{"id":"https://openalex.org/W1984164453","doi":"https://doi.org/10.1021/jo9712963","title":"Design and Synthesis of (Ribitylamino)uracils Bearing Fluorosulfonyl, Sulfonic Acid, and Carboxylic Acid Functionality as Inhibitors of Lumazine Synthase","display_name":"Design and Synthesis of (Ribitylamino)uracils Bearing Fluorosulfonyl, Sulfonic Acid, and Carboxylic Acid Functionality as Inhibitors of Lumazine Synthase","publication_year":1997,"publication_date":"1997-12-01","ids":{"openalex":"https://openalex.org/W1984164453","doi":"https://doi.org/10.1021/jo9712963","mag":"1984164453"},"language":"en","primary_location":{"id":"doi:10.1021/jo9712963","doi":"https://doi.org/10.1021/jo9712963","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jo9712963","pdf_url":null,"source":{"id":"https://openalex.org/S205050996","display_name":"The Journal of Organic Chemistry","issn_l":"0022-3263","issn":["0022-3263","1520-6904"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Organic Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5107458395","display_name":"Mark Cushman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Mark Cushman","raw_affiliation_strings":["Department of Medicinal Chemistry and Molecular Pharmacology, School of Pharmacy, Purdue University, West Lafayette, Indiana 47907, and Lehrstuhl f\u00fcr Organische Chemie und Biochemie, Technische Universit\u00e4t M\u00fcnchen, D-85747 Garching, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry and Molecular Pharmacology, School of Pharmacy, Purdue University, West Lafayette, Indiana 47907, and Lehrstuhl f\u00fcr Organische Chemie und Biochemie, Technische Universit\u00e4t M\u00fcnchen, D-85747 Garching, Germany","institution_ids":["https://openalex.org/I219193219","https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010325568","display_name":"Farahnaz Mavandadi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Farahnaz Mavandadi","raw_affiliation_strings":["Department of Medicinal Chemistry and Molecular Pharmacology, School of Pharmacy, Purdue University, West Lafayette, Indiana 47907, and Lehrstuhl f\u00fcr Organische Chemie und Biochemie, Technische Universit\u00e4t M\u00fcnchen, D-85747 Garching, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry and Molecular Pharmacology, School of Pharmacy, Purdue University, West Lafayette, Indiana 47907, and Lehrstuhl f\u00fcr Organische Chemie und Biochemie, Technische Universit\u00e4t M\u00fcnchen, D-85747 Garching, Germany","institution_ids":["https://openalex.org/I219193219","https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012019052","display_name":"Karl Kugelbrey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Karl Kugelbrey","raw_affiliation_strings":["Department of Medicinal Chemistry and Molecular Pharmacology, School of Pharmacy, Purdue University, West Lafayette, Indiana 47907, and Lehrstuhl f\u00fcr Organische Chemie und Biochemie, Technische Universit\u00e4t M\u00fcnchen, D-85747 Garching, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry and Molecular Pharmacology, School of Pharmacy, Purdue University, West Lafayette, Indiana 47907, and Lehrstuhl f\u00fcr Organische Chemie und Biochemie, Technische Universit\u00e4t M\u00fcnchen, D-85747 Garching, Germany","institution_ids":["https://openalex.org/I219193219","https://openalex.org/I62916508"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068798153","display_name":"Adelbert Bacher","orcid":"https://orcid.org/0000-0001-5174-4139","observed_orcids":["https://orcid.org/0000-0001-5174-4139"]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Adelbert Bacher","raw_affiliation_strings":["Department of Medicinal Chemistry and Molecular Pharmacology, School of Pharmacy, Purdue University, West Lafayette, Indiana 47907, and Lehrstuhl f\u00fcr Organische Chemie und Biochemie, Technische Universit\u00e4t