{"id":"https://openalex.org/W1984022930","doi":"https://doi.org/10.1074/jbc.m111.325761","title":"Tra2\u03b2 Protein Is Required for Tissue-specific Splicing of a Smooth Muscle Myosin Phosphatase Targeting Subunit Alternative Exon","display_name":"Tra2\u03b2 Protein Is Required for Tissue-specific Splicing of a Smooth Muscle Myosin Phosphatase Targeting Subunit Alternative Exon","publication_year":2012,"publication_date":"2012-03-23","ids":{"openalex":"https://openalex.org/W1984022930","doi":"https://doi.org/10.1074/jbc.m111.325761","mag":"1984022930","pmid":"https://pubmed.ncbi.nlm.nih.gov/22437831","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3351297"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m111.325761","doi":"https://doi.org/10.1074/jbc.m111.325761","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m111.325761","pdf_url":"http://www.jbc.org/article/S0021925820607931/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.jbc.org/article/S0021925820607931/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063590142","display_name":"Kang Fu","orcid":"https://orcid.org/0000-0002-7324-911X","observed_orcids":["https://orcid.org/0000-0002-7324-911X"]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kang Fu","raw_affiliation_strings":["Department of Medicine (Cardiology), Case Western Reserve University, Cleveland, Ohio 44106, USA","Departments of Medicine (Cardiology), Case Western Reserve University, Cleveland, Ohio 44106"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine (Cardiology), Case Western Reserve University, Cleveland, Ohio 44106, USA","institution_ids":["https://openalex.org/I58956616"]},{"raw_affiliation_string":"Departments of Medicine (Cardiology), Case Western Reserve University, Cleveland, Ohio 44106","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088277230","display_name":"Ylva Mende","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ylva Mende","raw_affiliation_strings":["Institute of Human Genetics, Institute for Genetics and Center for Molecular Medicine Cologne, University of Cologne, Cologne 50931, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Human Genetics, Institute for Genetics and Center for Molecular Medicine Cologne, University of Cologne, Cologne 50931, Germany","institution_ids":["https://openalex.org/I180923762"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026115955","display_name":"Bhupal Prasad Bhetwal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I134113660","display_name":"University of Nevada, Reno","ror":"https://ror.org/01keh0577","country_code":"US","type":"education","lineage":["https://openalex.org/I134113660"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bhupal P. Bhetwal","raw_affiliation_strings":["Department of Physiology and Cell Biology, Center of Biomedical Research Excellence, University of Nevada School of Medicine, Reno, Nevada 89557"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Cell Biology, Center of Biomedical Research Excellence, University of Nevada School of Medicine, Reno, Nevada 89557","institution_ids":["https://openalex.org/I134113660"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000504171","display_name":"Salah A. Baker","orcid":"https://orcid.org/0000-0002-1514-6876","observed_orcids":["https://orcid.org/0000-0002-1514-6876"]},"institutions":[{"id":"https://openalex.org/I134113660","display_name":"University of Nevada, Reno","ror":"https://ror.org/01keh0577","country_code":"US","type":"education","lineage":["https://openalex.org/I134113660"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Salah Baker","raw_affiliation_strings":["Department of Physiology and Cell Biology, Center of Biomedical Research Excellence, University of Nevada School of Medicine, Reno, Nevada 89557"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Cell Biology, Center of Biomedical Research Excellence, University of Nevada School of Medicine, Reno, Nevada 89557","institution_ids":["https://openalex.org/I134113660"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030809745","display_name":"Brian A. Perrino","orcid":"https://orcid.org/0000-0001-7429-9971","observed_orcids":["https://orcid.org/0000-0001-7429-9971"]},"institutions":[{"id":"https://openalex.org/I134113660","display_name":"University of