{"id":"https://openalex.org/W1985156966","doi":"https://doi.org/10.1038/nrm3699","title":"The biophysics and cell biology of lipid droplets","display_name":"The biophysics and cell biology of lipid droplets","publication_year":2013,"publication_date":"2013-11-13","ids":{"openalex":"https://openalex.org/W1985156966","doi":"https://doi.org/10.1038/nrm3699","mag":"1985156966","pmid":"https://pubmed.ncbi.nlm.nih.gov/24220094","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4526153"},"language":"en","primary_location":{"id":"doi:10.1038/nrm3699","doi":"https://doi.org/10.1038/nrm3699","is_oa":false,"landing_page_url":"https://doi.org/10.1038/nrm3699","pdf_url":null,"source":{"id":"https://openalex.org/S196724125","display_name":"Nature Reviews Molecular Cell Biology","issn_l":"1471-0072","issn":["1471-0072","1471-0080"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Reviews Molecular Cell Biology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4526153","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033444454","display_name":"Abdou Rachid Thiam","orcid":"https://orcid.org/0000-0001-7488-4724","observed_orcids":["https://orcid.org/0000-0001-7488-4724"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I29607241","display_name":"\u00c9cole Normale Sup\u00e9rieure - PSL","ror":"https://ror.org/05a0dhs15","country_code":"FR","type":"other","lineage":["https://openalex.org/I2746051580","https://openalex.org/I29607241"]},{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]},{"id":"https://openalex.org/I4387154366","display_name":"Universit\u00e9 Paris Diderot","ror":"https://ror.org/02n7qrg46","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241","https://openalex.org/I4387154366"]},{"id":"https://openalex.org/I4405264447","display_name":"Universit\u00e9 Pierre-et-Marie-Curie","ror":"https://ror.org/01yvrd251","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081","https://openalex.org/I4405264447"]}],"countries":["FR","US"],"is_corresponding":false,"raw_author_name":"Abdou Rachid Thiam","raw_affiliation_strings":["1] Yale School of Medicine, Department of Cell Biology, 333 Cedar Street, New Haven, Connecticut 06510, USA. [2] Laboratoire de Physique Statistique, Ecole Normale Sup\u00e9rieure de Paris, Universit\u00e9 Pierre et Marie Curie, Universit\u00e9 Paris Diderot, Centre National de la Recherche Scientifique, 24 rue Lhomond, 75005 Paris, France","Department of Cell Biology, Yale School of Medicine, 333 Cedar Street, New Haven, 06510, Connecticut, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1] Yale School of Medicine, Department of Cell Biology, 333 Cedar Street, New Haven, Connecticut 06510, USA. [2] Laboratoire de Physique Statistique, Ecole Normale Sup\u00e9rieure de Paris, Universit\u00e9 Pierre et Marie Curie, Universit\u00e9 Paris Diderot, Centre National de la Recherche Scientifique, 24 rue Lhomond, 75005 Paris, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I29607241","https://openalex.org/I4387154366","https://openalex.org/I4405264447"]},{"raw_affiliation_string":"Department of Cell Biology, Yale School of Medicine, 333 Cedar Street, New Haven, 06510, Connecticut, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083674919","display_name":"Robert V. Farese","orcid":"https://orcid.org/0000-0001-8103-2239","observed_orcids":["https://orcid.org/0000-0001-8103-2239"]},"institutions":[{"id":"https://openalex.org/I1321430492","display_name":"Gladstone Institutes","ror":"https://ror.org/038321296","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1321430492"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Robert V. Farese Jr","raw_affiliation_strings":["Departments of Medicine and Biochemistry and Biophysics, University of California, San Francisco, 94158, California, USA","Gladstone Institute of Cardiovascular Disease, 1650 Owens Street, San Francisco, 94158, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine and Biochemistry and Biophysics, University of California, San Francisco, 94158, California, USA","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Gladstone Institute of Cardiovascular Disease, 1650 Owens Street, San Francisco, 94158, California, USA","institution_ids":["https://openalex.org/I1321430492"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078087465","display_name":"Tobias C. Walther","orcid":"https://orcid.org/0000-0003-1442-1327","observed_orcids":["https://orcid.org/0000-0003-1442-1327"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Tobias C. Walther","raw_affiliation_strings":["Department of Cell Biology, Yale School of Medicine, 333 Cedar Street, New Haven, 06510, Connecticut, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, Yale School of Medicine, 333 Cedar Street, New Haven, 06510, Connecticut, USA","institution_ids":["https://openalex.org/I32971472"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5078087465","https://openalex.org/A5083674919"],"corresponding_institution_ids":["https://openalex.org/I1321430492","https://openalex.org/I180670191","https://openalex.org/I32971472"],"apc_list":null,"apc_paid":null,"fwci":5.9795,"has_fulltext":false,"cited_by_count":987,"citation_normalized_percentile":{"value":0.99408284,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"14","issue":"12","first_page":"775","last_page":"786"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13430","display_name":"Lipid