M\u00fcnchen, D-85747 Garching, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry and Molecular Pharmacology, School of Pharmacy, Purdue University, West Lafayette, Indiana 47907, and Lehrstuhl f\u00fcr Organische Chemie und Biochemie, Technische Universit\u00e4t M\u00fcnchen, D-85747 Garching, Germany","institution_ids":["https://openalex.org/I219193219","https://openalex.org/I62916508"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":0.2977,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.47227857,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"62","issue":"25","first_page":"8944","last_page":"8947"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.5932999849319458,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.5932999849319458,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14099","display_name":"Synthesis and Characterization of Heterocyclic Compounds","score":0.2054000049829483,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.046799998730421066,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lumazine-synthase","display_name":"lumazine synthase","score":0.8009999990463257},{"id":"https://openalex.org/keywords/riboflavin-biosynthesis","display_name":"riboflavin biosynthesis","score":0.5799999833106995},{"id":"https://openalex.org/keywords/enzyme-inhibitors","display_name":"enzyme inhibitors","score":0.7170000076293945},{"id":"https://openalex.org/keywords/sulfonic-acids","display_name":"sulfonic acids","score":0.7310000061988831},{"id":"https://openalex.org/keywords/carboxylic-acids","display_name":"carboxylic acids","score":0.984000027179718},{"id":"https://openalex.org/keywords/heterocycle-synthesis","display_name":"heterocyclic synthesis","score":0.5299999713897705},{"id":"https://openalex.org/keywords/enzyme-inhibition","display_name":"enzyme inhibition","score":0.367000013589859},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.5720000267028809},{"id":"https://openalex.org/keywords/fluorinated-heterocycles","display_name":"fluorinated heterocycles","score":0.3479999899864197}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9432144165039062},{"id":"https://openalex.org/C2779074116","wikidata":"https://www.wikidata.org/wiki/Q134856","display_name":"Carboxylic acid","level":2,"score":0.5596745610237122},{"id":"https://openalex.org/C2778502040","wikidata":"https://www.wikidata.org/wiki/Q250437","display_name":"Sulfonic acid","level":2,"score":0.5448912382125854},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.3296009302139282},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.32882827520370483}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1021/jo9712963","doi":"https://doi.org/10.1021/jo9712963","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jo9712963","pdf_url":null,"source":{"id":"https://openalex.org/S205050996","display_name":"The Journal of Organic Chemistry","issn_l":"0022-3263","issn":["0022-3263","1520-6904"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Organic Chemistry","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W10193788","https://openalex.org/W322095649","https://openalex.org/W1039779313","https://openalex.org/W1504957720","https://openalex.org/W1512810258","https://openalex.org/W1527512784","https://openalex.org/W1547638309","https://openalex.org/W1555028382","https://openalex.org/W1556401308","https://openalex.org/W1573505542","https://openalex.org/W1966766357","https://openalex.org/W1974442891","https://openalex.org/W1984112228","https://openalex.org/W1996692289","https://openalex.org/W2011338802","https://openalex.org/W2020890335","https://openalex.org/W2057271711","https://openalex.org/W2067698370","https://openalex.org/W2074082505","https://openalex.org/W2089961627","https://openalex.org/W2122833164","https://openalex.org/W2397880322","https://openalex.org/W2951621702","https://openalex.org/W4