation","score":0.7919999957084656},{"id":"https://openalex.org/keywords/vaccine-immunogenicity","display_name":"vaccine immunogenicity","score":0.7379999756813049},{"id":"https://openalex.org/keywords/vaccine-protection","display_name":"vaccine protection","score":0.33500000834465027},{"id":"https://openalex.org/keywords/t-cell-depletion","display_name":"T cell depletion","score":0.4129999876022339},{"id":"https://openalex.org/keywords/bystander-activation","display_name":"bystander activation","score":0.5329999923706055}],"concepts":[{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.7273487448692322},{"id":"https://openalex.org/C79484868","wikidata":"https://www.wikidata.org/wiki/Q5971673","display_name":"IL-2 receptor","level":4,"score":0.7020953893661499},{"id":"https://openalex.org/C2777594917","wikidata":"https://www.wikidata.org/wiki/Q478428","display_name":"Bovine herpesvirus 1","level":5,"score":0.6207194924354553},{"id":"https://openalex.org/C137061746","wikidata":"https://www.wikidata.org/wiki/Q736033","display_name":"Peripheral blood mononuclear cell","level":3,"score":0.5893466472625732},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5404369235038757},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.511737585067749},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.509276270866394},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.47578442096710205},{"id":"https://openalex.org/C22070199","wikidata":"https://www.wikidata.org/wiki/Q192995","display_name":"Vaccination","level":2,"score":0.4747246503829956},{"id":"https://openalex.org/C2777371288","wikidata":"https://www.wikidata.org/wiki/Q410130","display_name":"Interleukin 2","level":3,"score":0.4682161808013916},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.4425228536128998},{"id":"https://openalex.org/C2992881475","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T lymphocyte","level":3,"score":0.42252907156944275},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.35962986946105957},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3549165725708008},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.30579349398612976},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.29444000124931335},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.1630191206932068},{"id":"https://openalex.org/C2780727368","wikidata":"https://www.wikidata.org/wiki/Q1928978","display_name":"Viral disease","level":3,"score":0.05969715118408203},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C2776409557","wikidata":"https://www.wikidata.org/wiki/Q149348","display_name":"Herpesviridae","level":4,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006566","descriptor_name":"Herpesviridae Infections","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D007242","descriptor_name":"Herpesvirus 1, Bovine","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D014611","descriptor_name":"Vaccination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014765","descriptor_name":"Viral Vaccines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015375","descriptor_name":"Receptors, Interleukin-2","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D016692","descriptor_name":"Receptors, Antigen, T-Cell, gamma-delta","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1089/08828240260066305","doi":"https://doi.org/10.1089/08828240260066305","is_oa":false,"landing_page_url":"https://doi.org/10.1089/08828240260066305","pdf_url":null,"source":{"id":"https://openalex.org/S203476268","display_name":"Viral Immunology","issn_l":"0882-8245","issn":["0882-8245","1557-8976"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Viral Immunology","raw_type":"journal-article"},{"id":"pmid:12081020","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12081020","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Viral