{"id":"https://openalex.org/W1985105403","doi":"https://doi.org/10.1523/jneurosci.1190-07.2007","title":"Coregulation of Natively Expressed Pertussis Toxin-Sensitive Muscarinic Receptors with G-Protein-Activated Potassium Channels","display_name":"Coregulation of Natively Expressed Pertussis Toxin-Sensitive Muscarinic Receptors with G-Protein-Activated Potassium Channels","publication_year":2007,"publication_date":"2007-06-13","ids":{"openalex":"https://openalex.org/W1985105403","doi":"https://doi.org/10.1523/jneurosci.1190-07.2007","mag":"1985105403","pmid":"https://pubmed.ncbi.nlm.nih.gov/17567799","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6672446"},"language":"en","primary_location":{"id":"doi:10.1523/jneurosci.1190-07.2007","doi":"https://doi.org/10.1523/jneurosci.1190-07.2007","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.1190-07.2007","pdf_url":"https://www.jneurosci.org/content/jneuro/27/24/6388.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neuroscience","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.jneurosci.org/content/jneuro/27/24/6388.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012782054","display_name":"Sinead M. Clancy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1307098950","display_name":"Salk Institute for Biological Studies","ror":"https://ror.org/03xez1567","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1307098950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. M. Clancy","raw_affiliation_strings":["Peptide Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Peptide Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA","institution_ids":["https://openalex.org/I1307098950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019492505","display_name":"Stephanie B. Boyer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S. B. Boyer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5085780704","display_name":"Paul A. Slesinger","orcid":"https://orcid.org/0000-0002-3868-7528","observed_orcids":["https://orcid.org/0000-0002-3868-7528"]},"institutions":[{"id":"https://openalex.org/I1307098950","display_name":"Salk Institute for Biological Studies","ror":"https://ror.org/03xez1567","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1307098950"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P. A. Slesinger","raw_affiliation_strings":["Department of Neurosciences , University of California , San Diego , La Jolla , California 92093","Peptide Biology Laboratory , The Salk Institute for Biological Studies , La Jolla , California 92037 , and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosciences , University of California , San Diego , La Jolla , California 92093","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Peptide Biology Laboratory , The Salk Institute for Biological Studies , La Jolla , California 92037 , and","institution_ids":["https://openalex.org/I1307098950"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4352,"has_fulltext":true,"cited_by_count":22,"citation_normalized_percentile":{"value":0.54848313,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"27","issue":"24","first_page":"6388","last_page":"6399"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9096999764442444,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9096999764442444,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.07329999655485153,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.00800000037997961,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/muscarinic-receptors","display_name":"muscarinic receptors","score":0.9480000138282776},{"id":"https://openalex.org/keywords/kir3-channels","display_name":"Kir3 channels","score":0.8410000205039978},{"id":"https://openalex.org/keywords/pertussis-toxin-sensitive-g-proteins","display_name":"pertussis toxin-sensitive G proteins","score":0.8489999771118164},{"id":"https://openalex.org/keywords/m2-muscarinic-receptor","display_name":"M2 muscarinic receptor","score":0.9779999852180481},{"id":"https://openalex.org/keywords/muscarinic-m4-receptor","display_name":"M4 muscarinic receptor","score":0.9779999852180481},{"id":"https://openalex.org/keywords/sympathetic-neurons","display_name":"sympathetic neurons","score":0.9660000205039978},{"id":"https://openalex.org/keywords/oxotremorine","display_name":"oxotremorine","score":0.8220000267028809},{"id":"https://openalex.org/keywords/antimuscarinic-agents","display_name":"antimuscarinic agents","score":0.8149999976158142},{"id":"https://openalex.org/keywords/receptor-coupling","display_name":"receptor coupling","score":0.6480000019073486},{"id":"https://openalex.org/keywords/cholinergic-transmission","display_name":"cholinergic neurotransmission","score":0.6710000038146973}],"concepts":[{"id":"https://openalex.org/C33789571","wikidata":"https://www.wikidata.org/wiki/Q410959","display_name":"Muscarinic acetylcholine receptor","level":3,"score":0.8811864852905273},{"id":"https://openalex.org/C2778824757","wikidata":"https://www.wikidata.org/wiki/Q676896","display_name":"Oxotremorine","level":4,"score":0.7450487017631531},{"id":"https://openalex.org/C47488739","wikidata":"https://www.wikidata.org/wiki/Q17861931","display_name":"Muscarinic