{"id":"https://openalex.org/W1985016315","doi":"https://doi.org/10.1097/01.qai.0000176591.06549.de","title":"Safe Discontinuation of Primary Pneumocystis Prophylaxis in Southern Indian HIV-Infected Patients on Highly Active Antiretroviral Therapy","display_name":"Safe Discontinuation of Primary Pneumocystis Prophylaxis in Southern Indian HIV-Infected Patients on Highly Active Antiretroviral Therapy","publication_year":2005,"publication_date":"2005-10-11","ids":{"openalex":"https://openalex.org/W1985016315","doi":"https://doi.org/10.1097/01.qai.0000176591.06549.de","mag":"1985016315","pmid":"https://pubmed.ncbi.nlm.nih.gov/16249715"},"language":"en","primary_location":{"id":"doi:10.1097/01.qai.0000176591.06549.de","doi":"https://doi.org/10.1097/01.qai.0000176591.06549.de","is_oa":false,"landing_page_url":"https://doi.org/10.1097/01.qai.0000176591.06549.de","pdf_url":null,"source":{"id":"https://openalex.org/S157460402","display_name":"JAIDS Journal of Acquired Immune Deficiency Syndromes","issn_l":"1525-4135","issn":["1525-4135","1944-7884"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAIDS Journal of Acquired Immune Deficiency Syndromes","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111983364","display_name":"N. Kumarasamy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]},{"id":"https://openalex.org/I2800640726","display_name":"Miriam Hospital","ror":"https://ror.org/053exzj86","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800640726"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"N Kumarasamy","raw_affiliation_strings":["YRG Center for AIDS Research and Education, Chennai, India, \u2020Miriam Hospital, Brown University, Providence, RI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"YRG Center for AIDS Research and Education, Chennai, India, \u2020Miriam Hospital, Brown University, Providence, RI","institution_ids":["https://openalex.org/I27804330","https://openalex.org/I2800640726"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072347654","display_name":"Snigdha Vallabhaneni","orcid":"https://orcid.org/0000-0003-4149-9840","observed_orcids":["https://orcid.org/0000-0003-4149-9840"]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]},{"id":"https://openalex.org/I2800640726","display_name":"Miriam Hospital","ror":"https://ror.org/053exzj86","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800640726"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Snigdha Vallabhaneni","raw_affiliation_strings":["YRG Center for AIDS Research and Education, Chennai, India, \u2020Miriam Hospital, Brown University, Providence, RI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"YRG Center for AIDS Research and Education, Chennai, India, \u2020Miriam Hospital, Brown University, Providence, RI","institution_ids":["https://openalex.org/I27804330","https://openalex.org/I2800640726"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107345716","display_name":"Anitha Jebaraj Cecelia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]},{"id":"https://openalex.org/I2800640726","display_name":"Miriam Hospital","ror":"https://ror.org/053exzj86","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800640726"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Anitha J Cecelia","raw_affiliation_strings":["YRG Center for AIDS Research and Education, Chennai, India, \u2020Miriam Hospital, Brown University, Providence, RI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"YRG Center for AIDS Research and Education, Chennai, India, \u2020Miriam Hospital, Brown University, Providence, RI","institution_ids":["https://openalex.org/I27804330","https://openalex.org/I2800640726"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025150770","display_name":"Kenneth Hugh Mayer","orcid":"https://orcid.org/0000-0001-7460-733X","observed_orcids":["https://orcid.org/0000-0001-7460-733X","https://orcid.org/0000-0001-8034-5110"]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]},{"id":"https://openalex.org/I2800640726","display_name":"Miriam Hospital","ror":"https://ror.org/053exzj86","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800640726"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kenneth H Mayer","raw_affiliation_strings":["YRG Center for AIDS Research and Education, Chennai, India, \u2020Miriam Hospital, Brown University, Providence, RI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"YRG