{"id":"https://openalex.org/W1984583971","doi":"https://doi.org/10.1161/01.res.78.5.848","title":"Modification of Viral Myocarditis in Mice by Interleukin-6","display_name":"Modification of Viral Myocarditis in Mice by Interleukin-6","publication_year":1996,"publication_date":"1996-05-01","ids":{"openalex":"https://openalex.org/W1984583971","doi":"https://doi.org/10.1161/01.res.78.5.848","mag":"1984583971","pmid":"https://pubmed.ncbi.nlm.nih.gov/8620605"},"language":"en","primary_location":{"id":"doi:10.1161/01.res.78.5.848","doi":"https://doi.org/10.1161/01.res.78.5.848","is_oa":false,"landing_page_url":"https://doi.org/10.1161/01.res.78.5.848","pdf_url":null,"source":{"id":"https://openalex.org/S10652568","display_name":"Circulation Research","issn_l":"0009-7330","issn":["0009-7330","1524-4571"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5105361294","display_name":"Tsugiyasu Kanda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]},{"id":"https://openalex.org/I165735259","display_name":"Gunma University","ror":"https://ror.org/046fm7598","country_code":"JP","type":"education","lineage":["https://openalex.org/I165735259"]},{"id":"https://openalex.org/I2801362399","display_name":"St. Paul's Hospital","ror":"https://ror.org/00wzdr059","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801362399"]}],"countries":["CA","JP"],"is_corresponding":false,"raw_author_name":"Tsugiyasu Kanda","raw_affiliation_strings":["From the Department of Laboratory Medicine (T.K., I.K.) and the Second Department of Internal Medicine (R.N., S.I.), Gunma University School of Medicine, and the College of Medical Care and Technology (T.S.), Gunma University, Maebashi, Japan, and the Department of Pathology and Laboratory Medicine (J.E.W.M., D.Y., B.M.M.), University of British Columbia, St. Paul\u2019s Hospital, Vancouver, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Laboratory Medicine (T.K., I.K.) and the Second Department of Internal Medicine (R.N., S.I.), Gunma University School of Medicine, and the College of Medical Care and Technology (T.S.), Gunma University, Maebashi, Japan, and the Department of Pathology and Laboratory Medicine (J.E.W.M., D.Y., B.M.M.), University of British Columbia, St. Paul\u2019s Hospital, Vancouver, Canada","institution_ids":["https://openalex.org/I141945490","https://openalex.org/I165735259","https://openalex.org/I2801362399"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078646593","display_name":"Janet E. Wilson McManus","orcid":"https://orcid.org/0000-0001-7867-9998","observed_orcids":["https://orcid.org/0000-0001-7867-9998"]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]},{"id":"https://openalex.org/I165735259","display_name":"Gunma University","ror":"https://ror.org/046fm7598","country_code":"JP","type":"education","lineage":["https://openalex.org/I165735259"]},{"id":"https://openalex.org/I2801362399","display_name":"St. Paul's Hospital","ror":"https://ror.org/00wzdr059","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801362399"]}],"countries":["CA","JP"],"is_corresponding":false,"raw_author_name":"Janet E. Wilson McManus","raw_affiliation_strings":["From the Department of Laboratory Medicine (T.K., I.K.) and the Second Department of Internal Medicine (R.N., S.I.), Gunma University School of Medicine, and the College of Medical Care and Technology (T.S.), Gunma University, Maebashi, Japan, and the Department of Pathology and Laboratory Medicine (J.E.W.M., D.Y., B.M.M.), University of British Columbia, St. Paul\u2019s Hospital, Vancouver, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Laboratory Medicine (T.K., I.K.) and the Second Department of Internal Medicine (R.N., S.I.), Gunma University School of Medicine, and the College of Medical Care and Technology (T.S.), Gunma University, Maebashi, Japan, and the Department of Pathology and Laboratory Medicine (J.E.W.M., D.Y., B.M.M.), University of British Columbia, St. Paul\u2019s Hospital, Vancouver, Canada","institution_ids":["https://openalex.org/I141945490","https://openalex.org/I165735259","https://openalex.org/I2801362399"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113946000","display_name":"Ryozo