{"id":"https://openalex.org/W1984699600","doi":"https://doi.org/10.1073/pnas.0808933106","title":"LapD is a bis-(3\u2032,5\u2032)-cyclic dimeric GMP-binding protein that regulates surface attachment by Pseudomonas fluorescens Pf0\u20131","display_name":"LapD is a bis-(3\u2032,5\u2032)-cyclic dimeric GMP-binding protein that regulates surface attachment by Pseudomonas fluorescens Pf0\u20131","publication_year":2009,"publication_date":"2009-02-14","ids":{"openalex":"https://openalex.org/W1984699600","doi":"https://doi.org/10.1073/pnas.0808933106","mag":"1984699600","pmid":"https://pubmed.ncbi.nlm.nih.gov/19218451","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2651287"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.0808933106","doi":"https://doi.org/10.1073/pnas.0808933106","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.0808933106","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2651287","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071652506","display_name":"Peter D. Newell","orcid":"https://orcid.org/0000-0002-0959-5907","observed_orcids":["https://orcid.org/0000-0002-0959-5907"]},"institutions":[{"id":"https://openalex.org/I107672454","display_name":"Dartmouth College","ror":"https://ror.org/049s0rh22","country_code":"US","type":"education","lineage":["https://openalex.org/I107672454"]},{"id":"https://openalex.org/I4390039337","display_name":"Dartmouth Health","ror":"https://ror.org/01pa9ed26","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I107672454","https://openalex.org/I4390039337"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter D. Newell","raw_affiliation_strings":["Department of Microbiology and Immunology, Dartmouth Medical School, Hanover, NH 03755","Department of Microbiology and Immunology, Dartmouth Medical School, Hanover, NH 03755, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Dartmouth Medical School, Hanover, NH 03755","institution_ids":["https://openalex.org/I107672454","https://openalex.org/I4390039337"]},{"raw_affiliation_string":"Department of Microbiology and Immunology, Dartmouth Medical School, Hanover, NH 03755, USA","institution_ids":["https://openalex.org/I107672454"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057308175","display_name":"Russell D. Monds","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I107672454","display_name":"Dartmouth College","ror":"https://ror.org/049s0rh22","country_code":"US","type":"education","lineage":["https://openalex.org/I107672454"]},{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I4390039337","display_name":"Dartmouth Health","ror":"https://ror.org/01pa9ed26","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I107672454","https://openalex.org/I4390039337"]},{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Russell D. Monds","raw_affiliation_strings":["Department of Microbiology and Immunology, Dartmouth Medical School, Hanover, NH 03755","The Rockefeller University, New York, NY,","X Program, Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA 94305"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Dartmouth Medical School, Hanover, NH 03755","institution_ids":["https://openalex.org/I107672454","https://openalex.org/I4390039337"]},{"raw_affiliation_string":"The Rockefeller University, New York, NY,","institution_ids":["https://openalex.org/I83399316"]},{"raw_affiliation_string":"X Program, Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA 94305","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036077732","display_name":"George A. O\u2019Toole","orcid":"https://orcid.org/0000-0002-2861-4392","observed_orcids":["https://orcid.org/0000-0002-2861-4392"]},"institutions":[{"id":"https://openalex.org/I107672454","display_name":"Dartmouth College","ror":"https://ror.org/049s0rh22","country_code":"US","type":"education","lineage":["https://openalex.org/I107672454"]},{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I4390039337","display_name":"Dartmouth Health","ror":"https://ror.org/01pa9ed26","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I107672454","https://openalex.org/I4390039337"]},{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"George A. O'Toole","raw_affiliation_strings":["Department of Microbiology and Immunology, Dartmouth Medical School, Hanover, NH 03755","The Rockefeller University, New York, NY,","X Program, Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA 94305"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Dartmouth Medical School, Hanover, NH 03755","institution_ids":["https://openalex.org/I107672454","https://openalex.org/I4390039337"]},{"raw_affiliation_string":"The Rockefeller University, New York, NY,","institution_ids":["https://openalex.org/I83399316"]},{"raw_affiliation_string":"X