{"id":"https://openalex.org/W1984376469","doi":"https://doi.org/10.1002/1522-2594(200103)45:3<349::aid-mrm1045>3.0.co;2-8","title":"Study of tricarboxylic acid cycle flux changes in human visual cortex during hemifield visual stimulation using1H-{13C} MRS and fMRI","display_name":"Study of tricarboxylic acid cycle flux changes in human visual cortex during hemifield visual stimulation using1H-{13C} MRS and fMRI","publication_year":2001,"publication_date":"2001-01-01","ids":{"openalex":"https://openalex.org/W1984376469","doi":"https://doi.org/10.1002/1522-2594(200103)45:3<349::aid-mrm1045>3.0.co;2-8","mag":"1984376469","pmid":"https://pubmed.ncbi.nlm.nih.gov/11241689"},"language":"en","primary_location":{"id":"doi:10.1002/1522-2594(200103)45:3<349::aid-mrm1045>3.0.co;2-8","doi":"https://doi.org/10.1002/1522-2594(200103)45:3<349::aid-mrm1045>3.0.co;2-8","is_oa":true,"landing_page_url":"https://doi.org/10.1002/1522-2594(200103)45:3<349::aid-mrm1045>3.0.co;2-8","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/1522-2594%28200103%2945%3A3%3C349%3A%3AAID-MRM1045%3E3.0.CO%3B2-8","source":{"id":"https://openalex.org/S111160002","display_name":"Magnetic Resonance in Medicine","issn_l":"0740-3194","issn":["0740-3194","1522-2594"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-2","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Magnetic Resonance in Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/1522-2594%28200103%2945%3A3%3C349%3A%3AAID-MRM1045%3E3.0.CO%3B2-8","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Wei Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Wei Chen","raw_affiliation_strings":["Center for Magnetic Resonance Research, Radiology Department, University of Minnesota School of Medicine, Minneapolis, Minnesota 55455, USA. wei@cmrr.umn.edu","Center for Magnetic Resonance Research"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Magnetic Resonance Research, Radiology Department, University of Minnesota School of Medicine, Minneapolis, Minnesota 55455, USA. wei@cmrr.umn.edu","institution_ids":["https://openalex.org/I130238516"]},{"raw_affiliation_string":"Center for Magnetic Resonance Research","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111592162","display_name":"Xiao\u2010Hong Zhu","orcid":"https://orcid.org/0009-0008-5926-1869","observed_orcids":["https://orcid.org/0009-0008-5926-1869"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiao-Hong Zhu","raw_affiliation_strings":["Center for Magnetic Resonance Research, Radiology Department, University of Minnesota School of Medicine, Minneapolis, Minnesota","Center for Magnetic Resonance Research"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Magnetic Resonance Research, Radiology Department, University of Minnesota School of Medicine, Minneapolis, Minnesota","institution_ids":["https://openalex.org/I130238516"]},{"raw_affiliation_string":"Center for Magnetic Resonance Research","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029409294","display_name":"Rolf Gruetter A","orcid":"https://orcid.org/0000-0003-1870-4025","observed_orcids":["https://orcid.org/0000-0003-1870-4025"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rolf Gruetter","raw_affiliation_strings":["Center for Magnetic Resonance Research, Radiology Department, University of Minnesota School of Medicine, Minneapolis, Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Magnetic Resonance Research, Radiology Department, University of Minnesota School of Medicine, Minneapolis, Minnesota","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089855065","display_name":"Elizabeth R. Seaquist","orcid":"https://orcid.org/0000-0002-1945-1034","observed_orcids":["https://orcid.org/0000-0002-1945-1034"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elizabeth R. Seaquist","raw_affiliation_strings":["Center for Magnetic Resonance Research, Radiology Department, University of Minnesota School of Medicine, Minneapolis, Minnesota","Medicine - Endocrine and Diabetes Division"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Magnetic Resonance Research, Radiology Department, University of Minnesota School of Medicine, Minneapolis, Minnesota","institution_ids":["https://openalex.org/I130238516"]},{"raw_affiliation_string":"Medicine - Endocrine and Diabetes Division","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004118916","display_name":"Gregor Adriany","orcid":"https://orcid.org/0000-0002-6428-9005","observed_orcids":["https://orcid.org/0000-0002-6428-9005"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gregor Adriany","raw_affiliation_strings":["Center