{"id":"https://openalex.org/W1984440331","doi":"https://doi.org/10.1111/j.1651-2227.1985.tb10089.x","title":"Atherosclerosis precursors in Finnish children and adolescents. VII. Serum immunoreactive insulin","display_name":"Atherosclerosis precursors in Finnish children and adolescents. VII. Serum immunoreactive insulin","publication_year":1985,"publication_date":"1985-04-01","ids":{"openalex":"https://openalex.org/W1984440331","doi":"https://doi.org/10.1111/j.1651-2227.1985.tb10089.x","mag":"1984440331","pmid":"https://pubmed.ncbi.nlm.nih.gov/3911726"},"language":"en","primary_location":{"id":"doi:10.1111/j.1651-2227.1985.tb10089.x","doi":"https://doi.org/10.1111/j.1651-2227.1985.tb10089.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1651-2227.1985.tb10089.x","pdf_url":null,"source":{"id":"https://openalex.org/S178469169","display_name":"Acta Paediatrica","issn_l":"0365-1436","issn":["0365-1436","0803-5253","1651-2227"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-2","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Paediatrica","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025737519","display_name":"Pentti Lautala","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98381234","display_name":"University of Oulu","ror":"https://ror.org/03yj89h83","country_code":"FI","type":"education","lineage":["https://openalex.org/I98381234"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"P. LAUTALA","raw_affiliation_strings":["From the Department of Paediatrics, University of Oulu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Paediatrics, University of Oulu","institution_ids":["https://openalex.org/I98381234"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110003931","display_name":"Hans K. \u00c5kerblom","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I4210090554","display_name":"Helsinki Children's Hospital","ror":"https://ror.org/00dqfzf20","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2800394112","https://openalex.org/I4210090554","https://openalex.org/I4210166427"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"H. K. \u00c5KERBLOM","raw_affiliation_strings":["the Children's Hospital, University of Helsinki"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the Children's Hospital, University of Helsinki","institution_ids":["https://openalex.org/I133731052","https://openalex.org/I4210090554"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064118768","display_name":"Jorma S.A. Viikari","orcid":"https://orcid.org/0000-0001-6452-010X","observed_orcids":["https://orcid.org/0000-0001-6452-010X"]},"institutions":[{"id":"https://openalex.org/I155660961","display_name":"University of Turku","ror":"https://ror.org/05vghhr25","country_code":"FI","type":"education","lineage":["https://openalex.org/I155660961"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"J. VIIKARI","raw_affiliation_strings":["Department of Medicin, University of Turku"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicin, University of Turku","institution_ids":["https://openalex.org/I155660961"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087164348","display_name":"K Louhivuori","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"K. LOUHIVUORI","raw_affiliation_strings":["Department of Public Health Science, University of Helsinki"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Public Health Science, University of Helsinki","institution_ids":["https://openalex.org/I133731052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074473747","display_name":"Matti K. Uhari","orcid":"https://orcid.org/0000-0003-2965-8466","observed_orcids":["https://orcid.org/0000-0003-2965-8466"]},"institutions":[{"id":"https://openalex.org/I98381234","display_name":"University of Oulu","ror":"https://ror.org/03yj89h83","country_code":"FI","type":"education","lineage":["https://openalex.org/I98381234"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"M. UHARI","raw_affiliation_strings":["From the Department of Paediatrics, University of Oulu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Paediatrics, University of Oulu","institution_ids":["https://openalex.org/I98381234"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070424297","display_name":"Seppo Dahlstr\u00f6m","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I155660961","display_name":"University of Turku","ror":"https://ror.org/05vghhr25","country_code":"FI","type":"education","lineage":["https://openalex.org/I155660961"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"S. DAHLSTR\u00d6M","raw_affiliation_strings":["Departments of Paediatrics, Universities of Turku"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Paediatrics, Universities of Turku","institution_ids":["https://openalex.org/I155660961"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113059980","display_name":"Maylen