{"id":"https://openalex.org/W1985148379","doi":"https://doi.org/10.1016/0006-2952(66)90107-9","title":"Plasma enzymes that release kinins","display_name":"Plasma enzymes that release kinins","publication_year":1966,"publication_date":"1966-01-01","ids":{"openalex":"https://openalex.org/W1985148379","doi":"https://doi.org/10.1016/0006-2952(66)90107-9","mag":"1985148379","pmid":"https://pubmed.ncbi.nlm.nih.gov/4223064"},"language":"en","primary_location":{"id":"doi:10.1016/0006-2952(66)90107-9","doi":"https://doi.org/10.1016/0006-2952(66)90107-9","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0006-2952(66)90107-9","pdf_url":null,"source":{"id":"https://openalex.org/S185534594","display_name":"Biochemical Pharmacology","issn_l":"0006-2952","issn":["0006-2952","1873-2968"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072572110","display_name":"Olga B. Henriques","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800423888","display_name":"Instituto Butantan","ror":"https://ror.org/01whwkf30","country_code":"BR","type":"facility","lineage":["https://openalex.org/I2800423888"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Olga B. Henriques","raw_affiliation_strings":["Laborat\u00f3rio de Bioqu\u00edmica, Instituto Butantan, e Laborat\u00f3rios de Farmacologia e Bioqu\u00edmica, Escola Paulista de Medicina, S\u00e3o Paulo, Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laborat\u00f3rio de Bioqu\u00edmica, Instituto Butantan, e Laborat\u00f3rios de Farmacologia e Bioqu\u00edmica, Escola Paulista de Medicina, S\u00e3o Paulo, Brasil","institution_ids":["https://openalex.org/I2800423888"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038134793","display_name":"Alba A. C. Lavras","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800423888","display_name":"Instituto Butantan","ror":"https://ror.org/01whwkf30","country_code":"BR","type":"facility","lineage":["https://openalex.org/I2800423888"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Alba A.C. Lavras","raw_affiliation_strings":["Laborat\u00f3rio de Bioqu\u00edmica, Instituto Butantan, e Laborat\u00f3rios de Farmacologia e Bioqu\u00edmica, Escola Paulista de Medicina, S\u00e3o Paulo, Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laborat\u00f3rio de Bioqu\u00edmica, Instituto Butantan, e Laborat\u00f3rios de Farmacologia e Bioqu\u00edmica, Escola Paulista de Medicina, S\u00e3o Paulo, Brasil","institution_ids":["https://openalex.org/I2800423888"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042676323","display_name":"Mina Fichman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800423888","display_name":"Instituto Butantan","ror":"https://ror.org/01whwkf30","country_code":"BR","type":"facility","lineage":["https://openalex.org/I2800423888"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Mina Fichman","raw_affiliation_strings":["Laborat\u00f3rio de Bioqu\u00edmica, Instituto Butantan, e Laborat\u00f3rios de Farmacologia e Bioqu\u00edmica, Escola Paulista de Medicina, S\u00e3o Paulo, Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laborat\u00f3rio de Bioqu\u00edmica, Instituto Butantan, e Laborat\u00f3rios de Farmacologia e Bioqu\u00edmica, Escola Paulista de Medicina, S\u00e3o Paulo, Brasil","institution_ids":["https://openalex.org/I2800423888"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057882629","display_name":"Zuleika P. Picarelli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800423888","display_name":"Instituto Butantan","ror":"https://ror.org/01whwkf30","country_code":"BR","type":"facility","lineage":["https://openalex.org/I2800423888"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Zuleika P. Picarelli","raw_affiliation_strings":["Laborat\u00f3rio de Bioqu\u00edmica, Instituto Butantan, e Laborat\u00f3rios de Farmacologia e Bioqu\u00edmica, Escola Paulista de Medicina, S\u00e3o Paulo, Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laborat\u00f3rio de Bioqu\u00edmica, Instituto Butantan, e Laborat\u00f3rios de Farmacologia e Bioqu\u00edmica, Escola Paulista de Medicina, S\u00e3o Paulo, Brasil","institution_ids":["https://openalex.org/I2800423888"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I2800423888"],"apc_list":{"value":3590,"currency":"USD","value_usd":3590},"apc_paid":null,"fwci":6.9283,"has_fulltext":false,"cited_by_count":34,"citation_normalized_percentile":{"value":0.96793003,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":null,"biblio":{"volume":"15","issue":"1","first_page":"31","last_page":"40"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11917","display_name":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11917","display_name":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13725","display_name":"Pineapple and bromelain studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/kinin-release","display_name":"kinin