{"id":"https://openalex.org/W1983998889","doi":"https://doi.org/10.4103/2008-322x.150829","title":"Nutrient supplementation for age-related macular degeneration, cataract, and dry eye","display_name":"Nutrient supplementation for age-related macular degeneration, cataract, and dry eye","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W1983998889","doi":"https://doi.org/10.4103/2008-322x.150829","mag":"1983998889","pmid":"https://pubmed.ncbi.nlm.nih.gov/25709776","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4329711"},"language":"en","primary_location":{"id":"doi:10.4103/2008-322x.150829","doi":"https://doi.org/10.4103/2008-322x.150829","is_oa":true,"landing_page_url":"https://doi.org/10.4103/2008-322x.150829","pdf_url":null,"source":{"id":"https://openalex.org/S2764519907","display_name":"Journal of Ophthalmic and Vision Research","issn_l":"2008-2010","issn":["2008-2010","2008-322X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319396","host_organization_name":"Knowledge E","host_organization_lineage":["https://openalex.org/P4310319396"],"host_organization_lineage_names":["Knowledge E"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Ophthalmic and Vision Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.4103/2008-322x.150829","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021661809","display_name":"Paul S. Bernstein","orcid":"https://orcid.org/0000-0002-4228-7666","observed_orcids":["https://orcid.org/0000-0002-4228-7666"]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"PaulS Bernstein","raw_affiliation_strings":["Department of Ophthalmology and Visual Sciences, Moran Eye Center, University of Utah, Salt Lake City, Utah, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology and Visual Sciences, Moran Eye Center, University of Utah, Salt Lake City, Utah, USA","institution_ids":["https://openalex.org/I223532165"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111468682","display_name":"Ronald Hobbs","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"RonaldP Hobbs","raw_affiliation_strings":["Department of Ophthalmology and Visual Sciences, Moran Eye Center, University of Utah, Salt Lake City, Utah, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology and Visual Sciences, Moran Eye Center, University of Utah, Salt Lake City, Utah, USA","institution_ids":["https://openalex.org/I223532165"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5021661809"],"corresponding_institution_ids":["https://openalex.org/I223532165"],"apc_list":{"value":200,"currency":"USD","value_usd":200},"apc_paid":{"value":200,"currency":"USD","value_usd":200},"fwci":3.7397,"has_fulltext":false,"cited_by_count":44,"citation_normalized_percentile":{"value":0.92011346,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"9","issue":"4","first_page":"487","last_page":"487"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13112","display_name":"Nutrition and Health Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/age-related-macular-degeneration","display_name":"age-related macular degeneration","score":0.9819999933242798},{"id":"https://openalex.org/keywords/cataract","display_name":"cataract","score":0.9890000224113464},{"id":"https://openalex.org/keywords/dry-eye-disease","display_name":"dry eye","score":0.9240000247955322},{"id":"https://openalex.org/keywords/dietary-supplements","display_name":"dietary supplements","score":0.6919999718666077},{"id":"https://openalex.org/keywords/areds2","display_name":"AREDS2","score":0.8669999837875366},{"id":"https://openalex.org/keywords/lutein","display_name":"lutein","score":0.9850000143051147},{"id":"https://openalex.org/keywords/zeaxanthin","display_name":"zeaxanthin","score":1.0},{"id":"https://openalex.org/keywords/beta-carotene","display_name":"beta-carotene","score":0.9449999928474426},{"id":"https://openalex.org/keywords/omega-3-fatty-acids","display_name":"omega-3 fatty acids","score":0.9959999918937683},{"id":"https://openalex.org/keywords/amd-prevention","display_name":"AMD prevention","score":0.6430000066757202}],"concepts":[{"id":"https://openalex.org/C2776403814","wikidata":"https://www.wikidata.org/wiki/Q27429789","display_name":"Macular degeneration","level":2,"score":0.9499326944351196},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.91970294713974},{"id":"https://openalex.org/C2776099141","wikidata":"https://www.wikidata.org/wiki/Q169337","display_name":"Zeaxanthin","level":4,"score":0.8256251811981201},{"id":"https://openalex.org/C2778411929","wikidata":"https://www.wikidata.org/wiki/Q422067","display_name":"Lutein","level":3,"score":0.7181153297424316},{"id":"https://openalex.org/C2780225610","wikidata":"https://www.wikidata.org/wiki/Q127724","display_name":"Cataracts","level":2,"score":0.6193262338638306},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.43700116872787476},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.42690175771713257},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3266667127609253},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1829388439655304},{"id":"https://openalex.org/C28781525","wikidata":"https://www.wikidata.org/wiki/Q191907","display_name":"Carotenoid","level":2,"score":0.16320815682411194},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.11223047971725464},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0}],"mesh":[],"locations_count":6,"locations":[{"id":"doi:10.4103/2008-322x.150829","doi":"https://doi.org/10.4103/2008-322x.150829","is_oa":true,"landing_page_url":"https://doi.org/10.4103/2008-322x.150829","pdf_url":null,"source":{"id":"https://openalex.org/S2764519907","display_name":"Journal