{"id":"https://openalex.org/W1985169708","doi":"https://doi.org/10.1021/bc00024a004","title":"Synthesis of bulky .beta.-lactams for inhibition of cell surface .beta.-lactamase activity","display_name":"Synthesis of bulky .beta.-lactams for inhibition of cell surface .beta.-lactamase activity","publication_year":1993,"publication_date":"1993-11-01","ids":{"openalex":"https://openalex.org/W1985169708","doi":"https://doi.org/10.1021/bc00024a004","mag":"1985169708","pmid":"https://pubmed.ncbi.nlm.nih.gov/8305512"},"language":"en","primary_location":{"id":"doi:10.1021/bc00024a004","doi":"https://doi.org/10.1021/bc00024a004","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bc00024a004","pdf_url":null,"source":{"id":"https://openalex.org/S155115410","display_name":"Bioconjugate Chemistry","issn_l":"1043-1802","issn":["1043-1802","1520-4812"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioconjugate Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020541670","display_name":"D. Nedra Karunaratne","orcid":"https://orcid.org/0000-0003-0143-820X","observed_orcids":["https://orcid.org/0000-0003-0143-820X","https://orcid.org/0009-0009-0588-7628"]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"D. Nedra Karunaratne","raw_affiliation_strings":["Department of Microbiology, University of British Columbia, Vancouver, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, University of British Columbia, Vancouver, Canada","institution_ids":["https://openalex.org/I141945490"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Susan Farmer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Susan Farmer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5066530115","display_name":"Robert E. W. Hancock","orcid":"https://orcid.org/0000-0001-5989-8503","observed_orcids":["https://orcid.org/0000-0001-5989-8503","https://orcid.org/0000-0003-2231-4716","https://orcid.org/0000-0001-5465-3814"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert E. W. Hancock","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":0.3143,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.50808727,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"4","issue":"6","first_page":"434","last_page":"439"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13489","display_name":"Synthesis of \u03b2-Lactam Compounds","score":0.8109999895095825,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T13489","display_name":"Synthesis of \u03b2-Lactam Compounds","score":0.8109999895095825,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.11969999969005585,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10578","display_name":"Supramolecular Chemistry and Complexes","score":0.016200000420212746,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/beta-lactamase-inhibitors","display_name":"beta-lactamase inhibitors","score":0.871999979019165},{"id":"https://openalex.org/keywords/beta-cyclodextrin","display_name":"\u03b2-cyclodextrin","score":0.9279999732971191},{"id":"https://openalex.org/keywords/methicillin","display_name":"methicillin","score":0.9829999804496765},{"id":"https://openalex.org/keywords/hydrophilic-linkers","display_name":"hydrophilic linkers","score":0.7620000243186951},{"id":"https://openalex.org/keywords/spacer-length","display_name":"spacer length","score":0.8069999814033508},{"id":"https://openalex.org/keywords/sodium-metaperiodate-oxidation","display_name":"sodium metaperiodate oxidation","score":0.890999972820282},{"id":"https://openalex.org/keywords/outer-membrane-permeability","display_name":"outer membrane permeability","score":0.8320000171661377},{"id":"https://openalex.org/keywords/beta-lactam-antibiotics","display_name":"beta-lactam antibiotics","score":0.7129999995231628},{"id":"https://openalex.org/keywords/beta-lactamase-inhibition","display_name":"beta-lactamase inhibition","score":0.5830000042915344}],"concepts":[{"id":"https://openalex.org/C2778805511","wikidata":"https://www.wikidata.org/wiki/Q1713","display_name":"Citation","level":2,"score":0.7437368035316467},{"id":"https://openalex.org/C2778407487","wikidata":"https://www.wikidata.org/wiki/Q14565201","display_name":"Altmetrics","level":2,"score":0.7383729219436646},{"id":"https://openalex.org/C2776174256","wikidata":"https://www.wikidata.org/wiki/Q830842","display_name":"BETA (programming language)","level":2,"score":0.5920128226280212},{"id":"https://openalex.org/C2778447006","wikidata":"https://www.wikidata.org/wiki/Q1156474","display_name":"Icon","level":2,"score":0.5711187124252319},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5282865166664124},{"id":"https://openalex.org/C23123220","wikidata":"https://www.wikidata.org/wiki/Q816826","display_name":"Information