241822117"],"related_works":["https://openalex.org/W4254414505","https://openalex.org/W2070787653","https://openalex.org/W2950727554","https://openalex.org/W2048117288","https://openalex.org/W2074287512","https://openalex.org/W2073361852","https://openalex.org/W2147442178","https://openalex.org/W2026119781","https://openalex.org/W1980532193","https://openalex.org/W2012820507"],"abstract_inverted_index":{"ADVERTISEMENT":[0],"RETURN":[1],"TO":[2],"ISSUEPREVNoteNEXTDesign":[3],"and":[4,12,26,35,47,111,116,145,189,206,222,224,235],"Synthesis":[5],"of":[6,18,32,39,101,136,162],"(Ribitylamino)uracils":[7],"Bearing":[8],"Fluorosulfonyl,":[9],"Sulfonic":[10],"Acid,":[11],"Carboxylic":[13],"Acid":[14],"Functionality":[15],"as":[16],"Inhibitors":[17],"Lumazine":[19],"SynthaseMark":[20],"Cushman,":[21],"Farahnaz":[22],"Mavandadi,":[23],"Karl":[24],"Kugelbrey,":[25],"Adelbert":[27],"BacherView":[28],"Author":[29],"Information":[30],"Department":[31],"Medicinal":[33],"Chemistry":[34],"Molecular":[36],"Pharmacology,":[37],"School":[38],"Pharmacy,":[40],"Purdue":[41],"University,":[42],"West":[43],"Lafayette,":[44],"Indiana":[45],"47907,":[46],"Lehrstuhl":[48],"f\u00fcr":[49],"Organische":[50],"Chemie":[51],"und":[52],"Biochemie,":[53],"Technische":[54],"Universit\u00e4t":[55],"M\u00fcnchen,":[56],"D-85747":[57],"Garching,":[58],"Germany":[59],"Cite":[60],"this:":[61],"J.":[62],"Org.":[63],"Chem.":[64],"1997,":[65],"62,":[66],"25,":[67],"8944\u20138947Publication":[68],"Date":[69],"(Web):December":[70],"12,":[71],"1997Publication":[72],"History":[73],"Received15":[74],"July":[75],"1997Published":[76,79],"online12":[77],"December":[78,82],"inissue":[80],"1":[81],"1997https://pubs.acs.org/doi/10.1021/jo9712963https://doi.org/10.1021/jo9712963brief-reportACS":[83],"PublicationsCopyright":[84],"\u00a9":[85],"1997":[86],"American":[87],"Chemical":[88],"SocietyRequest":[89],"reuse":[90],"permissionsArticle":[91],"Views242Altmetric-Citations16LEARN":[92],"ABOUT":[93],"THESE":[94],"METRICSArticle":[95],"Views":[96],"are":[97,120,133],"the":[98,129,134,163,174,187,190,195,202,208],"COUNTER-compliant":[99],"sum":[100],"full":[102],"text":[103],"article":[104,168],"downloads":[105],"since":[106],"November":[107],"2008":[108],"(both":[109],"PDF":[110],"HTML)":[112],"across":[113],"all":[114],"institutions":[115],"individuals.":[117],"These":[118],"metrics":[119],"regularly":[121],"updated":[122,146],"to":[123,128],"reflect":[124],"usage":[125],"leading":[126],"up":[127],"last":[130],"few":[131],"days.Citations":[132],"number":[135],"other":[137],"articles":[138],"citing":[139],"this":[140],"article,":[141],"calculated":[142],"by":[143],"Crossref":[144,152],"daily.":[147],"Find":[148,198],"more":[149,199],"information":[150,200],"about":[151,186],"citation":[153],"counts.The":[154],"Altmetric":[155,203],"Attention":[156,204],"Score":[157,205],"is":[158,210],"a":[159,166,179],"quantitative":[160],"measure":[161],"attention":[164],"that":[165],"research":[167],"has":[169],"received":[170],"online.":[171],"Clicking":[172],"on":[173,201],"donut":[175],"icon":[176],"will":[177],"load":[178],"page":[180],"at":[181],"altmetric.com":[182],"with":[183,218],"additional":[184],"details":[185],"score":[188,209],"social":[191],"media":[192],"presence":[193],"for":[194],"given":[196],"article.":[197],"how":[207],"calculated.":[211],"Share":[212,227],"Add":[213],"toView":[214],"InAdd":[215],"Full":[216],"Text":[217],"ReferenceAdd":[219],"Description":[220],"ExportRISCitationCitation":[221],"abstractCitation":[223],"referencesMore":[225],"Options":[226],"onFacebookTwitterWechatLinked":[228],"InRedditEmail":[229],"Other":[230],"access":[231],"optionsGet":[232],"e-Alertsclose":[233],"SUBJECTS:Inhibitors,Molecules,Monomers,Peptides":[234],"proteins,Phosphates":[236],"Get":[237],"e-Alerts":[238]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