Nagai","orcid":"https://orcid.org/0000-0002-0911-7868","observed_orcids":["https://orcid.org/0000-0002-0911-7868"]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]},{"id":"https://openalex.org/I165735259","display_name":"Gunma University","ror":"https://ror.org/046fm7598","country_code":"JP","type":"education","lineage":["https://openalex.org/I165735259"]},{"id":"https://openalex.org/I2801362399","display_name":"St. Paul's Hospital","ror":"https://ror.org/00wzdr059","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801362399"]}],"countries":["CA","JP"],"is_corresponding":false,"raw_author_name":"Ryozo Nagai","raw_affiliation_strings":["From the Department of Laboratory Medicine (T.K., I.K.) and the Second Department of Internal Medicine (R.N., S.I.), Gunma University School of Medicine, and the College of Medical Care and Technology (T.S.), Gunma University, Maebashi, Japan, and the Department of Pathology and Laboratory Medicine (J.E.W.M., D.Y., B.M.M.), University of British Columbia, St. Paul\u2019s Hospital, Vancouver, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Laboratory Medicine (T.K., I.K.) and the Second Department of Internal Medicine (R.N., S.I.), Gunma University School of Medicine, and the College of Medical Care and Technology (T.S.), Gunma University, Maebashi, Japan, and the Department of Pathology and Laboratory Medicine (J.E.W.M., D.Y., B.M.M.), University of British Columbia, St. Paul\u2019s Hospital, Vancouver, Canada","institution_ids":["https://openalex.org/I141945490","https://openalex.org/I165735259","https://openalex.org/I2801362399"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Susumu Imai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]},{"id":"https://openalex.org/I165735259","display_name":"Gunma University","ror":"https://ror.org/046fm7598","country_code":"JP","type":"education","lineage":["https://openalex.org/I165735259"]},{"id":"https://openalex.org/I2801362399","display_name":"St. Paul's Hospital","ror":"https://ror.org/00wzdr059","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801362399"]}],"countries":["CA","JP"],"is_corresponding":false,"raw_author_name":"Susumu Imai","raw_affiliation_strings":["From the Department of Laboratory Medicine (T.K., I.K.) and the Second Department of Internal Medicine (R.N., S.I.), Gunma University School of Medicine, and the College of Medical Care and Technology (T.S.), Gunma University, Maebashi, Japan, and the Department of Pathology and Laboratory Medicine (J.E.W.M., D.Y., B.M.M.), University of British Columbia, St. Paul\u2019s Hospital, Vancouver, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Laboratory Medicine (T.K., I.K.) and the Second Department of Internal Medicine (R.N., S.I.), Gunma University School of Medicine, and the College of Medical Care and Technology (T.S.), Gunma University, Maebashi, Japan, and the Department of Pathology and Laboratory Medicine (J.E.W.M., D.Y., B.M.M.), University of British Columbia, St. Paul\u2019s Hospital, Vancouver, Canada","institution_ids":["https://openalex.org/I141945490","https://openalex.org/I165735259","https://openalex.org/I2801362399"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054250942","display_name":"Tadashi Suzuki","orcid":"https://orcid.org/0000-0003-1030-7631","observed_orcids":["https://orcid.org/0000-0003-1030-7631"]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]},{"id":"https://openalex.org/I165735259","display_name":"Gunma University","ror":"https://ror.org/046fm7598","country_code":"JP","type":"education","lineage":["https://openalex.org/I165735259"]},{"id":"https://openalex.org/I2801362399","display_name":"St. Paul's Hospital","ror":"https://ror.org/00wzdr059","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801362399"]}],"countries":["CA","JP"],"is_corresponding":false,"raw_author_name":"Tadashi Suzuki","raw_affiliation_strings":["From the Department of Laboratory Medicine (T.K., I.K.) and the Second Department of Internal Medicine (R.N., S.I.), Gunma University School of Medicine, and the College