Center for AIDS Research and Education, Chennai, India, \u2020Miriam Hospital, Brown University, Providence, RI","institution_ids":["https://openalex.org/I27804330","https://openalex.org/I2800640726"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111762686","display_name":"Suniti Solomon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]},{"id":"https://openalex.org/I2800640726","display_name":"Miriam Hospital","ror":"https://ror.org/053exzj86","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800640726"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Suniti Solomon","raw_affiliation_strings":["YRG Center for AIDS Research and Education, Chennai, India, \u2020Miriam Hospital, Brown University, Providence, RI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"YRG Center for AIDS Research and Education, Chennai, India, \u2020Miriam Hospital, Brown University, Providence, RI","institution_ids":["https://openalex.org/I27804330","https://openalex.org/I2800640726"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071465373","display_name":"Charles C. J. Carpenter","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]},{"id":"https://openalex.org/I2800640726","display_name":"Miriam Hospital","ror":"https://ror.org/053exzj86","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800640726"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charles C. J Carpenter","raw_affiliation_strings":["YRG Center for AIDS Research and Education, Chennai, India, \u2020Miriam Hospital, Brown University, Providence, RI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"YRG Center for AIDS Research and Education, Chennai, India, \u2020Miriam Hospital, Brown University, Providence, RI","institution_ids":["https://openalex.org/I27804330","https://openalex.org/I2800640726"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059896359","display_name":"Timothy Flanigan","orcid":"https://orcid.org/0000-0003-4355-9181","observed_orcids":["https://orcid.org/0000-0003-4355-9181"]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]},{"id":"https://openalex.org/I2800640726","display_name":"Miriam Hospital","ror":"https://ror.org/053exzj86","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800640726"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Timothy P Flanigan","raw_affiliation_strings":["YRG Center for AIDS Research and Education, Chennai, India, \u2020Miriam Hospital, Brown University, Providence, RI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"YRG Center for AIDS Research and Education, Chennai, India, \u2020Miriam Hospital, Brown University, Providence, RI","institution_ids":["https://openalex.org/I27804330","https://openalex.org/I2800640726"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5107345716","https://openalex.org/A5111762686","https://openalex.org/A5111983364"],"corresponding_institution_ids":["https://openalex.org/I27804330","https://openalex.org/I2800640726"],"apc_list":null,"apc_paid":null,"fwci":0.9557,"has_fulltext":false,"cited_by_count":19,"citation_normalized_percentile":{"value":0.76949126,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"40","issue":"3","first_page":"377","last_page":"378"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12369","display_name":"Pneumocystis jirovecii pneumonia detection and treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12369","display_name":"Pneumocystis jirovecii pneumonia detection and treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10082","display_name":"HIV/AIDS Research and Interventions","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10654","display_name":"Pneumonia and Respiratory Infections","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pneumocystis-jirovecii-pneumonia","display_name":"Pneumocystis carinii pneumonia","score":0.9380000233650208},{"id":"https://openalex.org/keywords/prophylaxis-discontinuation","display_name":"prophylaxis discontinuation","score":0.8949999809265137},{"id":"https://openalex.org/keywords/hiv-infection","display_name":"HIV infection","score":0.640999972820282},{"id":"https://openalex.org/keywords/highly-active-antiretroviral-therapy","display_name":"highly active antiretroviral therapy","score":0.9950000047683716},{"id":"https://openalex.org/keywords/trimethoprim-sulfamethoxazole","display_name":"trimethoprim-sulfamethoxazole","score":0.8119999766349792},{"id":"https://openalex.org/keywords/cd4-count","display_name":"CD4 