{"id":"https://openalex.org/W1984067136","doi":"https://doi.org/10.1902/jop.2000.71.5.803","title":"Pluronic Polyol Effects on Human Gingival Fibroblast Attachment and Growth","display_name":"Pluronic Polyol Effects on Human Gingival Fibroblast Attachment and Growth","publication_year":2000,"publication_date":"2000-05-01","ids":{"openalex":"https://openalex.org/W1984067136","doi":"https://doi.org/10.1902/jop.2000.71.5.803","mag":"1984067136","pmid":"https://pubmed.ncbi.nlm.nih.gov/10872963"},"language":"en","primary_location":{"id":"doi:10.1902/jop.2000.71.5.803","doi":"https://doi.org/10.1902/jop.2000.71.5.803","is_oa":false,"landing_page_url":"https://doi.org/10.1902/jop.2000.71.5.803","pdf_url":null,"source":{"id":"https://openalex.org/S58498366","display_name":"Journal of Periodontology","issn_l":"0022-3492","issn":["0022-3492","1049-8885","1943-3670"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Periodontology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001974613","display_name":"Steven D. Hokett","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1304082316","display_name":"United States Department of the Army","ror":"https://ror.org/035w1gb98","country_code":"US","type":"government","lineage":["https://openalex.org/I1304082316","https://openalex.org/I1330347796"]},{"id":"https://openalex.org/I4210088792","display_name":"United States Army","ror":"https://ror.org/00afsp483","country_code":"US","type":"government","lineage":["https://openalex.org/I1304082316","https://openalex.org/I1330347796","https://openalex.org/I4210088792"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Steven D. Hokett","raw_affiliation_strings":["U.S. Army Periodontic Residency Program, Dental Activity, Fort Gordon, GA 30905, USA. steven.hokett@se.amedd.army.mil","U.S. Army Periodontic Residency Program, Dental Activity, Fort Gordon, GA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"U.S. Army Periodontic Residency Program, Dental Activity, Fort Gordon, GA 30905, USA. steven.hokett@se.amedd.army.mil","institution_ids":["https://openalex.org/I1304082316","https://openalex.org/I4210088792"]},{"raw_affiliation_string":"U.S. Army Periodontic Residency Program, Dental Activity, Fort Gordon, GA","institution_ids":["https://openalex.org/I4210088792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012026016","display_name":"Michael F. Cuenin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210088792","display_name":"United States Army","ror":"https://ror.org/00afsp483","country_code":"US","type":"government","lineage":["https://openalex.org/I1304082316","https://openalex.org/I1330347796","https://openalex.org/I4210088792"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael F. Cuenin","raw_affiliation_strings":["U.S. Army Periodontic Residency Program, Dental Activity, Fort Gordon, GA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"U.S. Army Periodontic Residency Program, Dental Activity, Fort Gordon, GA","institution_ids":["https://openalex.org/I4210088792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113632621","display_name":"Robert B. O'Neal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert B. O'Neal","raw_affiliation_strings":["University of Washington, Department of Periodontics, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Washington, Department of Periodontics, Seattle, WA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":null,"display_name":"William A. Brennan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"William A. Brennan","raw_affiliation_strings":["Private practice, Green Bay, WI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Private practice, Green Bay, WI","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020018035","display_name":"Scott L. Strong","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Scott L. Strong","raw_affiliation_strings":["Private practice, Portland, OR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Private practice, Portland, OR","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049607639","display_name":"Royce R. Runner","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Royce R. Runner","raw_affiliation_strings":["Department of Clinical Investigations, D.D. Eisenhower Army Medical Center, Fort Gordon, GA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Investigations, D.D. Eisenhower Army Medical Center, Fort Gordon, GA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113808668","display_name":"James C. McPherson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"James C. McPherson","raw_affiliation_strings":["Department of Clinical Investigations, D.D. Eisenhower Army Medical Center, Fort Gordon, GA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Investigations, D.D. Eisenhower Army Medical Center, Fort Gordon, GA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014230085","display_name":"Thomas E. Van Dyke","orcid":"https://orcid.org/0000-0003-0568-124X","observed_orcids":["https://orcid.org/0000-0003-0568-124X"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas E. Van Dyke","raw_affiliation_strings":["Boston