{"id":"https://openalex.org/W1985019251","doi":"https://doi.org/10.1002/jbm.a.30567","title":"Development, implantation, in vivo elution, and retrieval of a biocompatible, sustained release subretinal drug delivery system","display_name":"Development, implantation, in vivo elution, and retrieval of a biocompatible, sustained release subretinal drug delivery system","publication_year":2005,"publication_date":"2005-11-21","ids":{"openalex":"https://openalex.org/W1985019251","doi":"https://doi.org/10.1002/jbm.a.30567","mag":"1985019251","pmid":"https://pubmed.ncbi.nlm.nih.gov/16302225"},"language":"en","primary_location":{"id":"doi:10.1002/jbm.a.30567","doi":"https://doi.org/10.1002/jbm.a.30567","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jbm.a.30567","pdf_url":null,"source":{"id":"https://openalex.org/S184573928","display_name":"Journal of Biomedical Materials Research Part A","issn_l":"1549-3296","issn":["1549-3296","1552-4965"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biomedical Materials Research Part A","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004659684","display_name":"Nathan R. F. Beeley","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I4210095445","display_name":"Doheny Eye Institute","ror":"https://ror.org/00qvx5329","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210095445"]},{"id":"https://openalex.org/I4210103876","display_name":"SurModics (United States)","ror":"https://ror.org/01h6pd645","country_code":"US","type":"company","lineage":["https://openalex.org/I4210103876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nathan R.F. Beeley","raw_affiliation_strings":["Doheny Retina Institute, Doheny Eye Institute and Department of Ophthalmology, Keck School of Medicine, University of Southern California, 1450 San Pablo Street, Los Angeles, 90033, USA","Doheny Retina Institute, Doheny Eye Institute and Department of Ophthalmology, Keck School of Medicine, University of Southern California, 1450 San Pablo Street, Los Angeles, California 90033","SurModics, Ophthalmology Division, 9924 West 74th Street, Eden Prairie, Minnesota 55344"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Doheny Retina Institute, Doheny Eye Institute and Department of Ophthalmology, Keck School of Medicine, University of Southern California, 1450 San Pablo Street, Los Angeles, 90033, USA","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I4210095445"]},{"raw_affiliation_string":"Doheny Retina Institute, Doheny Eye Institute and Department of Ophthalmology, Keck School of Medicine, University of Southern California, 1450 San Pablo Street, Los Angeles, California 90033","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I4210095445"]},{"raw_affiliation_string":"SurModics, Ophthalmology Division, 9924 West 74th Street, Eden Prairie, Minnesota 55344","institution_ids":["https://openalex.org/I4210103876"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055290552","display_name":"Jay M. Stewart","orcid":"https://orcid.org/0000-0003-1054-3423","observed_orcids":["https://orcid.org/0000-0003-1054-3423"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I4210095445","display_name":"Doheny Eye Institute","ror":"https://ror.org/00qvx5329","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210095445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jay M. Stewart","raw_affiliation_strings":["Doheny Retina Institute, Doheny Eye Institute and Department of Ophthalmology, Keck School of Medicine, University of Southern California, 1450 San Pablo Street, Los Angeles, California 90033"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Doheny Retina Institute, Doheny Eye Institute and Department of Ophthalmology, Keck School of Medicine, University of Southern California, 1450 San Pablo Street, Los Angeles, California 90033","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I4210095445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057405723","display_name":"R. Tano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I4210095445","display_name":"Doheny Eye Institute","ror":"https://ror.org/00qvx5329","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210095445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ryotaro Tano","raw_affiliation_strings":["Doheny Retina Institute, Doheny Eye Institute and Department of Ophthalmology, Keck School of Medicine, University of Southern California, 1450 San Pablo Street, Los Angeles, California 