{"id":"https://openalex.org/W1984680959","doi":"https://doi.org/10.1128/mcb.20.20.7490-7504.2000","title":"Increased Rates of Genomic Deletions Generated by Mutations in the Yeast Gene Encoding DNA Polymerase \u03b4 or by Decreases in the Cellular Levels of DNA Polymerase \u03b4","display_name":"Increased Rates of Genomic Deletions Generated by Mutations in the Yeast Gene Encoding DNA Polymerase \u03b4 or by Decreases in the Cellular Levels of DNA Polymerase \u03b4","publication_year":2000,"publication_date":"2000-10-15","ids":{"openalex":"https://openalex.org/W1984680959","doi":"https://doi.org/10.1128/mcb.20.20.7490-7504.2000","mag":"1984680959","pmid":"https://pubmed.ncbi.nlm.nih.gov/11003646","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/86302"},"language":"en","primary_location":{"id":"doi:10.1128/mcb.20.20.7490-7504.2000","doi":"https://doi.org/10.1128/mcb.20.20.7490-7504.2000","is_oa":false,"landing_page_url":"https://doi.org/10.1128/mcb.20.20.7490-7504.2000","pdf_url":null,"source":{"id":"https://openalex.org/S81455967","display_name":"Molecular and Cellular Biology","issn_l":"0270-7306","issn":["0270-7306","1067-8824","1098-5549"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and Cellular Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","datacite","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/86302","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068022981","display_name":"Robert J. Kokoska","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert J. Kokoska","raw_affiliation_strings":["Department of Biology, Curriculum in Genetics and Molecular Biology, University of North Carolina, Chapel Hill, North Carolina 27599-3280","Department of Biology, Curriculum in Genetics and Molecular Biology, University of North Carolina, Chapel Hill, North Carolina 27599-3280, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Curriculum in Genetics and Molecular Biology, University of North Carolina, Chapel Hill, North Carolina 27599-3280","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"Department of Biology, Curriculum in Genetics and Molecular Biology, University of North Carolina, Chapel Hill, North Carolina 27599-3280, USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110380778","display_name":"Lela Stefanovic","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lela Stefanovic","raw_affiliation_strings":["Department of Biology, Curriculum in Genetics and Molecular Biology, University of North Carolina, Chapel Hill, North Carolina 27599-3280"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Curriculum in Genetics and Molecular Biology, University of North Carolina, Chapel Hill, North Carolina 27599-3280","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044896430","display_name":"J. DeMai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeremy DeMai","raw_affiliation_strings":["Department of Biology, Curriculum in Genetics and Molecular Biology, University of North Carolina, Chapel Hill, North Carolina 27599-3280"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Curriculum in Genetics and Molecular Biology, University of North Carolina, Chapel Hill, North Carolina 27599-3280","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087254791","display_name":"Thomas D. Petes","orcid":"https://orcid.org/0000-0003-4890-8002","observed_orcids":["https://orcid.org/0000-0003-4890-8002"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas D. Petes","raw_affiliation_strings":["Department of Biology, Curriculum in Genetics and Molecular Biology, University of North Carolina, Chapel Hill, North Carolina 27599-3280"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Curriculum in Genetics and Molecular Biology, University of North Carolina, Chapel Hill, North Carolina 27599-3280","institution_ids":["https://openalex.org/I114027177"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I114027177"],"apc_list":null,"apc_paid":null,"fwci":1.9909,"has_fulltext":true,"cited_by_count":86,"citation_normalized_percentile":{"value":0.85945501,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"20","issue":"20","first_page":"7490","last_page":"7504"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9657999873161316,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9657999873161316,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.02969999983906746,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dna-polymerase-delta","display_name":"DNA polymerase delta","score":0.9819999933242798},{"id":"https://openalex.org/keywords/saccharomyces-cerevisiae","display_name":"Saccharomyces cerevisiae","score":0.8709999918937683},{"id":"https://openalex.org/keywords/mutator-phenotype","display_name":"mutator phenotype","score":0.8140000104904175},{"id":"https://openalex.org/keywords/genomic-deletions","display_name":"genomic deletions","score":0.9359999895095825},{"id":"https://openalex.org/keywords/exonuclease-proofreading","display_name":"exonuclease proofreading","score":0.8809999823570251},{"id":"https://openalex.org/keywords/genomic-stability","display_name":"genome stability","score":0.8700000047683716},{"id":"https://openalex.org/keywords/dna-damaging-agents","display_name":"DNA-damaging agents","score":0.6570000052452087}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8159377574920654},{"id":"https://openalex.org/C2756471","wikidata":"https://www.wikidata.org/wiki/Q206286","display_name":"DNA