Reiers\u00f8l Dahl","orcid":"https://orcid.org/0009-0001-5480-2362","observed_orcids":["https://orcid.org/0009-0001-5480-2362"]},"institutions":[{"id":"https://openalex.org/I155660961","display_name":"University of Turku","ror":"https://ror.org/05vghhr25","country_code":"FI","type":"education","lineage":["https://openalex.org/I155660961"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"M. DAHL","raw_affiliation_strings":["Departments of Paediatrics, Universities of Turku"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Paediatrics, Universities of Turku","institution_ids":["https://openalex.org/I155660961"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003639899","display_name":"P.\u2010L. L\u00c4HDE","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P.\u2010L. L\u00c4HDE","raw_affiliation_strings":["Tamper"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tamper","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004703575","display_name":"Erkki J. Pesonen","orcid":"https://orcid.org/0000-0001-9007-5214","observed_orcids":["https://orcid.org/0000-0001-9007-5214"]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I4210090554","display_name":"Helsinki Children's Hospital","ror":"https://ror.org/00dqfzf20","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2800394112","https://openalex.org/I4210090554","https://openalex.org/I4210166427"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"E. PESONEN","raw_affiliation_strings":["the Children's Hospital, University of Helsinki"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the Children's Hospital, University of Helsinki","institution_ids":["https://openalex.org/I133731052","https://openalex.org/I4210090554"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069622056","display_name":"Matti Pietik\u00e4inen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. PIETIK\u00c4INEN","raw_affiliation_strings":["Kuopio, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kuopio, Finland","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039329638","display_name":"P. SUONINEN","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P. SUONINEN","raw_affiliation_strings":["Kuopio, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kuopio, Finland","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000141478","display_name":"Mikael Knip","orcid":"https://orcid.org/0000-0003-0474-0033","observed_orcids":["https://orcid.org/0000-0003-0474-0033"]},"institutions":[{"id":"https://openalex.org/I98381234","display_name":"University of Oulu","ror":"https://ror.org/03yj89h83","country_code":"FI","type":"education","lineage":["https://openalex.org/I98381234"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"M. KNIP","raw_affiliation_strings":["From the Department of Paediatrics, University of Oulu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Paediatrics, University of Oulu","institution_ids":["https://openalex.org/I98381234"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4480,"currency":"USD","value_usd":4480},"apc_paid":null,"fwci":1.321,"has_fulltext":false,"cited_by_count":32,"citation_normalized_percentile":{"value":0.78164636,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":98},"biblio":{"volume":"74","issue":"s318","first_page":"127","last_page":"133"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.9663000106811523,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.9663000106811523,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10010","display_name":"Obesity, Physical Activity, Diet","score":0.007000000216066837,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.005900000222027302,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/coronary-risk-factors","display_name":"coronary risk factors","score":0.9409999847412109},{"id":"https://openalex.org/keywords/children-and-adolescents","display_name":"children and adolescents","score":0.8740000128746033},{"id":"https://openalex.org/keywords/pubertal-development","display_name":"pubertal development","score":0.859000027179718},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.8809999823570251},{"id":"https://openalex.org/keywords/body-mass-index","display_name":"body mass index","score":0.8460000157356262},{"id":"https://openalex.org/keywords/skinfold-thickness","display_name":"skinfold thickness","score":0.9269999861717224},{"id":"https://openalex.org/keywords/body-weight","display_name":"body weight","score":0.5249999761581421}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9435889720916748},{"id":"https://openalex.org/C2780221984","wikidata":"https://www.wikidata.org/wiki/Q131191","display_name":"Body mass