{"id":"https://openalex.org/W1984106926","doi":"https://doi.org/10.1038/srep07457","title":"Genome dynamics and evolution of Salmonella Typhi strains from the typhoid-endemic zones","display_name":"Genome dynamics and evolution of Salmonella Typhi strains from the typhoid-endemic zones","publication_year":2014,"publication_date":"2014-12-12","ids":{"openalex":"https://openalex.org/W1984106926","doi":"https://doi.org/10.1038/srep07457","mag":"1984106926","pmid":"https://pubmed.ncbi.nlm.nih.gov/25504040","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4264004"},"language":"en","primary_location":{"id":"doi:10.1038/srep07457","doi":"https://doi.org/10.1038/srep07457","is_oa":true,"landing_page_url":"https://doi.org/10.1038/srep07457","pdf_url":"https://www.nature.com/articles/srep07457.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/srep07457.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072088005","display_name":"Ramani Baddam","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36893310","display_name":"University of Hyderabad","ror":"https://ror.org/04a7rxb17","country_code":"IN","type":"education","lineage":["https://openalex.org/I36893310"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Ramani Baddam","raw_affiliation_strings":["Pathogen Biology Laboratory, Department of Biotechnology and Bioinformatics, School of Life Sciences, University of Hyderabad, Gachibowli, Hyderabad 500046, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathogen Biology Laboratory, Department of Biotechnology and Bioinformatics, School of Life Sciences, University of Hyderabad, Gachibowli, Hyderabad 500046, India","institution_ids":["https://openalex.org/I36893310"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061917831","display_name":"Narender Kumar","orcid":"https://orcid.org/0000-0003-2089-9626","observed_orcids":["https://orcid.org/0000-0003-2089-9626"]},"institutions":[{"id":"https://openalex.org/I36893310","display_name":"University of Hyderabad","ror":"https://ror.org/04a7rxb17","country_code":"IN","type":"education","lineage":["https://openalex.org/I36893310"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Narender Kumar","raw_affiliation_strings":["Pathogen Biology Laboratory, Department of Biotechnology and Bioinformatics, School of Life Sciences, University of Hyderabad, Gachibowli, Hyderabad 500046, India","Department of Biotechnology and Bioinformatics, Pathogen Biology Laboratory, School of Life Sciences, University of Hyderabad, Gachibowli, Hyderabad, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathogen Biology Laboratory, Department of Biotechnology and Bioinformatics, School of Life Sciences, University of Hyderabad, Gachibowli, Hyderabad 500046, India","institution_ids":["https://openalex.org/I36893310"]},{"raw_affiliation_string":"Department of Biotechnology and Bioinformatics, Pathogen Biology Laboratory, School of Life Sciences, University of Hyderabad, Gachibowli, Hyderabad, India","institution_ids":["https://openalex.org/I36893310"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110322877","display_name":"Sabiha Shaik","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36893310","display_name":"University of Hyderabad","ror":"https://ror.org/04a7rxb17","country_code":"IN","type":"education","lineage":["https://openalex.org/I36893310"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sabiha Shaik","raw_affiliation_strings":["Pathogen Biology Laboratory, Department of Biotechnology and Bioinformatics, School of Life Sciences, University of Hyderabad, Gachibowli, Hyderabad 500046, India","Department of Biotechnology and Bioinformatics, Pathogen Biology Laboratory, School of Life Sciences, University of Hyderabad, Gachibowli, Hyderabad, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathogen Biology Laboratory, Department of Biotechnology and Bioinformatics, School of Life Sciences, University of Hyderabad, Gachibowli, Hyderabad 500046, India","institution_ids":["https://openalex.org/I36893310"]},{"raw_affiliation_string":"Department of Biotechnology and Bioinformatics, Pathogen Biology Laboratory, School of Life Sciences, University