{"id":"https://openalex.org/W198454083","doi":null,"title":"The multiple membrane-spanning segments of the BNLF-1 oncogene from Epstein-Barr virus are required for transformation.","display_name":"The multiple membrane-spanning segments of the BNLF-1 oncogene from Epstein-Barr virus are required for transformation.","publication_year":1989,"publication_date":"1989-01-01","ids":{"openalex":"https://openalex.org/W198454083","mag":"198454083","pmid":"https://pubmed.ncbi.nlm.nih.gov/2536919"},"language":"en","primary_location":{"id":"pmid:2536919","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2536919","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncogene","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014193304","display_name":"Vijay R. Baichwal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"V R Baichwal","raw_affiliation_strings":["McArdle Laboratory for Cancer Research, University of Wisconsin-Madison 53706"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"McArdle Laboratory for Cancer Research, University of Wisconsin-Madison 53706","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001764333","display_name":"Bill Sugden","orcid":"https://orcid.org/0000-0002-8724-4504","observed_orcids":["https://orcid.org/0000-0002-8724-4504"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B Sugden","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.5647,"has_fulltext":false,"cited_by_count":85,"citation_normalized_percentile":{"value":0.95048325,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"4","issue":"1","first_page":"67","last_page":"74"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10625","display_name":"Herpesvirus Infections and Treatments","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epstein-barr-virus","display_name":"Epstein-Barr virus","score":0.9860000014305115},{"id":"https://openalex.org/keywords/latent-membrane-protein","display_name":"latent membrane protein","score":0.7850000262260437},{"id":"https://openalex.org/keywords/oncogenes","display_name":"oncogenes","score":0.6710000038146973},{"id":"https://openalex.org/keywords/membrane-spanning-segments","display_name":"membrane-spanning segments","score":0.8550000190734863},{"id":"https://openalex.org/keywords/transmembrane-domain","display_name":"transmembrane domain","score":0.628000020980835},{"id":"https://openalex.org/keywords/anchorage-independent-growth","display_name":"anchorage-independent growth","score":0.7239999771118164},{"id":"https://openalex.org/keywords/tumorigenicity","display_name":"tumorigenicity","score":0.878000020980835},{"id":"https://openalex.org/keywords/deletion-mutants","display_name":"deletion mutants","score":0.8569999933242798},{"id":"https://openalex.org/keywords/cytoplasmic-domain","display_name":"cytoplasmic domain","score":0.7710000276565552},{"id":"https://openalex.org/keywords/receptor-function","display_name":"receptor function","score":0.5120000243186951},{"id":"https://openalex.org/keywords/ligand-binding","display_name":"ligand binding","score":0.8859999775886536},{"id":"https://openalex.org/keywords/rhodopsin-like-receptors","display_name":"rhodopsin-like receptors","score":0.7020000219345093},{"id":"https://openalex.org/keywords/cell-transformation","display_name":"cell transformation","score":0.5270000100135803}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8988534212112427},{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.567746102809906},{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.5380551218986511},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.5277051329612732},{"id":"https://openalex.org/C144647389","wikidata":"https://www.wikidata.org/wiki/Q423042","display_name":"Membrane protein","level":3,"score":0.4965706467628479},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.4742024540901184},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.45751848816871643},{"id":"https://openalex.org/C146033667","wikidata":"https://www.wikidata.org/wiki/Q18033204","display_name":"Vesicle-associated membrane protein 8","level":4,"score":0.4350256323814392},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3711119294166565},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.32626283168792725},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.16807010769844055}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002448","descriptor_name":"Cell Adhesion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002458","descriptor_name":"Cell Fractionation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002471","descriptor_name":"Cell Transformation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002472","descriptor_name":"Cell Transformation, Viral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004854","descriptor_name":"Herpesvirus 4, Human","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009856","descriptor_name":"Oncogene Proteins, Viral","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009857","descriptor_name":"Oncogenes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D011233","descriptor_name":"Precipitin Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013539","descriptor_name":"Simian virus 40","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014763","descriptor_name":"Viral Matrix Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015151","descriptor_name":"Immunoblotting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:2536919","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2536919","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncogene","raw_type":"Journal Article"},{"id":"mag:198454083","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2536919","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.4043000042438507}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2413794146","https://openalex.org/W2463591261","https://openalex.org/W4241983754","https://openalex.org/W2040638887","https://openalex.org/W2144076363","https://openalex.org/W1934174439","https://openalex.org/W1861086068","https://openalex.org/W2079199354","https://openalex.org/W1505630375","https://openalex.org/W2094439850"],"abstract_inverted_index":{"The":[0,16],"BNLF-1":[1,17,81,111,132,158],"gene":[2,82],"from":[3,119],"Epstein-Barr":[4],"virus":[5],"(EBV)":[6],"induces":[7],"anchorage-independent":[8],"and":[9,26,50,83,148],"tumorigenic":[10],"growth":[11],"in":[12,40,145,156,162],"rodent":[13],"cell":[14],"lines.":[15],"protein":[18,35,66],"(also":[19],"termed":[20],"LMP)":[21],"is":[22,95,117,133],"a":[23,43,51,113,134,137,165],"membrane":[24],"protein,":[25],"its":[27,71,141,149],"predicted":[28],"amino":[29,48,56],"acid":[30],"sequence":[31],"indicates":[32],"that":[33,67,110,116,131],"the":[34,62,65,80,90,101,120,163,169],"has":[36,112],"six":[37],"membrane-spanning":[38,103],"segments":[39,104],"addition":[41],"to":[42,159,168],"short":[44],"amino-terminal":[45,150],"(approximately":[46,54],"25":[47],"acids)":[49,57],"long":[52],"carboxyl-terminal":[53,92],"200":[55],"cytoplasmic":[58,93,153],"domain.":[59],"To":[60],"identify":[61],"regions":[63],"of":[64,79,172],"are":[68,105],"essential":[69],"for":[70,86,97,136],"transforming":[72,87,98,127],"activity,":[73,99],"we":[74],"have":[75],"constructed":[76],"deletion":[77],"mutants":[78],"tested":[84],"them":[85],"activity.":[88],"Surprisingly,":[89],"entire":[91],"domain":[94,143,151],"dispensable":[96],"whereas":[100],"putative":[102],"essential.":[106],"These":[107],"observations":[108],"indicate":[109],"novel":[114],"function":[115],"distinct":[118],"functions":[121],"associated":[122],"with":[123,140],"other":[124],"membrane-associated":[125],"viral":[126],"proteins.":[128],"We":[129],"speculate":[130],"receptor":[135],"growth-promoting":[138],"agent,":[139],"trans-membrane":[142],"involved":[144,155],"ligand":[146],"binding,":[147],"or":[152],"loops":[154],"coupling":[157],"effector":[160],"molecules":[161],"cell,":[164],"situation":[166],"analogous":[167],"rhodopsin":[170],"group":[171],"receptors.":[173]},"counts_by_year":[{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
