{"id":"https://openalex.org/W1984600614","doi":"https://doi.org/10.1111/j.1365-2516.2009.02165.x","title":"Comparison of kaolin and tissue factor activated thromboelastography in haemophilia","display_name":"Comparison of kaolin and tissue factor activated thromboelastography in haemophilia","publication_year":2009,"publication_date":"2009-12-18","ids":{"openalex":"https://openalex.org/W1984600614","doi":"https://doi.org/10.1111/j.1365-2516.2009.02165.x","mag":"1984600614","pmid":"https://pubmed.ncbi.nlm.nih.gov/20028419"},"language":"en","primary_location":{"id":"doi:10.1111/j.1365-2516.2009.02165.x","doi":"https://doi.org/10.1111/j.1365-2516.2009.02165.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1365-2516.2009.02165.x","pdf_url":null,"source":{"id":"https://openalex.org/S37667796","display_name":"Haemophilia","issn_l":"1351-8216","issn":["1351-8216","1355-0691","1365-2516"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Haemophilia","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004338432","display_name":"Guy A. Young","orcid":"https://orcid.org/0000-0001-6013-1254","observed_orcids":["https://orcid.org/0000-0001-6013-1254"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I1336910626","display_name":"Children's Hospital Los Angeles","ror":"https://ror.org/00412ts95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336910626"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"G. YOUNG","raw_affiliation_strings":["Division of Hematology/Oncology, Children's Hospital Los Angeles, University of Southern California Keck School of Medicine, Los Angeles, CA 90027, USA. gyoung@chla.usc.edu","Division of Hematology/Oncology, Children's Hospital Los Angeles, University of Southern California Keck School of Medicine, Los Angeles, CA 90027, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology/Oncology, Children's Hospital Los Angeles, University of Southern California Keck School of Medicine, Los Angeles, CA 90027, USA. gyoung@chla.usc.edu","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I1336910626"]},{"raw_affiliation_string":"Division of Hematology/Oncology, Children's Hospital Los Angeles, University of Southern California Keck School of Medicine, Los Angeles, CA 90027, USA","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I1336910626"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014014938","display_name":"R. Zhang","orcid":"https://orcid.org/0009-0002-8141-3474","observed_orcids":["https://orcid.org/0009-0002-8141-3474"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I1336910626","display_name":"Children's Hospital Los Angeles","ror":"https://ror.org/00412ts95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336910626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. ZHANG","raw_affiliation_strings":["Division of Hematology/Oncology, Children\u2019s Hospital Los Angeles, University of Southern California Keck School of Medicine, Los Angeles, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology/Oncology, Children\u2019s Hospital Los Angeles, University of Southern California Keck School of Medicine, Los Angeles, CA","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I1336910626"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084015184","display_name":"Robert Miller","orcid":"https://orcid.org/0009-0004-9762-5222","observed_orcids":["https://orcid.org/0009-0004-9762-5222"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I1336910626","display_name":"Children's Hospital Los Angeles","ror":"https://ror.org/00412ts95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336910626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. MILLER","raw_affiliation_strings":["Division of Hematology/Oncology, Children\u2019s Hospital Los Angeles, University of Southern California Keck School of Medicine, Los Angeles, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology/Oncology, Children\u2019s Hospital Los Angeles, University of Southern California Keck School of Medicine, Los Angeles, CA","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I1336910626"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027215074","display_name":"Dena Yassin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1304278710","display_name":"Children's Hospital of Orange County","ror":"https://ror.org/0282qcz50","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1304278710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. YASSIN","raw_affiliation_strings":["Children\u2019s