polymerase","level":3,"score":0.7818893194198608},{"id":"https://openalex.org/C88354546","wikidata":"https://www.wikidata.org/wiki/Q3502973","display_name":"DNA polymerase II","level":5,"score":0.7325400114059448},{"id":"https://openalex.org/C164965036","wikidata":"https://www.wikidata.org/wiki/Q2529148","display_name":"DNA polymerase I","level":5,"score":0.6651635766029358},{"id":"https://openalex.org/C82381507","wikidata":"https://www.wikidata.org/wiki/Q416878","display_name":"Polymerase","level":3,"score":0.6159890294075012},{"id":"https://openalex.org/C31254050","wikidata":"https://www.wikidata.org/wiki/Q22328799","display_name":"DNA clamp","level":5,"score":0.5820509791374207},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5569227933883667},{"id":"https://openalex.org/C3018250846","wikidata":"https://www.wikidata.org/wiki/Q903441","display_name":"Methane sulfonate","level":4,"score":0.5506384968757629},{"id":"https://openalex.org/C76535049","wikidata":"https://www.wikidata.org/wiki/Q3487941","display_name":"DNA polymerase delta","level":5,"score":0.5312411785125732},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.47725388407707214},{"id":"https://openalex.org/C2777501222","wikidata":"https://www.wikidata.org/wiki/Q411664","display_name":"Exonuclease","level":4,"score":0.46627286076545715},{"id":"https://openalex.org/C112456955","wikidata":"https://www.wikidata.org/wiki/Q4118048","display_name":"Hot start PCR","level":5,"score":0.4464157521724701},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.3211372494697571},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3006531596183777},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.22354847192764282},{"id":"https://openalex.org/C49105822","wikidata":"https://www.wikidata.org/wiki/Q176996","display_name":"Polymerase chain reaction","level":3,"score":0.18396800756454468},{"id":"https://openalex.org/C157431215","wikidata":"https://www.wikidata.org/wiki/Q856465","display_name":"Nested polymerase chain reaction","level":4,"score":0.0},{"id":"https://openalex.org/C156719811","wikidata":"https://www.wikidata.org/wiki/Q28774","display_name":"Reverse transcriptase","level":4,"score":0.0}],"mesh":[{"descriptor_ui":"D004258","descriptor_name":"DNA Polymerase III","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004258","descriptor_name":"DNA Polymerase III","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004260","descriptor_name":"DNA Repair","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004260","descriptor_name":"DNA Repair","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005656","descriptor_name":"Fungal Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005656","descriptor_name":"Fungal Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005800","descriptor_name":"Genes, Fungal","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005800","descriptor_name":"Genes, Fungal","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008741","descriptor_name":"Methyl Methanesulfonate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011995","descriptor_name":"Recombination, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011995","descriptor_name":"Recombination, Genetic","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D014466","descriptor_name":"Ultraviolet Rays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016296","descriptor_name":"Mutagenesis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D016296","descriptor_name":"Mutagenesis","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":true},{"descriptor_ui":"D017353","descriptor_name":"Gene Deletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018900","descriptor_name":"Dinucleotide Repeats","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020125","descriptor_name":"Mutation, Missense","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051721","descriptor_name":"Rad52 DNA Repair and Recombination Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1128/mcb.20.20.7490-7504.2000","doi":"https://doi.org/10.1128/mcb.20.20.7490-7504.2000","is_oa":false,"landing_page_url":"https://doi.org/10.1128/mcb.20.20.7490-7504.2000","pdf_url":null,"source":{"id":"https://openalex.org/S81455967","display_name":"Molecular and Cellular Biology","issn_l":"0270-7306","issn":["0270-7306","1067-8824","1098-5549"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and Cellular Biology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:86302","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/86302","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Cell Biol","raw_type":"Text"},{"id":"pmid:11003646","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11003646","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and cellular biology","raw_type":"Journal Article"},{"id":"pmh:cdr.lib.unc.edu:n583z267v","doi":null,"is_oa":true,"landing_page_url":"https://doi.org/10.17615/axn8-ve41","pdf_url":"https://doi.org/10.17615/axn8-ve41","source":{"id":"https://openalex.org/S4306401075","display_name":"Carolina Digital Repository (University of North Carolina at Chapel Hill)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114027177","host_organization_name":"University of North Carolina at Chapel Hill","host_organization_lineage":["https://openalex.org/I114027177"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Molecular