of Medical Care and Technology (T.S.), Gunma University, Maebashi, Japan, and the Department of Pathology and Laboratory Medicine (J.E.W.M., D.Y., B.M.M.), University of British Columbia, St. Paul\u2019s Hospital, Vancouver, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Laboratory Medicine (T.K., I.K.) and the Second Department of Internal Medicine (R.N., S.I.), Gunma University School of Medicine, and the College of Medical Care and Technology (T.S.), Gunma University, Maebashi, Japan, and the Department of Pathology and Laboratory Medicine (J.E.W.M., D.Y., B.M.M.), University of British Columbia, St. Paul\u2019s Hospital, Vancouver, Canada","institution_ids":["https://openalex.org/I141945490","https://openalex.org/I165735259","https://openalex.org/I2801362399"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000734385","display_name":"Decheng Yang","orcid":"https://orcid.org/0000-0002-3177-0070","observed_orcids":["https://orcid.org/0000-0002-3177-0070"]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]},{"id":"https://openalex.org/I165735259","display_name":"Gunma University","ror":"https://ror.org/046fm7598","country_code":"JP","type":"education","lineage":["https://openalex.org/I165735259"]},{"id":"https://openalex.org/I2801362399","display_name":"St. Paul's Hospital","ror":"https://ror.org/00wzdr059","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801362399"]}],"countries":["CA","JP"],"is_corresponding":false,"raw_author_name":"DeCheng Yang","raw_affiliation_strings":["From the Department of Laboratory Medicine (T.K., I.K.) and the Second Department of Internal Medicine (R.N., S.I.), Gunma University School of Medicine, and the College of Medical Care and Technology (T.S.), Gunma University, Maebashi, Japan, and the Department of Pathology and Laboratory Medicine (J.E.W.M., D.Y., B.M.M.), University of British Columbia, St. Paul\u2019s Hospital, Vancouver, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Laboratory Medicine (T.K., I.K.) and the Second Department of Internal Medicine (R.N., S.I.), Gunma University School of Medicine, and the College of Medical Care and Technology (T.S.), Gunma University, Maebashi, Japan, and the Department of Pathology and Laboratory Medicine (J.E.W.M., D.Y., B.M.M.), University of British Columbia, St. Paul\u2019s Hospital, Vancouver, Canada","institution_ids":["https://openalex.org/I141945490","https://openalex.org/I165735259","https://openalex.org/I2801362399"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058694015","display_name":"Bruce M. McManus","orcid":"https://orcid.org/0000-0002-1685-2529","observed_orcids":["https://orcid.org/0000-0002-1685-2529"]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]},{"id":"https://openalex.org/I165735259","display_name":"Gunma University","ror":"https://ror.org/046fm7598","country_code":"JP","type":"education","lineage":["https://openalex.org/I165735259"]},{"id":"https://openalex.org/I2801362399","display_name":"St. Paul's Hospital","ror":"https://ror.org/00wzdr059","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801362399"]}],"countries":["CA","JP"],"is_corresponding":false,"raw_author_name":"Bruce M. McManus","raw_affiliation_strings":["From the Department of Laboratory Medicine (T.K., I.K.) and the Second Department of Internal Medicine (R.N., S.I.), Gunma University School of Medicine, and the College of Medical Care and Technology (T.S.), Gunma University, Maebashi, Japan, and the Department of Pathology and Laboratory Medicine (J.E.W.M., D.Y., B.M.M.), University of British Columbia, St. Paul\u2019s Hospital, Vancouver, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Laboratory Medicine (T.K., I.K.) and the Second Department of Internal Medicine (R.N., S.I.), Gunma University School of Medicine, and the College of Medical Care and Technology (T.S.), Gunma University, Maebashi, Japan, and the Department of Pathology and Laboratory Medicine (J.E.W.M., D.Y., B.M.M.), University of British Columbia, St. Paul\u2019s