{"id":"https://openalex.org/W1984635589","doi":"https://doi.org/10.1172/jci108830","title":"Bicarbonate transport by rabbit cortical collecting tubules. Effect of acid and alkali loads in vivo on transport in vitro.","display_name":"Bicarbonate transport by rabbit cortical collecting tubules. Effect of acid and alkali loads in vivo on transport in vitro.","publication_year":1977,"publication_date":"1977-09-01","ids":{"openalex":"https://openalex.org/W1984635589","doi":"https://doi.org/10.1172/jci108830","mag":"1984635589","pmid":"https://pubmed.ncbi.nlm.nih.gov/19497","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/372423"},"language":"en","primary_location":{"id":"doi:10.1172/jci108830","doi":"https://doi.org/10.1172/jci108830","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci108830","pdf_url":"http://www.jci.org/articles/view/108830/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.jci.org/articles/view/108830/files/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112316635","display_name":"T. D. McKinney","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T D McKinney","raw_affiliation_strings":["From the National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20014"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20014","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025916093","display_name":"Maurice B. Burg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I1322918889","display_name":"United States Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889"]},{"id":"https://openalex.org/I4210103776","display_name":"Nashville VA Medical Center","ror":"https://ror.org/024xyyq03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210101790","https://openalex.org/I4210103776","https://openalex.org/I4210112672"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M B Burg","raw_affiliation_strings":["From the National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20014","Nephrology Division , Veterans Administration Hospital , Nashville , Tenn. 37203 "],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20014","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489"]},{"raw_affiliation_string":"Nephrology Division , Veterans Administration Hospital , Nashville , Tenn. 37203 ","institution_ids":["https://openalex.org/I1322918889","https://openalex.org/I4210103776"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5200,"currency":"USD","value_usd":5200},"apc_paid":null,"fwci":5.3873,"has_fulltext":true,"cited_by_count":180,"citation_normalized_percentile":{"value":0.9505618,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"60","issue":"3","first_page":"766","last_page":"768"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12840","display_name":"Renal function and acid-base balance","score":0.8744999766349792,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12840","display_name":"Renal function and acid-base balance","score":0.8744999766349792,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.10840000212192535,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10606","display_name":"Kidney Stones and Urolithiasis Treatments","score":0.010200000368058681,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bicarbonate-transport","display_name":"bicarbonate transport","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cortical-collecting-tubule","display_name":"cortical collecting tubule","score":0.9639999866485596},{"id":"https://openalex.org/keywords/urine-ph","display_name":"urine pH","score":0.7990000247955322},{"id":"https://openalex.org/keywords/acid-load","display_name":"acid load","score":0.5889999866485596},{"id":"https://openalex.org/keywords/ammonium-chloride","display_name":"ammonium chloride","score":0.7649999856948853},{"id":"https://openalex.org/keywords/sodium-bicarbonate","display_name":"sodium bicarbonate","score":0.8849999904632568},{"id":"https://openalex.org/keywords/renal-acid-base-balance","display_name":"renal acid-base balance","score":0.6150000095367432},{"id":"https://openalex.org/keywords/rabbit-kidney","display_name":"rabbit kidney","score":0.4169999957084656}],"concepts":[{"id":"https://openalex.org/C2781112554","wikidata":"https://www.wikidata.org/wiki/Q409202","display_name":"Bicarbonate","level":2,"score":0.946534276008606},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.7813391089439392},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.7181262969970703},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6603069305419922},{"id":"https://openalex.org/C2780026642","wikidata":"https://www.wikidata.org/wiki/Q40924","display_name":"Urine","level":2,"score":0.6408593058586121},{"id":"https://openalex.org/C2776420369","wikidata":"https://www.wikidata.org/wiki/Q179731","display_name":"Sodium bicarbonate","level":2,"score":0.6119731664657593},{"id":"https://openalex.org/C10146269","wikidata":"https://www.wikidata.org/wiki/Q185557","display_name":"Excretion","level":2,"score":0.4945976436138153},{"id":"https://openalex.org/C131631996","wikidata":"https://www.wikidata.org/wiki/Q1141325","display_name":"Lumen (anatomy)","level":2,"score":0.48354005813598633},{"id":"https://openalex.org/C158171629","wikidata":"https://www.wikidata.org/wiki/Q6998414","display_name":"Net acid excretion","level":3,"score":0.42519450187683105},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3616066873073578},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3022732138633728},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18995943665504456},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.08732059597969055},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000643","descriptor_name":"Ammonium Chloride","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001639","descriptor_name":"Bicarbonates","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001639","descriptor_name":"Bicarbonates","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001692","descriptor_name":"Biological Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002245","descriptor_name":"Carbon Dioxide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007672","descriptor_name":"Kidney Cortex","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007684","descriptor_name":"Kidney Tubules","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012964","descriptor_name":"Sodium","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1172/jci108830","doi":"https://doi.org/10.1172/jci108830","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci108830","pdf_url":"http://www.jci.org/articles/view/108830/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:372423","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/372423","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Invest","raw_type":"Text"},{"id":"pmid:19497","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19497","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical investigation","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1172/jci108830","doi":"https://doi.org/10.1172/jci108830","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci108830","pdf_url":"http://www.jci.org/articles/view/108830/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1984635589.pdf","grobid_xml":"https://content.openalex.org/works/W1984635589.grobid-xml"},"referenced_works_count":8,"referenced_works":["https://openalex.org/W1996594976","https://openalex.org/W2026596960","https://openalex.org/W2180037647","https://openalex.org/W2416743722","https://openalex.org/W2430026476","https://openalex.org/W2431341975","https://openalex.org/W2431908336","https://openalex.org/W2470626057"],"related_works":["https://openalex.org/W7099655126","https://openalex.org/W2466107741","https://openalex.org/W2037215946","https://openalex.org/W2019401494","https://openalex.org/W2416165468","https://openalex.org/W2000410542","https://openalex.org/W2438430319","https://openalex.org/W2046379164","https://openalex.org/W2338932258","https://openalex.org/W3023044114"],"abstract_inverted_index":{"Rabbit":[0],"cortical":[1,146],"collecting":[2,147],"tubules":[3,99,128,148],"were":[4,27,53,84,116],"perfused":[5],"in":[6,43,61,101,130,153,170],"vitro":[7,102,131,154],"to":[8,186],"investigate":[9],"the":[10,41,44,50,70,75,82,88,91,114,140,157,164,168,187],"control":[11,188],"of":[12,40,46,142,167,189],"bicarbonate":[13,33,104,134,143,191],"transport.":[14,80],"Bicarbonate":[15],"was":[16,55,73,95,107,122,161],"measured":[17],"by":[18,145,163],"microcalorimetry":[19],"as":[20],"total":[21],"CO2.":[22],"The":[23,37],"perfusate":[24],"and":[25,97,126,160],"bath":[26],"identical":[28],"solutions":[29],"containing":[30],"25":[31],"mM":[32],"at":[34,49],"pH":[35,39,159],"7.4.":[36,56],"mean":[38],"urine":[42,94,121,158],"bladders":[45],"untreated":[47],"rabbits":[48,83,115],"time":[51],"they":[52],"killed":[54],"Their":[57],"individual":[58],"tubules,":[59],"studied":[60,100,129,149],"vitro,":[62],"either":[63],"absorbed":[64,103],"or":[65,174],"secreted":[66,133],"bicarbonate,":[67],"and,":[68],"combining":[69],"results,":[71],"there":[72,106],"on":[74],"average":[76],"no":[77],"significant":[78],"net":[79,108,136],"When":[81],"treated":[85,117],"with":[86,118,156,172],"NH4Cl":[87],"day":[89],"before":[90],"experiment,":[92],"their":[93,98,120,127],"acidic":[96],"(i.e.,":[105,135],"lumen-to-bath":[109],"transport).":[110,138],"In":[111],"contrast,":[112],"when":[113],"NaHCO3,":[119],"significantly":[123],"more":[124],"alkaline,":[125],"generally":[132],"bath-to-lumen":[137],"Thus,":[139],"direction":[141],"transport":[144],"under":[150],"standard":[151],"conditions":[152],"correlated":[155],"determined":[162],"preceding":[165],"treatment":[166],"animals":[169],"vivo":[171],"acidifying":[173],"alkalinizing":[175],"salts.":[176],"These":[177],"results":[178],"demonstrate":[179],"a":[180],"previously":[181],"unrecognized":[182],"mechanism":[183],"which":[184],"contributes":[185],"urinary":[190],"excretion.":[192]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":6}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}