of Hyderabad, Gachibowli, Hyderabad, India","institution_ids":["https://openalex.org/I36893310"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000760256","display_name":"Aditya Kumar Lankapalli","orcid":"https://orcid.org/0000-0002-9921-680X","observed_orcids":["https://orcid.org/0000-0002-9921-680X"]},"institutions":[{"id":"https://openalex.org/I36893310","display_name":"University of Hyderabad","ror":"https://ror.org/04a7rxb17","country_code":"IN","type":"education","lineage":["https://openalex.org/I36893310"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Aditya Kumar Lankapalli","raw_affiliation_strings":["Pathogen Biology Laboratory, Department of Biotechnology and Bioinformatics, School of Life Sciences, University of Hyderabad, Gachibowli, Hyderabad 500046, India","Department of Biotechnology and Bioinformatics, Pathogen Biology Laboratory, School of Life Sciences, University of Hyderabad, Gachibowli, Hyderabad, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathogen Biology Laboratory, Department of Biotechnology and Bioinformatics, School of Life Sciences, University of Hyderabad, Gachibowli, Hyderabad 500046, India","institution_ids":["https://openalex.org/I36893310"]},{"raw_affiliation_string":"Department of Biotechnology and Bioinformatics, Pathogen Biology Laboratory, School of Life Sciences, University of Hyderabad, Gachibowli, Hyderabad, India","institution_ids":["https://openalex.org/I36893310"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045733858","display_name":"Niyaz Ahmed","orcid":"https://orcid.org/0000-0001-6425-7583","observed_orcids":["https://orcid.org/0000-0001-6425-7583"]},"institutions":[{"id":"https://openalex.org/I36893310","display_name":"University of Hyderabad","ror":"https://ror.org/04a7rxb17","country_code":"IN","type":"education","lineage":["https://openalex.org/I36893310"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Niyaz Ahmed","raw_affiliation_strings":["Pathogen Biology Laboratory, Department of Biotechnology and Bioinformatics, School of Life Sciences, University of Hyderabad, Gachibowli, Hyderabad 500046, India","Department of Biotechnology and Bioinformatics, Pathogen Biology Laboratory, School of Life Sciences, University of Hyderabad, Gachibowli, Hyderabad, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathogen Biology Laboratory, Department of Biotechnology and Bioinformatics, School of Life Sciences, University of Hyderabad, Gachibowli, Hyderabad 500046, India","institution_ids":["https://openalex.org/I36893310"]},{"raw_affiliation_string":"Department of Biotechnology and Bioinformatics, Pathogen Biology Laboratory, School of Life Sciences, University of Hyderabad, Gachibowli, Hyderabad, India","institution_ids":["https://openalex.org/I36893310"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5045733858"],"corresponding_institution_ids":["https://openalex.org/I36893310"],"apc_list":{"value":2690,"currency":"USD","value_usd":2690},"apc_paid":{"value":2690,"currency":"USD","value_usd":2690},"fwci":1.4315,"has_fulltext":true,"cited_by_count":24,"citation_normalized_percentile":{"value":0.82128436,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"4","issue":"1","first_page":"7457","last_page":"7457"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10486","display_name":"Salmonella and Campylobacter epidemiology","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10486","display_name":"Salmonella and Campylobacter epidemiology","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/salmonella-enterica-serovar-typhi","display_name":"Salmonella typhi","score":0.9990000128746033},{"id":"https://openalex.org/keywords/typhoid-fever","display_name":"typhoid fever","score":0.9909999966621399},{"id":"https://openalex.org/keywords/pan-genome","display_name":"pan-genome","score":0.8849999904632568},{"id":"https://openalex.org/keywords/core-genome","display_name":"core genome","score":0.8519999980926514},{"id":"https://openalex.org/keywords/accessory-genome","display_name":"accessory genome","score":0.7730000019073486},{"id":"https://openalex.org/keywords/functional-genes","display_name":"functional