{"id":"https://openalex.org/W1984516218","doi":"https://doi.org/10.1038/nrneurol.2012.136","title":"The benefits of exercise training in multiple sclerosis","display_name":"The benefits of exercise training in multiple sclerosis","publication_year":2012,"publication_date":"2012-07-24","ids":{"openalex":"https://openalex.org/W1984516218","doi":"https://doi.org/10.1038/nrneurol.2012.136","mag":"1984516218","pmid":"https://pubmed.ncbi.nlm.nih.gov/22825702"},"language":"en","primary_location":{"id":"doi:10.1038/nrneurol.2012.136","doi":"https://doi.org/10.1038/nrneurol.2012.136","is_oa":false,"landing_page_url":"https://doi.org/10.1038/nrneurol.2012.136","pdf_url":null,"source":{"id":"https://openalex.org/S22232893","display_name":"Nature Reviews Neurology","issn_l":"1759-4758","issn":["1759-4758","1759-4766"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Reviews Neurology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033579432","display_name":"Robert Wayne Motl","orcid":"https://orcid.org/0000-0002-5894-2290","observed_orcids":["https://orcid.org/0000-0002-5894-2290"]},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Robert W. Motl","raw_affiliation_strings":["Department of Kinesiology and Community Health, University of Illinois, Urbana-Champaign, 233 Freer Hall, Urbana, IL 61801, USA. robmotl@illinois.edu","Department of Kinesiology and Community Health, University of Illinois, Urbana-Champaign, 233 Freer Hall, Urbana, IL 61801, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Kinesiology and Community Health, University of Illinois, Urbana-Champaign, 233 Freer Hall, Urbana, IL 61801, USA. robmotl@illinois.edu","institution_ids":["https://openalex.org/I157725225"]},{"raw_affiliation_string":"Department of Kinesiology and Community Health, University of Illinois, Urbana-Champaign, 233 Freer Hall, Urbana, IL 61801, USA","institution_ids":["https://openalex.org/I157725225"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089783020","display_name":"Lara A. Pilutti","orcid":"https://orcid.org/0000-0002-3074-4903","observed_orcids":["https://orcid.org/0000-0002-3074-4903"]},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lara A. Pilutti","raw_affiliation_strings":["Department of Kinesiology and Community Health, University of Illinois, Urbana-Champaign, 233 Freer Hall, Urbana, 61801, IL, USA","Department of Kinesiology and Community Health, University of Illinois, Urbana, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Kinesiology and Community Health, University of Illinois, Urbana-Champaign, 233 Freer Hall, Urbana, 61801, IL, USA","institution_ids":["https://openalex.org/I157725225"]},{"raw_affiliation_string":"Department of Kinesiology and Community Health, University of Illinois, Urbana, USA","institution_ids":["https://openalex.org/I157725225"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5033579432"],"corresponding_institution_ids":["https://openalex.org/I157725225"],"apc_list":null,"apc_paid":null,"fwci":3.7381,"has_fulltext":false,"cited_by_count":429,"citation_normalized_percentile":{"value":0.96567718,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"8","issue":"9","first_page":"487","last_page":"497"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10114","display_name":"Balance, Gait, and Falls Prevention","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3612","display_name":"Physical Therapy, Sports Therapy and Rehabilitation"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10510","display_name":"Stroke Rehabilitation and Recovery","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2742","display_name":"Rehabilitation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multiple-sclerosis","display_name":"multiple sclerosis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/exercise-training","display_name":"exercise training","score":1.0},{"id":"https://openalex.org/keywords/international-classification-of-functioning-disability-and-health","display_name":"International Classification of Functioning, Disability and Health","score":0.9800000190734863},{"id":"https://openalex.org/keywords/muscle-strength","display_name":"muscle strength","score":0.5699999928474426},{"id":"https://openalex.org/keywords/cardiorespiratory-fitness","display_name":"cardiorespiratory fitness","score":0.996999979019165},{"id":"https://openalex.org/keywords/walking-performance","display_name":"walking performance","score":0.9240000247955322},{"id":"https://openalex.org/keywords/fatigue","display_name":"fatigue","score":0.906000018119812},{"id":"https://openalex.org/keywords/gait","display_name":"gait","score":0.8870000243186951},{"id":"https://openalex.org/keywords/balance","display_name":"balance","score":0.9990000128746033},{"id":"https://openalex.org/keywords/quality-of-life","display_name":"quality of