{"id":"https://openalex.org/W1985167488","doi":"https://doi.org/10.1016/j.taap.2014.11.010","title":"Mitochondrial targeting of bilirubin regulatory enzymes: An adaptive response to oxidative stress","display_name":"Mitochondrial targeting of bilirubin regulatory enzymes: An adaptive response to oxidative stress","publication_year":2014,"publication_date":"2014-12-03","ids":{"openalex":"https://openalex.org/W1985167488","doi":"https://doi.org/10.1016/j.taap.2014.11.010","mag":"1985167488","pmid":"https://pubmed.ncbi.nlm.nih.gov/25478736"},"language":"en","primary_location":{"id":"doi:10.1016/j.taap.2014.11.010","doi":"https://doi.org/10.1016/j.taap.2014.11.010","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.taap.2014.11.010","pdf_url":null,"source":{"id":"https://openalex.org/S42307217","display_name":"Toxicology and Applied Pharmacology","issn_l":"0041-008X","issn":["0041-008X","1096-0333"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology and Applied Pharmacology","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W1985167488"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029511592","display_name":"Siti Nur Fadzilah Muhsain","orcid":"https://orcid.org/0000-0002-0068-7784","observed_orcids":["https://orcid.org/0000-0002-0068-7784"]},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Siti Nur Fadzilah Muhsain","raw_affiliation_strings":["The University of Queensland, National Research Centre for Environmental Toxicology (Entox), 4072 Brisbane, Queensland, Australia; Faculty of Pharmacy, University Teknologi Mara, Malaysia. Electronic address: sitinurfadzilah077@ppinang.uitm.edu.my"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Queensland, National Research Centre for Environmental Toxicology (Entox), 4072 Brisbane, Queensland, Australia; Faculty of Pharmacy, University Teknologi Mara, Malaysia. Electronic address: sitinurfadzilah077@ppinang.uitm.edu.my","institution_ids":["https://openalex.org/I165143802"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111893153","display_name":"Matti Alarik Lang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Matti A. Lang","raw_affiliation_strings":["The University of Queensland, National Research Centre for Environmental Toxicology (Entox), 4072 Brisbane, Queensland, Australia. Electronic address: m.lang@uq.edu.au"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Queensland, National Research Centre for Environmental Toxicology (Entox), 4072 Brisbane, Queensland, Australia. Electronic address: m.lang@uq.edu.au","institution_ids":["https://openalex.org/I165143802"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075940999","display_name":"A\u2019edah Abu-Bakar","orcid":"https://orcid.org/0000-0002-6138-4234","observed_orcids":["https://orcid.org/0000-0002-6138-4234"]},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"A'edah Abu-Bakar","raw_affiliation_strings":["The University of Queensland, National Research Centre for Environmental Toxicology (Entox), 4072 Brisbane, Queensland, Australia. Electronic address: a.abubakar@uq.edu.au"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Queensland, National Research Centre for Environmental Toxicology (Entox), 4072 Brisbane, Queensland, Australia. Electronic address: a.abubakar@uq.edu.au","institution_ids":["https://openalex.org/I165143802"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5075940999"],"corresponding_institution_ids":["https://openalex.org/I165143802"],"apc_list":{"value":4200,"currency":"USD","value_usd":4200},"apc_paid":null,"fwci":0.5206,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.56919944,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"282","issue":"1","first_page":"77","last_page":"89"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11848","display_name":"Heme Oxygenase-1 and Carbon Monoxide","score":0.8622999787330627,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11848","display_name":"Heme Oxygenase-1 and Carbon Monoxide","score":0.8622999787330627,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12068","display_name":"Neonatal Health and Biochemistry","score":0.11010000109672546,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11332","display_name":"Genomics, phytochemicals, and oxidative stress","score":0.00419999985024333,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bilirubin","display_name":"bilirubin","score":0.953000009059906},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.6589999794960022},{"id":"https://openalex.org/keywords/mitochondrial-targeting","display_name":"mitochondrial