for Magnetic Resonance Research, Radiology Department, University of Minnesota School of Medicine, Minneapolis, Minnesota","Center for Magnetic Resonance Research"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Magnetic Resonance Research, Radiology Department, University of Minnesota School of Medicine, Minneapolis, Minnesota","institution_ids":["https://openalex.org/I130238516"]},{"raw_affiliation_string":"Center for Magnetic Resonance Research","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054800712","display_name":"K\u01cemil U\u01e7urbil","orcid":"https://orcid.org/0000-0002-8475-9334","observed_orcids":["https://orcid.org/0000-0002-8475-9334"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kamil Ugurbil","raw_affiliation_strings":["Center for Magnetic Resonance Research, Radiology Department, University of Minnesota School of Medicine, Minneapolis, Minnesota","Center for Magnetic Resonance Research"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Magnetic Resonance Research, Radiology Department, University of Minnesota School of Medicine, Minneapolis, Minnesota","institution_ids":["https://openalex.org/I130238516"]},{"raw_affiliation_string":"Center for Magnetic Resonance Research","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I130238516"],"apc_list":{"value":3680,"currency":"USD","value_usd":3680},"apc_paid":null,"fwci":8.2465,"has_fulltext":true,"cited_by_count":112,"citation_normalized_percentile":{"value":0.9806947,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"45","issue":"3","first_page":"349","last_page":"355"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11809","display_name":"Advanced NMR Techniques and Applications","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tricarboxylic-acid-cycle","display_name":"TCA cycle","score":0.9430000185966492},{"id":"https://openalex.org/keywords/tca-cycle-flux","display_name":"TCA cycle flux","score":0.7710000276565552},{"id":"https://openalex.org/keywords/visual-cortex","display_name":"visual cortex","score":0.7929999828338623},{"id":"https://openalex.org/keywords/cerebral-metabolic-rate-for-oxygen","display_name":"cerebral oxygen consumption","score":0.8769999742507935},{"id":"https://openalex.org/keywords/cerebral-blood-flow","display_name":"cerebral blood flow","score":0.996999979019165},{"id":"https://openalex.org/keywords/13c-labeled-glucose","display_name":"13C-labeled glucose","score":0.8330000042915344},{"id":"https://openalex.org/keywords/bold-effect","display_name":"BOLD effect","score":0.7059999704360962},{"id":"https://openalex.org/keywords/brain-energy-metabolism","display_name":"brain energy metabolism","score":0.5879999995231628},{"id":"https://openalex.org/keywords/hemodynamic-response","display_name":"hemodynamic response","score":0.5149999856948853}],"concepts":[{"id":"https://openalex.org/C157767197","wikidata":"https://www.wikidata.org/wiki/Q886843","display_name":"Cerebral blood flow","level":2,"score":0.684262752532959},{"id":"https://openalex.org/C2779345533","wikidata":"https://www.wikidata.org/wiki/Q75785","display_name":"Visual cortex","level":2,"score":0.6327658295631409},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.6029767394065857},{"id":"https://openalex.org/C61174792","wikidata":"https://www.wikidata.org/wiki/Q420510","display_name":"Glutamate receptor","level":3,"score":0.5370579957962036},{"id":"https://openalex.org/C2777670902","wikidata":"https://www.wikidata.org/wiki/Q492038","display_name":"Human brain","level":2,"score":0.4729097783565521},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4681539833545685},{"id":"https://openalex.org/C2777348757","wikidata":"https://www.wikidata.org/wiki/Q2346577","display_name":"Cortex (anatomy)","level":2,"score":0.4370438754558563},{"id":"https://openalex.org/C74254510","wikidata":"https://www.wikidata.org/wiki/Q7240508","display_name":"Premovement neuronal activity","level":2,"score":0.43000873923301697},{"id":"https://openalex.org/C70289976","wikidata":"https://www.wikidata.org/wiki/Q17143603","display_name":"Oxygenation","level":2,"score":0.4223173260688782},{"id":"https://openalex.org/C165135838","wikidata":"https://www.wikidata.org/wiki/Q133895","display_name":"Citric acid cycle","level":3,"score":0.41235706210136414},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.37629586458206177},{"id":"https://openalex.org/C46141821","wikidata":"https://www.wikidata.org/wiki/Q209402","display_name":"Nuclear magnetic