count","score":0.7059999704360962},{"id":"https://openalex.org/keywords/treatment-interruption","display_name":"treatment interruption","score":0.5960000157356262},{"id":"https://openalex.org/keywords/opportunistic-infection-prophylaxis","display_name":"opportunistic infection prophylaxis","score":0.6000000238418579},{"id":"https://openalex.org/keywords/south-india","display_name":"South India","score":0.5389999747276306}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8078486919403076},{"id":"https://openalex.org/C2778715236","wikidata":"https://www.wikidata.org/wiki/Q55622662","display_name":"Discontinuation","level":2,"score":0.7391310930252075},{"id":"https://openalex.org/C2777530519","wikidata":"https://www.wikidata.org/wiki/Q416206","display_name":"Pentamidine","level":3,"score":0.6845202445983887},{"id":"https://openalex.org/C2777559004","wikidata":"https://www.wikidata.org/wiki/Q134478","display_name":"Pneumocystis jirovecii","level":3,"score":0.6420858502388},{"id":"https://openalex.org/C2779196057","wikidata":"https://www.wikidata.org/wiki/Q835718","display_name":"Opportunistic infection","level":4,"score":0.605262815952301},{"id":"https://openalex.org/C2777160144","wikidata":"https://www.wikidata.org/wiki/Q15401586","display_name":"Pneumocystis pneumonia","level":4,"score":0.5666680335998535},{"id":"https://openalex.org/C2776688490","wikidata":"https://www.wikidata.org/wiki/Q1069606","display_name":"Chemoprophylaxis","level":2,"score":0.5176099538803101},{"id":"https://openalex.org/C2777914695","wikidata":"https://www.wikidata.org/wiki/Q12192","display_name":"Pneumonia","level":2,"score":0.46157559752464294},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.44359099864959717},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.44199076294898987},{"id":"https://openalex.org/C2909201284","wikidata":"https://www.wikidata.org/wiki/Q835718","display_name":"AIDS-Related Opportunistic Infections","level":5,"score":0.43720343708992004},{"id":"https://openalex.org/C2778994148","wikidata":"https://www.wikidata.org/wiki/Q7205993","display_name":"Pneumocystosis","level":5,"score":0.43612924218177795},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.35978931188583374},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3302513659000397},{"id":"https://openalex.org/C2776452011","wikidata":"https://www.wikidata.org/wiki/Q311463","display_name":"Sida","level":4,"score":0.3272291421890259},{"id":"https://openalex.org/C2780727368","wikidata":"https://www.wikidata.org/wiki/Q1928978","display_name":"Viral disease","level":3,"score":0.2541991174221039},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.24228861927986145},{"id":"https://openalex.org/C2993443204","wikidata":"https://www.wikidata.org/wiki/Q134478","display_name":"Pneumocystis carinii","level":4,"score":0.21971839666366577}],"mesh":[{"descriptor_ui":"D000890","descriptor_name":"Anti-Infective Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000981","descriptor_name":"Antiprotozoal Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D003622","descriptor_name":"Dapsone","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007194","descriptor_name":"India","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010419","descriptor_name":"Pentamidine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D011020","descriptor_name":"Pneumonia, Pneumocystis","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D011020","descriptor_name":"Pneumonia, Pneumocystis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D011020","descriptor_name":"Pneumonia, Pneumocystis","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D015662","descriptor_name":"Trimethoprim, Sulfamethoxazole Drug Combination","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D018791","descriptor_name":"CD4 Lymphocyte Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023241","descriptor_name":"Antiretroviral Therapy, Highly Active","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D028761","descriptor_name":"Withholding Treatment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D044966","descriptor_name":"Anti-Retroviral Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/01.qai.0000176591.06549.de","doi":"https://doi.org/10.1097/01.qai.0000176591.06549.de","is_oa":false,"landing_page_url":"https://doi.org/10.1097/01.qai.0000176591.06549.de","pdf_url":null,"source":{"id":"https://openalex.org/S157460402","display_name":"JAIDS