Nevada, Reno","ror":"https://ror.org/01keh0577","country_code":"US","type":"education","lineage":["https://openalex.org/I134113660"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian A. Perrino","raw_affiliation_strings":["Department of Physiology and Cell Biology, Center of Biomedical Research Excellence, University of Nevada School of Medicine, Reno, Nevada 89557"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Cell Biology, Center of Biomedical Research Excellence, University of Nevada School of Medicine, Reno, Nevada 89557","institution_ids":["https://openalex.org/I134113660"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051623556","display_name":"Brunhilde Wirth","orcid":"https://orcid.org/0000-0003-4051-5191","observed_orcids":["https://orcid.org/0000-0003-4051-5191"]},"institutions":[{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Brunhilde Wirth","raw_affiliation_strings":["Institute of Human Genetics, Institute for Genetics and Center for Molecular Medicine Cologne, University of Cologne, Cologne 50931, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Human Genetics, Institute for Genetics and Center for Molecular Medicine Cologne, University of Cologne, Cologne 50931, Germany","institution_ids":["https://openalex.org/I180923762"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037275495","display_name":"Steven A. Fisher","orcid":"https://orcid.org/0000-0002-8785-2227","observed_orcids":["https://orcid.org/0000-0002-8785-2227"]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Steven A. Fisher","raw_affiliation_strings":["Departments of Medicine (Cardiology), Case Western Reserve University, Cleveland, Ohio 44106","Physiology and Biophysics, Case Western Reserve University, Cleveland, Ohio 44106"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine (Cardiology), Case Western Reserve University, Cleveland, Ohio 44106","institution_ids":["https://openalex.org/I58956616"]},{"raw_affiliation_string":"Physiology and Biophysics, Case Western Reserve University, Cleveland, Ohio 44106","institution_ids":["https://openalex.org/I58956616"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5037275495"],"corresponding_institution_ids":["https://openalex.org/I58956616"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":1.2599,"has_fulltext":true,"cited_by_count":23,"citation_normalized_percentile":{"value":0.76841797,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"287","issue":"20","first_page":"16575","last_page":"16585"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12610","display_name":"RNA regulation and disease","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tra2beta","display_name":"Tra2\u03b2","score":0.9459999799728394},{"id":"https://openalex.org/keywords/mypt1","display_name":"MYPT1","score":0.671999990940094},{"id":"https://openalex.org/keywords/alternative-splicing","display_name":"alternative splicing","score":0.9210000038146973},{"id":"https://openalex.org/keywords/exon-23","display_name":"exon 23","score":0.7350000143051147},{"id":"https://openalex.org/keywords/smooth-muscle","display_name":"smooth muscle","score":0.8510000109672546},{"id":"https://openalex.org/keywords/intestinal-smooth-muscle","display_name":"intestinal smooth muscle","score":0.8159999847412109},{"id":"https://openalex.org/keywords/leucine-zipper","display_name":"leucine zipper","score":0.8410000205039978},{"id":"https://openalex.org/keywords/gene-dosage","display_name":"gene dosage","score":0.7429999709129333}],"concepts":[{"id":"https://openalex.org/C6997183","wikidata":"https://www.wikidata.org/wiki/Q271727","display_name":"Myosin","level":2,"score":0.7672897577285767},{"id":"https://openalex.org/C36823959","wikidata":"https://www.wikidata.org/wiki/Q373027","display_name":"Exon","level":3,"score":0.6915056705474854},{"id":"https://openalex.org/C194583182","wikidata":"https://www.wikidata.org/wiki/Q21114084","display_name":"Alternative splicing","level":4,"score":0.65873783826828},{"id":"https://openalex.org/C104292427","wikidata":"https://www.wikidata.org/wiki/Q899781","display_name":"Protein subunit","level":3,"score":0.5886309742927551},{"id":"https://openalex.org/C54458228","wikidata":"https://www.wikidata.org/wiki/Q237218","display_name":"RNA