Hospital, Vancouver, Canada","institution_ids":["https://openalex.org/I141945490","https://openalex.org/I165735259","https://openalex.org/I2801362399"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075528734","display_name":"Isao Kobayashi","orcid":"https://orcid.org/0000-0002-2750-3244","observed_orcids":["https://orcid.org/0000-0002-2750-3244"]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]},{"id":"https://openalex.org/I165735259","display_name":"Gunma University","ror":"https://ror.org/046fm7598","country_code":"JP","type":"education","lineage":["https://openalex.org/I165735259"]},{"id":"https://openalex.org/I2801362399","display_name":"St. Paul's Hospital","ror":"https://ror.org/00wzdr059","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801362399"]}],"countries":["CA","JP"],"is_corresponding":false,"raw_author_name":"Isao Kobayashi","raw_affiliation_strings":["From the Department of Laboratory Medicine (T.K., I.K.) and the Second Department of Internal Medicine (R.N., S.I.), Gunma University School of Medicine, and the College of Medical Care and Technology (T.S.), Gunma University, Maebashi, Japan, and the Department of Pathology and Laboratory Medicine (J.E.W.M., D.Y., B.M.M.), University of British Columbia, St. Paul\u2019s Hospital, Vancouver, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Laboratory Medicine (T.K., I.K.) and the Second Department of Internal Medicine (R.N., S.I.), Gunma University School of Medicine, and the College of Medical Care and Technology (T.S.), Gunma University, Maebashi, Japan, and the Department of Pathology and Laboratory Medicine (J.E.W.M., D.Y., B.M.M.), University of British Columbia, St. Paul\u2019s Hospital, Vancouver, Canada","institution_ids":["https://openalex.org/I141945490","https://openalex.org/I165735259","https://openalex.org/I2801362399"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.2311,"has_fulltext":false,"cited_by_count":83,"citation_normalized_percentile":{"value":0.87261624,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"78","issue":"5","first_page":"848","last_page":"856"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11112","display_name":"Viral Infections and Immunology Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11112","display_name":"Viral Infections and Immunology Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/viral-myocarditis","display_name":"viral myocarditis","score":0.9670000076293945},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.9929999709129333},{"id":"https://openalex.org/keywords/encephalomyocarditis-virus","display_name":"encephalomyocarditis virus","score":0.9980000257492065},{"id":"https://openalex.org/keywords/antiviral-cytokines","display_name":"antiviral cytokines","score":0.6919999718666077},{"id":"https://openalex.org/keywords/myocardial-injury","display_name":"myocardial injury","score":0.6809999942779541},{"id":"https://openalex.org/keywords/natural-killer-cells","display_name":"natural killer cells","score":0.7110000252723694},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.7459999918937683},{"id":"https://openalex.org/keywords/interferon","display_name":"interferon","score":0.75},{"id":"https://openalex.org/keywords/neutralizing-antibodies","display_name":"neutralizing antibodies","score":0.949999988079071},{"id":"https://openalex.org/keywords/viral-replication","display_name":"viral replication","score":0.6759999990463257},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.8610000014305115},{"id":"https://openalex.org/keywords/c3h-hej-mice","display_name":"C3H/HeJ mice","score":0.847000002861023},{"id":"https://openalex.org/keywords/survival-rate","display_name":"survival rate","score":0.7680000066757202},{"id":"https://openalex.org/keywords/heart-weight-to-body-weight-ratio","display_name":"heart-to-body weight ratio","score":0.7509999871253967},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.5370000004768372}],"concepts":[{"id":"https://openalex.org/C2780875844","wikidata":"https://www.wikidata.org/wiki/Q186235","display_name":"Myocarditis","level":2,"score":0.7361131906509399},{"id":"https://openalex.org/C2909190889","wikidata":"https://www.wikidata.org/wiki/Q186235","display_name":"Viral