Journal of Acquired Immune Deficiency Syndromes","issn_l":"1525-4135","issn":["1525-4135","1944-7884"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAIDS Journal of Acquired Immune Deficiency Syndromes","raw_type":"journal-article"},{"id":"pmid:16249715","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16249715","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of acquired immune deficiency syndromes (1999)","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320308981","display_name":"Infectious Diseases Society of America","ror":"https://ror.org/03f1p6998"},{"id":"https://openalex.org/F4320332505","display_name":"U.S. Public Health Service","ror":"https://ror.org/05xf94514"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W1999500342","https://openalex.org/W2008524609","https://openalex.org/W2054219948","https://openalex.org/W2070526586","https://openalex.org/W2075288369","https://openalex.org/W2110799375","https://openalex.org/W2114699011","https://openalex.org/W2132136467","https://openalex.org/W2135896456","https://openalex.org/W2146628582","https://openalex.org/W2157060630","https://openalex.org/W2336509748","https://openalex.org/W2339872299"],"related_works":["https://openalex.org/W2098793037","https://openalex.org/W2328458117","https://openalex.org/W2110799375","https://openalex.org/W2335339633","https://openalex.org/W7029586539","https://openalex.org/W2114699011","https://openalex.org/W2320463093","https://openalex.org/W4233827239","https://openalex.org/W2337061131","https://openalex.org/W7096611458"],"abstract_inverted_index":{"To":[0],"the":[1,121,131,153,202,215,253,360,431,474,485,512,569,585,596,599],"Editor:":[2],"Pneumocystis":[3],"jirovecii":[4],"pneumonia":[5],"(PCP),":[6],"which":[7,609],"occurs":[8],"primarily":[9],"in":[10,48,62,102,113,159,172,189,210,499,608,634],"HIV-infected":[11,49,63,223],"individuals":[12,500],"with":[13,32,65,169],"CD4":[14,66,173,269,297,329,346,410,433,459],"cell":[15,67,174,434,460],"counts":[16,68,175,298,330,411,461],"less":[17],"than":[18],"200":[19,351],"cells/mm3,":[20,70],"is":[21,83,100,187,525,593],"an":[22,79,170,393,546],"important":[23],"cause":[24],"of":[25,44,52,75,107,148,155,204,206,230,272,299,348,372,377,387,392,424,438,440,449,457,473,477,511,530,532,541,554,576,590,603],"morbidity":[26,45],"and":[27,46,94,129,144,161,241,302,328,374,381,430,465,536,550,614,617,619,641,643,651,685],"mortality.1,2":[28],"Primary":[29,337],"PCP":[30,57,157,208,244,338,469,493,515,542,555,629],"prophylaxis":[31,54,99,158,209,245,339,404,420,441,494,543,556,627],"cotrimoxazole,":[33],"dapsone,":[34],"or":[35,78,285,315,324,470,516],"aerosolized":[36],"pentamidine":[37],"has":[38,58,116,130],"been":[39,60,117],"shown":[40],"to":[41,55,119,125,167,176,185,312,397,463,523,560,564,622,645],"reduce":[42],"rates":[43],"mortality":[47],"individuals.3-7":[50],"Administration":[51],"cotrimoxazole":[53,368,403,577],"prevent":[56,126],"therefore":[59],"recommended":[61],"adults":[64],"<200":[69],"CD4%":[71],"<14%,":[72],"a":[73,231,303,345,366,422,446,506,528,604],"history":[74],"oropharyngeal":[76],"candidiasis,":[77],"AIDS-defining":[80],"illness.8":[81],"Cotrimoxazole":[82],"also":[84],"effective":[85,123,502],"at":[86,180,290,349,436,584],"preventing":[87,103],"other":[88,479],"opportunistic":[89,104,127],"infections":[90,128],"like":[91],"toxoplasmosis":[92],"encephalitis":[93],"bacterial":[95],"pneumonias.9":[96],"Although":[97],"antibiotic":[98],"valuable":[101],"infections,":[105],"use":[106],"highly":[108],"active":[109],"antiretroviral":[110,194,503,537,565,623,646],"therapy":[111,314,647],"(HAART)":[112],"immunocompromised":[114],"patients":[115,163,211,226,343,513,559],"found":[118],"be":[120,496,561,579,631],"most":[122,132],"way":[124],"profound":[133],"impact":[134],"on":[135,201,222,279,357,419,501],"mortality.10":[136],"The":[137,250,414,588],"United":[138],"States":[139],"Public":[140],"Health":[141],"Service":[142],"(USPHS)":[143],"Infectious":[145],"Diseases":[146],"Society":[147],"America":[149],"(IDSA)":[150],"guidelines":[151],"recommend":[152],"discontinuation":[154,205,439,456,540],"primary":[156,207,254,492,626],"adult":[160],"adolescent":[162],"who":[164],"have":[