{"id":"https://openalex.org/W1985012550","doi":"https://doi.org/10.1007/bf00685941","title":"5-Fluorouracil's cytotoxicity is enhanced both in vitro and in vivo by concomitant treatment with hyperthermia and dipyridamole","display_name":"5-Fluorouracil's cytotoxicity is enhanced both in vitro and in vivo by concomitant treatment with hyperthermia and dipyridamole","publication_year":1992,"publication_date":"1992-01-01","ids":{"openalex":"https://openalex.org/W1985012550","doi":"https://doi.org/10.1007/bf00685941","mag":"1985012550","pmid":"https://pubmed.ncbi.nlm.nih.gov/1537070"},"language":"en","primary_location":{"id":"doi:10.1007/bf00685941","doi":"https://doi.org/10.1007/bf00685941","is_oa":false,"landing_page_url":"https://doi.org/10.1007/bf00685941","pdf_url":null,"source":{"id":"https://openalex.org/S117498271","display_name":"Cancer Chemotherapy and Pharmacology","issn_l":"0344-5704","issn":["0344-5704","1432-0843"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Chemotherapy and Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004420462","display_name":"Yoshihiko Maehara","orcid":"https://orcid.org/0000-0002-1532-3537","observed_orcids":["https://orcid.org/0000-0002-1532-3537","https://orcid.org/0009-0006-6480-304X"]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]},{"id":"https://openalex.org/I4210097767","display_name":"Kyushu University Hospital","ror":"https://ror.org/00ex2fc97","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I135598925","https://openalex.org/I4210097767"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshihiko Maehara","raw_affiliation_strings":["Department of Surgery II, Kyushu University Hospital, Faculty of Medicine, Fukuoka, Japan","Department of Surgery II, Faculty of Medicine, Kyushu University, 812, Fukuoka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery II, Kyushu University Hospital, Faculty of Medicine, Fukuoka, Japan","institution_ids":["https://openalex.org/I4210097767"]},{"raw_affiliation_string":"Department of Surgery II, Faculty of Medicine, Kyushu University, 812, Fukuoka, Japan","institution_ids":["https://openalex.org/I135598925"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102284696","display_name":"Yoshihisa Sakaguchi","orcid":"https://orcid.org/0009-0006-1751-8799","observed_orcids":["https://orcid.org/0009-0006-1751-8799"]},"institutions":[{"id":"https://openalex.org/I4210097767","display_name":"Kyushu University Hospital","ror":"https://ror.org/00ex2fc97","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I135598925","https://openalex.org/I4210097767"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshihisa Sakaguchi","raw_affiliation_strings":["Cancer Center of Kyushu University Hospital, Faculty of Medicine, Kyushu University, 812, Fukuoka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Center of Kyushu University Hospital, Faculty of Medicine, Kyushu University, 812, Fukuoka, Japan","institution_ids":["https://openalex.org/I4210097767"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110127747","display_name":"Ikuo Takahashi","orcid":"https://orcid.org/0009-0008-0401-5521","observed_orcids":["https://orcid.org/0009-0008-0401-5521"]},"institutions":[{"id":"https://openalex.org/I4210097767","display_name":"Kyushu University Hospital","ror":"https://ror.org/00ex2fc97","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I135598925","https://openalex.org/I4210097767"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ikuo Takahashi","raw_affiliation_strings":["Cancer Center of Kyushu University Hospital, Faculty of Medicine, Kyushu University, 812, Fukuoka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Center of Kyushu University Hospital, Faculty of Medicine, Kyushu University, 812, Fukuoka, Japan","institution_ids":["https://openalex.org/I4210097767"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104028544","display_name":"Motofumi Yoshida","orcid":"https://orcid.org/0000-0002-6544-8629","observed_orcids":["https://orcid.org/0000-0002-6544-8629"]},"institutions":[{"id":"https://openalex.org/I4210097767","display_name":"Kyushu University Hospital","ror":"https://ror.org/00ex2fc97","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I135598925","https://openalex.org/I4210097767"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Motofumi Yoshida","raw_affiliation_strings":["Cancer Center of Kyushu University Hospital, Faculty of Medicine, Kyushu University, 812, Fukuoka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Center of Kyushu University Hospital, Faculty of Medicine, Kyushu University, 812, Fukuoka, Japan","institution_ids":["https://openalex.org/I4210097767"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113525095","display_name":"Hiroki