{"id":"https://openalex.org/W1985177950","doi":"https://doi.org/10.1172/jci110041","title":"Regulation of secretion in Clara cells: studies using the isolated perfused rat lung.","display_name":"Regulation of secretion in Clara cells: studies using the isolated perfused rat lung.","publication_year":1981,"publication_date":"1981-02-01","ids":{"openalex":"https://openalex.org/W1985177950","doi":"https://doi.org/10.1172/jci110041","mag":"1985177950","pmid":"https://pubmed.ncbi.nlm.nih.gov/6257761","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/370574"},"language":"en","primary_location":{"id":"doi:10.1172/jci110041","doi":"https://doi.org/10.1172/jci110041","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci110041","pdf_url":"http://www.jci.org/articles/view/110041/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.jci.org/articles/view/110041/files/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111457852","display_name":"GLORIA DECARLO MASSARO","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G D Massaro","raw_affiliation_strings":["Oak Asthma Research and Treatment Facility, University of Miami School of Medicine, Miami, Florida 33101;","Pulmonary Division ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oak Asthma Research and Treatment Facility, University of Miami School of Medicine, Miami, Florida 33101;","institution_ids":["https://openalex.org/I145608581"]},{"raw_affiliation_string":"Pulmonary Division ,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028870380","display_name":"Charles M. Fischman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C M Fischman","raw_affiliation_strings":["Oak Asthma Research and Treatment Facility, University of Miami School of Medicine, Miami, Florida 33101;","Pulmonary Division ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oak Asthma Research and Treatment Facility, University of Miami School of Medicine, Miami, Florida 33101;","institution_ids":["https://openalex.org/I145608581"]},{"raw_affiliation_string":"Pulmonary Division ,","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"M J Chiang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M J Chiang","raw_affiliation_strings":["Oak Asthma Research and Treatment Facility, University of Miami School of Medicine, Miami, Florida 33101;","Pulmonary Division ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oak Asthma Research and Treatment Facility, University of Miami School of Medicine, Miami, Florida 33101;","institution_ids":["https://openalex.org/I145608581"]},{"raw_affiliation_string":"Pulmonary Division ,","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"C Amado","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C Amado","raw_affiliation_strings":["Oak Asthma Research and Treatment Facility, University of Miami School of Medicine, Miami, Florida 33101;","Pulmonary Division ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oak Asthma Research and Treatment Facility, University of Miami School of Medicine, Miami, Florida 33101;","institution_ids":["https://openalex.org/I145608581"]},{"raw_affiliation_string":"Pulmonary Division ,","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112176931","display_name":"D. Massaro","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D Massaro","raw_affiliation_strings":["Oak Asthma Research and Treatment Facility, University of Miami School of Medicine, Miami, Florida 33101;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oak Asthma Research and Treatment Facility, University of Miami School of Medicine, Miami, Florida 33101;","institution_ids":["https://openalex.org/I145608581"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I145608581"],"apc_list":{"value":5200,"currency":"USD","value_usd":5200},"apc_paid":null,"fwci":3.1644,"has_fulltext":true,"cited_by_count":39,"citation_normalized_percentile":{"value":0.90974259,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":null,"biblio":{"volume":"67","issue":"2","first_page":"345","last_page":"351"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.17329999804496765,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.17329999804496765,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.15610000491142273,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10549","display_name":"Neonatal Respiratory Health Research","score":0.10050000250339508,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/club-cells","display_name":"Clara cells","score":0.9940000176429749},{"id":"https://openalex.org/keywords/isolated-perfused-lung","display_name":"isolated perfused lung","score":0.7720000147819519},{"id":"https://openalex.org/keywords/beta-adrenergic-stimulation","display_name":"beta-adrenergic stimulation","score":0.9139999747276306},{"id":"https://openalex.org/keywords/cholinergic-inhibition","display_name":"cholinergic inhibition","score":0.8560000061988831},{"id":"https://openalex.org/keywords/isoproterenol","display_name":"isoproterenol","score":0.9150000214576721},{"id":"https://openalex.org/keywords/propranolol","display_name":"propranolol","score":0.9580000042915344},{"id":"https://openalex.org/keywords/pilocarpine","display_name":"pilocarpine","score":1.0},{"id":"https://openalex.org/keywords/camp","display_name":"cyclic AMP","score":0.8220000267028809},{"id":"https://openalex.org/keywords/cgmp","display_name":"cyclic GMP","score":0.972000002861023},{"id":"https://openalex.org/keywords/tidal-volume","display_name":"tidal volume","score":0.7070000171661377},{"id":"https://openalex.org/keywords/secretory-granules","display_name":"secretory granules","score":0.9520000219345093}],"concepts":[{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.8462926149368286},{"id":"https://openalex.org/C2778151854","wikidata":"https://www.wikidata.org/wiki/Q423364","display_name":"Propranolol","level":2,"score":0.6806141138076782},{"id":"https://openalex.org/C22885893","wikidata":"https://www.wikidata.org/wiki/Q4862743","display_name":"Cholinergic","level":2,"score":0.6222894191741943},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6196304559707642},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6150151491165161},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4781937599182129},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.4625982344150543},{"id":"https://openalex.org/C158453852","wikidata":"https://www.wikidata.org/wiki/Q4684738","display_name":"Adrenergic","level":3,"score":0.4195525050163269},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3409826159477234},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.20737802982330322},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.17775413393974304},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.17486003041267395}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001980","descriptor_name":"Bronchi","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D001980","descriptor_name":"Bronchi","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001980","descriptor_name":"Bronchi","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003594","descriptor_name":"Cytoplasmic