release","score":0.8199999928474426},{"id":"https://openalex.org/keywords/plasma-kallikrein","display_name":"plasma kallikrein","score":0.9539999961853027},{"id":"https://openalex.org/keywords/plasmin","display_name":"plasmin","score":0.9909999966621399},{"id":"https://openalex.org/keywords/kininogen","display_name":"kininogen","score":0.8040000200271606},{"id":"https://openalex.org/keywords/plasminogen-activation","display_name":"plasminogen activation","score":0.5490000247955322},{"id":"https://openalex.org/keywords/enzyme-substrate-specificity","display_name":"enzyme substrate specificity","score":0.5289999842643738}],"concepts":[{"id":"https://openalex.org/C52853521","wikidata":"https://www.wikidata.org/wiki/Q423285","display_name":"Kallikrein","level":3,"score":0.9254400730133057},{"id":"https://openalex.org/C2781071845","wikidata":"https://www.wikidata.org/wiki/Q21173374","display_name":"Plasmin","level":3,"score":0.902051568031311},{"id":"https://openalex.org/C2777902427","wikidata":"https://www.wikidata.org/wiki/Q6413860","display_name":"Kininogen","level":4,"score":0.7431564927101135},{"id":"https://openalex.org/C2776246183","wikidata":"https://www.wikidata.org/wiki/Q421924","display_name":"Kinin","level":4,"score":0.7309039831161499},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.692892849445343},{"id":"https://openalex.org/C94412978","wikidata":"https://www.wikidata.org/wiki/Q103135","display_name":"Hydrolysis","level":2,"score":0.48572736978530884},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4640011191368103},{"id":"https://openalex.org/C2777468819","wikidata":"https://www.wikidata.org/wiki/Q173670","display_name":"Arginine","level":3,"score":0.4236522316932678},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.3814164400100708},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.36385348439216614},{"id":"https://openalex.org/C2779591629","wikidata":"https://www.wikidata.org/wiki/Q24745328","display_name":"Bradykinin","level":3,"score":0.17698296904563904},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.12232095003128052},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001681","descriptor_name":"Biological Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002364","descriptor_name":"Caseins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002845","descriptor_name":"Chromatography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004798","descriptor_name":"Enzymes","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D005341","descriptor_name":"Fibrinolysin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006168","descriptor_name":"Guinea Pigs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006736","descriptor_name":"Horses","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007082","descriptor_name":"Ileum","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007610","descriptor_name":"Kallikreins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007705","descriptor_name":"Kinins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008239","descriptor_name":"Lysine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0006-2952(66)90107-9","doi":"https://doi.org/10.1016/0006-2952(66)90107-9","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0006-2952(66)90107-9","pdf_url":null,"source":{"id":"https://openalex.org/S185534594","display_name":"Biochemical Pharmacology","issn_l":"0006-2952","issn":["0006-2952","1873-2968"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Pharmacology","raw_type":"journal-article"},{"id":"pmid:4223064","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4223064","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical pharmacology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W78896514","https://openalex.org/W167519726","https://openalex.org/W1775749144","https://openalex.org/W1971501265","https://openalex.org/W1973824141","https://openalex.org/W1984368902","https://openalex.org/W1999297920","https://openalex.org/W2005426195","https://openalex.org/W2026427086","https://openalex.org/W2032877623","https://openalex.org/W2045810451","https://openalex.org/W2050856570","https://openalex.org/W2079313403","https://openalex.org/W2102953443","https://openalex.org/W2118632547","https://openalex.org/W2225843353","https://openalex.org/W2228471243","https://openalex.org/W2415793327","https://openalex.org/W2416459903","https://openalex.org/W2444443944","https://openalex.org/W4240382863","https://openalex.org/W4300501360"],"related_works":["https://openalex.org/W2092268553","https://openalex.org/W2054956753","https://openalex.org/W2440041653","https://openalex.org/W2192505924","https://openalex.org/W2001153776","https://openalex.org/W2426180170","https://openalex.org/W1991399665","https://openalex.org/W2888918080","https://openalex.org/W2009163326","https://openalex.org/W4206600929"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}