{"id":"https://openalex.org/W1985159472","doi":"https://doi.org/10.1152/ajpregu.00585.2012","title":"Activation of cannabinoid receptor 2 inhibits experimental cystitis","display_name":"Activation of cannabinoid receptor 2 inhibits experimental cystitis","publication_year":2013,"publication_date":"2013-03-21","ids":{"openalex":"https://openalex.org/W1985159472","doi":"https://doi.org/10.1152/ajpregu.00585.2012","mag":"1985159472","pmid":"https://pubmed.ncbi.nlm.nih.gov/23515618","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3652164"},"language":"en","primary_location":{"id":"doi:10.1152/ajpregu.00585.2012","doi":"https://doi.org/10.1152/ajpregu.00585.2012","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpregu.00585.2012","pdf_url":null,"source":{"id":"https://openalex.org/S59702976","display_name":"American Journal of Physiology-Regulatory, Integrative and Comparative Physiology","issn_l":"0363-6119","issn":["0363-6119","1522-1490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Regulatory, Integrative and Comparative Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/articles/PMC3652164","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103124581","display_name":"Zunyi Wang","orcid":"https://orcid.org/0000-0002-1003-5456","observed_orcids":["https://orcid.org/0000-0002-1003-5456"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Zun-Yi Wang","raw_affiliation_strings":["Department of Surgical Sciences, University of Wisconsin-Madison, Madison, Wisconsin; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgical Sciences, University of Wisconsin-Madison, Madison, Wisconsin; and","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021921939","display_name":"Peiqing Wang","orcid":"https://orcid.org/0000-0002-4649-1875","observed_orcids":["https://orcid.org/0000-0002-4649-1875"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peiqing Wang","raw_affiliation_strings":["Department of Surgical Sciences, University of Wisconsin-Madison, Madison, Wisconsin; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgical Sciences, University of Wisconsin-Madison, Madison, Wisconsin; and","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082427145","display_name":"Dale E. Bjorling","orcid":"https://orcid.org/0000-0003-4680-7670","observed_orcids":["https://orcid.org/0000-0003-4680-7670"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dale E. Bjorling","raw_affiliation_strings":["Department of Surgical Sciences, University of Wisconsin-Madison, Madison, Wisconsin; and","Department of Urology, University of Wisconsin-Madison, Madison, Wisconsin"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgical Sciences, University of Wisconsin-Madison, Madison, Wisconsin; and","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"Department of Urology, University of Wisconsin-Madison, Madison, Wisconsin","institution_ids":["https://openalex.org/I135310074"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5103124581"],"corresponding_institution_ids":["https://openalex.org/I135310074"],"apc_list":null,"apc_paid":null,"fwci":3.4267,"has_fulltext":false,"cited_by_count":38,"citation_normalized_percentile":{"value":0.91157468,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"304","issue":"10","first_page":"R846","last_page":"R853"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10414","display_name":"Cannabis and Cannabinoid Research","score":0.9657999873161316,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10414","display_name":"Cannabis and Cannabinoid Research","score":0.9657999873161316,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10279","display_name":"Urinary Bladder and Prostate Research","score":0.021700000390410423,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.005100000184029341,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cb2-receptor","display_name":"CB2 receptor","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cystitis","display_name":"cystitis","score":0.8029999732971191},{"id":"https://openalex.org/keywords/am630","display_name":"AM630","score":0.9169999957084656},{"id":"https://openalex.org/keywords/mapk-erk-pathway","display_name":"MAPK/ERK pathway","score":0.9350000023841858},{"id":"https://openalex.org/keywords/p38-mapk","display_name":"p38 MAPK","score":0.6729999780654907},{"id":"https://openalex.org/keywords/jnk","display_name":"JNK","score":0.9990000128746033},{"id":"https://openalex.org/keywords/acrolein","display_name":"acrolein","score":0.7329999804496765},{"id":"https://openalex.org/keywords/urothelial-cells","display_name":"urothelial cells","score":0.8899999856948853},{"id":"https://openalex.org/keywords/bladder-pain","display_name":"bladder pain","score":0.6200000047683716},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.6420000195503235}],"concepts":[{"id":"https://openalex.org/C93248783","wikidata":"https://www.wikidata.org/wiki/Q21150595","display_name":"Cannabinoid receptor type 2","level":5,"score":0.8192906379699707},{"id":"https://openalex.org/C2780871563","wikidata":"https://www.wikidata.org/wiki/Q422936","display_name":"Cannabinoid","level":3,"score":0.7499220967292786},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.7348886728286743},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6688071489334106},{"id":"https://openalex.org/C148001335","wikidata":"https://www.wikidata.org/wiki/Q421237","display_name":"Cannabinoid