splicing","level":4,"score":0.4807164967060089},{"id":"https://openalex.org/C178666793","wikidata":"https://www.wikidata.org/wiki/Q422476","display_name":"Phosphatase","level":3,"score":0.4405096769332886},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.43600425124168396},{"id":"https://openalex.org/C74581901","wikidata":"https://www.wikidata.org/wiki/Q14876107","display_name":"MYH7","level":4,"score":0.4176502227783203},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.381169855594635},{"id":"https://openalex.org/C8035138","wikidata":"https://www.wikidata.org/wiki/Q6017854","display_name":"Myosin light-chain kinase","level":3,"score":0.36378350853919983},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.34368887543678284},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3361886739730835},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1307058334350586},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.11657342314720154},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.10811668634414673}],"mesh":[{"descriptor_ui":"D000068103","descriptor_name":"Serine-Arginine Splicing Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005091","descriptor_name":"Exons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006152","descriptor_name":"Cyclic GMP","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006152","descriptor_name":"Cyclic GMP","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009124","descriptor_name":"Muscle Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009124","descriptor_name":"Muscle Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009126","descriptor_name":"Muscle Relaxation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009219","descriptor_name":"Myosin-Light-Chain Kinase","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D009219","descriptor_name":"Myosin-Light-Chain Kinase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009928","descriptor_name":"Organ Specificity","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016601","descriptor_name":"RNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016601","descriptor_name":"RNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017398","descriptor_name":"Alternative Splicing","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D032389","descriptor_name":"Myocytes, Smooth Muscle","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D032389","descriptor_name":"Myocytes, Smooth Muscle","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D043263","descriptor_name":"Myosin-Light-Chain Phosphatase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1074/jbc.m111.325761","doi":"https://doi.org/10.1074/jbc.m111.325761","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m111.325761","pdf_url":"http://www.jbc.org/article/S0021925820607931/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2647753","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3351297","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:22437831","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22437831","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3351297","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3351297/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Biol Chem","raw_type":"Text"},{"id":"mag:2563758105","doi":null,"is_oa":false,"landing_page_url":"https://www.jbc.org/content/287/20/16575.full.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"doi:10.1074/jbc.m111.325761","doi":"https://doi.org/10.1074/jbc.m111.325761","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m111.325761","pdf_url":"http://www.jbc.org/article/S0021925820607931/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G3067874792","display_name":"Smooth Muscle Myosin Phosphatase Subunit Isoforms","funder_award_id":"R01HL066171","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G4887920218","display_name":null,"funder_award_id":"GM103513","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G8182721732","display_name":"Smooth Muscle Plasticity: A