{"id":"https://openalex.org/W1984827993","doi":"https://doi.org/10.1097/00006123-200102000-00024","title":"Expression of Endothelial Cell Angiogenesis Receptors in Human Cerebrovascular Malformations","display_name":"Expression of Endothelial Cell Angiogenesis Receptors in Human Cerebrovascular Malformations","publication_year":2001,"publication_date":"2001-02-01","ids":{"openalex":"https://openalex.org/W1984827993","doi":"https://doi.org/10.1097/00006123-200102000-00024","mag":"1984827993","pmid":"https://pubmed.ncbi.nlm.nih.gov/11220380"},"language":"en","primary_location":{"id":"doi:10.1097/00006123-200102000-00024","doi":"https://doi.org/10.1097/00006123-200102000-00024","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00006123-200102000-00024","pdf_url":null,"source":{"id":"https://openalex.org/S111727011","display_name":"Neurosurgery","issn_l":"0148-396X","issn":["0148-396X","1081-1281","1524-4040"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurosurgery","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067431508","display_name":"Ryunosuke Uranishi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ryunosuke Uranishi","raw_affiliation_strings":["The Neurovascular Surgery Program, Departments of Neurosurgery (RU, NIB, P-YN, IAA) and Pathology (JHK), Yale University School of Medicine, New Haven, Connecticut"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Neurovascular Surgery Program, Departments of Neurosurgery (RU, NIB, P-YN, IAA) and Pathology (JHK), Yale University School of Medicine, New Haven, Connecticut","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020727758","display_name":"Nikolay I. Baev","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nikolay I. Baev","raw_affiliation_strings":["The Neurovascular Surgery Program, Departments of Neurosurgery (RU, NIB, P-YN, IAA) and Pathology (JHK), Yale University School of Medicine, New Haven, Connecticut"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Neurovascular Surgery Program, Departments of Neurosurgery (RU, NIB, P-YN, IAA) and Pathology (JHK), Yale University School of Medicine, New Haven, Connecticut","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084704079","display_name":"Puay-Yong Ng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Puay-Yong Ng","raw_affiliation_strings":["The Neurovascular Surgery Program, Departments of Neurosurgery (RU, NIB, P-YN, IAA) and Pathology (JHK), Yale University School of Medicine, New Haven, Connecticut"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Neurovascular Surgery Program, Departments of Neurosurgery (RU, NIB, P-YN, IAA) and Pathology (JHK), Yale University School of Medicine, New Haven, Connecticut","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100426061","display_name":"Jung Ho Kim","orcid":"https://orcid.org/0000-0002-6944-473X","observed_orcids":["https://orcid.org/0000-0002-6944-473X"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jung H. Kim","raw_affiliation_strings":["The Neurovascular Surgery Program, Departments of Neurosurgery (RU, NIB, P-YN, IAA) and Pathology (JHK), Yale University School of Medicine, New Haven, Connecticut"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Neurovascular Surgery Program, Departments of Neurosurgery (RU, NIB, P-YN, IAA) and Pathology (JHK), Yale University School of Medicine, New Haven, Connecticut","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087790193","display_name":"Issam A. Awad","orcid":"https://orcid.org/0000-0003-1510-602X","observed_orcids":["https://orcid.org/0000-0003-1510-602X"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Issam A. Awad","raw_affiliation_strings":["The Neurovascular Surgery Program, Departments of Neurosurgery (RU, NIB, P-YN, IAA) and Pathology (JHK), Yale University School of Medicine, New Haven, Connecticut"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Neurovascular Surgery Program, Departments of Neurosurgery (RU, NIB, P-YN, IAA) and Pathology (JHK), Yale University School of Medicine, New Haven, Connecticut","institution_ids":["https://openalex.org/I32971472"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I32971472"],"apc_list":null,"apc_paid":null,"fwci":3.8101,"has_fulltext":false,"cited_by_count":102,"citation_normalized_percentile":{"value":0.92978374,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"48","issue":"2","first_page":"359","last_page":"368"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11402","display_name":"Vascular Malformations Diagnosis and Treatment","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11402","display_name":"Vascular Malformations Diagnosis and Treatment","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10980","display_name":"Vascular Malformations and Hemangiomas","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cerebral-cavernous-malformations","display_name":"cerebral cavernous malformations","score":0.9229999780654907},{"id":"https://openalex.org/keywords/arteriovenous-malformation","display_name":"arteriovenous malformation","score":1.0},{"id":"https://openalex.org/keywords/cerebrovascular-malformations","display_name":"cerebral vascular