resonance","level":1,"score":0.33240121603012085},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.275665819644928},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.24347129464149475},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.19546374678611755},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16879165172576904},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.15355771780014038},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0695415735244751},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002952","descriptor_name":"Citric Acid Cycle","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D004292","descriptor_name":"Dominance, Cerebral","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007089","descriptor_name":"Image Enhancement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009682","descriptor_name":"Magnetic Resonance Spectroscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010101","descriptor_name":"Oxygen Consumption","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D010775","descriptor_name":"Photic Stimulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011768","descriptor_name":"Pyruvate Dehydrogenase Complex","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014785","descriptor_name":"Vision, Ocular","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D014793","descriptor_name":"Visual Cortex","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1002/1522-2594(200103)45:3<349::aid-mrm1045>3.0.co;2-8","doi":"https://doi.org/10.1002/1522-2594(200103)45:3<349::aid-mrm1045>3.0.co;2-8","is_oa":true,"landing_page_url":"https://doi.org/10.1002/1522-2594(200103)45:3<349::aid-mrm1045>3.0.co;2-8","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/1522-2594%28200103%2945%3A3%3C349%3A%3AAID-MRM1045%3E3.0.CO%3B2-8","source":{"id":"https://openalex.org/S111160002","display_name":"Magnetic Resonance in Medicine","issn_l":"0740-3194","issn":["0740-3194","1522-2594"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-2","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Magnetic Resonance in Medicine","raw_type":"journal-article"},{"id":"pmid:11241689","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11241689","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Magnetic resonance in medicine","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.398.7397","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.398.7397","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"text"},{"id":"pmh:oai:infoscience.epfl.ch:177530","doi":null,"is_oa":true,"landing_page_url":"http://infoscience.epfl.ch/record/177530","pdf_url":null,"source":{"id":"https://openalex.org/S4306400487","display_name":"Infoscience (Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I5124864","host_organization_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","host_organization_lineage":["https://openalex.org/I5124864"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:infoscience.tind.io:177530","doi":null,"is_oa":true,"landing_page_url":"http://infoscience.epfl.ch/record/177530","pdf_url":null,"source":{"id":"https://openalex.org/S4306400487","display_name":"Infoscience (Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I5124864","host_organization_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","host_organization_lineage":["https://openalex.org/I5124864"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"research article"}],"best_oa_location":{"id":"doi:10.1002/1522-2594(200103)45:3<349::aid-mrm1045>3.0.co;2-8","doi":"https://doi.org/10.1002/1522-2594(200103)45:3<349::aid-mrm1045>3.0.co;2-8","is_oa":true,"landing_page_url":"https://doi.org/10.1002/1522-2594(200103)45:3<349::aid-mrm1045>3.0.co;2-8","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/1522-2594%28200103%2945%3A3%3C349%3A%3AAID-MRM1045%3E3.0.CO%3B2-8","source":{"id":"https://openalex.org/S111160002","display_name":"Magnetic Resonance in Medicine","issn_l":"0740-3194","issn":["0740-3194","1522-2594"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-2","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Magnetic Resonance in Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6240000128746033}],"study_designs":[],"awards":[{"id":"https://openalex.org/G231033738","display_name":"GCRC-General Clinical Research Center","funder_award_id":"M01RR000400","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G6148595033","display_name":"FUNCTIONAL MRI MAPPING OF HUMAN THALAMOCORTICAL NETWORKS","funder_award_id":"R01NS039043","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G6199242283","display_name":"DYNAMIC STUDY OF HUMAN BRAIN ACTIVITY WITH FMRI AND