acetylcholine receptor M2","level":4,"score":0.688517689704895},{"id":"https://openalex.org/C207723603","wikidata":"https://www.wikidata.org/wiki/Q17861926","display_name":"Muscarinic acetylcholine receptor M1","level":4,"score":0.6553049683570862},{"id":"https://openalex.org/C49773422","wikidata":"https://www.wikidata.org/wiki/Q4859345","display_name":"Pertussis toxin","level":4,"score":0.5823502540588379},{"id":"https://openalex.org/C26702167","wikidata":"https://www.wikidata.org/wiki/Q901988","display_name":"Metabotropic receptor","level":4,"score":0.5784400105476379},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5054988861083984},{"id":"https://openalex.org/C64123433","wikidata":"https://www.wikidata.org/wiki/Q17861965","display_name":"Muscarinic acetylcholine receptor M4","level":4,"score":0.4850984811782837},{"id":"https://openalex.org/C80631254","wikidata":"https://www.wikidata.org/wiki/Q407438","display_name":"G protein","level":3,"score":0.44883012771606445},{"id":"https://openalex.org/C2776723954","wikidata":"https://www.wikidata.org/wiki/Q3001265","display_name":"Muscarinic antagonist","level":4,"score":0.4306703805923462},{"id":"https://openalex.org/C116289061","wikidata":"https://www.wikidata.org/wiki/Q17861955","display_name":"Muscarinic acetylcholine receptor M3","level":4,"score":0.43002602458000183},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4270564913749695},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.39547544717788696},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3749037981033325},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.32368946075439453},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20993289351463318},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.1518630087375641}],"mesh":[{"descriptor_ui":"D000704","descriptor_name":"Analysis of Variance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004705","descriptor_name":"Endocytosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005680","descriptor_name":"gamma-Aminobutyric Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008564","descriptor_name":"Membrane Potentials","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008564","descriptor_name":"Membrane Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D010095","descriptor_name":"Oxotremorine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D010095","descriptor_name":"Oxotremorine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D016716","descriptor_name":"PC12 Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018408","descriptor_name":"Patch-Clamp Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D018721","descriptor_name":"Muscarinic Agonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018727","descriptor_name":"Muscarinic Antagonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020932","descriptor_name":"Nerve Growth Factor","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D043585","descriptor_name":"Receptor, Muscarinic M2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D043585","descriptor_name":"Receptor, Muscarinic M2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051676","descriptor_name":"G Protein-Coupled Inwardly-Rectifying Potassium Channels","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051676","descriptor_name":"G Protein-Coupled Inwardly-Rectifying Potassium Channels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1523/jneurosci.1190-07.2007","doi":"https://doi.org/10.1523/jneurosci.1190-07.2007","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.1190-07.2007","pdf_url":"https://www.jneurosci.org/content/jneuro/27/24/6388.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neuroscience","raw_type":"journal-article"},{"id":"pmid:17567799","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17567799","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of neuroscience : the official journal of the Society for Neuroscience","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6672446","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6672446/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Neurosci","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.327.4909","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.327.4909","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.jneurosci.org/content/27/24/6388.full.pdf","raw_type":"text"},{"id":"mag:2186250930","doi":null,"is_oa":false,"landing_page_url":"https://www.jneurosci.org/content/27/24/6388.full.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"doi:10.1523/jneurosci.1190-07.2007","doi":"https://doi.org/10.1523/jneurosci.1190-07.2007","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.1190-07.2007","pdf_url":"https://www.jneurosci.org/content/jneuro/27/24/6388.