genes","score":0.5799999833106995},{"id":"https://openalex.org/keywords/metabolic-genes","display_name":"metabolic genes","score":0.6399999856948853},{"id":"https://openalex.org/keywords/strain-heterogeneity","display_name":"strain heterogeneity","score":0.7670000195503235},{"id":"https://openalex.org/keywords/metabolic-adaptation","display_name":"metabolic adaptation","score":0.6449999809265137},{"id":"https://openalex.org/keywords/southeast-asia","display_name":"Southeast Asia","score":0.8119999766349792},{"id":"https://openalex.org/keywords/oceania","display_name":"Oceania","score":0.8899999856948853}],"concepts":[{"id":"https://openalex.org/C34957205","wikidata":"https://www.wikidata.org/wiki/Q277338","display_name":"Pseudogene","level":4,"score":0.9280261993408203},{"id":"https://openalex.org/C520601542","wikidata":"https://www.wikidata.org/wiki/Q83319","display_name":"Typhoid fever","level":2,"score":0.73908931016922},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.721499502658844},{"id":"https://openalex.org/C2994552716","wikidata":"https://www.wikidata.org/wiki/Q21600865","display_name":"Salmonella typhi","level":4,"score":0.7041426301002502},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6853914260864258},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6327093243598938},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.562828004360199},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4578183889389038},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.32471805810928345},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.17793357372283936},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0796210765838623},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001210","descriptor_name":"Asia, Southeastern","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012485","descriptor_name":"Salmonella typhi","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014435","descriptor_name":"Typhoid Fever","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D014435","descriptor_name":"Typhoid Fever","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016680","descriptor_name":"Genome, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019353","descriptor_name":"Endemic Diseases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020071","descriptor_name":"Interspersed Repetitive Sequences","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1038/srep07457","doi":"https://doi.org/10.1038/srep07457","is_oa":true,"landing_page_url":"https://doi.org/10.1038/srep07457","pdf_url":"https://www.nature.com/articles/srep07457.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4264004","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4264004","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sci Rep","raw_type":"Text"},{"id":"pmid:25504040","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25504040","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1038/srep07457","doi":"https://doi.org/10.1038/srep07457","is_oa":true,"landing_page_url":"https://doi.org/10.1038/srep07457","pdf_url":"https://www.nature.com/articles/srep07457.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8371999859809875}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.7799999713897705}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1984106926.pdf","grobid_xml":"https://content.openalex.org/works/W1984106926.grobid-xml"},"referenced_works_count":60,"referenced_works":["https://openalex.org/W1938034723","https://openalex.org/W1974702731","https://openalex.org/W1976763516","https://openalex.org/W1981292743","https://openalex.org/W1984159720","https://openalex.org/W2005568288","https://openalex.org/W2008856488","https://openalex.org/W2012196585","https://openalex.org/W2012976783","https://openalex.org/W2013083473","https://openalex.org/W2015213608","https://openalex.org/W2020709171","https://openalex.org/W2028582544","https://openalex.org/W2033713984","https://openalex.org/W2034223856","https://openalex.org/W2036837554","https://openalex.org/W2041257508","https://openalex.org/W2045843097","https://openalex.org/W2050884031","https://openalex.org/W2052426953","