immunology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W180084230","https://openalex.org/W1503279681","https://openalex.org/W1560278958","https://openalex.org/W1879467706","https://openalex.org/W1895680870","https://openalex.org/W1967317248","https://openalex.org/W1970099195","https://openalex.org/W1992418360","https://openalex.org/W1992424182","https://openalex.org/W2005230073","https://openalex.org/W2005600841","https://openalex.org/W2016994014","https://openalex.org/W2029800900","https://openalex.org/W2047871359","https://openalex.org/W2106781718","https://openalex.org/W2111378221","https://openalex.org/W2153290904","https://openalex.org/W2165090864","https://openalex.org/W2186540741"],"related_works":["https://openalex.org/W2029800900","https://openalex.org/W652668439","https://openalex.org/W2419417065","https://openalex.org/W2149459355","https://openalex.org/W2218976362","https://openalex.org/W188616797","https://openalex.org/W2186540741","https://openalex.org/W1999408301","https://openalex.org/W2065058252","https://openalex.org/W2524242830"],"abstract_inverted_index":{"Expression":[0,283],"of":[1,16,45,69,75,144,197,224,231,260,284,295],"the":[2,67,70,90,93,98,134,154,171,191,214,229,258,263],"high-affinity":[3],"interleukin":[4],"2":[5],"receptor":[6],"alpha":[7],"chain":[8],"(CD25)":[9],"was":[10,157,195],"used":[11],"to":[12,54,133,163,177,205,209,249,281,287],"monitor":[13],"antigen-specific":[14,296],"activation":[15,212],"T":[17,24,151,185,202,226,235,240,246,265,297],"lymphocyte":[18,266,298],"subsets":[19],"(CD4+,":[20],"CD8+,":[21,148,199],"and":[22,63,97,106,118,127,149,182],"gammadelta":[23,150,201,239,245],"cells)":[25],"from":[26,89,116,153,190,271],"cattle":[27],"immunized":[28,117],"with":[29,42,72,126,207,220,253,273],"modified":[30,46,76],"live":[31,47,77,129,164,175,221],"bovine":[32],"herpesvirus-1":[33],"(BHV-1).":[34],"Calves":[35],"seronegative":[36],"for":[37,123,292],"BHV-1":[38,50,80,130,165,176,208,254,275],"were":[39,87,121,269],"either":[40],"vaccinated":[41,53,61],"one":[43],"dose":[44],"vaccine":[48,78],"containing":[49,79],"or":[51,200,244],"not":[52,238,256],"serve":[55],"as":[56,82],"negative":[57],"controls.":[58,84],"Two":[59],"animals":[60,120,194],"7":[62],"5":[64,124],"weeks":[65],"before":[66],"start":[68],"experiment":[71],"two":[73],"doses":[74],"served":[81],"positive":[83,94,192],"Blood":[85],"samples":[86],"taken":[88],"nonvaccinate":[91],"group,":[92,96],"control":[95,119,193],"vaccinate":[99,155],"group":[100,156],"at":[101,276],"0,":[102],"21,":[103],"35,":[104],"60,":[105],"90":[107],"days":[108,125,278],"postinoculation":[109],"(PI).":[110],"Isolated":[111],"peripheral":[112],"blood":[113,189],"mononuclear":[114],"cells":[115,227,247],"incubated":[122,219],"without":[128],"ISU99.":[131],"Compared":[132],"nonvaccinates,":[135],"a":[136,289],"significant":[137],"(p":[138],"<":[139],"0.05)":[140],"increase":[141],"in":[142,160,180,213,250],"expression":[143,216,230,259],"CD25":[145,215,232,261,285],"by":[146,233,262],"CD4+,":[147,198],"lymphocytes":[152,179,203],"detected":[158],"following":[159,301],"vitro":[161,181,251],"exposure":[162],"after":[166],"vaccination.":[167,302],"This":[168],"is":[169],"apparently":[170],"first":[172],"report":[173],"using":[174],"stimulate":[178],"showing":[183],"CD8+":[184,234,243],"cell":[186],"activation.":[187],"Peripheral":[188],"depleted":[196],"prior":[204,248],"incubation":[206],"assess":[210],"bystander":[211],"assay.":[217],"When":[218],"BHV-1,":[222],"depletion":[223],"CD4+":[225],"depressed":[228],"cells,":[236],"but":[237],"cells.":[241],"Depleting":[242],"culture":[252],"did":[255],"affect":[257],"remaining":[264],"subsets.":[267],"Vaccinates":[268],"protected":[270],"challenge":[272],"virulent":[274],"110":[277],"postvaccination":[279],"compared":[280],"nonvaccinates.":[282],"appears":[286],"be":[288],"useful":[290],"marker":[291],"evaluating":[293],"induction":[294],"subset":[299],"responses":[300]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