University, Goldman School of Dentistry, Department of Periodontics, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Boston University, Goldman School of Dentistry, Department of Periodontics, Boston, MA","institution_ids":["https://openalex.org/I111088046"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5001974613"],"corresponding_institution_ids":["https://openalex.org/I1304082316","https://openalex.org/I4210088792"],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":null,"fwci":0.8434,"has_fulltext":false,"cited_by_count":39,"citation_normalized_percentile":{"value":0.73022569,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"71","issue":"5","first_page":"803","last_page":"809"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11570","display_name":"Periodontal Regeneration and Treatments","score":0.3386000096797943,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11570","display_name":"Periodontal Regeneration and Treatments","score":0.3386000096797943,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.2590000033378601,"subfield":{"id":"https://openalex.org/subfields/2742","display_name":"Rehabilitation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":0.15189999341964722,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/poloxamer-188","display_name":"poloxamer 188","score":0.921999990940094},{"id":"https://openalex.org/keywords/pluronic-f127","display_name":"Pluronic F127","score":1.0},{"id":"https://openalex.org/keywords/human-gingival-fibroblasts","display_name":"human gingival fibroblasts","score":0.9700000286102295},{"id":"https://openalex.org/keywords/cell-attachment","display_name":"cell attachment","score":0.9800000190734863},{"id":"https://openalex.org/keywords/cell-spreading","display_name":"cell spreading","score":0.671999990940094},{"id":"https://openalex.org/keywords/dentin","display_name":"dentin","score":0.6169999837875366},{"id":"https://openalex.org/keywords/surfactants","display_name":"surfactants","score":0.6990000009536743},{"id":"https://openalex.org/keywords/gingival-wound-healing","display_name":"gingival wound healing","score":0.8450000286102295},{"id":"https://openalex.org/keywords/cell-growth","display_name":"cell growth","score":0.5580000281333923},{"id":"https://openalex.org/keywords/drug-carriers","display_name":"drug carriers","score":0.4309999942779541}],"concepts":[{"id":"https://openalex.org/C101335993","wikidata":"https://www.wikidata.org/wiki/Q408943","display_name":"Poloxamer","level":4,"score":0.8524183034896851},{"id":"https://openalex.org/C2779102032","wikidata":"https://www.wikidata.org/wiki/Q342717","display_name":"Acridine orange","level":3,"score":0.7890154719352722},{"id":"https://openalex.org/C2779263046","wikidata":"https://www.wikidata.org/wiki/Q189637","display_name":"Dentin","level":2,"score":0.6899790167808533},{"id":"https://openalex.org/C2780381497","wikidata":"https://www.wikidata.org/wiki/Q463418","display_name":"Fibroblast","level":3,"score":0.629284143447876},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5812376141548157},{"id":"https://openalex.org/C2780269544","wikidata":"https://www.wikidata.org/wiki/Q1509074","display_name":"Wound healing","level":2,"score":0.49746063351631165},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4388817250728607},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.3771756589412689},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3476426601409912},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.34678882360458374},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.3310726583003998},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.30103105306625366},{"id":"https://openalex.org/C199343813","wikidata":"https://www.wikidata.org/wiki/Q12128","display_name":"Dentistry","level":1,"score":0.2359687089920044},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.1650882363319397},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.16499441862106323},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1192384660243988},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.0},{"id":"https://openalex.org/C15920480","wikidata":"https://www.wikidata.org/wiki/Q421281","display_name":"Copolymer","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000704","descriptor_name":"Analysis of Variance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002448","descriptor_name":"Cell Adhesion","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003804","descriptor_name":"Dentin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005881","descriptor_name":"Gingiva","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D005881","descriptor_name":"Gingiva","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010969","descriptor_name":"Plastics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013501","descriptor_name":"Surface-Active Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013501","descriptor_name":"Surface-Active Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D020442","descriptor_name":"Poloxamer","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D020442","descriptor_name":"Poloxamer","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1902/jop.2000.71.5.803","doi":"https://doi.org/10.1902/jop.2000.71.5.803","is_oa":false,"landing_page_url":"https://doi.org/10.1902/jop.2000.71.5.803","pdf_url":null,"source":{"id":"https://openalex.org/S58498366","display_name":"Journal