retrieval","level":1,"score":0.49136438965797424},{"id":"https://openalex.org/C518677369","wikidata":"https://www.wikidata.org/wiki/Q202833","display_name":"Social media","level":2,"score":0.475015252828598},{"id":"https://openalex.org/C136764020","wikidata":"https://www.wikidata.org/wiki/Q466","display_name":"World Wide Web","level":1,"score":0.4051315188407898},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D002463","descriptor_name":"Cell Membrane Permeability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002626","descriptor_name":"Chemistry, Pharmaceutical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003505","descriptor_name":"Cyclodextrins","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D003505","descriptor_name":"Cyclodextrins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004337","descriptor_name":"Drug Carriers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008712","descriptor_name":"Methicillin","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D008712","descriptor_name":"Methicillin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008712","descriptor_name":"Methicillin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008970","descriptor_name":"Molecular Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012995","descriptor_name":"Solubility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014867","descriptor_name":"Water","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D047392","descriptor_name":"beta-Cyclodextrins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D065093","descriptor_name":"beta-Lactamase Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1021/bc00024a004","doi":"https://doi.org/10.1021/bc00024a004","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bc00024a004","pdf_url":null,"source":{"id":"https://openalex.org/S155115410","display_name":"Bioconjugate Chemistry","issn_l":"1043-1802","issn":["1043-1802","1520-4812"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioconjugate Chemistry","raw_type":"journal-article"},{"id":"pmid:8305512","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8305512","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioconjugate chemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.4043000042438507}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/6","display_name":"Clean water and sanitation","score":0.7300000190734863}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W1968834637","https://openalex.org/W1984700054","https://openalex.org/W1986790126","https://openalex.org/W1991665650","https://openalex.org/W1996779216","https://openalex.org/W2023487177","https://openalex.org/W2043989787","https://openalex.org/W2069449656","https://openalex.org/W2079390694","https://openalex.org/W2095166719","https://openalex.org/W2095546309","https://openalex.org/W2111516721","https://openalex.org/W2416236221"],"related_works":["https://openalex.org/W2010441071","https://openalex.org/W1991167655","https://openalex.org/W4393944120","https://openalex.org/W2137079393","https://openalex.org/W2022656554","https://openalex.org/W7216787225","https://openalex.org/W2068838088","https://openalex.org/W1998475468","https://openalex.org/W2334749627","https://openalex.org/W2131089152"],"abstract_inverted_index":{"Procedures":[0],"are":[1],"described":[2],"for":[3,51,70,117],"the":[4,25,30,34,42,54,60,78,106,109],"preparation":[5],"of":[6,9,12,37,41,77,100,108,120],"a":[7,48],"series":[8],"compounds":[10,67],"consisting":[11],"methicillin":[13,27,84],"linked":[14],"to":[15,24,28,53,59],"beta-cyclodextrin":[16,43,82],"through":[17],"variable":[18],"hydrophilic":[19],"linkers.":[20],"beta-Cyclodextrin":[21],"was":[22,57,85],"coupled":[23,58],"antibiotic":[26,31],"prevent":[29],"from":[32],"permeating":[33],"outer":[35],"membranes":[36],"bacteria.":[38],"Stoichiometric":[39],"oxidation":[40],"with":[44,94],"sodium":[45],"metaperiodate":[46],"provided":[47],"functional":[49],"group":[50],"coupling":[52],"linker.":[55],"Methicillin":[56],"linker":[61],"via":[62],"its":[63],"carboxyl":[64],"group.":[65],"These":[66],"were":[68,97],"tested":[69],"activity":[71],"toward":[72],"purified":[73],"beta-lactamase.":[74,101,121],"The":[75],"length":[76,107],"spacer":[79,110],"arm":[80],"between":[81],"and":[83,90],"crucial":[86],"in":[87],"binding":[88],"beta-lactamase":[89],"inhibiting":[91],"activity.":[92],"Compounds":[93],"longer":[95],"spacers":[96],"effective":[98],"inhibitors":[99],"We":[102],"have":[103],"deduced":[104],"that":[105],"should":[111],"be":[112],"greater":[113],"than":[114],"16":[115],"A":[116],"optimum":[118],"inhibition":[119]},"counts_by_year":[{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}