Program, Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA 94305","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5036077732"],"corresponding_institution_ids":["https://openalex.org/I107672454","https://openalex.org/I4210137306","https://openalex.org/I4390039337","https://openalex.org/I83399316","https://openalex.org/I97018004"],"apc_list":null,"apc_paid":null,"fwci":10.6245,"has_fulltext":false,"cited_by_count":290,"citation_normalized_percentile":{"value":0.99156092,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"106","issue":"9","first_page":"3461","last_page":"3466"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10593","display_name":"Bacterial biofilms and quorum sensing","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10593","display_name":"Bacterial biofilms and quorum sensing","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12434","display_name":"Phosphodiesterase function and regulation","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lapd","display_name":"LAPD","score":0.953000009059906},{"id":"https://openalex.org/keywords/c-di-gmp-signaling","display_name":"c-di-GMP signaling","score":0.8830000162124634},{"id":"https://openalex.org/keywords/surface-adhesion","display_name":"surface adhesion","score":0.8759999871253967},{"id":"https://openalex.org/keywords/biofilm-formation","display_name":"biofilm formation","score":1.0},{"id":"https://openalex.org/keywords/inside-out-signaling","display_name":"inside-out signaling","score":0.8330000042915344},{"id":"https://openalex.org/keywords/periplasmic-domain","display_name":"periplasmic domain","score":0.9089999794960022},{"id":"https://openalex.org/keywords/eal-domain","display_name":"EAL domain","score":0.8330000042915344},{"id":"https://openalex.org/keywords/diguanylate-cyclase","display_name":"diguanylate cyclase","score":0.9409999847412109},{"id":"https://openalex.org/keywords/c-di-gmp-phosphodiesterase","display_name":"c-di-GMP phosphodiesterase","score":0.9380000233650208},{"id":"https://openalex.org/keywords/inorganic-phosphate","display_name":"inorganic phosphate","score":0.8889999985694885},{"id":"https://openalex.org/keywords/second-messengers","display_name":"second messengers","score":0.37299999594688416}],"concepts":[{"id":"https://openalex.org/C201663137","wikidata":"https://www.wikidata.org/wiki/Q21198990","display_name":"Periplasmic space","level":4,"score":0.9661273956298828},{"id":"https://openalex.org/C2776835041","wikidata":"https://www.wikidata.org/wiki/Q135292","display_name":"Pseudomonas fluorescens","level":3,"score":0.6104713678359985},{"id":"https://openalex.org/C163235415","wikidata":"https://www.wikidata.org/wiki/Q899814","display_name":"Second messenger system","level":3,"score":0.5742942690849304},{"id":"https://openalex.org/C58123911","wikidata":"https://www.wikidata.org/wiki/Q467410","display_name":"Biofilm","level":3,"score":0.5570839643478394},{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.5520395636558533},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5364193916320801},{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.47940966486930847},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4758013188838959},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.42837047576904297},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.38242340087890625},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.37646687030792236},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36447596549987793},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.19659548997879028},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07769957184791565},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.07145842909812927},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001422","descriptor_name":"Bacterial Adhesion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006152","descriptor_name":"Cyclic GMP","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D006152","descriptor_name":"Cyclic GMP","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011551","descriptor_name":"Pseudomonas fluorescens","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011551","descriptor_name":"Pseudomonas fluorescens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015106","descriptor_name":"3',5'-Cyclic-GMP Phosphodiesterases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018829","descriptor_name":"Adhesins, Bacterial","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D047908","descriptor_name":"Intracellular Signaling Peptides and Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D047908","descriptor_name":"Intracellular Signaling Peptides and Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D055503","descriptor_name":"Protein Multimerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1073/pnas.0808933106","doi":"https://doi.org/10.1073/pnas.0808933106","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.0808933106","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:1502344","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2651287","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:2651287","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2651287","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:19218451","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19218451","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:1502344","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2651287","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G4641558758","display_name":"CAREER: Biofilm Formation and Biological Control in         Pseudomonas","funder_award_id":"9984521","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G6981840230","display_name":"Molecular and Cellular Biology at Dartmouth","funder_award_id":"T32GM008704","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W1751810238","https://openalex.org/W1976347829","https://openalex.org/W1979261950","https://openalex.org/W1999046178","https://openalex.org/W2016502854","https://openalex.org/W2024360412","https://openalex.org/W2035077457","https://openalex.org/W2043082285","https://openalex.org/W2056969605","https://openalex.org/W2061036236","https://openalex.org/W2065479717","https://openalex.org/W2067477145","https://openalex.org/W2068254342","https://openalex.org/W2087017025","https://openalex.org/W2089846493","https://openalex.org/W2098108206","https://openalex.org/W2105618126","https://openalex.org/W2107213260","https://openalex.org/W2112584669","https://openalex.org/W2114051710","https://openalex.org/W2118415186","https://openalex.org/W2119129131","https://openalex.org/W2122924296","https://openalex.org/W2132057657","https://openalex.org/W2147922175","https://openalex.org/W2151490567","https://openalex.org/W2153941254","https://openalex.org/W2156795637","https://openalex.org/W2157556993","https://openalex.org/W2159671166","https://openalex.org/W2171286149","https://openalex.org/W2172180816"],"related_works":["https://openalex.org/W2052618033","https://openalex.org/W2082220748","https://openalex.org/W6902672531","https://openalex.org/W1983029663","https://openalex.org/W2142854987","https://openalex.org/W1169270067","https://openalex.org/W1775802776","https://openalex.org/W4225409022","https://openalex.org/W2118415186","https://openalex.org/W2056783468"],"abstract_inverted_index":{"The":[0],"second":[1],"messenger":[2],"cyclic":[3],"dimeric":[4],"GMP":[5],"(c-di-GMP)":[6],"regulates":[7],"surface":[8,36,148],"attachment":[9,37,67],"and":[10,24,38,76,81,86,110,146],"biofilm":[11,39,57],"formation":[12,40,58],"by":[13,41,59,138,150],"many":[14],"bacteria.":[15],"For":[16],"Pseudomonas":[17],"fluorescens":[18],"Pf0-1,":[19],"c-di-GMP":[20,52,62,82,89,106,129,136],"impacts":[21],"the":[22,27,65,108,115,128],"secretion":[23],"localization":[25,145],"of":[26,134,143],"adhesin":[28],"LapA,":[29],"which":[30],"is":[31],"absolutely":[32],"required":[33],"for":[34],"stable":[35],"this":[42,45,112],"bacterium.":[43],"In":[44],"study":[46],"we":[47,122],"characterize":[48],"LapD,":[49],"a":[50,91],"unique":[51],"effector":[53],"protein":[54],"that":[55,98,124],"controls":[56],"communicating":[60,111],"intracellular":[61,135],"levels":[63,137],"to":[64,88,114,141],"membrane-localized":[66],"machinery":[68],"via":[69,117],"its":[70,118],"periplasmic":[71,119],"domain.":[72,94,120],"LapD":[73,99,125],"contains":[74],"degenerate":[75,92],"enzymatically":[77],"inactive":[78],"diguanylate":[79],"cyclase":[80],"phosphodiesterase":[83],"(EAL)":[84],"domains":[85],"binds":[87],"through":[90],"EAL":[93],"We":[95],"present":[96],"evidence":[97],"utilizes":[100],"an":[101],"inside-out":[102],"signaling":[103],"mechanism:":[104],"binding":[105],"in":[107],"cytoplasm":[109],"signal":[113],"periplasm":[116],"Furthermore,":[121],"show":[123],"serves":[126],"as":[127],"receptor":[130],"connecting":[131],"environmental":[132],"modulation":[133],"inorganic":[139],"phosphate":[140],"regulation":[142],"LapA":[144],"thus":[147],"commitment":[149],"P.":[151],"fluorescens.":[152]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":12},{"year":2024,"cited_by_count":12},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":13},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":16},{"year":2019,"cited_by_count":14},{"year":2018,"cited_by_count":19},{"year":2017,"cited_by_count":16},{"year":2016,"cited_by_count":17},{"year":2015,"cited_by_count":21},{"year":2014,"cited_by_count":28},{"year":2013,"cited_by_count":17},{"year":2012,"cited_by_count":35}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}