https://openalex.org/W2055615325","https://openalex.org/W2059144407","https://openalex.org/W2066036014","https://openalex.org/W2075371279","https://openalex.org/W2077033059","https://openalex.org/W2091030812","https://openalex.org/W2091270609","https://openalex.org/W2091543364","https://openalex.org/W2093610003","https://openalex.org/W2100363512","https://openalex.org/W2102898060","https://openalex.org/W2103441770","https://openalex.org/W2105537192","https://openalex.org/W2109169305","https://openalex.org/W2109730437","https://openalex.org/W2110213626","https://openalex.org/W2110397906","https://openalex.org/W2111548431","https://openalex.org/W2115149444","https://openalex.org/W2116435681","https://openalex.org/W2122270655","https://openalex.org/W2127232702","https://openalex.org/W2130124027","https://openalex.org/W2133253129","https://openalex.org/W2134338877","https://openalex.org/W2135146244","https://openalex.org/W2135182970","https://openalex.org/W2137015675","https://openalex.org/W2137553534","https://openalex.org/W2139627484","https://openalex.org/W2142402047","https://openalex.org/W2143014410","https://openalex.org/W2149452073","https://openalex.org/W2150113767","https://openalex.org/W2150550043","https://openalex.org/W2154223634","https://openalex.org/W2155404525","https://openalex.org/W2156749020","https://openalex.org/W2164217177","https://openalex.org/W2167187617"],"related_works":["https://openalex.org/W2012976783","https://openalex.org/W7099482628","https://openalex.org/W2028582544","https://openalex.org/W2167187617","https://openalex.org/W2143750684","https://openalex.org/W2110397906","https://openalex.org/W4410570776","https://openalex.org/W2912982186","https://openalex.org/W2015213608","https://openalex.org/W2058818856"],"abstract_inverted_index":{"Typhoid":[0],"fever":[1],"poses":[2],"significant":[3,118],"burden":[4],"on":[5],"healthcare":[6],"systems":[7],"in":[8,92,111,120,175,188],"Southeast":[9,55],"Asia":[10,56],"and":[11,17,57,65,99,104,116,162,195],"other":[12],"endemic":[13],"countries.":[14],"Several":[15],"epidemiological":[16],"genomic":[18],"studies":[19],"have":[20],"attributed":[21],"pseudogenisation":[22,87],"to":[23,201],"be":[24],"the":[25,30,42,155,165,180,183],"major":[26,133],"driving":[27],"force":[28],"for":[29,77,205],"evolution":[31],"of":[32,48,54,60,102,135,150,157,160,185],"Salmonella":[33],"Typhi":[34,50,198],"although":[35],"its":[36,206],"real":[37],"potential":[38,194],"remains":[39],"elusive.":[40],"In":[41,167],"present":[43],"study,":[44],"we":[45,95],"analyzed":[46],"genomes":[47,69],"S.":[49,93,197],"from":[51,62,82],"different":[52],"parts":[53],"Oceania,":[58],"comprising":[59],"isolates":[61],"outbreak,":[63],"sporadic":[64],"carrier":[66],"cases.":[67],"The":[68],"showed":[70],"high":[71],"genetic":[72],"relatedness":[73],"with":[74,144,191],"limited":[75],"opportunity":[76],"gene":[78,114,142],"acquisition":[79],"as":[80,137,139],"evident":[81],"pan-genome":[83,100],"structure.":[84],"Given":[85],"that":[86,196],"is":[88],"an":[89,147],"active":[90],"process":[91],"Typhi,":[94],"further":[96],"investigated":[97],"core":[98,112,140],"profiles":[101],"functional":[103,113,125,141,161],"pseudogenes":[105,136,163],"separately.":[106],"We":[107],"observed":[108],"a":[109,117,132,189],"decline":[110],"content":[115,153],"increase":[119],"accessory":[121,151],"pseudogene":[122,152],"content.":[123],"Upon":[124],"classification,":[126],"genes":[127,171],"encoding":[128],"metabolic":[129,193,202],"functions":[130],"formed":[131],"constituent":[134],"well":[138],"clusters":[143],"SNPs.":[145],"Further,":[146],"in-depth":[148],"analysis":[149],"revealed":[154],"existence":[156,184],"heterogeneous":[158,186],"complements":[159],"among":[164],"strains.":[166],"addition,":[168],"these":[169],"polymorphic":[170],"were":[172],"also":[173],"enriched":[174],"metabolism":[176],"related":[177],"functions.":[178],"Thus,":[179],"study":[181],"highlights":[182],"strains":[187],"population":[190],"varying":[192],"possibly":[199],"resorts":[200],"fine":[203],"tuning":[204],"adaptation.":[207]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}