Granules","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003994","descriptor_name":"Bucladesine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003995","descriptor_name":"Dibutyryl Cyclic GMP","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007545","descriptor_name":"Isoproterenol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010477","descriptor_name":"Perfusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010862","descriptor_name":"Pilocarpine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011433","descriptor_name":"Propranolol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013990","descriptor_name":"Tidal Volume","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1172/jci110041","doi":"https://doi.org/10.1172/jci110041","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci110041","pdf_url":"http://www.jci.org/articles/view/110041/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:370574","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/370574","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Invest","raw_type":"Text"},{"id":"pmid:6257761","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6257761","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical investigation","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1172/jci110041","doi":"https://doi.org/10.1172/jci110041","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci110041","pdf_url":"http://www.jci.org/articles/view/110041/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8199999928474426,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.41999998688697815,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1985177950.pdf","grobid_xml":"https://content.openalex.org/works/W1985177950.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W1527012038","https://openalex.org/W1530516343","https://openalex.org/W1594194663","https://openalex.org/W1730892553","https://openalex.org/W1984436011","https://openalex.org/W1994395442","https://openalex.org/W2016417523","https://openalex.org/W2047917371","https://openalex.org/W2065829059","https://openalex.org/W2082821507","https://openalex.org/W2083923976","https://openalex.org/W2092713296","https://openalex.org/W2114094740","https://openalex.org/W2135008519","https://openalex.org/W2143638749","https://openalex.org/W2180987957","https://openalex.org/W2188524866","https://openalex.org/W2319554819","https://openalex.org/W2319849592","https://openalex.org/W2329442555","https://openalex.org/W2402189690","https://openalex.org/W2408998546","https://openalex.org/W2413437557","https://openalex.org/W2417938945","https://openalex.org/W2430720179","https://openalex.org/W2461633873","https://openalex.org/W2796747456","https://openalex.org/W2798643531","https://openalex.org/W4237394135","https://openalex.org/W4239861201","https://openalex.org/W4290155223","https://openalex.org/W6667058824","https://openalex.org/W6671081193","https://openalex.org/W6841077399"],"related_works":["https://openalex.org/W1985049240","https://openalex.org/W2047917371","https://openalex.org/W2147440171","https://openalex.org/W2416766757","https://openalex.org/W2042660749","https://openalex.org/W2399736404","https://openalex.org/W2466342182","https://openalex.org/W2128862609","https://openalex.org/W2288720021","https://openalex.org/W3014953814"],"abstract_inverted_index":{"Previous":[0],"studies":[1,22],"from":[2],"our":[3],"laboratory":[4],"indicated":[5],"that":[6,92,110,171],"both":[7],"beta-adrenergic":[8,117,225],"and":[9,43,67,109,159,207],"cholinergic":[10],"agents":[11],"stimulate":[12,130],"in":[13,40,47,93,99,106,124,132,212,230,235],"vivo":[14],"secretion":[15,39,72,105,131,164,234],"by":[16,73,115,165,178,203],"rat":[17,60],"bronchiolar":[18,87],"Clara":[19,41,88,107,166,180,236],"cells.":[20,89,167,237],"Those":[21],"also":[23,162],"provided":[24],"support":[25],"for":[26],"an":[27],"in-series":[28],"beta-adrenergic-cholinergic":[29],"stimulation":[30],"of":[31,38,50,79,82,86,142,156,160,216,224,233],"secretion.":[32],"To":[33],"further":[34],"explore":[35],"the":[36,48,56,75,83,94,100,116,125,133,139,194,213,231],"regulation":[37,232],"cells,":[42],"to":[44,70,185,189],"do":[45],"it":[46,137],"absence":[49],"systemic":[51],"influences,":[52],"we":[53,221],"have":[54,63],"used":[55,65],"isolated":[57,95,134],"ventilated":[58],"perfused":[59,96],"lung.":[61],"We":[62,90],"again":[64],"morphometry":[66],"electron":[68],"microscopy":[69],"assess":[71],"measuring":[74],"volume":[76,206],"density":[77],"(fraction":[78],"cell":[80],"volume)":[81],"secretory":[84,140],"granules":[85],"found":[91,222],"lung,":[97],"as":[98],"intact":[101,126],"animal,":[102,127],"isoproterenol":[103],"stimulated":[104,147,163,184],"cells":[108,181],"this":[111,153,217],"effect":[112,141],"was":[113],"blocked":[114],"antagonist":[118],"propranolol.":[119],"Pilocarpine,":[120],"unlike":[121],"its":[122],"action":[123],"did":[128,150],"not":[129,151],"lung;":[135],"rather":[136],"inhibited":[138],"isoproterenol.":[143],"Increased":[144],"tidal-volume":[145],"ventilation":[146],"secretion;":[148],"propranolol":[149],"block":[152],"effect.":[154],"Analogs":[155],"cyclic":[157],"(c)AMP":[158],"cGMP":[161,208],"These":[168],"findings":[169],"indicate":[170],"there":[172],"are":[173],"at":[174],"least":[175],"two":[176],"mechanisms":[177],"which":[179],"can":[182],"be":[183,190,210],"secrete.":[186],"One":[187],"seems":[188],"beta-adrenergic-cAMP":[191],"mediated":[192],"but":[193],"triggering":[195],"event":[196],"is":[197,201],"unknown.":[198],"The":[199],"other":[200],"initiated":[202],"increased":[204],"tidal":[205],"may":[209],"involved":[211],"intracellular":[214],"mediation":[215],"stimulatory":[218],"event.":[219],"Finally,":[220],"evidence":[223],"(stimulatory)":[226],"-cholinergic":[227],"(inhibitory":[228],"antagonism":[229]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