Myocarditis","level":3,"score":0.7346474528312683},{"id":"https://openalex.org/C3020625565","wikidata":"https://www.wikidata.org/wiki/Q194908","display_name":"Interleukin 1\u03b2","level":4,"score":0.5170391201972961},{"id":"https://openalex.org/C74172505","wikidata":"https://www.wikidata.org/wiki/Q194908","display_name":"Interleukin","level":3,"score":0.5131855607032776},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4909217953681946},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4871339499950409},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3730548620223999},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3383183479309082},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32881519198417664},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.2856941819190979}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000914","descriptor_name":"Antibodies, Viral","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D004686","descriptor_name":"Encephalomyocarditis virus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D004686","descriptor_name":"Encephalomyocarditis virus","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008809","descriptor_name":"Mice, Inbred C3H","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009205","descriptor_name":"Myocarditis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009205","descriptor_name":"Myocarditis","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D009205","descriptor_name":"Myocarditis","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009929","descriptor_name":"Organ Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017403","descriptor_name":"In Situ Hybridization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018188","descriptor_name":"Cardiovirus Infections","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1161/01.res.78.5.848","doi":"https://doi.org/10.1161/01.res.78.5.848","is_oa":false,"landing_page_url":"https://doi.org/10.1161/01.res.78.5.848","pdf_url":null,"source":{"id":"https://openalex.org/S10652568","display_name":"Circulation Research","issn_l":"0009-7330","issn":["0009-7330","1524-4571"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation Research","raw_type":"journal-article"},{"id":"pmid:8620605","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8620605","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9980000257492065,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W57077356","https://openalex.org/W95884546","https://openalex.org/W204546040","https://openalex.org/W1504397512","https://openalex.org/W1506036490","https://openalex.org/W1525458152","https://openalex.org/W1537196256","https://openalex.org/W1562725259","https://openalex.org/W1652537748","https://openalex.org/W1662919691","https://openalex.org/W1704362931","https://openalex.org/W1863799486","https://openalex.org/W1933146641","https://openalex.org/W1965995080","https://openalex.org/W1987676609","https://openalex.org/W1989497089","https://openalex.org/W2002076761","https://openalex.org/W2006704738","https://openalex.org/W2011903225","https://openalex.org/W2020316938","https://openalex.org/W2020548973","https://openalex.org/W2036452124","https://openalex.org/W2039985913","https://openalex.org/W2070737639","https://openalex.org/W2073777388","https://openalex.org/W2079304803","https://openalex.org/W2101911216","https://openalex.org/W2106786890","https://openalex.org/W2132123340","https://openalex.org/W2135150905","https://openalex.org/W2145430197","https://openalex.org/W2162425639","https://openalex.org/W2162756907","https://openalex.org/W2168822788","https://openalex.org/W2254552946","https://openalex.org/W2270820102","https://openalex.org/W2411825271","https://openalex.org/W2413391905","https://openalex.org/W2416407061","https://openalex.org/W2468571675"],"related_works":["https://openalex.org/W1987730573","https://openalex.org/W2358397981","https://openalex.org/W2026403721","https://openalex.org/W1985878164","https://openalex.org/W2144328146","https://openalex.org/W2046065747","https://openalex.org/W2065858326","https://openalex.org/W1981465323","https://openalex.org/W1987470401","https://openalex.org/W2139555730"],"abstract_inverted_index":{"Inflammatory":[0],"cytokines":[1],"play":[2],"a":[3,148],"key":[4],"role":[5,31],"in":[6,23,34,42,57,63,67,92,179,184,195,210,231,263,318,327,338,352,364,381,403,413],"the":[7,30,47,54,58,64,185,196,199,288,300,319,324,328,339,370,373,382,404],"myocardial":[8,174,261,350],"injury":[9,262],"produced":[10],"by":[11,38,66,94],"viral":[12,24,35,55,61,90,177,190,193,355,365,385,396],"myocarditis.":[13,356,414],"Although":[14,376],"interleukin-6":[15],"(IL-6)":[16],"reportedly":[17],"possesses":[18],"antiviral":[19],"properties,":[20],"its":[21],"effect":[22],"myocarditis":[25,36],"is":[26,378,411],"unclear.":[27],"To":[28],"investigate":[29],"of":[32,127,154,201,220,252,278,294,302,307,323,336,343,358,372,384,390,395],"IL-6":[33,51,129,155,348,374,377,410],"induced":[37],"encephalomyocarditis":[39],"virus":[40,175],"(EMCV)":[41],"mice,":[43],"we":[44],"evaluated":[45],"(1)":[46],"survival":[48],"rate":[49],"following":[50],"administration,":[52],"(2)":[53],"titer":[56,191,200,219],"heart,":[59],"(3)":[60],"replication":[62,178,194,366,397],"heart":[65,197,253,340],"situ":[68],"hybridization,":[69],"(4)":[70],"histopathological":[71],"changes":[72],"using":[73],"immunohistochemical":[74],"staining,":[75],"(5)":[76],"neutralizing":[77,221],"antibody":[78],"against":[79,223],"EMCV,":[80],"(6)":[81],"circulating":[82,202],"interferon":[83],"and":[84,96,112,181,192,204,246,260,274,299,321,341,393],"tumor":[85],"necrosis":[86],"factor-alpha":[87],"(TNF-alpha),":[88],"(7)":[89],"suppression":[91],"vitro":[93],"IL-6,":[95],"(8)":[97],"natural":[98],"killer":[99],"(NK)-cell":[100],"activity.":[101],"Eight-week-old":[102],"C3H/HeJ":[103],"mice":[104,167,240,353],"were":[105,113,168,187,241,266],"injected":[106,115,157],"intraperitoneally":[107],"with":[108,123,235,314,354,362],"EMCV":[109,224],"(day":[110],"0)":[111],"also":[114],"subcutaneously":[116],"twice":[117],"daily":[118],"for":[119,144,161],"4":[120,145,162],"consecutive":[121],"days":[122,163,244,272],"10":[124,245,273],"micrograms/0.1":[125],"mL":[126,151],"human":[128],"on":[130,158,170,243,271,281,311],"day":[131,135,140,159,171,282,312],"-4":[132],"(group":[133,137,142,164],"A),":[134],"0":[136,160],"B),":[138],"or":[139],"+4":[141],"D)":[143],"days.":[146],"As":[147],"control,":[149],"0.1":[150],"PBS":[152],"instead":[153],"was":[156,208,225],"C).":[165],"Certain":[166],"killed":[169,242],"4.":[172],"The":[173,218,238,250,276,292],"titers,":[176],"situ,":[180],"NK-cell":[182,206],"activity":[183,207],"spleen":[186,320,342],"determined.":[188],"Decreased":[189],"reduced":[198,267],"TNF-alpha,":[203],"lower":[205],"observed":[209,317,326],"group":[211,214,232,236,264,269,279,308,344],"B":[212,233,265,280,309],"versus":[213,268],"C":[215,270],"(control":[216],"group).":[217],"antibodies":[222],"significantly":[226],"(P":[227],"<":[228],".05)":[229],"increased":[230,310,334],"compared":[234],"C.":[237],"remaining":[239],"30":[247,283],"after":[248],"infection.":[249],"ratio":[251,293,301],"weight":[254,258,296,304],"(HW)":[255],"to":[256,297,305,368],"body":[257],"(BW)":[259],"30.":[275],"HW":[277],"did":[284],"not":[285],"differ":[286],"from":[287],"normal":[289],"control":[290],"group.":[291],"splenic":[295],"BW":[298,306],"thymic":[303],"10,":[313],"expanded":[315],"follicles":[316],"enlargement":[322],"medulla":[325],"thymus.":[329],"Immunohistochemical":[330],"study":[331],"revealed":[332],"an":[333],"percentage":[335],"macrophages":[337],"B.":[345],"In":[346],"summary,":[347],"reduces":[349],"damage":[351],"Modification":[357],"immune":[359,391],"responses":[360,392],"together":[361],"reduction":[363],"appears":[367],"be":[369],"mechanism":[371],"effect.":[375],"likely":[379],"important":[380],"process":[383],"antigen":[386],"presentation,":[387],"early":[388],"activation":[389],"attenuation":[394],"appear":[398],"most":[399],"significant,":[400],"as":[401],"reflected":[402],"limited":[405],"time":[406],"window":[407],"during":[408],"which":[409],"effective":[412]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