targeting","score":0.8360000252723694},{"id":"https://openalex.org/keywords/heme-oxygenase-1","display_name":"heme oxygenase-1","score":0.9589999914169312},{"id":"https://openalex.org/keywords/cyp2a5","display_name":"CYP2A5","score":0.9810000061988831},{"id":"https://openalex.org/keywords/bilirubin-oxidation","display_name":"bilirubin oxidation","score":0.8669999837875366},{"id":"https://openalex.org/keywords/nrf2-translocation","display_name":"Nrf2 nuclear translocation","score":0.8240000009536743},{"id":"https://openalex.org/keywords/protein-carbonylation","display_name":"protein carbonylation","score":0.746999979019165},{"id":"https://openalex.org/keywords/adrenodoxin-reductase","display_name":"adrenodoxin reductase","score":0.8799999952316284},{"id":"https://openalex.org/keywords/liver-mitochondria","display_name":"liver mitochondria","score":0.6959999799728394},{"id":"https://openalex.org/keywords/microsomes","display_name":"microsomes","score":0.7200000286102295},{"id":"https://openalex.org/keywords/ugt1a1","display_name":"UGT1A1","score":0.8149999976158142},{"id":"https://openalex.org/keywords/cytochrome-c","display_name":"cytochrome c","score":0.6359999775886536},{"id":"https://openalex.org/keywords/membrane-potential","display_name":"membrane potential","score":0.7540000081062317}],"concepts":[{"id":"https://openalex.org/C87644729","wikidata":"https://www.wikidata.org/wiki/Q547502","display_name":"Microsome","level":3,"score":0.712596595287323},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.6929634809494019},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5600301027297974},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.537014365196228},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5146373510360718},{"id":"https://openalex.org/C2779219270","wikidata":"https://www.wikidata.org/wiki/Q419972","display_name":"Heme oxygenase","level":4,"score":0.5141471028327942},{"id":"https://openalex.org/C2779730776","wikidata":"https://www.wikidata.org/wiki/Q5631153","display_name":"HMOX1","level":5,"score":0.5126087069511414},{"id":"https://openalex.org/C123249941","wikidata":"https://www.wikidata.org/wiki/Q306116","display_name":"Cytochrome c oxidase","level":3,"score":0.483095645904541},{"id":"https://openalex.org/C2776217839","wikidata":"https://www.wikidata.org/wiki/Q189621","display_name":"Heme","level":3,"score":0.475088506937027},{"id":"https://openalex.org/C57600042","wikidata":"https://www.wikidata.org/wiki/Q227564","display_name":"Oxidative phosphorylation","level":2,"score":0.46588531136512756},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.452536404132843},{"id":"https://openalex.org/C75385678","wikidata":"https://www.wikidata.org/wiki/Q4896390","display_name":"Inner mitochondrial membrane","level":3,"score":0.4418390393257141},{"id":"https://openalex.org/C2779907587","wikidata":"https://www.wikidata.org/wiki/Q14901439","display_name":"Glucuronidation","level":4,"score":0.4105381965637207},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.40772002935409546}],"mesh":[{"descriptor_ui":"D000072467","descriptor_name":"Cytochrome P450 Family 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000099148","descriptor_name":"UGT1A1 Enzyme","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000222","descriptor_name":"Adaptation, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001189","descriptor_name":"Aryl Hydrocarbon Hydroxylases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D001189","descriptor_name":"Aryl Hydrocarbon Hydroxylases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001663","descriptor_name":"Bilirubin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005287","descriptor_name":"Ferredoxin-NADP Reductase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008811","descriptor_name":"Mice, Inbred DBA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008862","descriptor_name":"Microsomes, Liver","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008930","descriptor_name":"Mitochondria, Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008930","descriptor_name":"Mitochondria, Liver","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014453","descriptor_name":"Glucuronosyltransferase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016877","descriptor_name":"Oxidants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D021581","descriptor_name":"Active Transport, Cell