{"id":"https://openalex.org/W1984408317","doi":"https://doi.org/10.1111/j.1399-0039.1983.tb01188.x","title":"Family and population studies of HLA and coeliac disease in the West of Ireland","display_name":"Family and population studies of HLA and coeliac disease in the West of Ireland","publication_year":1983,"publication_date":"1983-09-01","ids":{"openalex":"https://openalex.org/W1984408317","doi":"https://doi.org/10.1111/j.1399-0039.1983.tb01188.x","mag":"1984408317","pmid":"https://pubmed.ncbi.nlm.nih.gov/6636110"},"language":"en","primary_location":{"id":"doi:10.1111/j.1399-0039.1983.tb01188.x","doi":"https://doi.org/10.1111/j.1399-0039.1983.tb01188.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1399-0039.1983.tb01188.x","pdf_url":null,"source":{"id":"https://openalex.org/S141055564","display_name":"Tissue Antigens","issn_l":"0001-2815","issn":["0001-2815","1399-0039"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tissue Antigens","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110115648","display_name":"Rachel M. McKenna","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I188760350","display_name":"Ollscoil na Gaillimhe \u2013 University of Galway","ror":"https://ror.org/03bea9k73","country_code":"IE","type":"education","lineage":["https://openalex.org/I188760350"]}],"countries":["IE"],"is_corresponding":true,"raw_author_name":"RACHEL MCKENNA","raw_affiliation_strings":["Departments of Medicine and Paediatrics, University College Galway, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine and Paediatrics, University College Galway, Ireland","institution_ids":["https://openalex.org/I188760350"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112291232","display_name":"Fiona M Stevens","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I188760350","display_name":"Ollscoil na Gaillimhe \u2013 University of Galway","ror":"https://ror.org/03bea9k73","country_code":"IE","type":"education","lineage":["https://openalex.org/I188760350"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"F. M STEVENS","raw_affiliation_strings":["Departments of Medicine and Paediatrics, University College Galway, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine and Paediatrics, University College Galway, Ireland","institution_ids":["https://openalex.org/I188760350"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111840358","display_name":"B McNicholl","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I188760350","display_name":"Ollscoil na Gaillimhe \u2013 University of Galway","ror":"https://ror.org/03bea9k73","country_code":"IE","type":"education","lineage":["https://openalex.org/I188760350"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"B MCNICHOLL","raw_affiliation_strings":["Departments of Medicine and Paediatrics, University College Galway, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine and Paediatrics, University College Galway, Ireland","institution_ids":["https://openalex.org/I188760350"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003033060","display_name":"S. Scholz","orcid":"https://orcid.org/0009-0001-4759-9271","observed_orcids":["https://orcid.org/0009-0001-4759-9271"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S SCHOLZ","raw_affiliation_strings":["Tissue Typing Laboratory, Munich, F.R.G"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tissue Typing Laboratory, Munich, F.R.G","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108243390","display_name":"Ekkehard D. Albert","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E ALBERT","raw_affiliation_strings":["Tissue Typing Laboratory, Munich, F.R.G"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tissue Typing Laboratory, Munich, F.R.G","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083528580","display_name":"Colm McCarthy","orcid":"https://orcid.org/0000-0002-2567-3899","observed_orcids":["https://orcid.org/0000-0002-2567-3899"]},"institutions":[{"id":"https://openalex.org/I188760350","display_name":"Ollscoil na Gaillimhe \u2013 University of Galway","ror":"https://ror.org/03bea9k73","country_code":"IE","type":"education","lineage":["https://openalex.org/I188760350"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"C. F MCCARTHY","raw_affiliation_strings":["Departments of Medicine and Paediatrics, University College Galway, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine and Paediatrics, University College Galway, Ireland","institution_ids":["https://openalex.org/I188760350"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5110115648"],"corresponding_institution_ids":["https://openalex.org/I188760350"],"apc_list":null,"apc_paid":null,"fwci":1.6625,"has_fulltext":false,"cited_by_count":24,"citation_normalized_percentile":{"value":0.81880158,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"22","issue":"3","first_page":"175","last_page":"181"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11348","display_name":"Celiac Disease Research and Management","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11348","display_name":"Celiac Disease Research and Management","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10733","display_name":"Wheat and Barley Genetics and Pathology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/celiac-disease","display_name":"celiac disease","score":0.9819999933242798},{"id":"https://openalex.org/keywords/hla-dr3","display_name":"HLA-DR3","score":0.8830000162124634},{"id":"https://openalex.org/keywords/hla-dr7","display_name":"HLA-DR7","score":0.9909999966621399},{"id":"https://openalex.org/keywords/hla-a","display_name":"HLA-A","score":0.5820000171661377},{"id":"https://openalex.org/keywords/hla-b","display_name":"HLA-B","score":0.9980000257492065},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.8569999933242798},{"id":"https://openalex.org/keywords/family-segregation-analysis","display_name":"family