{"id":"https://openalex.org/W1985147007","doi":"https://doi.org/10.1016/0952-3278(93)90023-p","title":"Bimodal regulation of adenylate cyclase by prostaglandin E2 receptors in porcine ciliary epithelium","display_name":"Bimodal regulation of adenylate cyclase by prostaglandin E2 receptors in porcine ciliary epithelium","publication_year":1993,"publication_date":"1993-10-01","ids":{"openalex":"https://openalex.org/W1985147007","doi":"https://doi.org/10.1016/0952-3278(93)90023-p","mag":"1985147007","pmid":"https://pubmed.ncbi.nlm.nih.gov/8259373"},"language":"en","primary_location":{"id":"doi:10.1016/0952-3278(93)90023-p","doi":"https://doi.org/10.1016/0952-3278(93)90023-p","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0952-3278(93)90023-p","pdf_url":null,"source":{"id":"https://openalex.org/S9307485","display_name":"Prostaglandins Leukotrienes and Essential Fatty Acids","issn_l":"0952-3278","issn":["0952-3278","1532-2823"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Prostaglandins, Leukotrienes and Essential Fatty Acids","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041047829","display_name":"NOBUAKI SANO","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"N. Sano","raw_affiliation_strings":["Department of Ophthalmology, Wayne State University School of Medicine, Detroit, MI 48201"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Wayne State University School of Medicine, Detroit, MI 48201","institution_ids":["https://openalex.org/I185443292"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002507714","display_name":"Hitoshi Shichi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H. Shichi","raw_affiliation_strings":["Department of Ophthalmology, Wayne State University School of Medicine, Detroit, MI 48201, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Wayne State University School of Medicine, Detroit, MI 48201, USA","institution_ids":["https://openalex.org/I185443292"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I185443292"],"apc_list":{"value":3790,"currency":"USD","value_usd":3790},"apc_paid":null,"fwci":0.3124,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.54373522,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"49","issue":"4","first_page":"765","last_page":"769"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.7192000150680542,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.7192000150680542,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.1039000004529953,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.03400000184774399,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prostaglandin-e2-receptor","display_name":"prostaglandin E2 receptor","score":0.9539999961853027},{"id":"https://openalex.org/keywords/adenylate-cyclase-regulation","display_name":"adenylate cyclase regulation","score":0.8830000162124634},{"id":"https://openalex.org/keywords/ciliary-epithelium","display_name":"ciliary epithelium","score":0.9459999799728394},{"id":"https://openalex.org/keywords/pigmented-epithelium","display_name":"pigmented epithelium","score":0.9940000176429749},{"id":"https://openalex.org/keywords/receptor-subtypes","display_name":"receptor subtypes","score":0.7670000195503235},{"id":"https://openalex.org/keywords/camp","display_name":"cyclic AMP","score":0.5450000166893005},{"id":"https://openalex.org/keywords/aqueous-humor-production","display_name":"aqueous humor production","score":0.9359999895095825},{"id":"https://openalex.org/keywords/aqueous-humor-outflow","display_name":"aqueous humor outflow","score":0.8460000157356262},{"id":"https://openalex.org/keywords/porcine-eyes","display_name":"porcine eyes","score":0.6639999747276306}],"concepts":[{"id":"https://openalex.org/C180526460","wikidata":"https://www.wikidata.org/wiki/Q356240","display_name":"Adenylate kinase","level":3,"score":0.8384389877319336},{"id":"https://openalex.org/C2780069284","wikidata":"https://www.wikidata.org/wiki/Q5198121","display_name":"Cyclase","level":3,"score":0.8370630741119385},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.6127544045448303},{"id":"https://openalex.org/C2776991684","wikidata":"https://www.wikidata.org/wiki/Q190012","display_name":"Adenosine","level":2,"score":0.5562800168991089},{"id":"https://openalex.org/C2776668983","wikidata":"https://www.wikidata.org/wiki/Q210041","display_name":"Cyclic adenosine monophosphate","level":3,"score":0.530908465385437},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.5245452523231506},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.49979329109191895},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.48114240169525146},{"id":"https://openalex.org/C2780664492","wikidata":"https://www.wikidata.org/wiki/Q209717","display_name":"Prostaglandin","level":2,"score":0.4485366642475128},{"id":"https://openalex.org/C2777956040","wikidata":"https://www.wikidata.org/wiki/Q416554","display_name":"Prostaglandin E2","level":2,"score":0.44566431641578674},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.4224362373352051},{"id":"https://openalex.org/C2778434524","wikidata":"https://www.wikidata.org/wiki/Q1048080","display_name":"Ciliary body","level":2,"score":0.41394928097724915},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.389815092086792},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.38457760214805603},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.38396066427230835},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3821524977684021},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3758901357650757},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000242","descriptor_name":"Cyclic AMP","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000262","descriptor_name":"Adenylyl Cyclases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001667","descriptor_name":"Binding, Competitive","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002924","descriptor_name":"Ciliary Body","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004848","descriptor_name":"Epithelium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015232","descriptor_name":"Dinoprostone","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015290","descriptor_name":"Second Messenger Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018078","descriptor_name":"Receptors, Prostaglandin E","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/0952-3278(93)90023-p","doi":"https://doi.org/10.1016/0952-3278(93)90023-p","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0952-3278(93)90023-p","pdf_url":null,"source":{"id":"https://openalex.org/S9307485","display_name":"Prostaglandins Leukotrienes and Essential Fatty Acids","issn_l":"0952-3278","issn":["0952-3278","1532-2823"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Prostaglandins, Leukotrienes and Essential Fatty Acids","raw_type":"journal-article"},{"id":"pmid:8259373","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8259373","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Prostaglandins, leukotrienes, and essential fatty acids","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3838664701","display_name":"DRUG METABOLISM IN THE EYE","funder_award_id":"R01EY004694","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"}],"funders":[{"id":"https://openalex.org/F4320306811","display_name":"Research to Prevent Blindness","ror":"https://ror.org/04drjs621"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W4256171","https://openalex.org/W160701115","https://openalex.org/W181792848","https://openalex.org/W625075573","https://openalex.org/W631486094","https://openalex.org/W1972500637","https://openalex.org/W1972735012","https://openalex.org/W1976691398","https://openalex.org/W1985453680","https://openalex.org/W2000313101","https://openalex.org/W2015286298","https://openalex.org/W2059589670","https://openalex.org/W2061114165","https://openalex.org/W2063968553","https://openalex.org/W2082124289","https://openalex.org/W2163464966","https://openalex.org/W4232534952","https://openalex.org/W6600173657"],"related_works":["https://openalex.org/W2090272621","https://openalex.org/W2015286298","https://openalex.org/W2046962290","https://openalex.org/W2058918625","https://openalex.org/W2084397565","https://openalex.org/W2026535172","https://openalex.org/W2175429806","https://openalex.org/W2009194925","https://openalex.org/W4256171","https://openalex.org/W2003576178"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