90033"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Doheny Retina Institute, Doheny Eye Institute and Department of Ophthalmology, Keck School of Medicine, University of Southern California, 1450 San Pablo Street, Los Angeles, California 90033","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I4210095445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085987347","display_name":"Laurie R. Lawin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210103876","display_name":"SurModics (United States)","ror":"https://ror.org/01h6pd645","country_code":"US","type":"company","lineage":["https://openalex.org/I4210103876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Laurie R. Lawin","raw_affiliation_strings":["SurModics, Ophthalmology Division, 9924 West 74th Street, Eden Prairie, Minnesota 55344"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SurModics, Ophthalmology Division, 9924 West 74th Street, Eden Prairie, Minnesota 55344","institution_ids":["https://openalex.org/I4210103876"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007280018","display_name":"Ralph A. Chappa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210103876","display_name":"SurModics (United States)","ror":"https://ror.org/01h6pd645","country_code":"US","type":"company","lineage":["https://openalex.org/I4210103876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ralph A. Chappa","raw_affiliation_strings":["SurModics, Ophthalmology Division, 9924 West 74th Street, Eden Prairie, Minnesota 55344"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SurModics, Ophthalmology Division, 9924 West 74th Street, Eden Prairie, Minnesota 55344","institution_ids":["https://openalex.org/I4210103876"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103678358","display_name":"Guanting Qiu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I4210095445","display_name":"Doheny Eye Institute","ror":"https://ror.org/00qvx5329","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210095445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Guanting Qiu","raw_affiliation_strings":["Doheny Retina Institute, Doheny Eye Institute and Department of Ophthalmology, Keck School of Medicine, University of Southern California, 1450 San Pablo Street, Los Angeles, California 90033"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Doheny Retina Institute, Doheny Eye Institute and Department of Ophthalmology, Keck School of Medicine, University of Southern California, 1450 San Pablo Street, Los Angeles, California 90033","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I4210095445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049328478","display_name":"Aron B. Anderson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210103876","display_name":"SurModics (United States)","ror":"https://ror.org/01h6pd645","country_code":"US","type":"company","lineage":["https://openalex.org/I4210103876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aron B. Anderson","raw_affiliation_strings":["SurModics, Ophthalmology Division, 9924 West 74th Street, Eden Prairie, Minnesota 55344"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SurModics, Ophthalmology Division, 9924 West 74th Street, Eden Prairie, Minnesota 55344","institution_ids":["https://openalex.org/I4210103876"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111436011","display_name":"Eugene de Juan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I4210095445","display_name":"Doheny Eye Institute","ror":"https://ror.org/00qvx5329","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210095445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eugene de Juan","raw_affiliation_strings":["Doheny Retina Institute, Doheny Eye Institute and Department of Ophthalmology, Keck School of Medicine, University of Southern California, 1450 San Pablo Street, Los Angeles, California 90033"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Doheny Retina Institute, Doheny Eye Institute and Department of Ophthalmology, Keck School of Medicine, University of Southern California, 1450 San Pablo Street, Los Angeles, California 90033","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I4210095445"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008938394","display_name":"Signe E. Varner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210103876","display_name":"SurModics (United States)","ror":"https://ror.org/01h6pd645","country_code":"US","type":"company","lineage":["https://openalex.org/I4210103876"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Signe