receptor","level":4,"score":0.6283031702041626},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5754680037498474},{"id":"https://openalex.org/C51551487","wikidata":"https://www.wikidata.org/wiki/Q2043632","display_name":"p38 mitogen-activated protein kinases","level":4,"score":0.514546811580658},{"id":"https://openalex.org/C2779245659","wikidata":"https://www.wikidata.org/wiki/Q1633866","display_name":"Hyperalgesia","level":4,"score":0.5091347098350525},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4700932204723358},{"id":"https://openalex.org/C2776158853","wikidata":"https://www.wikidata.org/wiki/Q4652514","display_name":"AM251","level":5,"score":0.4608594477176666},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.45028218626976013},{"id":"https://openalex.org/C46721173","wikidata":"https://www.wikidata.org/wiki/Q368952","display_name":"Endocannabinoid system","level":3,"score":0.4498622715473175},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.433268278837204},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4159048795700073},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.35755613446235657},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.32872533798217773},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.25289058685302734},{"id":"https://openalex.org/C15490471","wikidata":"https://www.wikidata.org/wiki/Q2734305","display_name":"Nociception","level":3,"score":0.2414085566997528},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09661659598350525}],"mesh":[{"descriptor_ui":"D000171","descriptor_name":"Acrolein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003556","descriptor_name":"Cystitis","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D003556","descriptor_name":"Cystitis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003556","descriptor_name":"Cystitis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006930","descriptor_name":"Hyperalgesia","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D006930","descriptor_name":"Hyperalgesia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006930","descriptor_name":"Hyperalgesia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007192","descriptor_name":"Indenes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007192","descriptor_name":"Indenes","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010147","descriptor_name":"Pain Measurement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011720","descriptor_name":"Pyrazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011720","descriptor_name":"Pyrazoles","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D012720","descriptor_name":"Severity of Illness Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020928","descriptor_name":"Mitogen-Activated Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D043885","descriptor_name":"Receptor, Cannabinoid, CB2","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D043885","descriptor_name":"Receptor, Cannabinoid, CB2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D043885","descriptor_name":"Receptor, Cannabinoid, CB2","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D063386","descriptor_name":"Cannabinoid Receptor Agonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D063386","descriptor_name":"Cannabinoid Receptor Agonists","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D063387","descriptor_name":"Cannabinoid Receptor Antagonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1152/ajpregu.00585.2012","doi":"https://doi.org/10.1152/ajpregu.00585.2012","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpregu.00585.2012","pdf_url":null,"source":{"id":"https://openalex.org/S59702976","display_name":"American Journal of Physiology-Regulatory, Integrative and Comparative Physiology","issn_l":"0363-6119","issn":["0363-6119","1522-1490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Regulatory, Integrative and Comparative Physiology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2995698","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3652164","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3652164","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3652164","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Physiol Regul Integr Comp Physiol","raw_type":"Text"},{"id":"pmid:23515618","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23515618","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of physiology. Regulatory, integrative and comparative physiology","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2995698","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3652164","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1852109105","display_name":"Neurovascular and Behavorial Response to Cystitis","funder_award_id":"R01DK066349","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G725978747","display_name":"Endogenous Cannabinoids and NGF Signaling in Pain Associated with