FMRS","funder_award_id":"R01NS038070","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G6412933429","display_name":"NMR Imaging and Spectroscopy","funder_award_id":"P41RR008079","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G7067230863","display_name":"Measurement of glucose homeostasis in human brain by NMR","funder_award_id":"R01NS035192","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G7196297690","display_name":"Dynamic MRI and MRS studies of focal neural activation","funder_award_id":"R01NS038672","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1984376469.pdf","grobid_xml":"https://content.openalex.org/works/W1984376469.grobid-xml"},"referenced_works_count":30,"referenced_works":["https://openalex.org/W1574637310","https://openalex.org/W1966943328","https://openalex.org/W1967009686","https://openalex.org/W1971082120","https://openalex.org/W1978262170","https://openalex.org/W1983500965","https://openalex.org/W1993303421","https://openalex.org/W2002660165","https://openalex.org/W2010127368","https://openalex.org/W2015251934","https://openalex.org/W2018343414","https://openalex.org/W2021496866","https://openalex.org/W2022500753","https://openalex.org/W2022594676","https://openalex.org/W2044239486","https://openalex.org/W2050154889","https://openalex.org/W2050717100","https://openalex.org/W2052750469","https://openalex.org/W2058027749","https://openalex.org/W2077911717","https://openalex.org/W2093366270","https://openalex.org/W2093842581","https://openalex.org/W2098610274","https://openalex.org/W2106031669","https://openalex.org/W2120800380","https://openalex.org/W2121587775","https://openalex.org/W2132901379","https://openalex.org/W2152346792","https://openalex.org/W2170117095","https://openalex.org/W2442289071"],"related_works":["https://openalex.org/W7100715110","https://openalex.org/W2089863048","https://openalex.org/W2886742813","https://openalex.org/W2130199588","https://openalex.org/W2098610274","https://openalex.org/W2041277840","https://openalex.org/W2018108370","https://openalex.org/W1988794652","https://openalex.org/W2030275767","https://openalex.org/W2055750134"],"abstract_inverted_index":{"The":[0,117,142],"relationships":[1],"between":[2,12],"brain":[3,61],"activity":[4,191],"and":[5,8,21,105,179,196],"accompanying":[6],"hemodynamic":[7],"metabolic":[9,15],"alterations,":[10],"particularly":[11],"the":[13,35,46,59,82,111,115,121,125,159,167,193,205],"cerebral":[14,22],"rate":[16,36,127],"of":[17,37,65,81,114,128,131,137,173],"oxygen":[18],"utilization":[19],"(CMR(O2))":[20],"blood":[23,208],"flow":[24],"(CBF),":[25],"are":[26],"not":[27],"thoroughly":[28],"established.":[29],"CMR(O2)":[30,146,178,188],"is":[31],"closely":[32],"coupled":[33],"to":[34,99,155],"tricarboxylic":[38],"acid":[39],"(TCA)":[40],"cycle":[41,70],"flux.":[42],"In":[43],"this":[44],"study,":[45],"changes":[47,144],"in":[48,58,67,110,124,145,162,192,214],"glutamate":[49,132,163],"labeling":[50,164],"during":[51,72,139,189],"(13)C":[52],"labeled":[53],"glucose":[54],"administration":[55],"were":[56],"determined":[57],"human":[60],"as":[62],"an":[63,170,200],"index":[64],"alterations":[66],"neuronal":[68,74],"TCA":[69],"turnover":[71,126],"increased":[73],"activity.":[75],"Two-volume":[76],"(1)H-[(13)C]":[77],"MR":[78],"spectroscopy":[79],"(MRS)":[80],"visual":[83,95,140,194],"cortex":[84],"was":[85,97,133],"combined":[86],"with":[87],"functional":[88],"MRI":[89],"(fMRI)":[90],"at":[91],"4":[92],"Tesla.":[93],"Hemifield":[94],"stimulation":[96],"employed":[98],"obtain":[100],"data":[101],"simultaneously":[102],"from":[103],"activated":[104],"control":[106],"regions":[107],"located":[108],"symmetrically":[109],"two":[112],"hemispheres":[113],"brain.":[116],"results":[118,168],"showed":[119],"that":[120,136,182,198],"fractional":[122,143,160,183],"change":[123,161,202],"C4":[129],"carbon":[130],"less":[134,157],"than":[135,158],"CBF":[138,184],"stimulation.":[141],"(Delta":[147],"CMR(O2))":[148],"induced":[149],"by":[150],"activation":[151],"must":[152],"be":[153],"equal":[154],"or":[156],"kinetics.":[165],"Therefore,":[166],"impose":[169],"upper":[171],"limit":[172],"approximately":[174],"30%":[175],"for":[176],"Delta":[177,187],"demonstrate:":[180],"1)":[181],"increases":[185],"exceed":[186],"elevated":[190],"cortex,":[195],"2)":[197],"such":[199],"unequal":[201],"would":[203],"explain":[204],"observed":[206],"positive":[207],"oxygenation":[209],"level":[210],"dependent":[211],"(BOLD)":[212],"effect":[213],"fMRI.":[215],"Magn":[216],"Reson":[217],"Med":[218],"45:349-355,":[219],"2001.":[220]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}