malformations","score":0.9810000061988831},{"id":"https://openalex.org/keywords/endothelial-cells","display_name":"endothelial cells","score":0.8059999942779541},{"id":"https://openalex.org/keywords/vegf-receptors","display_name":"VEGF receptors","score":0.8920000195503235},{"id":"https://openalex.org/keywords/tie2","display_name":"Tie2","score":0.8149999976158142},{"id":"https://openalex.org/keywords/tie1","display_name":"Tie1","score":0.9200000166893005},{"id":"https://openalex.org/keywords/flk-1","display_name":"Flk-1","score":0.8569999933242798},{"id":"https://openalex.org/keywords/flt-1","display_name":"Flt-1","score":0.9959999918937683},{"id":"https://openalex.org/keywords/cd31","display_name":"CD31","score":0.9629999995231628},{"id":"https://openalex.org/keywords/von-willebrand-factor","display_name":"von Willebrand factor","score":0.9800000190734863},{"id":"https://openalex.org/keywords/angiogenic-factors","display_name":"angiogenic factors","score":0.9350000023841858}],"concepts":[{"id":"https://openalex.org/C2778939058","wikidata":"https://www.wikidata.org/wiki/Q4046167","display_name":"CD31","level":3,"score":0.860244631767273},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.7968429327011108},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7429459095001221},{"id":"https://openalex.org/C2779394231","wikidata":"https://www.wikidata.org/wiki/Q412310","display_name":"Von Willebrand factor","level":3,"score":0.6513304114341736},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.644679844379425},{"id":"https://openalex.org/C2777025900","wikidata":"https://www.wikidata.org/wiki/Q29725","display_name":"Vascular endothelial growth factor","level":3,"score":0.5697063207626343},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5136277079582214},{"id":"https://openalex.org/C2779603958","wikidata":"https://www.wikidata.org/wiki/Q1584110","display_name":"Arteriovenous malformation","level":2,"score":0.4261566996574402},{"id":"https://openalex.org/C123012128","wikidata":"https://www.wikidata.org/wiki/Q5376430","display_name":"Endothelial stem cell","level":3,"score":0.4166445732116699},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.403395414352417},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.21692055463790894},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18121877312660217},{"id":"https://openalex.org/C167734588","wikidata":"https://www.wikidata.org/wiki/Q4356503","display_name":"VEGF receptors","level":2,"score":0.16461163759231567},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.09913933277130127},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.07774218916893005},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002426","descriptor_name":"Cavernous Sinus","qualifier_ui":"Q000002","qualifier_name":"abnormalities","is_major_topic":true},{"descriptor_ui":"D002426","descriptor_name":"Cavernous Sinus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002426","descriptor_name":"Cavernous Sinus","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002538","descriptor_name":"Intracranial Arteriovenous Malformations","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002538","descriptor_name":"Intracranial Arteriovenous Malformations","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012016","descriptor_name":"Reference Values","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014841","descriptor_name":"von Willebrand Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016326","descriptor_name":"Extracellular Matrix Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017978","descriptor_name":"Receptors, Growth Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019408","descriptor_name":"Platelet Endothelial Cell Adhesion Molecule-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020794","descriptor_name":"Receptor Protein-Tyrosine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D040262","descriptor_name":"Receptors, Vascular Endothelial Growth Factor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040281","descriptor_name":"Vascular Endothelial Growth Factor Receptor-1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042764","descriptor_name":"Receptors, TIE","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042787","descriptor_name":"Receptor, TIE-2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042810","descriptor_name":"Receptor, TIE-1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1097/00006123-200102000-00024","doi":"https://doi.org/10.1097/00006123-200102000-00024","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00006123-200102000-00024","pdf_url":null,"source":{"id":"https://openalex.org/S111727011","display_name":"Neurosurgery","issn_l":"0148-396X","issn":["0148-396X","1081-1281","1524-4040"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurosurgery","raw_type":"journal-article"},{"id":"doi:10.1227/00006123-200102000-00024","doi":"https://doi.org/10.1227/00006123-200102000-00024","is_oa":false,"landing_page_url":"https://doi.org/10.1227/00006123-200102000-00024","pdf_url":null,"source":{"id":"https://openalex.org/S111727011","display_name":"Neurosurgery","issn_l":"0148-396X","issn":["0148-396X","1081-1281","1524-4040"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurosurgery","raw_type":"journal-article"},{"id":"pmid:11220380","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11220380","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurosurgery","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1279207035","display_name":"PHENOTYPE-GENOTYPE