life","score":0.9929999709129333},{"id":"https://openalex.org/keywords/depression","display_name":"depression","score":0.6420000195503235},{"id":"https://openalex.org/keywords/cognition","display_name":"cognition","score":0.8349999785423279},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.8679999709129333},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.8519999980926514},{"id":"https://openalex.org/keywords/demyelination","display_name":"demyelination","score":0.6380000114440918}],"concepts":[{"id":"https://openalex.org/C115219716","wikidata":"https://www.wikidata.org/wiki/Q917426","display_name":"International Classification of Functioning, Disability and Health","level":3,"score":0.8040246367454529},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.68382728099823},{"id":"https://openalex.org/C99508421","wikidata":"https://www.wikidata.org/wiki/Q2678675","display_name":"Physical medicine and rehabilitation","level":1,"score":0.6502204537391663},{"id":"https://openalex.org/C2780640218","wikidata":"https://www.wikidata.org/wiki/Q8277","display_name":"Multiple sclerosis","level":2,"score":0.6358281373977661},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5242764353752136},{"id":"https://openalex.org/C2776035688","wikidata":"https://www.wikidata.org/wiki/Q1606558","display_name":"Affect (linguistics)","level":2,"score":0.4988586902618408},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.4979081153869629},{"id":"https://openalex.org/C2779951463","wikidata":"https://www.wikidata.org/wiki/Q7268788","display_name":"Quality of life (healthcare)","level":2,"score":0.47960364818573},{"id":"https://openalex.org/C103038586","wikidata":"https://www.wikidata.org/wiki/Q1152037","display_name":"Aerobic exercise","level":2,"score":0.43166959285736084},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.4306378662586212},{"id":"https://openalex.org/C151800584","wikidata":"https://www.wikidata.org/wiki/Q2370000","display_name":"Gait","level":2,"score":0.4269292950630188},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.4109959006309509},{"id":"https://openalex.org/C2778818304","wikidata":"https://www.wikidata.org/wiki/Q1819478","display_name":"Rehabilitation","level":2,"score":0.34599775075912476},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.2393486499786377},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.11766237020492554},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C46312422","wikidata":"https://www.wikidata.org/wiki/Q11024","display_name":"Communication","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005081","descriptor_name":"Exercise Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009103","descriptor_name":"Multiple Sclerosis","qualifier_ui":"Q000534","qualifier_name":"rehabilitation","is_major_topic":true},{"descriptor_ui":"D010809","descriptor_name":"Physical Fitness","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011788","descriptor_name":"Quality of Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053580","descriptor_name":"Muscle Strength","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1038/nrneurol.2012.136","doi":"https://doi.org/10.1038/nrneurol.2012.136","is_oa":false,"landing_page_url":"https://doi.org/10.1038/nrneurol.2012.136","pdf_url":null,"source":{"id":"https://openalex.org/S22232893","display_name":"Nature Reviews Neurology","issn_l":"1759-4758","issn":["1759-4758","1759-4766"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Reviews Neurology","raw_type":"journal-article"},{"id":"pmid:22825702","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22825702","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature reviews. Neurology","raw_type":"Journal Article"},{"id":"mag:2598593765","doi":null,"is_oa":false,"landing_page_url":"http://www.nature.com/nrneurol/journal/v8/n9/pdf/nrneurol.2012.136.pdf?WT.ec_id=NRNEUROL-201209","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":162,"referenced_works":["https://openalex.org/W16535422","https://openalex.org/W143737675","https://openalex.org/W1575472286","https://openalex.org/W1600075299","https://openalex.org/W1602829472","https://openalex.org/W1849469560","https://openalex.org/W1853966758","https://openalex.org/W1876524869","https://openalex.org/W1904453581","https://openalex.org/W1964142942","https://openalex.org/W1964217371","https://openalex.org/W1964480634","https://openalex.org/W1965232494","https://openalex.org/W1966830462","https://openalex.org/W1967860258","https://openalex.org/W1968705453","https://openalex.org/W1968998994","https://openalex.org/W1969437084","https://openalex.org/W1974654819","https://openalex.org/W1975087653","https://openalex.org/W1976518090","https://openalex.org/W1977768965","https://openalex.org/W1979363817","https://openalex.org/W1981740502","https://openalex.org/W1985754065","https://openalex.org/W1986173197","https://openalex.org/W1987964163","https://openalex.org/W1988429877","https://openalex.org/W1988630041","https://openalex.org/W1988746590","https://openalex.org/W1989605260","https://openalex.org/W1990213619","https://openalex.org/W1991608106","https://openalex.org/W1992731626","https://openalex.org/W1993614109","https://openalex.org/W1994684119","https://openalex.org/W2000001497","https://openalex.org/W2000265708","https://openalex.org/W2004397938","https://openalex.org/W2004752476","https://openalex.org/W2005390537","https://openalex.org/W2006