COBRE","funder_award_id":"P20GM103513","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1984022930.pdf","grobid_xml":"https://content.openalex.org/works/W1984022930.grobid-xml"},"referenced_works_count":49,"referenced_works":["https://openalex.org/W24300959","https://openalex.org/W53954117","https://openalex.org/W1946215568","https://openalex.org/W1965215719","https://openalex.org/W1970544179","https://openalex.org/W1975244725","https://openalex.org/W1988797182","https://openalex.org/W1994924520","https://openalex.org/W1998762151","https://openalex.org/W1999720081","https://openalex.org/W2000786552","https://openalex.org/W2003605043","https://openalex.org/W2005971493","https://openalex.org/W2014691356","https://openalex.org/W2020509735","https://openalex.org/W2023446937","https://openalex.org/W2024036230","https://openalex.org/W2028295033","https://openalex.org/W2038841716","https://openalex.org/W2043251964","https://openalex.org/W2045175368","https://openalex.org/W2045340640","https://openalex.org/W2046191115","https://openalex.org/W2055198152","https://openalex.org/W2057157392","https://openalex.org/W2061301971","https://openalex.org/W2068462080","https://openalex.org/W2076241630","https://openalex.org/W2085220858","https://openalex.org/W2089742414","https://openalex.org/W2105082030","https://openalex.org/W2106564957","https://openalex.org/W2107881958","https://openalex.org/W2109936378","https://openalex.org/W2131627985","https://openalex.org/W2136563400","https://openalex.org/W2137167283","https://openalex.org/W2139737134","https://openalex.org/W2140526178","https://openalex.org/W2140954307","https://openalex.org/W2143080261","https://openalex.org/W2143528835","https://openalex.org/W2143873927","https://openalex.org/W2153279694","https://openalex.org/W2160588382","https://openalex.org/W2162680756","https://openalex.org/W2168298132","https://openalex.org/W2187198777","https://openalex.org/W2344869320"],"related_works":["https://openalex.org/W3173981279","https://openalex.org/W2563758105","https://openalex.org/W1975984988","https://openalex.org/W7015711146","https://openalex.org/W114441871","https://openalex.org/W2143080261","https://openalex.org/W4210386251","https://openalex.org/W1964287231","https://openalex.org/W2187198777","https://openalex.org/W1978386292"],"abstract_inverted_index":{"Alternative":[0],"splicing":[1,45,60,75,220,234],"of":[2,27,42,49,56,151,173,199,206,221,235,241],"the":[3,25,47,68,79,95,114,121,138,169,184,191,200,203,218,225,233,239],"smooth":[4,28,90,116,154,171,228,242],"muscle":[5,29,91,117,155,172,201,243],"myosin":[6],"phosphatase":[7],"targeting":[8],"subunit":[9],"(Mypt1)":[10],"exon":[11],"23":[12],"(E23)":[13],"is":[14,108,131,215],"tissue-specific":[15,40,219],"and":[16,53,72,100,123],"developmentally":[17],"regulated":[18],"and,":[19],"thus,":[20],"an":[21],"attractive":[22],"model":[23],"for":[24,190,217],"study":[26,65],"phenotypic":[30],"specification.":[31],"We":[32,211],"have":[33],"proposed":[34],"that":[35,213],"Tra2\u03b2":[36,54,71,81,134,152,178,214],"functions":[37],"as":[38,94,111,120],"a":[39,144,160],"activator":[41],"Mypt1":[43,57,73,106,129,147,164,185,222,236],"E23":[44,58,74,107,130,148,165,186,223],"on":[46],"basis":[48],"concordant":[50,142],"expression":[51],"patterns":[52],"activation":[55],"mini-gene":[59],"in":[61,76,78,88,104,127,137,153,163,168,224],"vitro.":[62],"In":[63],"this":[64],"we":[66],"examined":[67],"relationship":[69],"between":[70],"vivo":[77],"mouse.":[80],"was":[82,135],"2-":[83],"to":[84,146,177,183,202,244],"5-fold":[85],"more":[86],"abundant":[87],"phasic":[89,226],"tissues,":[92,118],"such":[93,119],"portal":[96],"vein,":[97],"small":[98,101,139],"intestine,":[99],"mesenteric":[102],"artery,":[103],"which":[105,128],"predominately":[109,132],"included":[110],"compared":[112],"with":[113,143],"tonic":[115],"aorta":[122],"inferior":[124],"vena":[125],"cava,":[126],"skipped.":[133],"up-regulated":[136],"intestine":[140],"postnatally,":[141],"switch":[145,182],"splicing.":[149],"Targeting":[150],"cells":[156],"using":[157],"SM22\u03b1-Cre":[158],"caused":[159,196],"substantial":[161],"reduction":[162],"inclusion":[166],"specifically":[167],"intestinal":[170,227],"heterozygotes,":[174],"indicating":[175],"sensitivity":[176,198,240],"gene":[179],"dosage.":[180],"The":[181],"skipped":[187],"isoform":[188],"coding":[189],"C-terminal":[192],"leucine":[193],"zipper":[194],"motif":[195],"increased":[197],"relaxant":[204],"effects":[205],"8-Br-cyclic":[207],"guanosine":[208],"monophosphate":[209],"(cGMP).":[210],"conclude":[212],"necessary":[216],"muscle.":[229],"Tra2\u03b2,":[230],"by":[231],"regulating":[232],"E23,":[237],"sets":[238],"cGMP-mediated":[245],"relaxation.":[246]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":4}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2016-06-24T00:00:00"}