E. Varner","raw_affiliation_strings":["SurModics, Ophthalmology Division, 9924 West 74th Street, Eden Prairie, Minnesota 55344"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SurModics, Ophthalmology Division, 9924 West 74th Street, Eden Prairie, Minnesota 55344","institution_ids":["https://openalex.org/I4210103876"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5008938394"],"corresponding_institution_ids":["https://openalex.org/I4210103876"],"apc_list":{"value":4220,"currency":"USD","value_usd":4220},"apc_paid":null,"fwci":2.1081,"has_fulltext":false,"cited_by_count":35,"citation_normalized_percentile":{"value":0.82267951,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"76A","issue":"4","first_page":"690","last_page":"698"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.004600000102072954,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11377","display_name":"Retinal and Macular Surgery","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sustained-release-implants","display_name":"sustained-release implants","score":0.6790000200271606},{"id":"https://openalex.org/keywords/biocompatible-implants","display_name":"biocompatible implants","score":0.5960000157356262},{"id":"https://openalex.org/keywords/nickel-titanium-alloys","display_name":"NiTi","score":0.6919999718666077},{"id":"https://openalex.org/keywords/poly-methyl-methacrylate","display_name":"poly(methyl methacrylate)","score":0.8650000095367432},{"id":"https://openalex.org/keywords/poly-butyl-methacrylate","display_name":"poly(butyl methacrylate)","score":0.9779999852180481},{"id":"https://openalex.org/keywords/ethylene-vinyl-acetate-copolymer","display_name":"ethylene-vinyl acetate copolymer","score":0.9940000176429749},{"id":"https://openalex.org/keywords/triamcinolone-acetonide","display_name":"triamcinolone acetonide","score":0.9990000128746033},{"id":"https://openalex.org/keywords/rapamycin","display_name":"rapamycin","score":1.0},{"id":"https://openalex.org/keywords/implant-retrieval","display_name":"implant retrieval","score":0.6629999876022339},{"id":"https://openalex.org/keywords/retinal-disease","display_name":"retinal disease","score":0.593999981880188},{"id":"https://openalex.org/keywords/rabbit-model","display_name":"rabbit model","score":0.46799999475479126},{"id":"https://openalex.org/keywords/ocular-toxicity","display_name":"ocular toxicity","score":0.4000000059604645}],"concepts":[{"id":"https://openalex.org/C2781411149","wikidata":"https://www.wikidata.org/wiki/Q486975","display_name":"Implant","level":2,"score":0.6738063097000122},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.5510290265083313},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.5299317240715027},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5169705748558044},{"id":"https://openalex.org/C2778903070","wikidata":"https://www.wikidata.org/wiki/Q2211240","display_name":"Triamcinolone acetonide","level":2,"score":0.4997429847717285},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.44607287645339966},{"id":"https://openalex.org/C1318750","wikidata":"https://www.wikidata.org/wiki/Q865663","display_name":"Biocompatible material","level":2,"score":0.42619261145591736},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.4133952856063843},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3704015016555786},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001672","descriptor_name":"Biocompatible Materials","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001672","descriptor_name":"Biocompatible Materials","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001672","descriptor_name":"Biocompatible Materials","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012160","descriptor_name":"Retina","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012160","descriptor_name":"Retina","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012160","descriptor_name":"Retina","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1002/jbm.a.30567","doi":"https://doi.org/10.1002/jbm.a.30567","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jbm.a.30567","pdf_url":null,"source":{"id":"https://openalex.org/S184573928","display_name":"Journal of Biomedical Materials Research Part A","issn_l":"1549-3296","issn":["1549-3296","1552-4965"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biomedical Materials Research Part