of Periodontology","issn_l":"0022-3492","issn":["0022-3492","1049-8885","1943-3670"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Periodontology","raw_type":"journal-article"},{"id":"pmid:10872963","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10872963","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of periodontology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8199999928474426,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332447","display_name":"U.S. Army","ror":"https://ror.org/00afsp483"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W1508470956","https://openalex.org/W1587747486","https://openalex.org/W1964222459","https://openalex.org/W1972349165","https://openalex.org/W1987547436","https://openalex.org/W1987568997","https://openalex.org/W1990095864","https://openalex.org/W2012626831","https://openalex.org/W2015191850","https://openalex.org/W2017184985","https://openalex.org/W2017202080","https://openalex.org/W2019867412","https://openalex.org/W2036007321","https://openalex.org/W2046966825","https://openalex.org/W2057135911","https://openalex.org/W2058891154","https://openalex.org/W2065531809","https://openalex.org/W2067323919","https://openalex.org/W2078338668","https://openalex.org/W2093648765","https://openalex.org/W2104335895","https://openalex.org/W2130505599","https://openalex.org/W2145733225","https://openalex.org/W2145855364","https://openalex.org/W2163235934","https://openalex.org/W2313427689","https://openalex.org/W2316580644","https://openalex.org/W2329194486","https://openalex.org/W2334182661","https://openalex.org/W2401438549","https://openalex.org/W2417714132"],"related_works":["https://openalex.org/W2354725908","https://openalex.org/W4389279427","https://openalex.org/W4407073729","https://openalex.org/W2414075885","https://openalex.org/W2123350559","https://openalex.org/W4242083476","https://openalex.org/W2883686556","https://openalex.org/W1989788732","https://openalex.org/W2467338943","https://openalex.org/W106032776"],"abstract_inverted_index":{"BACKGROUND:":[0],"Enhanced":[1],"speed":[2],"of":[3,32,42,47,67,121,132,155,174,183,200,221,246],"human":[4,68,141,247],"gingival":[5,69,248],"fibroblast":[6],"(HGF)":[7,71],"spreading":[8],"and":[9,21,59,65,74,97,117,147,169,181,188,203,241],"attachment,":[10],"as":[11,53,144],"affected":[12],"by":[13,127,176,196,205,237],"ionic":[14],"bonding":[15],"interactions,":[16],"may":[17,229],"facilitate":[18],"cell":[19],"orientation":[20],"subsequent":[22],"collagen":[23],"synthesis":[24],"to":[25,36,72,108,185],"promote":[26],"early":[27,233,239],"wound":[28,235],"healing.":[29],"The":[30],"purpose":[31],"this":[33],"study":[34],"was":[35],"determine":[37],"the":[38,63,129,243],"in":[39,102,119,225,232],"vitro":[40],"effects":[41],"pluronic":[43],"polyols,":[44,218],"a":[45,145,153,211,219],"family":[46,220],"widely":[48,222],"used":[49,52,223],"surfactants":[50],"currently":[51],"drug":[54],"carriers":[55],"for":[56],"antibiotic,":[57],"anti-inflammatory,":[58],"anti-neoplastic":[60],"agents,":[61],"on":[62],"attachment":[64,209,240],"growth":[66,182,244],"fibroblasts":[70],"dentin":[73,142,175,189],"plastic":[75,187],"surfaces":[76],"using":[77,140],"established":[78],"tissue":[79],"culture":[80,84],"techniques.":[81],"METHODS:":[82],"Plastic":[83],"wells":[85],"containing":[86],"Eagle's":[87],"minimal":[88],"essential":[89],"media":[90],"(EMEM)":[91],"with":[92,115,166,208],"10%":[93],"fetal":[94],"calf":[95],"serum":[96,194],"Pluronic":[98,148,201,217],"F-68":[99,149,202],"or":[100,150],"F-127":[101,151,204],"concentrations":[103,199],"from":[104],"1.2":[105,109,156],"x":[106,110,157],"10(-2)":[107],"10(-10)":[111],"M":[112],"were":[113,125,138,164,190],"incubated":[114],"HGF":[116,163,184],"run":[118],"replicates":[120],"ten.":[122],"Attached":[123],"cells":[124],"quantified":[126,170],"measuring":[128],"optical":[130],"density":[131],"methylene":[133],"blue-stained":[134],"cells.":[135],"Additional":[136],"experiments":[137],"conducted":[139],"sections":[143],"substrate":[146],"at":[152,213],"concentration":[154],"10(-8)":[158],"M.":[159],"In":[160],"these":[161],"experiments,":[162],"stained":[165],"acridine":[167],"orange":[168],"per":[171],"unit":[172],"area":[173],"fluorescence":[177],"microscopy.":[178],"RESULTS:":[179],"Attachment":[180],"both":[186],"significantly":[191],"increased":[192],"over":[193],"controls":[195],"very":[197,226],"low":[198,227],"30":[206],"minutes,":[207],"reaching":[210],"plateau":[212],"2":[214],"hours.":[215],"CONCLUSIONS:":[216],"surfactants,":[224],"dosages":[228],"be":[230],"beneficial":[231],"postsurgical":[234],"healing":[236],"facilitating":[238],"enhancing":[242],"rate":[245],"fibroblasts.":[249]},"counts_by_year":[{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}