segregation analysis","score":0.7139999866485596},{"id":"https://openalex.org/keywords/haplotype-analysis","display_name":"haplotype analysis","score":0.7710000276565552},{"id":"https://openalex.org/keywords/sib-pair-analysis","display_name":"sib-pair analysis","score":0.8769999742507935},{"id":"https://openalex.org/keywords/first-degree-relatives","display_name":"first-degree relatives","score":0.7329999804496765},{"id":"https://openalex.org/keywords/hla-region","display_name":"HLA region","score":0.43299999833106995},{"id":"https://openalex.org/keywords/chromosome-6","display_name":"chromosome 6","score":0.675000011920929},{"id":"https://openalex.org/keywords/relative-risk","display_name":"relative risk","score":0.6039999723434448},{"id":"https://openalex.org/keywords/west-of-ireland","display_name":"West of Ireland","score":0.7289999723434448}],"concepts":[{"id":"https://openalex.org/C2780349322","wikidata":"https://www.wikidata.org/wiki/Q11088","display_name":"Coeliac disease","level":3,"score":0.9193956851959229},{"id":"https://openalex.org/C188997412","wikidata":"https://www.wikidata.org/wiki/Q1640386","display_name":"Proband","level":4,"score":0.8408079743385315},{"id":"https://openalex.org/C188280979","wikidata":"https://www.wikidata.org/wiki/Q911125","display_name":"Human leukocyte antigen","level":3,"score":0.8087519407272339},{"id":"https://openalex.org/C197754878","wikidata":"https://www.wikidata.org/wiki/Q80711","display_name":"Haplotype","level":4,"score":0.7426667809486389},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5998063683509827},{"id":"https://openalex.org/C2775866039","wikidata":"https://www.wikidata.org/wiki/Q14906952","display_name":"HLA-A","level":4,"score":0.5528603196144104},{"id":"https://openalex.org/C2991794364","wikidata":"https://www.wikidata.org/wiki/Q69949253","display_name":"Family studies","level":2,"score":0.5459384918212891},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5387173295021057},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.454147070646286},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4435954988002777},{"id":"https://openalex.org/C2781209916","wikidata":"https://www.wikidata.org/wiki/Q3215756","display_name":"Typing","level":2,"score":0.4390681982040405},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.41197001934051514},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.37409037351608276},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3488067388534546},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.22987186908721924},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.16660615801811218},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11439815163612366},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.08142781257629395},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002446","descriptor_name":"Celiac Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005787","descriptor_name":"Gene Frequency","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006680","descriptor_name":"HLA Antigens","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007494","descriptor_name":"Ireland","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1399-0039.1983.tb01188.x","doi":"https://doi.org/10.1111/j.1399-0039.1983.tb01188.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1399-0039.1983.tb01188.x","pdf_url":null,"source":{"id":"https://openalex.org/S141055564","display_name":"Tissue Antigens","issn_l":"0001-2815","issn":["0001-2815","1399-0039"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tissue Antigens","raw_type":"journal-article"},{"id":"pmid:6636110","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6636110","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tissue antigens","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":7,"referenced_works":["https://openalex.org/W77947708","https://openalex.org/W1970768730","https://openalex.org/W2015800825","https://openalex.org/W2018961168","https://openalex.org/W2085668507","https://openalex.org/W2322147732","https://openalex.org/W4376537370"],"related_works":["https://openalex.org/W2097430118","https://openalex.org/W1977831598","https://openalex.org/W2059341144","https://openalex.org/W2000963912","https://openalex.org/W2032291432","https://openalex.org/W2092219330","https://openalex.org/W71470137","https://openalex.org/W65508234","https://openalex.org/W2126859012","https://openalex.org/W1899151383"],"abstract_inverted_index":{"Tissue":[0],"typing":[1],"(HLA-A,":[2],"-B":[3],"and":[4,16,36,53],"-DR)":[5],"was":[6],"carried":[7],"out":[8],"on":[9,17],"92":[10],"patients":[11,35],"with":[12,50,62],"coeliac":[13,58,83],"disease":[14],"(CD)":[15],"a":[18],"further":[19],"71":[20],"first":[21],"degree":[22],"relatives":[23],"of":[24,26,30,64,75],"13":[25],"these":[27,57],"patients.":[28],"Results":[29],"antigen":[31,96],"frequencies":[32],"in":[33,39,71],"unrelated":[34],"segregation":[37],"analysis":[38],"families":[40,59,80],"shows":[41],"that":[42,61],"HLA-DR3":[43],"but":[44],"not":[45],"HLA-DR7":[46],"is":[47,97],"positively":[48],"associated":[49],"CD.":[51],"Haplotype":[52],"sib-pair":[54],"data":[55],"from":[56],"suggest":[60],"all":[63],"them,":[65],"genetic":[66],"susceptibility":[67],"to":[68,90],"CD":[69],"lies":[70],"the":[72,76,82,87],"HLA":[73],"region":[74],"sixth":[77],"chromosome.":[78],"In":[79],"where":[81],"proband":[84],"has":[85],"HLA-DR3,":[86],"relative":[88],"risk":[89],"siblings":[91],"who":[92],"also":[93],"have":[94],"this":[95],"increased":[98],"35":[99],"times.":[100]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