IN GEREBRAL VASCULAR MALFORMATIOINS","funder_award_id":"K24NS002153","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G8767737453","display_name":"PATHOBIOLOGY OF CEREBRAL CAVERNOUS MALFORMATION","funder_award_id":"R01NS036194","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320323434","display_name":"Nara Medical University","ror":"https://ror.org/045ysha14"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W2320996","https://openalex.org/W103956845","https://openalex.org/W200667596","https://openalex.org/W1229236830","https://openalex.org/W1608253138","https://openalex.org/W1962538984","https://openalex.org/W1970614272","https://openalex.org/W1972320565","https://openalex.org/W1972760800","https://openalex.org/W1978851591","https://openalex.org/W1986559037","https://openalex.org/W1988655450","https://openalex.org/W1996430165","https://openalex.org/W2018426847","https://openalex.org/W2038569417","https://openalex.org/W2039842966","https://openalex.org/W2046416427","https://openalex.org/W2046516822","https://openalex.org/W2060372234","https://openalex.org/W2066308459","https://openalex.org/W2066888615","https://openalex.org/W2076654705","https://openalex.org/W2077746894","https://openalex.org/W2082256624","https://openalex.org/W2084947524","https://openalex.org/W2087218466","https://openalex.org/W2090763994","https://openalex.org/W2112531069","https://openalex.org/W2132366506","https://openalex.org/W2136480937","https://openalex.org/W2138519685","https://openalex.org/W2140459348","https://openalex.org/W2140598880","https://openalex.org/W2141046053","https://openalex.org/W2148071652","https://openalex.org/W2152215024","https://openalex.org/W2168736535","https://openalex.org/W2410831513","https://openalex.org/W3107122518","https://openalex.org/W6600080492","https://openalex.org/W6641085495","https://openalex.org/W6714914217"],"related_works":["https://openalex.org/W2076654705","https://openalex.org/W2377280706","https://openalex.org/W2083632122","https://openalex.org/W2068583565","https://openalex.org/W1968144742","https://openalex.org/W2328390701","https://openalex.org/W1963737666","https://openalex.org/W2378260756","https://openalex.org/W2079530892","https://openalex.org/W2348156628"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"further":[2],"understand":[3],"the":[4,11,107,126,132,152,177,201,207,239],"role":[5],"of":[6,13,28,48,97,116,134,159,196,219,230,255,260],"angiogenic":[7],"growth":[8,33,74],"factors":[9],"in":[10,39,90,151,171,176,186,192,200,216],"development":[12],"cerebral":[14],"cavernous":[15],"malformations":[16,20],"(CCMs)":[17],"and":[18,36,52,67,72,82,87,100,106,119,146,166,173,188,223,244,250],"arteriovenous":[19],"(AVMs),":[21],"we":[22],"investigated":[23],"endothelial":[24,32],"cell":[25],"(EC)":[26],"expression":[27,254],"receptors":[29,76,164],"for":[30,139],"vascular":[31],"factor":[34,66,75,129],"(VEGF)":[35],"angiopoietin":[37,261],"systems":[38],"patients":[40],"with":[41,61],"surgically":[42],"resected":[43],"lesions.":[44],"METHODS:":[45],"Paraffin-embedded":[46],"sections":[47],"five":[49],"AVMs,":[50,105,118],"CCMs,":[51,104,117],"normal":[53,108,120,245,264],"control":[54,109,121,153,178,202,224],"brain":[55,110,122,154,179,203,225,246,265],"tissue":[56,111,123,155,180,204,226,247,266],"samples":[57,124,181],"were":[58,136,148],"stained":[59],"immunohistochemically":[60],"antibodies":[62],"to":[63,162,235,238],"von":[64,127],"Willebrand":[65,128],"CD31":[68,140,237],"(to":[69],"characterize":[70],"ECs)":[71],"angiogenesis":[73],"Flt-1":[77,167],"(VEGF-R1),":[78],"Flk-1":[79,165],"(VEGF-R2),":[80],"Tie-1,":[81],"Tie-2.":[83],"We":[84],"counted":[85],"large":[86],"small":[88],"vessels":[89,161,198,218],"each":[91,94,98],"specimen,":[92],"assessed":[93],"specimen's":[95],"immunoexpression":[96],"antigen,":[99],"analyzed":[101],"differences":[102],"between":[103],"samples.":[112,156,227],"RESULTS:":[113],"The":[114,157],"ECs":[115,133,229],"expressed":[125,150,191,215],"uniformly,":[130],"but":[131,206,258],"CCMs":[135,174,189,231,251],"largely":[137],"negative":[138],"(P":[141,182],"<":[142,183],"0.05).":[143,184],"Flk-1,":[144],"Flt-1,":[145],"Tie-2":[147,185],"not":[149,210,233,259],"proportion":[158],"immunopositive":[160,197],"VEGF":[163,256],"was":[168,190,209,214],"significantly":[169],"greater":[170,253],"AVMs":[172,187,243,249],"than":[175,199,263],"a":[193],"higher":[194],"percentage":[195],"samples,":[205],"difference":[208],"statistically":[211],"significant.":[212],"Tie-1":[213],"rare":[217],"all":[220],"lesion":[221],"types":[222],"CONCLUSION:":[228],"do":[232],"seem":[234],"express":[236],"same":[240],"extent":[241],"that":[242],"do.":[248],"show":[252],"receptors,":[257,262],"does.":[267]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