165],"responded":[166],"HAART":[168,186,213,240,273,281,524],"increase":[171,464],">200":[177,412],"cells/mm3":[178,352],"for":[179,289,353,421,548,628,682],"least":[181,291,350],"3":[182,335,354],"months.8":[183],"Access":[184],"increasing":[188,526],"developing":[190,216,519,635],"countries":[191,636],"through":[192],"ongoing":[193],"roll-out":[195,538],"programs.11":[196],"There":[197],"are":[198,256,648],"no":[199,466],"data":[200,221],"safety":[203],"taking":[212,365,384],"from":[214,252,484],"world.":[217],"Here,":[218],"we":[219],"present":[220],"southern":[224],"Indian":[225],"who,":[227],"as":[228,527],"part":[229,602],"randomized":[232,311,605],"controlled":[233,606],"trial":[234,607],"examining":[235],"treatment":[236],"interruption":[237],"strategies,":[238],"initiated":[239],"then":[242],"discontinued":[243,341,402,498,633],"after":[246,455],"reaching":[247],"immunologic":[248],"stability.":[249],"results":[251,489,592],"study":[255],"reported":[257],"elsewhere.12":[258],"Forty":[259],"participants":[260,295,400,417,467,475,600],"(60%":[261],"male,":[262],"median":[263,423,432,447,508],"age":[264],"=":[265,274],"33":[266],"years,":[267],"baseline":[268],"before":[270],"initiation":[271],"162":[275],"cells/mm3)":[276],"were":[277,310,319,331,364,418,601],"placed":[278],"generic":[280,534],"(lamivudine":[282],"+":[283,287],"zidovudine":[284],"stavudine":[286],"efavirenz)":[288],"6":[292],"months.":[293,336],"When":[294],"achieved":[296],">300":[300],"cells/\u03bcL":[301],"plasma":[304],"viral":[305],"load":[306],"<400":[307],"copies/mL,":[308],"they":[309,406,610],"1-week-on-1-week-off":[313],"continuous":[316],"therapy.":[317,504,624],"Participants":[318],"followed":[320],"once":[321,333,379,389],"every":[322,334],"month":[323],"sooner,":[325],"if":[326,638],"needed,":[327],"obtained":[332],"was":[340,383,442],"when":[342],"had":[344],"count":[347,435],"months":[355,426,451],"while":[356],"HAART.":[358],"Of":[359],"40":[361],"participants,":[362],"39":[363],"double-strength":[367],"tablet":[369],"(160":[370],"mg":[371,376,386],"trimethoprim":[373],"800":[375],"sulfamethoxazole)":[378],"daily":[380,390],"1":[382],"100":[385],"dapsone":[388],"because":[391,405],"initial":[394],"hypersensitivity":[395],"reaction":[396],"cotrimoxazole.":[398],"Two":[399],"never":[401],"did":[407],"not":[408],"achieve":[409],"cells/mm3.":[413,444],"remaining":[415],"38":[416],"15.4":[425,450],"(range:":[427,452],"4.6-78.2":[428],"months),":[429],"time":[437],"324":[443],"During":[445],"follow-up":[448,616,640],"2.0-22.1":[453],"months)":[454],"prophylaxis,":[458],"continued":[462],"developed":[468,486,514],"toxoplasmosis.":[471,517],"None":[472],"died":[476],"any":[478],"cause.":[480],"Like":[481],"previous":[482],"studies":[483],"world,13-15":[487],"our":[488],"suggest":[490],"that":[491,598],"can":[495,578,630],"safely":[497,632],"After":[505],"15-month":[507],"follow-up,":[509],"none":[510],"In":[518,572],"countries,":[520],"where":[521],"access":[522,621,642],"result":[529],"production":[531],"cheaper":[533],"drugs":[535],"programs,":[539],"may":[544,557],"become":[545],"option":[547],"more":[549,551,562],"patients.":[552],"Discontinuation":[553],"enable":[558],"adherent":[563],"regimens":[566],"by":[567,581,595],"reducing":[568],"pill":[570],"burden.16":[571],"addition,":[573],"long-term":[574],"toxicities":[575],"prevented":[580],"discontinuing":[582],"it":[583],"appropriate":[586],"time.":[587],"interpretation":[589],"these":[591],"limited":[594],"fact":[597],"received":[611],"regular":[612],"clinical":[613],"laboratory":[615],"free":[618],"uninterrupted":[620],"Therefore,":[625],"only":[637],"patient":[639],"adherence":[644],"thorough,":[649],"continuous,":[650],"reliable.":[652],"N.":[653],"Kumarasamy,":[654],"MBBS,":[655],"PhD*":[656],"Snigdha":[657],"Vallabhaneni,":[658],"BA\u2020":[659],"Anitha":[660],"J.":[661,673],"Cecelia,":[662],"MSc*":[663],"Kenneth":[664],"H.":[665],"Mayer,":[666],"MD\u2020":[667,675,679],"Suniti":[668],"Solomon,":[669],"MD*":[670],"Charles":[671],"C.":[672],"Carpenter,":[674],"Timothy":[676],"P.":[677],"Flanigan,":[678],"*YRG":[680],"Center":[681],"AIDS":[683],"Research":[684],"Education":[686],"Chennai,":[687],"India":[688],"\u2020Miriam":[689],"Hospital,":[690],"Brown":[691],"University":[692],"Providence,":[693],"RI":[694]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
