{"id":"https://openalex.org/W1984028801","doi":"https://doi.org/10.1159/000054335","title":"Evidence for GnRH Regulation by Leptin: Leptin Administration Prevents Reduced Pulsatile LH Secretion during Fasting","display_name":"Evidence for GnRH Regulation by Leptin: Leptin Administration Prevents Reduced Pulsatile LH Secretion during Fasting","publication_year":1998,"publication_date":"1998-01-01","ids":{"openalex":"https://openalex.org/W1984028801","doi":"https://doi.org/10.1159/000054335","mag":"1984028801","pmid":"https://pubmed.ncbi.nlm.nih.gov/9662716"},"language":"en","primary_location":{"id":"doi:10.1159/000054335","doi":"https://doi.org/10.1159/000054335","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000054335","pdf_url":null,"source":{"id":"https://openalex.org/S84102376","display_name":"Neuroendocrinology","issn_l":"0028-3835","issn":["0028-3835","1423-0194"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuroendocrinology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034047394","display_name":"Shoji Nagatani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shoji Nagatani","raw_affiliation_strings":["Reproductive Sciences Program, University of Michigan, Ann Arbor 48109-0404, USA","Reproductive Sciences Program and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Reproductive Sciences Program, University of Michigan, Ann Arbor 48109-0404, USA","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Reproductive Sciences Program and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045219667","display_name":"Padma Guthikonda","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Padma Guthikonda","raw_affiliation_strings":["Reproductive Sciences Program and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Reproductive Sciences Program and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107701187","display_name":"Robert C. Thompson","orcid":"https://orcid.org/0000-0001-6297-3340","observed_orcids":["https://orcid.org/0000-0001-6297-3340"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert C. Thompson","raw_affiliation_strings":["Reproductive Sciences Program and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Reproductive Sciences Program and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078622682","display_name":"Hiroko Tsukamura","orcid":"https://orcid.org/0000-0003-2775-6652","observed_orcids":["https://orcid.org/0000-0003-2775-6652"]},"institutions":[{"id":"https://openalex.org/I60134161","display_name":"Nagoya University","ror":"https://ror.org/04chrp450","country_code":"JP","type":"education","lineage":["https://openalex.org/I60134161"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroko Tsukamura","raw_affiliation_strings":["School of Agricultural Sciences, Nagoya University, Nagoya, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Agricultural Sciences, Nagoya University, Nagoya, Japan","institution_ids":["https://openalex.org/I60134161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004598177","display_name":"Kei\u2010ichiro Maeda","orcid":"https://orcid.org/0000-0002-8201-1066","observed_orcids":["https://orcid.org/0000-0002-8201-1066"]},"institutions":[{"id":"https://openalex.org/I60134161","display_name":"Nagoya University","ror":"https://ror.org/04chrp450","country_code":"JP","type":"education","lineage":["https://openalex.org/I60134161"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kei-Ichiro Maeda","raw_affiliation_strings":["School of Agricultural Sciences, Nagoya University, Nagoya, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Agricultural Sciences, Nagoya University, Nagoya, Japan","institution_ids":["https://openalex.org/I60134161"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110900180","display_name":"Douglas L. Foster","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Douglas L. Foster","raw_affiliation_strings":["Departments of Obstetrics and Gynecology and Biology, University of Michigan, Ann Arbor, Mich., USA","Reproductive Sciences Program and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Obstetrics and Gynecology and Biology, University of Michigan, Ann Arbor, Mich., USA","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Reproductive Sciences Program and","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":16.8265,"has_fulltext":false,"cited_by_count":299,"citation_normalized_percentile":{"value":0.99809251,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"67","issue":"6","first_page":"370","last_page":"376"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/leptin","display_name":"leptin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/gonadotropin-releasing-hormone","display_name":"gonadotropin-releasing hormone","score":0.9319999814033508},{"id":"https://openalex.org/keywords/luteinizing-hormone-secretion","display_name":"luteinizing hormone secretion","score":0.8130000233650208},{"id":"https://openalex.org/keywords/pulsatile-lh-secretion","display_name":"pulsatile LH secretion","score":0.7720000147819519},{"id":"https://openalex.org/keywords/fasting","display_name":"fasting","score":0.984000027179718},{"id":"https://openalex.org/keywords/malnutrition","display_name":"malnutrition","score":0.6100000143051147},{"id":"https://openalex.org/keywords/reproductive-function","display_name":"reproductive function","score":0.6000000238418579},{"id":"https://openalex.org/keywords/estrogen","display_name":"estrogen","score":0.7009999752044678},{"id":"https://openalex.org/keywords/insulin","display_name":"insulin","score":0.7020000219345093},{"id":"https://openalex.org/keywords/hypothalamic-pituitary-gonadal-axis","display_name":"hypothalamic-pituitary-gonadal axis","score":0.843999981880188}],"concepts":[{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8973548412322998},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8906981945037842},{"id":"https://openalex.org/C2780613262","wikidata":"https://www.wikidata.org/wiki/Q223739","display_name":"Leptin","level":3,"score":0.8434865474700928},{"id":"https://openalex.org/C79191276","wikidata":"https://www.wikidata.org/wiki/Q7259620","display_name":"Pulsatile