Hospital of Orange County, Orange, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children\u2019s Hospital of Orange County, Orange, CA, USA","institution_ids":["https://openalex.org/I1304278710"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020726409","display_name":"Diane Jean Nugent","orcid":"https://orcid.org/0000-0002-1109-0879","observed_orcids":["https://orcid.org/0000-0002-1109-0879"]},"institutions":[{"id":"https://openalex.org/I1304278710","display_name":"Children's Hospital of Orange County","ror":"https://ror.org/0282qcz50","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1304278710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. J. NUGENT","raw_affiliation_strings":["Children\u2019s Hospital of Orange County, Orange, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children\u2019s Hospital of Orange County, Orange, CA, USA","institution_ids":["https://openalex.org/I1304278710"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5004338432"],"corresponding_institution_ids":["https://openalex.org/I1174212","https://openalex.org/I1336910626"],"apc_list":{"value":4760,"currency":"USD","value_usd":4760},"apc_paid":null,"fwci":1.0962,"has_fulltext":false,"cited_by_count":24,"citation_normalized_percentile":{"value":0.79494012,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"16","issue":"3","first_page":"518","last_page":"524"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11280","display_name":"Hemophilia Treatment and Research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11280","display_name":"Hemophilia Treatment and Research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11116","display_name":"Trauma, Hemostasis, Coagulopathy, Resuscitation","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10693","display_name":"Blood transfusion and management","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thromboelastography","display_name":"thromboelastography","score":0.9330000281333923},{"id":"https://openalex.org/keywords/tissue-factor-activation","display_name":"tissue factor activation","score":0.9860000014305115},{"id":"https://openalex.org/keywords/factor-viii-inhibitors","display_name":"factor VIII inhibitors","score":0.7149999737739563},{"id":"https://openalex.org/keywords/recombinant-factor-viia","display_name":"recombinant factor VIIa","score":0.9229999780654907},{"id":"https://openalex.org/keywords/bypassing-agents","display_name":"bypassing agents","score":0.8050000071525574},{"id":"https://openalex.org/keywords/coagulation-monitoring","display_name":"coagulation monitoring","score":0.6060000061988831}],"concepts":[{"id":"https://openalex.org/C2777664302","wikidata":"https://www.wikidata.org/wiki/Q4463725","display_name":"Thromboelastography","level":3,"score":0.9923385977745056},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8348971605300903},{"id":"https://openalex.org/C2777151630","wikidata":"https://www.wikidata.org/wiki/Q14878075","display_name":"Tissue factor pathway inhibitor","level":4,"score":0.7314605712890625},{"id":"https://openalex.org/C186738567","wikidata":"https://www.wikidata.org/wiki/Q412841","display_name":"Tissue factor","level":3,"score":0.6806141138076782},{"id":"https://openalex.org/C2777232031","wikidata":"https://www.wikidata.org/wiki/Q2092064","display_name":"Haemophilia A","level":3,"score":0.6480616331100464},{"id":"https://openalex.org/C2778385053","wikidata":"https://www.wikidata.org/wiki/Q134003","display_name":"Haemophilia","level":2,"score":0.6079486608505249},{"id":"https://openalex.org/C2778382381","wikidata":"https://www.wikidata.org/wiki/Q179217","display_name":"Coagulation","level":2,"score":0.5232162475585938},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.4078437089920044},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.35181546211242676},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.34989994764328003},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3232380151748657}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001777","descriptor_name":"Blood Coagulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004347","descriptor_name":"Drug Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005169","descriptor_name":"Factor VIII","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006467","descriptor_name":"Hemophilia A","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006467","descriptor_name":"Hemophilia A","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007616","descriptor_name":"Kaolin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007616","descriptor_name":"Kaolin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013916","descriptor_name":"Thrombelastography","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D015942","descriptor_name":"Factor VIIa","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1365-2516.2009.02165.x","doi":"https://doi.org/10.1111/j.1365-2516.2009.02165.