Nucleus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044925","descriptor_name":"Oxidoreductases Acting on CH-CH Group Donors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050050","descriptor_name":"Protein Carbonylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051267","descriptor_name":"NF-E2-Related Factor 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051547","descriptor_name":"Heme Oxygenase-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.taap.2014.11.010","doi":"https://doi.org/10.1016/j.taap.2014.11.010","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.taap.2014.11.010","pdf_url":null,"source":{"id":"https://openalex.org/S42307217","display_name":"Toxicology and Applied Pharmacology","issn_l":"0041-008X","issn":["0041-008X","1096-0333"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology and Applied Pharmacology","raw_type":"journal-article"},{"id":"pmid:25478736","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25478736","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology and applied pharmacology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6384620860","display_name":null,"funder_award_id":"UQECR2013002328","funder_id":"https://openalex.org/F4320320984","funder_display_name":"University of Queensland"}],"funders":[{"id":"https://openalex.org/F4320310077","display_name":"National Research Centre","ror":"https://ror.org/02n85j827"},{"id":"https://openalex.org/F4320311869","display_name":"Queensland Health","ror":"https://ror.org/00c1dt378"},{"id":"https://openalex.org/F4320320984","display_name":"University of Queensland","ror":"https://ror.org/00rqy9422"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":67,"referenced_works":["https://openalex.org/W41364010","https://openalex.org/W183120241","https://openalex.org/W1436936464","https://openalex.org/W1486627395","https://openalex.org/W1491243950","https://openalex.org/W1523213544","https://openalex.org/W1534400312","https://openalex.org/W1585595042","https://openalex.org/W1775749144","https://openalex.org/W1963675326","https://openalex.org/W1964374446","https://openalex.org/W1964879817","https://openalex.org/W1965410733","https://openalex.org/W1965752252","https://openalex.org/W1969690844","https://openalex.org/W1972015914","https://openalex.org/W1980057848","https://openalex.org/W1980608195","https://openalex.org/W1980648213","https://openalex.org/W1983227864","https://openalex.org/W1992937990","https://openalex.org/W1998693229","https://openalex.org/W2001859397","https://openalex.org/W2004747619","https://openalex.org/W2005117526","https://openalex.org/W2009221661","https://openalex.org/W2013896134","https://openalex.org/W2017026597","https://openalex.org/W2023318431","https://openalex.org/W2027367821","https://openalex.org/W2034833926","https://openalex.org/W2048697090","https://openalex.org/W2054523971","https://openalex.org/W2057294473","https://openalex.org/W2058280551","https://openalex.org/W2058487112","https://openalex.org/W2059643569","https://openalex.org/W2062685624","https://openalex.org/W2062897750","https://openalex.org/W2070764343","https://openalex.org/W2073819646","https://openalex.org/W2087777085","https://openalex.org/W2089871171","https://openalex.org/W2090636372","https://openalex.org/W2091296592","https://openalex.org/W2091368779","https://openalex.org/W2094570479","https://openalex.org/W2098602095","https://openalex.org/W2106521316","https://openalex.org/W2112418230","https://openalex.org/W2120856924","https://openalex.org/W2122900878","https://openalex.org/W2128347141","https://openalex.org/W2132804094","https://openalex.org/W2136926962","https://openalex.org/W2152939975","https://openalex.org/W2157502169","https://openalex.org/W2231680249","https://openalex.org/W2329855654","https://openalex.org/W2339736327","https://openalex.org/W2409651635","https://openalex.org/W2414996903","https://openalex.org/W2418113965","https://openalex.org/W2462880913","https://openalex.org/W6601684858","https://openalex.org/W6629140012","https://openalex.org/W6714451021"],"related_works":["https://openalex.org/W59521777","https://openalex.org/W7096740969","https://openalex.org/W1970077557","https://openalex.org/W1976691420","https://openalex.org/W2414996903","https://openalex.org/W1996948427","https://openalex.org/W4412988405","https://openalex.org/W2769779833","https://openalex.org/W109025034","https://openalex.org/W2105273833"],"abstract_inverted_index":null,"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