and Cellular Biology, 20(20)","raw_type":"Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.542.9334","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.542.9334","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://mcb.asm.org/content/20/20/7490.full.pdf","raw_type":"text"},{"id":"doi:10.17615/axn8-ve41","doi":"https://doi.org/10.17615/axn8-ve41","is_oa":true,"landing_page_url":"https://doi.org/10.17615/axn8-ve41","pdf_url":null,"source":{"id":"https://openalex.org/S7407051488","display_name":"UNC Libraries","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:86302","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/86302","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Cell Biol","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G6661908424","display_name":"Genetic regulation of genome stability in yeast","funder_award_id":"R01GM052319","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G6904957252","display_name":"YEAST DNA REPLICATION MUTANTS AND GENOME STABILITY","funder_award_id":"F32GM017879","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1984680959.pdf","grobid_xml":"https://content.openalex.org/works/W1984680959.grobid-xml"},"referenced_works_count":65,"referenced_works":["https://openalex.org/W128683993","https://openalex.org/W969149482","https://openalex.org/W992047112","https://openalex.org/W1480404031","https://openalex.org/W1522668252","https://openalex.org/W1561042802","https://openalex.org/W1663652489","https://openalex.org/W1784582953","https://openalex.org/W1894612901","https://openalex.org/W1945353891","https://openalex.org/W1953194129","https://openalex.org/W1966072209","https://openalex.org/W1969737313","https://openalex.org/W1979095965","https://openalex.org/W1981277651","https://openalex.org/W1983552075","https://openalex.org/W1988134858","https://openalex.org/W2002407831","https://openalex.org/W2011026782","https://openalex.org/W2011719683","https://openalex.org/W2013652332","https://openalex.org/W2013735712","https://openalex.org/W2016721288","https://openalex.org/W2019932549","https://openalex.org/W2025010288","https://openalex.org/W2033172386","https://openalex.org/W2036259181","https://openalex.org/W2038529419","https://openalex.org/W2039152230","https://openalex.org/W2046445620","https://openalex.org/W2049528447","https://openalex.org/W2060418366","https://openalex.org/W2069218295","https://openalex.org/W2075150455","https://openalex.org/W2079761426","https://openalex.org/W2089509232","https://openalex.org/W2092611033","https://openalex.org/W2094023740","https://openalex.org/W2100057937","https://openalex.org/W2102470371","https://openalex.org/W2106130068","https://openalex.org/W2110627805","https://openalex.org/W2111777915","https://openalex.org/W2115416778","https://openalex.org/W2117092833","https://openalex.org/W2131639139","https://openalex.org/W2132474153","https://openalex.org/W2133882122","https://openalex.org/W2135135381","https://openalex.org/W2140368248","https://openalex.org/W2144550200","https://openalex.org/W2156077683","https://openalex.org/W2163550224","https://openalex.org/W2170472485","https://openalex.org/W2179032951","https://openalex.org/W2188023518","https://openalex.org/W2240246689","https://openalex.org/W2265759920","https://openalex.org/W2314225431","https://openalex.org/W2322672979","https://openalex.org/W2412153698","https://openalex.org/W4212952704","https://openalex.org/W4240065971","https://openalex.org/W4285719527","https://openalex.org/W4298198812"],"related_works":["https://openalex.org/W4298361266","https://openalex.org/W7097995234","https://openalex.org/W32978508","https://openalex.org/W2124120917","https://openalex.org/W2181660414","https://openalex.org/W2606804825","https://openalex.org/W1976279799","https://openalex.org/W2912304807","https://openalex.org/W1873598986","https://openalex.org/W7214193103"],"abstract_inverted_index":{"In":[0,81],"Saccharomyces":[1],"cerevisiae,":[2],"POL3":[3,14],"encodes":[4],"the":[5,19,24,35,55,65,88,111,121,124],"catalytic":[6],"subunit":[7],"of":[8,23,37,48,54,67,77,90,102,126],"DNA":[9,78,92,103,127],"polymerase":[10,25,79,93,104,128],"delta.":[11],"While":[12],"yeast":[13],"mutant":[15],"strains":[16],"that":[17,58,85,119],"lack":[18],"proofreading":[20],"exonuclease":[21,56],"activity":[22],"have":[26,59],"a":[27,46,60,96],"strong":[28],"mutator":[29,61,98],"phenotype,":[30,62],"little":[31],"is":[32,130],"known":[33],"regarding":[34],"role":[36],"other":[38],"Pol3p":[39],"domains":[40],"in":[41,51,87,95,107,132],"mutation":[42],"avoidance.":[43],"We":[44,117],"identified":[45],"number":[47],"pol3":[49],"mutations":[50],"regions":[52],"outside":[53],"domain":[57],"substantially":[63],"elevating":[64],"frequency":[66,76],"deletions.":[68],"These":[69],"deletions":[70],"appear":[71],"to":[72,110],"reflect":[73],"an":[74],"increased":[75,108],"slippage.":[80],"addition,":[82],"we":[83],"demonstrate":[84],"reduction":[86],"level":[89],"wild-type":[91],"results":[94],"similar":[97],"phenotype.":[99],"Lowered":[100],"levels":[101],"also":[105],"result":[106],"sensitivity":[109],"DNA-damaging":[112],"agent":[113],"methyl":[114],"methane":[115],"sulfonate.":[116],"conclude":[118],"both":[120],"quantity":[122],"and":[123],"quality":[125],"delta":[129],"important":[131],"ensuring":[133],"genome":[134],"stability.":[135]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}