Kusumoto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210097767","display_name":"Kyushu University Hospital","ror":"https://ror.org/00ex2fc97","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I135598925","https://openalex.org/I4210097767"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroki Kusumoto","raw_affiliation_strings":["Cancer Center of Kyushu University Hospital, Faculty of Medicine, Kyushu University, 812, Fukuoka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Center of Kyushu University Hospital, Faculty of Medicine, Kyushu University, 812, Fukuoka, Japan","institution_ids":["https://openalex.org/I4210097767"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110038701","display_name":"Hidetaka Masuda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200314755","display_name":"Kyushu Dental University","ror":"https://ror.org/03bwzch55","country_code":"JP","type":"education","lineage":["https://openalex.org/I200314755"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hidetaka Masuda","raw_affiliation_strings":["Department of Surgery, Kyushu Dental College, 803, Kitakyushu, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Kyushu Dental College, 803, Kitakyushu, Japan","institution_ids":["https://openalex.org/I200314755"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113510006","display_name":"Keiz\u014d Sugimachi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]},{"id":"https://openalex.org/I4210097767","display_name":"Kyushu University Hospital","ror":"https://ror.org/00ex2fc97","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I135598925","https://openalex.org/I4210097767"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Keizo Sugimachi","raw_affiliation_strings":["Cancer Center of Kyushu University Hospital, Faculty of Medicine, Kyushu University, 812, Fukuoka, Japan","Department of Surgery II, Faculty of Medicine, Kyushu University, 812, Fukuoka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Center of Kyushu University Hospital, Faculty of Medicine, Kyushu University, 812, Fukuoka, Japan","institution_ids":["https://openalex.org/I4210097767"]},{"raw_affiliation_string":"Department of Surgery II, Faculty of Medicine, Kyushu University, 812, Fukuoka, Japan","institution_ids":["https://openalex.org/I135598925"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4390,"currency":"USD","value_usd":4390},"apc_paid":null,"fwci":0.3835,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.56935577,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"29","issue":"4","first_page":"257","last_page":"260"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10958","display_name":"Ultrasound and Hyperthermia Applications","score":0.88919997215271,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10958","display_name":"Ultrasound and Hyperthermia Applications","score":0.88919997215271,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.03460000082850456,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.02280000038444996,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/5-fluorouracil","display_name":"5-fluorouracil","score":1.0},{"id":"https://openalex.org/keywords/hyperthermia","display_name":"hyperthermia","score":0.9900000095367432},{"id":"https://openalex.org/keywords/dipyridamole","display_name":"dipyridamole","score":1.0},{"id":"https://openalex.org/keywords/combination-chemotherapy","display_name":"combination chemotherapy","score":0.6660000085830688},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.7789999842643738},{"id":"https://openalex.org/keywords/b16-melanoma","display_name":"B16 melanoma","score":0.9800000190734863},{"id":"https://openalex.org/keywords/tumor-growth-inhibition","display_name":"tumor growth inhibition","score":0.7649999856948853},{"id":"https://openalex.org/keywords/succinate-dehydrogenase-inhibition","display_name":"succinate dehydrogenase inhibition","score":0.9589999914169312},{"id":"https://openalex.org/keywords/drug-sensitization","display_name":"drug sensitization","score":0.550000011920929},{"id":"https://openalex.org/keywords/cancer-therapy","display_name":"cancer