flow","level":2,"score":0.7559657692909241},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.5508168935775757},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5330888628959656},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.18528172373771667}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004958","descriptor_name":"Estradiol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005215","descriptor_name":"Fasting","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007986","descriptor_name":"Luteinizing Hormone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007987","descriptor_name":"Gonadotropin-Releasing Hormone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010052","descriptor_name":"Ovariectomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010507","descriptor_name":"Periodicity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020738","descriptor_name":"Leptin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1159/000054335","doi":"https://doi.org/10.1159/000054335","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000054335","pdf_url":null,"source":{"id":"https://openalex.org/S84102376","display_name":"Neuroendocrinology","issn_l":"0028-3835","issn":["0028-3835","1423-0194"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuroendocrinology","raw_type":"journal-article"},{"id":"pmid:9662716","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9662716","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuroendocrinology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6662060375","display_name":"NEUROENDOCRINOLOGY OF PUBERTY","funder_award_id":"R01HD018394","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G8015059059","display_name":"CENTER FOR THE STUDY OF REPRODUCTION","funder_award_id":"P30HD018258","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"}],"funders":[{"id":"https://openalex.org/F4320307105","display_name":"Amgen","ror":"https://ror.org/03g03ge92"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W1580569338","https://openalex.org/W1863858311","https://openalex.org/W1880023255","https://openalex.org/W1963736268","https://openalex.org/W1965318996","https://openalex.org/W1975400348","https://openalex.org/W1978777200","https://openalex.org/W1979556744","https://openalex.org/W1981762970","https://openalex.org/W1987420152","https://openalex.org/W1989667491","https://openalex.org/W1996713062","https://openalex.org/W1997157145","https://openalex.org/W1997400422","https://openalex.org/W2004267191","https://openalex.org/W2006272024","https://openalex.org/W2011039259","https://openalex.org/W2012517940","https://openalex.org/W2013682843","https://openalex.org/W2019137326","https://openalex.org/W2020562485","https://openalex.org/W2024551842","https://openalex.org/W2027014045","https://openalex.org/W2032969797","https://openalex.org/W2038995495","https://openalex.org/W2055956383","https://openalex.org/W2062256488","https://openalex.org/W2064583088","https://openalex.org/W2073828263","https://openalex.org/W2091087465","https://openalex.org/W2098627686","https://openalex.org/W2122729366","https://openalex.org/W2139743744"],"related_works":["https://openalex.org/W4246703146","https://openalex.org/W2073073415","https://openalex.org/W2126482970","https://openalex.org/W2103450911","https://openalex.org/W2036958830","https://openalex.org/W2027437492","https://openalex.org/W2038122474","https://openalex.org/W1965429608","https://openalex.org/W1981541508","https://openalex.org/W2026429560"],"abstract_inverted_index":{"Administration":[0],"of":[1,15,38,56,138,158,191,200],"leptin":[2,50,114,130,163],"during":[3,64,77,134],"undernutrition":[4],"improves":[5],"reproductive":[6],"function,":[7],"but":[8],"whether":[9],"this":[10,170,186],"occurs":[11,63,187],"at":[12],"the":[13,16,29,36,53,121,136,154,189,193],"level":[14],"brain,":[17],"pituitary,":[18],"or":[19,73,156],"gonads":[20],"is":[21,35],"not":[22,143,196],"yet":[23],"clear.":[24],"The":[25,160],"present":[26],"study":[27],"tested":[28],"hypothesis":[30],"that":[31,162,169],"one":[32],"important":[33],"mechanism":[34,194],"control":[37],"pulsatile":[39,57,181],"gonadotropin-releasing":[40,182],"hormone":[41,59,172,183],"(GnRH)":[42],"secretion.":[43,184],"Our":[44],"approach":[45],"was":[46,75,92],"to":[47,177],"determine":[48],"if":[49],"could":[51],"prevent":[52],"marked":[54],"suppression":[55,137],"luteinizing":[58],"(LH)":[60],"secretion":[61],"which":[62,179],"fasting.":[65,107,118],"Leptin":[66,145],"(3":[67],"micrograms/g":[68],"i.p.;":[69],"three":[70],"times/48":[71],"h)":[72],"vehicle":[74],"administered":[76],"a":[78,148],"48-hour":[79],"fast":[80],"in":[81,94,153,188],"adult":[82],"ovariectomized":[83,86],"and":[84,105,113],"estrogen-treated":[85],"rats":[87],"(n":[88],"=":[89],"5-7/group).":[90],"LH":[91,122,139,150,165],"measured":[93],"blood":[95],"samples":[96],"collected":[97],"every":[98],"6":[99],"min":[100],"for":[101],"2":[102],"h":[103],"before":[104],"after":[106,117],"In":[108],"vehicle-treated":[109],"animals,":[110],"plasma":[111],"insulin":[112],"levels":[115],"decreased":[116,126],"As":[119],"expected,":[120],"pulse":[123,140,151,166],"frequency":[124,141,152,167],"also":[125],"markedly.":[127],"When":[128],"circulating":[129],"remained":[131],"artificially":[132],"elevated":[133],"fasting,":[135],"did":[142],"occur.":[144],"treatment":[146],"maintained":[147],"high":[149],"presence":[155],"absence":[157,190],"estrogen.":[159],"finding":[161],"modulates":[164],"indicates":[168],"fat-derived":[171],"conveys":[173],"information":[174],"about":[175],"nutrition":[176],"mechanisms":[178],"regulate":[180],"Because":[185],"estrogen,":[192],"does":[195],"necessarily":[197],"involve":[198],"modulation":[199],"negative":[201],"feedback.":[202]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":11},{"year":2013,"cited_by_count":12},{"year":2012,"cited_by_count":14}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
