{"id":"https://openalex.org/W1984495092","doi":"https://doi.org/10.1021/np030505d","title":"Phelligridins C\u2212F: Cytotoxic Pyrano[4,3-c][2]benzopyran-1,6-dione and Furo[3,2-c]pyran-4-one Derivatives from the Fungus Phellinus igniarius","display_name":"Phelligridins C\u2212F: Cytotoxic Pyrano[4,3-c][2]benzopyran-1,6-dione and Furo[3,2-c]pyran-4-one Derivatives from the Fungus Phellinus igniarius","publication_year":2004,"publication_date":"2004-04-21","ids":{"openalex":"https://openalex.org/W1984495092","doi":"https://doi.org/10.1021/np030505d","mag":"1984495092","pmid":"https://pubmed.ncbi.nlm.nih.gov/15165144"},"language":"en","primary_location":{"id":"doi:10.1021/np030505d","doi":"https://doi.org/10.1021/np030505d","is_oa":false,"landing_page_url":"https://doi.org/10.1021/np030505d","pdf_url":null,"source":{"id":"https://openalex.org/S166799026","display_name":"Journal of Natural Products","issn_l":"0163-3864","issn":["0163-3864","1520-6025"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Natural Products","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103328827","display_name":"Shunyan Mo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shunyan Mo","raw_affiliation_strings":["Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China","institution_ids":["https://openalex.org/I200296433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024841956","display_name":"Sujuan Wang","orcid":"https://orcid.org/0000-0002-0254-1383","observed_orcids":["https://orcid.org/0000-0002-0254-1383"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Sujuan Wang","raw_affiliation_strings":["Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China","institution_ids":["https://openalex.org/I200296433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013948781","display_name":"Guang\u2010Xiong Zhou","orcid":"https://orcid.org/0000-0002-7595-2757","observed_orcids":["https://orcid.org/0000-0002-7595-2757"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guangxiong Zhou","raw_affiliation_strings":["Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China","institution_ids":["https://openalex.org/I200296433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111699413","display_name":"Yongchun Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yongchun Yang","raw_affiliation_strings":["Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China","institution_ids":["https://openalex.org/I200296433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100380347","display_name":"Yan Li","orcid":"https://orcid.org/0000-0002-4658-2080","observed_orcids":["https://orcid.org/0000-0002-4658-2080"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yan Li","raw_affiliation_strings":["Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China","institution_ids":["https://openalex.org/I200296433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100649680","display_name":"Xiaoguang Chen","orcid":"https://orcid.org/0000-0001-6798-3687","observed_orcids":["https://orcid.org/0000-0001-6798-3687","https://orcid.org/0000-0003-2035-4431"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoguang Chen","raw_affiliation_strings":["Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China","institution_ids":["https://openalex.org/I200296433"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056424801","display_name":"Jian\u2010Gong Shi","orcid":"https://orcid.org/0000-0003-3701-0627","observed_orcids":["https://orcid.org/0000-0003-3701-0627"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jiangong Shi","raw_affiliation_strings":["Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China","institution_ids":["https://openalex.org/I200296433"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5056424801"],"corresponding_institution_ids":["https://openalex.org/I200296433"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":3.0007,"has_fulltext":false,"cited_by_count":171,"citation_normalized_percentile":{"value":0.89683794,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"67","issue":"5","first_page":"823","last_page":"828"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.95169997215271,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.95169997215271,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12257","display_name":"Bioactive natural compounds","score":0.01720000058412552,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12673","display_name":"Microbial Metabolism and Applications","score":0.0035000001080334187,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/phellinus-igniarius","display_name":"Phellinus igniarius","score":0.9739999771118164},{"id":"https://openalex.org/keywords/fungal-natural-products","display_name":"fungal natural products","score":0.652999997138977},{"id":"https://openalex.org/keywords/hispolon","display_name":"hispolon","score":0.7490000128746033},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.7730000019073486},{"id":"https://openalex.org/keywords/a549-cells","display_name":"A549 cells","score":0.878000020980835},{"id":"https://openalex.org/keywords/structure-elucidation","display_name":"structure elucidation","score":0.7940000295639038},{"id":"https://openalex.org/keywords/biogenetic-pathway","display_name":"biogenetic pathway","score":0.6790000200271606}],"concepts":[{"id":"https://openalex.org/C2779383672","wikidata":"https://www.wikidata.org/wiki/Q408428","display_name":"Syringic acid","level":4,"score":0.7514462471008301},{"id":"https://openalex.org/C2777505907","wikidata":"https://www.wikidata.org/wiki/Q217356","display_name":"Pyran","level":2,"score":0.7124748826026917},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.700037956237793},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.645275354385376},{"id":"https://openalex.org/C2776286485","wikidata":"https://www.wikidata.org/wiki/Q421311","display_name":"Benzopyran","level":2,"score":0.645213782787323},{"id":"https://openalex.org/C2781203734","wikidata":"https://www.wikidata.org/wiki/Q418599","display_name":"Protocatechuic