Cystitis","funder_award_id":"R01DK088806","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":79,"referenced_works":["https://openalex.org/W646114512","https://openalex.org/W1508264626","https://openalex.org/W1546484483","https://openalex.org/W1561891673","https://openalex.org/W1578820780","https://openalex.org/W1589958543","https://openalex.org/W1594786713","https://openalex.org/W1759868377","https://openalex.org/W1880626333","https://openalex.org/W1964020207","https://openalex.org/W1964037009","https://openalex.org/W1975486846","https://openalex.org/W1979203254","https://openalex.org/W1980122275","https://openalex.org/W1982644673","https://openalex.org/W1989263093","https://openalex.org/W1990210398","https://openalex.org/W1991497365","https://openalex.org/W1993835153","https://openalex.org/W1996405087","https://openalex.org/W1999457976","https://openalex.org/W2000215414","https://openalex.org/W2001196318","https://openalex.org/W2008616142","https://openalex.org/W2009436798","https://openalex.org/W2011962376","https://openalex.org/W2013094714","https://openalex.org/W2015638728","https://openalex.org/W2017876495","https://openalex.org/W2021033497","https://openalex.org/W2021645396","https://openalex.org/W2021681296","https://openalex.org/W2025278422","https://openalex.org/W2029300839","https://openalex.org/W2032288100","https://openalex.org/W2033931579","https://openalex.org/W2038586108","https://openalex.org/W2046550691","https://openalex.org/W2049395687","https://openalex.org/W2053024917","https://openalex.org/W2053461680","https://openalex.org/W2054361538","https://openalex.org/W2055746391","https://openalex.org/W2056993290","https://openalex.org/W2059988860","https://openalex.org/W2064907044","https://openalex.org/W2066803728","https://openalex.org/W2067243772","https://openalex.org/W2070535004","https://openalex.org/W2076257628","https://openalex.org/W2077358692","https://openalex.org/W2078044085","https://openalex.org/W2080086221","https://openalex.org/W2082155672","https://openalex.org/W2082237701","https://openalex.org/W2085684647","https://openalex.org/W2086475285","https://openalex.org/W2092238235","https://openalex.org/W2096748864","https://openalex.org/W2100181368","https://openalex.org/W2109013410","https://openalex.org/W2110331119","https://openalex.org/W2113471632","https://openalex.org/W2119417389","https://openalex.org/W2124883636","https://openalex.org/W2125266565","https://openalex.org/W2139546732","https://openalex.org/W2141026666","https://openalex.org/W2142393381","https://openalex.org/W2146663965","https://openalex.org/W2148930855","https://openalex.org/W2150573822","https://openalex.org/W2152358123","https://openalex.org/W2158969445","https://openalex.org/W2160805419","https://openalex.org/W2164676774","https://openalex.org/W2172201406","https://openalex.org/W4211115748","https://openalex.org/W4211232815"],"related_works":["https://openalex.org/W2136017232","https://openalex.org/W2086230767","https://openalex.org/W2105689564","https://openalex.org/W3138575081","https://openalex.org/W1989263093","https://openalex.org/W7162557020","https://openalex.org/W7207104056","https://openalex.org/W1971161131","https://openalex.org/W2605066555","https://openalex.org/W2139546732"],"abstract_inverted_index":{"Cannabinoids":[0],"have":[1],"been":[2],"shown":[3],"to":[4,182],"exert":[5],"analgesic":[6],"and":[7,10,22,28,40,42,70,88,127,216],"anti-inflammatory":[8],"effects,":[9],"the":[11,58,81,93,102,111,159,165,176,200],"effects":[12,157,178],"of":[13,34,64,95,113,121,134,158,179,193,199,213],"cannabinoids":[14],"are":[15,30,90],"mediated":[16,187],"primarily":[17],"by":[18,68,164,188],"cannabinoid":[19],"receptors":[20],"1":[21],"2":[23],"(CB1and":[24],"CB2).":[25],"Both":[26],"CB1":[27],"CB2":[29,46,59,104,160,167,180,205],"present":[31],"in":[32,50,92,123,218],"bladders":[33],"various":[35],"species,":[36],"including":[37],"human,":[38],"monkey,":[39],"rodents,":[41],"it":[43],"appears":[44],"that":[45,99,204],"is":[47,206],"highly":[48],"expressed":[49],"urothelial":[51],"cells.":[52],"We":[53,77,97,173],"investigated":[54,79],"whether":[55,80],"treatment":[56,100,212],"with":[57,75,101,141,150],"agonist":[60,105,161],"GP1a":[61,106,142],"alters":[62],"severity":[63,112],"experimental":[65],"cystitis":[66,151],"induced":[67],"acrolein":[69,122],"referred":[71,146],"mechanical":[72,147],"hyperalgesia":[73,148],"associated":[74,149],"cystitis.":[76],"also":[78],"mitogen-activated":[82],"protein":[83],"kinases":[84],"(MAPK),":[85],"ERK1/2,":[86],"p38,":[87],"JNK":[89],"involved":[91],"functions":[94],"CB2.":[96],"found":[98],"selective":[103,166],"(1-10":[107],"mg/kg,":[108,171],"ip)":[109],"inhibited":[110,145],"bladder":[114,190,214],"inflammation":[115,215],"3":[116],"h":[117],"after":[118],"intravesical":[119],"instillation":[120],"a":[124,132,207],"dose-dependent":[125],"manner,":[126],"inhibition":[128],"reached":[129],"significance":[130],"at":[131,184],"dose":[133],"10":[135],"mg/kg":[136],"(P":[137,152],"<":[138,153],"0.05).":[139,154],"Treatment":[140],"(10":[143,170],"mg/kg)":[144],"The":[155,197],"inhibitory":[156,177],"were":[162],"prevented":[163],"antagonist":[168],"AM630":[169],"sc).":[172],"further":[174],"demonstrated":[175],"appear":[181],"be":[183],"least":[185],"partly":[186],"reducing":[189],"inflammation-induced":[191],"activation":[192],"ERK1/2":[194],"MAPK":[195],"pathway.":[196],"results":[198],"current":[201],"study":[202],"indicate":[203],"potential":[208],"therapeutic":[209],"target":[210],"for":[211],"pain":[217],"patients.":[219]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