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1365-2516.2009.02165.x","pdf_url":null,"source":{"id":"https://openalex.org/S37667796","display_name":"Haemophilia","issn_l":"1351-8216","issn":["1351-8216","1355-0691","1365-2516"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Haemophilia","raw_type":"journal-article"},{"id":"pmid:20028419","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20028419","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Haemophilia : the official journal of the World Federation of Hemophilia","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W1552116618","https://openalex.org/W1578972647","https://openalex.org/W1983705991","https://openalex.org/W1984703733","https://openalex.org/W1991130709","https://openalex.org/W1991248841","https://openalex.org/W1994393898","https://openalex.org/W2056520690","https://openalex.org/W2061726015","https://openalex.org/W2081809208","https://openalex.org/W2133535613","https://openalex.org/W2138914609","https://openalex.org/W2321723077","https://openalex.org/W4233184002"],"related_works":["https://openalex.org/W2535378072","https://openalex.org/W1992502443","https://openalex.org/W2061726015","https://openalex.org/W1972343156","https://openalex.org/W2045090736","https://openalex.org/W3003360969","https://openalex.org/W2055450420","https://openalex.org/W1983705991","https://openalex.org/W2330460854","https://openalex.org/W2162671203"],"abstract_inverted_index":{"A":[0,82],"limitation":[1],"of":[2,14,37,67,84,89,123,144,156,179,187,202,205,239],"bypassing":[3,38],"agent":[4,39],"therapy":[5,40],"for":[6,31,96,158,199],"haemophilia":[7,242],"patients":[8,101,118,243],"with":[9,102,119,244],"inhibitors":[10],"is":[11],"the":[12,20,29,35,73,93,141,160,185,190,203,210,228,237],"absence":[13],"a":[15,56,134,168,176],"laboratory":[16],"assay,":[17],"which":[18],"predicts":[19],"clinical":[21],"response":[22],"to":[23,33,61,86,133,167,175,235],"treatment.":[24],"Recent":[25],"investigations":[26],"have":[27,79],"demonstrated":[28],"potential":[30],"thromboelastography":[32,97,111,221,234],"assess":[34,236],"effects":[36,204,238],"in":[41,52,100,173,189,215,241],"this":[42,216],"patient":[43],"population.":[44],"While":[45],"tissue":[46,74,90,108,145,180],"factor":[47,75,91,109,146,181],"activation":[48,76,94,213],"has":[49],"been":[50,80],"used":[51],"several":[53],"prior":[54],"studies,":[55],"recent":[57],"multicentre":[58],"study":[59],"failed":[60],"demonstrate":[62,129],"an":[63,225],"expected":[64],"concentration-response":[65],"effect":[66],"rFVIIa":[68,124,157,188,206,240],"and":[69,107,116,120,125,138,153,162,171,196],"called":[70],"into":[71],"question":[72],"methods":[77],"that":[78,130],"employed.":[81],"comparison":[83,174],"kaolin":[85,106,131,209,219],"two":[87],"concentrations":[88],"as":[92],"method":[95,214],"was":[98],"investigated":[99],"haemophilia.":[103],"We":[104],"performed":[105],"activated":[110,220],"on":[112],"blood":[113],"from":[114],"inhibitor":[115,161,191],"non-inhibitor":[117,163],"without":[121],"addition":[122,155,186],"rFVIII.":[126],"The":[127,193],"results":[128],"leads":[132],"longer":[135,169,194],"R,":[136],"K":[137,172,197],"angle":[139],"than":[140],"higher":[142],"dilution":[143,178],"(1:17":[147],"000)":[148,183],"at":[149],"baseline":[150],"(no":[151],"factor)":[152],"after":[154],"both":[159],"patients.":[164,192],"Kaolin":[165],"led":[166],"R":[170,195],"low":[177],"(1:42":[182],"following":[184],"allows":[198],"better":[200],"discrimination":[201],"thus":[207],"making":[208],"most":[211,229],"sensitive":[212],"setting.":[217],"Thus":[218],"should":[222],"be":[223],"considered":[224],"effective,":[226,230],"perhaps":[227],"activator":[231],"when":[232],"utilizing":[233],"inhibitors.":[245]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}