acid","level":3,"score":0.5953779220581055},{"id":"https://openalex.org/C2777829905","wikidata":"https://www.wikidata.org/wiki/Q384111","display_name":"Betulinic acid","level":2,"score":0.5430090427398682},{"id":"https://openalex.org/C2778224086","wikidata":"https://www.wikidata.org/wiki/Q414116","display_name":"Caffeic acid","level":3,"score":0.509107768535614},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.4977729618549347},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.2847437858581543},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.18001598119735718},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.12517622113227844},{"id":"https://openalex.org/C2778362808","wikidata":"https://www.wikidata.org/wiki/Q375837","display_name":"Gallic acid","level":3,"score":0.10544705390930176},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.10286933183670044},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001572","descriptor_name":"Benzofurans","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D001572","descriptor_name":"Benzofurans","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001572","descriptor_name":"Benzofurans","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001578","descriptor_name":"Benzopyrans","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D001578","descriptor_name":"Benzopyrans","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001578","descriptor_name":"Benzopyrans","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002681","descriptor_name":"China","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004354","descriptor_name":"Drug Screening Assays, Antitumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008968","descriptor_name":"Molecular Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011124","descriptor_name":"Polyporaceae","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D013237","descriptor_name":"Stereoisomerism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/np030505d","doi":"https://doi.org/10.1021/np030505d","is_oa":false,"landing_page_url":"https://doi.org/10.1021/np030505d","pdf_url":null,"source":{"id":"https://openalex.org/S166799026","display_name":"Journal of Natural Products","issn_l":"0163-3864","issn":["0163-3864","1520-6025"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Natural Products","raw_type":"journal-article"},{"id":"pmid:15165144","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15165144","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of natural products","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.4000000059604645}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":8,"referenced_works":["https://openalex.org/W2054411124","https://openalex.org/W2056580915","https://openalex.org/W2061382159","https://openalex.org/W2070523366","https://openalex.org/W2915397794","https://openalex.org/W4240580829","https://openalex.org/W4246463141","https://openalex.org/W4251754366"],"related_works":["https://openalex.org/W1982574675","https://openalex.org/W2024359976","https://openalex.org/W983756562","https://openalex.org/W2243562378","https://openalex.org/W2771821686","https://openalex.org/W2989239199","https://openalex.org/W3174523694","https://openalex.org/W4303645553","https://openalex.org/W2747041142","https://openalex.org/W2464922309"],"abstract_inverted_index":{"Three":[0],"unique":[1],"pyrano[4,3-c][2]benzopyran-1,6-dione":[2],"derivatives":[3],"and":[4,27,32,51,53,76,84,99],"a":[5,92,100],"new":[6,61],"furo[3,2-c]pyran-4-one,":[7],"named":[8],"phelligridins":[9],"C-F":[10],"(2-5),":[11],"together":[12],"with":[13],"hispolon":[14],"(8),":[15],"(E)-4-(3,4-dihydroxyphenyl)but-3-en-2-one":[16],"(9),":[17],"4-hydroxybenzaldehyde,":[18],"protocatechualdehyde,":[19],"syringic":[20],"acid,":[21,23,25],"protocatechuic":[22],"caffeic":[24],"isoergosterone,":[26],"octadecyl":[28],"ferulate":[29],"were":[30,43,63],"isolated":[31],"identified":[33],"from":[34],"the":[35,60,110],"ethanolic":[36],"extract":[37],"of":[38,59,112],"Phellinus":[39],"igniarius.":[40],"Their":[41],"structures":[42,58],"determined":[44],"by":[45],"spectroscopic":[46],"methods":[47],"including":[48,82],"IR,":[49],"MS,":[50],"1D":[52],"2D":[54],"NMR":[55],"experiments.":[56],"The":[57],"compounds":[62,81],"characterized":[64],"as":[65],"3-(4-hydroxystyryl)-8,9-dihydroxypyrano[4,3-c]isochromene-4-one":[66],"(2),":[67],"3-(3,4-hydroxystyryl)-8,9-dihydroxypyrano[4,3-c]isochromene-4-one":[68],"(3),":[69],"8,9-dihydroxy-3-[5',6'-dihydroxy-5'":[70],"'-methyl-3'":[71],"'-oxo-spiro[fural-2'":[72],"'(3'":[73],"'H),1'-indene]-2'-yl]-1H,6H-pyrano[4,3-c][2]benzopyran-1,6-dione":[74],"(4),":[75],"(3Z)-3-(3,4-dihydroxybenzylidene)-6-(3,4-dihydroxystyryl)-2,3-dihydro-2-methoxy-2-(2-oxo-propyl)furo[3,2-c]pyran-4-one":[77],"(5),":[78],"respectively.":[79],"Some":[80],"2":[83],"3":[85],"showed":[86],"in":[87],"vitro":[88],"selective":[89],"cytotoxicity":[90],"against":[91],"human":[93],"lung":[94],"cancer":[95,102],"cell":[96,103],"line":[97,104],"(A549)":[98],"liver":[101],"(Bel7402).":[105],"Possible":[106],"biogenetic":[107],"sequences":[108],"to":[109],"formation":[111],"1-9":[113],"are":[114],"postulated.":[115]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":12},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":10},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":11},{"year":2012,"cited_by_count":9}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2016-06-24T00:00:00"}