945377","https://openalex.org/W2008120870","https://openalex.org/W2009836285","https://openalex.org/W2011596538","https://openalex.org/W2016217467","https://openalex.org/W2018048616","https://openalex.org/W2020022772","https://openalex.org/W2020767502","https://openalex.org/W2026092771","https://openalex.org/W2026795289","https://openalex.org/W2028842616","https://openalex.org/W2031669983","https://openalex.org/W2031878678","https://openalex.org/W2034432056","https://openalex.org/W2036439226","https://openalex.org/W2036853725","https://openalex.org/W2036882089","https://openalex.org/W2038078074","https://openalex.org/W2043400629","https://openalex.org/W2046965150","https://openalex.org/W2049197285","https://openalex.org/W2050099111","https://openalex.org/W2053142633","https://openalex.org/W2053402968","https://openalex.org/W2053695178","https://openalex.org/W2054950091","https://openalex.org/W2057237240","https://openalex.org/W2058151281","https://openalex.org/W2059164443","https://openalex.org/W2059638344","https://openalex.org/W2060129459","https://openalex.org/W2063470028","https://openalex.org/W2065031884","https://openalex.org/W2068329556","https://openalex.org/W2069614919","https://openalex.org/W2070476479","https://openalex.org/W2071015042","https://openalex.org/W2072559038","https://openalex.org/W2077728451","https://openalex.org/W2077730410","https://openalex.org/W2078673824","https://openalex.org/W2079736504","https://openalex.org/W2079880019","https://openalex.org/W2080380500","https://openalex.org/W2081969380","https://openalex.org/W2082209838","https://openalex.org/W2088162861","https://openalex.org/W2088512589","https://openalex.org/W2089422236","https://openalex.org/W2090866605","https://openalex.org/W2092878063","https://openalex.org/W2095918175","https://openalex.org/W2097023480","https://openalex.org/W2098642616","https://openalex.org/W2099287139","https://openalex.org/W2099731130","https://openalex.org/W2100597227","https://openalex.org/W2101542474","https://openalex.org/W2102570265","https://openalex.org/W2103416107","https://openalex.org/W2107501599","https://openalex.org/W2107997122","https://openalex.org/W2108752110","https://openalex.org/W2108918457","https://openalex.org/W2109448373","https://openalex.org/W2112017258","https://openalex.org/W2112374874","https://openalex.org/W2113002628","https://openalex.org/W2113922021","https://openalex.org/W2114060341","https://openalex.org/W2114808411","https://openalex.org/W2118092438","https://openalex.org/W2121149730","https://openalex.org/W2122036147","https://openalex.org/W2125299317","https://openalex.org/W2125657871","https://openalex.org/W2128303179","https://openalex.org/W2129030266","https://openalex.org/W2129688566","https://openalex.org/W2130144851","https://openalex.org/W2131709112","https://openalex.org/W2132955590","https://openalex.org/W2134707082","https://openalex.org/W2135347195","https://openalex.org/W2137935656","https://openalex.org/W2139615206","https://openalex.org/W2139889284","https://openalex.org/W2144355149","https://openalex.org/W2145481931","https://openalex.org/W2145870733","https://openalex.org/W2147702281","https://openalex.org/W2148186809","https://openalex.org/W2148563799","https://openalex.org/W2153038533","https://openalex.org/W2153406727","https://openalex.org/W2154514379","https://openalex.org/W2156527590","https://openalex.org/W2157087000","https://openalex.org/W2157831456","https://openalex.org/W2158156478","https://openalex.org/W2158250395","https://openalex.org/W2159896438","https://openalex.org/W2161157523","https://openalex.org/W2161851141","https://openalex.org/W2162006280","https://openalex.org/W2163950729","https://openalex.org/W2165469641","https://openalex.org/W2166354070","https://openalex.org/W2167882173","https://openalex.org/W2168649763","https://openalex.org/W2168660650","https://openalex.org/W2169408223","https://openalex.org/W2187477173","https://openalex.org/W2227813149","https://openalex.org/W2297433731","https://openalex.org/W2317591766","https://openalex.org/W2324056668","https://openalex.org/W2331930580","https://openalex.org/W2527832785","https://openalex.org/W2771489791","https://openalex.org/W2774395284"],"related_works":["https://openalex.org/W2598593765","https://openalex.org/W4387949950","https://openalex.org/W2166332121","https://openalex.org/W2988924358","https://openalex.org/W4394858784","https://openalex.org/W2076411626","https://openalex.org/W1981740502","https://openalex.org/W7009837673","https://openalex.org/W4403628136","https://openalex.org/W4285219245"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":19},{"year":2025,"cited_by_count":28},{"year":2024,"cited_by_count":32},{"year":2023,"cited_by_count":25},{"year":2022,"cited_by_count":28},{"year":2021,"cited_by_count":51},{"year":2020,"cited_by_count":36},{"year":2019,"cited_by_count":36},{"year":2018,"cited_by_count":27},{"year":2017,"cited_by_count":41},{"year":2016,"cited_by_count":26},{"year":2015,"cited_by_count":31},{"year":2014,"cited_by_count":26},{"year":2013,"cited_by_count":21},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}