therapy","score":0.4259999990463257}],"concepts":[{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.7743068337440491},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.7627307176589966},{"id":"https://openalex.org/C2776890861","wikidata":"https://www.wikidata.org/wiki/Q419374","display_name":"Dipyridamole","level":2,"score":0.697587788105011},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.673490583896637},{"id":"https://openalex.org/C2779949491","wikidata":"https://www.wikidata.org/wiki/Q242165","display_name":"Hyperthermia","level":2,"score":0.6612299680709839},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.585408091545105},{"id":"https://openalex.org/C2780456651","wikidata":"https://www.wikidata.org/wiki/Q238512","display_name":"Fluorouracil","level":3,"score":0.5394365191459656},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.5315451622009277},{"id":"https://openalex.org/C2779384505","wikidata":"https://www.wikidata.org/wiki/Q17007513","display_name":"Concomitant","level":2,"score":0.5267690420150757},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.4995841979980469},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4877775311470032},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.42942002415657043},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3952201306819916},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3101881146430969},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.27751028537750244},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17088261246681213},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.15685969591140747},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003131","descriptor_name":"Combined Modality Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004176","descriptor_name":"Dipyridamole","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D004176","descriptor_name":"Dipyridamole","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D004354","descriptor_name":"Drug Screening Assays, Antitumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004357","descriptor_name":"Drug Synergism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005472","descriptor_name":"Fluorouracil","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D005472","descriptor_name":"Fluorouracil","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006979","descriptor_name":"Hyperthermia, Induced","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008546","descriptor_name":"Melanoma, Experimental","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D008546","descriptor_name":"Melanoma, Experimental","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009368","descriptor_name":"Neoplasm Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013385","descriptor_name":"Succinate Dehydrogenase","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/bf00685941","doi":"https://doi.org/10.1007/bf00685941","is_oa":false,"landing_page_url":"https://doi.org/10.1007/bf00685941","pdf_url":null,"source":{"id":"https://openalex.org/S117498271","display_name":"Cancer Chemotherapy and Pharmacology","issn_l":"0344-5704","issn":["0344-5704","1432-0843"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Chemotherapy and Pharmacology","raw_type":"journal-article"},{"id":"pmid:1537070","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1537070","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer chemotherapy and pharmacology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W156159502","https://openalex.org/W202108712","https://openalex.org/W328989892","https://openalex.org/W1481194953","https://openalex.org/W1485750767","https://openalex.org/W1505848873","https://openalex.org/W1556164072","https://openalex.org/W1581152304","https://openalex.org/W1596387860","https://openalex.org/W1602459695","https://openalex.org/W1608405655","https://openalex.org/W1660270104","https://openalex.org/W1854431912","https://openalex.org/W1967251768","https://openalex.org/W1974203483","https://openalex.org/W1997231925","https://openalex.org/W2011453771","https://openalex.org/W2020686935","https://openalex.org/W2024200018","https://openalex.org/W2026846913","https://openalex.org/W2042142121","https://openalex.org/W2056762121","https://openalex.org/W2066180364","https://openalex.org/W2068305318","https://openalex.org/W2083605995","https://openalex.org/W2093313567","https://openalex.org/W2094604771","https://openalex.org/W2103804638","https://openalex.org/W2127956317","https://openalex.org/W2140674603","https://openalex.org/W2140927361","https://openalex.org/W2167969835","https://openalex.org/W2237040806","https://openalex.org/W2401008228","https://openalex.org/W2403298803","https://openalex.org/W2405680396","https://openalex.org/W2409906548","https://openalex.org/W2413340883","https://openalex.org/W2416393508","https://openalex.org/W2418875927","https://openalex.org/W2483011995","https://openalex.org/W3142016190","https://openalex.org/W4406988168"],"related_works":["https://openalex.org/W2401008228","https://openalex.org/W2517050254","https://openalex.org/W10085734","https://openalex.org/W2409777370","https://openalex.org/W2431991978","https://openalex.org/W2323179771","https://openalex.org/W223089590","https://openalex.org/W2056762121","https://openalex.org/W2025537895","https://openalex.org/W2409906548"],"abstract_inverted_index":null,"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}