metabolism and disorders","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lipid-droplets","display_name":"lipid droplets","score":1.0},{"id":"https://openalex.org/keywords/emulsions","display_name":"emulsions","score":0.8550000190734863},{"id":"https://openalex.org/keywords/oil-in-water-emulsions","display_name":"oil-in-water emulsions","score":0.8659999966621399},{"id":"https://openalex.org/keywords/lipid-droplet-formation","display_name":"lipid droplet formation","score":0.7429999709129333},{"id":"https://openalex.org/keywords/lipid-droplet-homeostasis","display_name":"lipid droplet homeostasis","score":0.9430000185966492},{"id":"https://openalex.org/keywords/membrane-lipid-synthesis","display_name":"membrane lipid synthesis","score":0.5730000138282776}],"concepts":[{"id":"https://openalex.org/C25095133","wikidata":"https://www.wikidata.org/wiki/Q573950","display_name":"Lipid droplet","level":2,"score":0.773679256439209},{"id":"https://openalex.org/C98539663","wikidata":"https://www.wikidata.org/wiki/Q220599","display_name":"Cytosol","level":3,"score":0.7339204549789429},{"id":"https://openalex.org/C168240541","wikidata":"https://www.wikidata.org/wiki/Q45948","display_name":"Organelle","level":2,"score":0.685149073600769},{"id":"https://openalex.org/C2778918659","wikidata":"https://www.wikidata.org/wiki/Q186915","display_name":"Phospholipid","level":3,"score":0.5685713887214661},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5287534594535828},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4937301576137543},{"id":"https://openalex.org/C39944091","wikidata":"https://www.wikidata.org/wiki/Q423279","display_name":"Lipid bilayer","level":3,"score":0.4832395017147064},{"id":"https://openalex.org/C4733338","wikidata":"https://www.wikidata.org/wiki/Q2792936","display_name":"Lipid metabolism","level":2,"score":0.47432535886764526},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.4719116985797882},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4640485644340515},{"id":"https://openalex.org/C2778123984","wikidata":"https://www.wikidata.org/wiki/Q187634","display_name":"Emulsion","level":2,"score":0.4471304416656494},{"id":"https://openalex.org/C134088382","wikidata":"https://www.wikidata.org/wiki/Q6556364","display_name":"Lipid microdomain","level":3,"score":0.4288448393344879},{"id":"https://openalex.org/C107565407","wikidata":"https://www.wikidata.org/wiki/Q6815134","display_name":"Membrane lipids","level":3,"score":0.4195917546749115},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.3932141363620758},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3568803668022156},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.265900194644928},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008560","descriptor_name":"Membrane Fluidity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008563","descriptor_name":"Membrane Lipids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013500","descriptor_name":"Surface Tension","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015388","descriptor_name":"Organelles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015388","descriptor_name":"Organelles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D050356","descriptor_name":"Lipid Metabolism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057927","descriptor_name":"Hydrophobic and Hydrophilic Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1038/nrm3699","doi":"https://doi.org/10.1038/nrm3699","is_oa":false,"landing_page_url":"https://doi.org/10.1038/nrm3699","pdf_url":null,"source":{"id":"https://openalex.org/S196724125","display_name":"Nature Reviews Molecular Cell Biology","issn_l":"1471-0072","issn":["1471-0072","1471-0080"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Reviews Molecular Cell Biology","raw_type":"journal-article"},{"id":"pmid:24220094","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24220094","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature reviews. Molecular cell biology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4526153","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4526153","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Nat Rev Mol Cell Biol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4526153","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4526153","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Nat Rev Mol Cell Biol","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G4808899026","display_name":"The Mechanisms of Lipid Droplet Formation and Regulation","funder_award_id":"R01GM099844","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G821481872","display_name":"Mechanisms of Lipid Droplet Protein Targeting","funder_award_id":"R01GM097194","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000869253","display_name":"UCSF Liver