index","level":2,"score":0.647848904132843},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6062437295913696},{"id":"https://openalex.org/C3018906752","wikidata":"https://www.wikidata.org/wiki/Q844935","display_name":"Coronary heart disease","level":2,"score":0.5176308751106262},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.5122258067131042},{"id":"https://openalex.org/C3020081911","wikidata":"https://www.wikidata.org/wiki/Q3918988","display_name":"Serum concentration","level":2,"score":0.5071141719818115},{"id":"https://openalex.org/C147583825","wikidata":"https://www.wikidata.org/wiki/Q620876","display_name":"Body weight","level":2,"score":0.5056145191192627},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.47395941615104675},{"id":"https://openalex.org/C986699","wikidata":"https://www.wikidata.org/wiki/Q7939","display_name":"El Ni\u00f1o","level":2,"score":0.4638775587081909}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001827","descriptor_name":"Body Height","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001835","descriptor_name":"Body Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003327","descriptor_name":"Coronary Disease","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005387","descriptor_name":"Finland","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011627","descriptor_name":"Puberty","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011863","descriptor_name":"Radioimmunoassay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012306","descriptor_name":"Risk","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012424","descriptor_name":"Rural Population","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012737","descriptor_name":"Sex Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012885","descriptor_name":"Skinfold Thickness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014505","descriptor_name":"Urban Population","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1651-2227.1985.tb10089.x","doi":"https://doi.org/10.1111/j.1651-2227.1985.tb10089.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1651-2227.1985.tb10089.x","pdf_url":null,"source":{"id":"https://openalex.org/S178469169","display_name":"Acta Paediatrica","issn_l":"0365-1436","issn":["0365-1436","0803-5253","1651-2227"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-2","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Paediatrica","raw_type":"journal-article"},{"id":"pmid:3911726","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3911726","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta paediatrica Scandinavica. Supplement","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W1983114326","https://openalex.org/W1995926025","https://openalex.org/W2015130365","https://openalex.org/W2041170215","https://openalex.org/W2042615171","https://openalex.org/W2050620078","https://openalex.org/W2054271400","https://openalex.org/W2058599631","https://openalex.org/W2064634707","https://openalex.org/W2071794065","https://openalex.org/W2076159599","https://openalex.org/W2078073869","https://openalex.org/W2088036472","https://openalex.org/W2090738888","https://openalex.org/W2104799382","https://openalex.org/W2139656347","https://openalex.org/W2430988737"],"related_works":["https://openalex.org/W2160670320","https://openalex.org/W1989588012","https://openalex.org/W2148765517","https://openalex.org/W1993779130","https://openalex.org/W2573207054","https://openalex.org/W2407704514","https://openalex.org/W1974871319","https://openalex.org/W2900772334","https://openalex.org/W2162013961","https://openalex.org/W2497852837"],"abstract_inverted_index":{"In":[0],"the":[1,6,33,49,65,84,105],"Finnish":[2],"Multicentre":[3],"Study":[4],"of":[5,9,35,51,67,72,83],"risk":[7],"factors":[8],"coronary":[10],"heart":[11],"disease":[12],"serum":[13,44,73],"immunoreactive":[14],"insulin":[15],"(IRI)":[16],"was":[17],"measured":[18],"in":[19,38,43,59,62,100],"3,486":[20],"children":[21],"and":[22,80,96],"adolescents":[23],"aged":[24],"3-18":[25],"years.":[26],"Serum":[27,54,86],"IRI":[28,45,55,74,87],"increased":[29],"with":[30,48,90],"age":[31,34,66,102],"till":[32],"15":[36],"years":[37,69],"both":[39],"sexes.":[40],"The":[41],"increase":[42],"levelled":[46],"off":[47],"progression":[50],"pubertal":[52],"development.":[53],"levels":[56],"were":[57],"higher":[58],"girls":[60],"than":[61],"boys":[63],"from":[64,78],"6":[68],"onwards.":[70],"Comparison":[71],"gave":[75],"identical":[76],"results":[77],"eastern":[79],"western":[81],"parts":[82],"country.":[85],"correlated":[88],"positively":[89],"skinfold":[91],"thickness,":[92],"weight,":[93],"relative":[94],"weight":[95],"body":[97],"mass":[98],"index":[99],"all":[101],"groups":[103],"except":[104],"3-year-old":[106],"children.":[107]},"counts_by_year":[{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}