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neuroscience","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8048999905586243,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1086881855","display_name":"Mechanisms of Protein Regulation of Potassium Channels","funder_award_id":"R01NS037682","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320308324","display_name":"McKnight Foundation","ror":"https://ror.org/003ghvj67"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1985105403.pdf","grobid_xml":"https://content.openalex.org/works/W1985105403.grobid-xml"},"referenced_works_count":74,"referenced_works":["https://openalex.org/W948550917","https://openalex.org/W1492607105","https://openalex.org/W1493120336","https://openalex.org/W1499240512","https://openalex.org/W1515479627","https://openalex.org/W1515795053","https://openalex.org/W1533708729","https://openalex.org/W1878271255","https://openalex.org/W1967206508","https://openalex.org/W1969469810","https://openalex.org/W1970092573","https://openalex.org/W1971332068","https://openalex.org/W1976409519","https://openalex.org/W1978044509","https://openalex.org/W1981893607","https://openalex.org/W1982292983","https://openalex.org/W1983399409","https://openalex.org/W1983819790","https://openalex.org/W1984034731","https://openalex.org/W1984139177","https://openalex.org/W1989425013","https://openalex.org/W1991585392","https://openalex.org/W1994737823","https://openalex.org/W1995952358","https://openalex.org/W1996405522","https://openalex.org/W1997511216","https://openalex.org/W1997698405","https://openalex.org/W2000556605","https://openalex.org/W2007027293","https://openalex.org/W2007289852","https://openalex.org/W2009445378","https://openalex.org/W2009667219","https://openalex.org/W2012927321","https://openalex.org/W2015426350","https://openalex.org/W2017689107","https://openalex.org/W2021246898","https://openalex.org/W2022936592","https://openalex.org/W2026533430","https://openalex.org/W2032466814","https://openalex.org/W2035646776","https://openalex.org/W2040896718","https://openalex.org/W2044695265","https://openalex.org/W2046002448","https://openalex.org/W2061858869","https://openalex.org/W2062346208","https://openalex.org/W2062497863","https://openalex.org/W2064096152","https://openalex.org/W2066015662","https://openalex.org/W2078047724","https://openalex.org/W2078800834","https://openalex.org/W2080669192","https://openalex.org/W2081389808","https://openalex.org/W2086134394","https://openalex.org/W2088239473","https://openalex.org/W2092760601","https://openalex.org/W2095269345","https://openalex.org/W2095565163","https://openalex.org/W2099452732","https://openalex.org/W2099975963","https://openalex.org/W2101521576","https://openalex.org/W2123631380","https://openalex.org/W2123789039","https://openalex.org/W2133264846","https://openalex.org/W2136094046","https://openalex.org/W2143466853","https://openalex.org/W2143660373","https://openalex.org/W2145929692","https://openalex.org/W2148499477","https://openalex.org/W2158662449","https://openalex.org/W2168532677","https://openalex.org/W2184780217","https://openalex.org/W2210422481","https://openalex.org/W2404274487","https://openalex.org/W2414942492"],"related_works":["https://openalex.org/W7095169441","https://openalex.org/W2117979776","https://openalex.org/W2064436493","https://openalex.org/W1977597134","https://openalex.org/W2003971289","https://openalex.org/W2013056417","https://openalex.org/W2058100090","https://openalex.org/W1967513924","https://openalex.org/W1965663770","https://openalex.org/W2402442675"],"abstract_inverted_index":{"Many":[0],"inhibitory":[1],"neurotransmitters":[2],"in":[3,29,101,147],"the":[4,19,139,148],"brain":[5],"activate":[6],"Kir3":[7,26,89,104,127,134,145],"channels":[8,27,82],"by":[9],"stimulating":[10],"pertussis":[11],"toxin":[12],"(PTX)-sensitive":[13],"G-protein-coupled":[14],"receptors.":[15],"Here,":[16],"we":[17],"investigated":[18],"regulation":[20],"of":[21,76,110,123,143],"native":[22],"muscarinic":[23,55,67,78,87,96,114],"receptors":[24,79,115,125],"and":[25,42,51,61,120,126],"expressed":[28,112],"NGF-differentiated":[30],"PC12":[31],"cells,":[32],"which":[33],"are":[34],"similar":[35],"to":[36,85],"sympathetic":[37],"neurons.":[38],"Quantitative":[39],"reverse":[40],"transcription-PCR":[41],"immunocytochemistry":[43],"revealed":[44],"that":[45],"NGF":[46],"treatment":[47],"significantly":[48],"upregulated":[49,66],"mRNA":[50],"protein":[52],"for":[53,132],"m2":[54,77],"receptors,":[56],"PTX-sensitive":[57],"G":[58],"alpha(o)":[59],"G-proteins,":[60],"Kir3.2c":[62,81],"channels.":[63,128],"Surprisingly,":[64],"these":[65],"receptor/Kir3":[68],"signaling":[69,135],"complexes":[70],"were":[71],"functionally":[72],"silent.":[73],"Ectopic":[74],"expression":[75,119],"or":[80],"was":[83],"unable":[84],"produce":[86],"receptor-activated":[88],"currents":[90],"with":[91,95],"oxotremorine.":[92],"Remarkably,":[93],"pretreatment":[94],"(m2/m4)":[97],"receptor":[98],"antagonists":[99],"resulted":[100],"robust":[102],"oxotremorine-activated":[103],"currents.":[105],"Thus,":[106],"sustained":[107],"cholinergic":[108],"stimulation":[109],"natively":[111],"m2/m4":[113],"controlled":[116],"cell":[117],"surface":[118],"functional":[121],"coupling":[122],"both":[124],"This":[129],"new":[130],"pathway":[131],"controlling":[133],"could":[136],"help":[137],"limit":[138],"potential":[140],"harmful":[141],"effects":[142],"excessive":[144],"activity":[146],"brain.":[149]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}