Center","funder_award_id":"P30DK026743","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":119,"referenced_works":["https://openalex.org/W583872774","https://openalex.org/W1480562807","https://openalex.org/W1593931056","https://openalex.org/W1642248471","https://openalex.org/W1648506109","https://openalex.org/W1685802105","https://openalex.org/W1895078941","https://openalex.org/W1966833519","https://openalex.org/W1968126541","https://openalex.org/W1970551770","https://openalex.org/W1972448190","https://openalex.org/W1972449427","https://openalex.org/W1978093763","https://openalex.org/W1982535786","https://openalex.org/W1983289884","https://openalex.org/W1984689638","https://openalex.org/W1985310598","https://openalex.org/W1990763472","https://openalex.org/W1994667669","https://openalex.org/W1995557559","https://openalex.org/W1997238838","https://openalex.org/W1998269914","https://openalex.org/W1999242918","https://openalex.org/W2001776102","https://openalex.org/W2002232196","https://openalex.org/W2005025746","https://openalex.org/W2007390316","https://openalex.org/W2007483105","https://openalex.org/W2007505836","https://openalex.org/W2010130739","https://openalex.org/W2011197197","https://openalex.org/W2011209922","https://openalex.org/W2012296410","https://openalex.org/W2013185153","https://openalex.org/W2013703493","https://openalex.org/W2014560331","https://openalex.org/W2017511982","https://openalex.org/W2019913278","https://openalex.org/W2026497980","https://openalex.org/W2027598069","https://openalex.org/W2029639174","https://openalex.org/W2031362507","https://openalex.org/W2034597340","https://openalex.org/W2037141003","https://openalex.org/W2038591621","https://openalex.org/W2039976941","https://openalex.org/W2041016731","https://openalex.org/W2041506421","https://openalex.org/W2042768848","https://openalex.org/W2044073767","https://openalex.org/W2044584707","https://openalex.org/W2046708296","https://openalex.org/W2046963477","https://openalex.org/W2047498251","https://openalex.org/W2051636768","https://openalex.org/W2055651091","https://openalex.org/W2056194646","https://openalex.org/W2059275312","https://openalex.org/W2060902424","https://openalex.org/W2064585995","https://openalex.org/W2066927092","https://openalex.org/W2069457144","https://openalex.org/W2070645541","https://openalex.org/W2070998260","https://openalex.org/W2071608742","https://openalex.org/W2072291193","https://openalex.org/W2072422173","https://openalex.org/W2072551674","https://openalex.org/W2072767820","https://openalex.org/W2075312095","https://openalex.org/W2078926728","https://openalex.org/W2079599967","https://openalex.org/W2084177233","https://openalex.org/W2086500706","https://openalex.org/W2087776349","https://openalex.org/W2092628520","https://openalex.org/W2093672729","https://openalex.org/W2094744133","https://openalex.org/W2095798272","https://openalex.org/W2097275712","https://openalex.org/W2100253993","https://openalex.org/W2100867316","https://openalex.org/W2101675947","https://openalex.org/W2105010006","https://openalex.org/W2105383906","https://openalex.org/W2106469122","https://openalex.org/W2111528756","https://openalex.org/W2113121382","https://openalex.org/W2113549154","https://openalex.org/W2118984478","https://openalex.org/W2119977642","https://openalex.org/W2120820877","https://openalex.org/W2121233961","https://openalex.org/W2123151328","https://openalex.org/W2125219081","https://openalex.org/W2125355462","https://openalex.org/W2126671215","https://openalex.org/W2129744834","https://openalex.org/W2136343577","https://openalex.org/W2139399016","https://openalex.org/W2141521022","https://openalex.org/W2144786229","https://openalex.org/W2149189186","https://openalex.org/W2153708911","https://openalex.org/W2156605941","https://openalex.org/W2157314258","https://openalex.org/W2157355372","https://openalex.org/W2160323598","https://openalex.org/W2165145063","https://openalex.org/W2165286872","https://openalex.org/W2170752133","https://openalex.org/W2314945655","https://openalex.org/W2330147581","https://openalex.org/W2485244922","https://openalex.org/W2599371646","https://openalex.org/W4212889658","https://openalex.org/W4238583717","https://openalex.org/W4242125333","https://openalex.org/W4298386547"],"related_works":["https://openalex.org/W2743619083","https://openalex.org/W2651326043","https://openalex.org/W2911424973","https://openalex.org/W3011853822","https://openalex.org/W4409050099","https://openalex.org/W4211093860","https://openalex.org/W4398784637","https://openalex.org/W3000608516","https://openalex.org/W1965516447","https://openalex.org/W2772291676"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":62},{"year":2025,"cited_by_count":68},{"year":2024,"cited_by_count":104},{"year":2023,"cited_by_count":78},{"year":2022,"cited_by_count":77},{"year":2021,"cited_by_count":101},{"year":2020,"cited_by_count":77},{"year":2019,"cited_by_count":68},{"year":2018,"cited_by_count":91},{"year":2017,"cited_by_count":87},{"year":2016,"cited_by_count":73},{"year":2015,"cited_by_count":59},{"year":2014,"cited_by_count":39},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