A","raw_type":"journal-article"},{"id":"pmid:16302225","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16302225","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of biomedical materials research. Part A","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.800000011920929}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1396024002","display_name":"Core Grant for Vision Research","funder_award_id":"P30EY003040","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G2453337557","display_name":null,"funder_award_id":"#EY03040","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"}],"funders":[{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W122692372","https://openalex.org/W1448492189","https://openalex.org/W1802218256","https://openalex.org/W1980576996","https://openalex.org/W2036017553","https://openalex.org/W2043080448","https://openalex.org/W2057616845","https://openalex.org/W2060790398","https://openalex.org/W2110175853","https://openalex.org/W2144960239","https://openalex.org/W2165039742","https://openalex.org/W2165265638","https://openalex.org/W2171645153","https://openalex.org/W3199981447"],"related_works":["https://openalex.org/W2057616845","https://openalex.org/W2018437090","https://openalex.org/W2971448344","https://openalex.org/W2261845727","https://openalex.org/W2017617247","https://openalex.org/W2048203843","https://openalex.org/W2901414955","https://openalex.org/W2059803272","https://openalex.org/W7099911048","https://openalex.org/W2379220414"],"abstract_inverted_index":{"A":[0],"biocompatible,":[1],"sustained-release":[2],"subretinal":[3,74],"drug-delivery":[4],"platform":[5],"was":[6,106],"developed":[7,148,152],"to":[8,83,240],"overcome":[9],"the":[10,73,99,115,120,131,140,145,167,174,180,185,212,216,241,248,252],"therapeutic":[11],"accessibility":[12],"limitations":[13],"of":[14,53,76,133,142,166,194,251],"current":[15],"retinal":[16,181],"disease":[17],"treatments.":[18],"The":[19,39,48,59,67],"prototype":[20],"implants":[21,175,214],"were":[22,69,81,96,207],"fabricated":[23],"by":[24,46,111,119,156,179],"coating":[25,49,244],"nitinol,":[26],"poly(methyl":[27],"methacrylate)":[28,55],"or":[29,65,204,230],"chromic":[30],"gut":[31],"core":[32],"filaments,":[33],"with":[34,211],"a":[35,51,87,137,192],"drug-eluting":[36],"polymer":[37,40,242],"matrix.":[38],"coatings":[41],"are":[42,176],"manufactured":[43],"and":[44,56,91,144,169,183,226,237],"coated":[45],"SurModics.":[47],"is":[50,61],"mixture":[52],"poly(butyl":[54],"poly(ethylene-co-vinyl":[57],"acetate).":[58],"drug":[60,234],"either":[62],"triamcinolone":[63,189],"acetonide":[64,190],"sirolimus.":[66],"rods":[68],"successfully":[70],"implanted":[71],"into":[72],"space":[75],"20/24":[77],"rabbits.":[78],"Four":[79],"rabbits":[80,110,129,155],"lost":[82],"early":[84],"surgery":[85],"from":[86],"dysfunctional":[88],"infusion":[89],"line":[90],"hemorrhage.":[92],"No":[93],"serious":[94],"complications":[95],"observed":[97],"during":[98,130],"4-week":[100],"follow-up":[101],"period.":[102],"Slight":[103],"conjunctival":[104],"redness":[105,116],"reported":[107],"in":[108,127,153],"all":[109],"1-day":[112],"follow-up,":[113,158],"but":[114,159],"had":[117,136],"subsided":[118,160],"following":[121,245],"week.":[122],"Intraocular":[123],"lens":[124],"touch":[125],"occurred":[126],"six":[128],"implantations;":[132],"these,":[134],"four":[135],"lensectomy":[138],"at":[139,195,215],"time":[141],"surgery,":[143],"remaining":[146],"two":[147],"cataract.":[149],"Corneal":[150],"edema":[151],"three":[154],"1-week":[157],"within":[161],"2":[162],"weeks.":[163],"Initial":[164],"observations":[165],"implantation":[168],"elution":[170,250],"characteristics":[171],"revealed":[172,227],"that":[173,184],"well":[177],"tolerated":[178],"tissue":[182],"implant":[186],"can":[187],"elute":[188],"for":[191],"period":[193],"least":[196],"4":[197],"weeks":[198],"without":[199],"eliciting":[200],"an":[201,222],"inflammatory":[202],"response":[203],"complications.":[205],"There":[206],"adverse":[208],"clinical":[209],"indications":[210],"sirolimus-loaded":[213],"delivered":[217],"dose.":[218],"Device":[219],"retrieval":[220,246],"required":[221],"uncomplicated":[223],"surgical":[224],"procedure,":[225],"no":[228],"associated":[229],"adherent":[231],"tissue.":[232],"Implant":[233],"content":[235],"analysis":[236],"opacity":[238],"changes":[239],"matrix":[243],"demonstrated":[247],"sustained":[249],"drug.":[253]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2016-06-24T00:00:00"}