of Ophthalmic and Vision Research","issn_l":"2008-2010","issn":["2008-2010","2008-322X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319396","host_organization_name":"Knowledge E","host_organization_lineage":["https://openalex.org/P4310319396"],"host_organization_lineage_names":["Knowledge E"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Ophthalmic and Vision Research","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3301085","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4329711","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4329711","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4329711","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Ophthalmic Vis Res","raw_type":"Text"},{"id":"pmid:25709776","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25709776","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of ophthalmic & vision research","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:60a70e985d164a91af0dccc3d2928ca1","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/60a70e985d164a91af0dccc3d2928ca1","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Ophthalmic & Vision Research, Vol 9, Iss 4, Pp 487-493 (2014)","raw_type":"article"},{"id":"mag:2554303878","doi":null,"is_oa":false,"landing_page_url":"http://www.sid.ir/en/VEWSSID/J_pdf/118320150414.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"doi:10.4103/2008-322x.150829","doi":"https://doi.org/10.4103/2008-322x.150829","is_oa":true,"landing_page_url":"https://doi.org/10.4103/2008-322x.150829","pdf_url":null,"source":{"id":"https://openalex.org/S2764519907","display_name":"Journal of Ophthalmic and Vision Research","issn_l":"2008-2010","issn":["2008-2010","2008-322X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319396","host_organization_name":"Knowledge E","host_organization_lineage":["https://openalex.org/P4310319396"],"host_organization_lineage_names":["Knowledge E"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Ophthalmic and Vision Research","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9907000064849854,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7026095150","display_name":"BIOCHEMISTRY AND PHARMACOLOGY OF THE MACULAR CAROTENOIDS","funder_award_id":"R29EY011600","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G9000888392","display_name":"Biochemistry and Pharmacology of the Macular Carotenoids","funder_award_id":"R01EY011600","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"}],"funders":[{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":62,"referenced_works":["https://openalex.org/W46518765","https://openalex.org/W78314616","https://openalex.org/W90671621","https://openalex.org/W95909858","https://openalex.org/W167611758","https://openalex.org/W187461181","https://openalex.org/W201137484","https://openalex.org/W1544641566","https://openalex.org/W1560566950","https://openalex.org/W1576657234","https://openalex.org/W1603583995","https://openalex.org/W1882802735","https://openalex.org/W1949401286","https://openalex.org/W1966039186","https://openalex.org/W1973499965","https://openalex.org/W1973676412","https://openalex.org/W1976479568","https://openalex.org/W1991167891","https://openalex.org/W1991728641","https://openalex.org/W1996763041","https://openalex.org/W1996938622","https://openalex.org/W2007111898","https://openalex.org/W2016246837","https://openalex.org/W2019705371","https://openalex.org/W2024054650","https://openalex.org/W2031353914","https://openalex.org/W2034865775","https://openalex.org/W2035310463","https://openalex.org/W2044127304","https://openalex.org/W2057101455","https://openalex.org/W2060401007","https://openalex.org/W2064170412","https://openalex.org/W2064183377","https://openalex.org/W2078614826","https://openalex.org/W2088119156","https://openalex.org/W2089822043","https://openalex.org/W2092388050","https://openalex.org/W2095472567","https://openalex.org/W2103525707","https://openalex.org/W2108581685","https://openalex.org/W2117396891","https://openalex.org/W2121383837","https://openalex.org/W2122414444","https://openalex.org/W2122539248","https://openalex.org/W2127748405","https://openalex.org/W2129528814","https://openalex.org/W2132378522","https://openalex.org/W2140068099","https://openalex.org/W2144839999","https://openalex.org/W2147370249","https://openalex.org/W2151687122","https://openalex.org/W2152617705","https://openalex.org/W2154992699","https://openalex.org/W2163174380","https://openalex.org/W2163721731","https://openalex.org/W2167535056","https://openalex.org/W2167601697","https://openalex.org/W2327515496","https://openalex.org/W2419255724","https://openalex.org/W2569177514","https://openalex.org/W2598520882","https://openalex.org/W4238940178"],"related_works":["https://openalex.org/W2125880559","https://openalex.org/W1727801201","https://openalex.org/W7154492801","https://openalex.org/W2228317445","https://openalex.org/W2576430281","https://openalex.org/W2152418427","https://openalex.org/W3087479891","https://openalex.org/W2014260894","https://openalex.org/W2568609612","https://openalex.org/W4415261108"],"abstract_inverted_index":{"There":[0],"have":[1,57],"been":[2,148],"enormous":[3],"advances":[4],"in":[5,45],"the":[6,10,35,49,79,88,103,113,116,140,154],"past":[7],"decade":[8],"for":[9,75,112],"treatment":[11,74],"of":[12,51,105,115,122,139,144,156],"age-related":[13,89],"macular":[14],"degeneration":[15],"(AMD);":[16],"however,":[17],"these":[18],"treatments":[19],"are":[20],"expensive":[21],"and":[22,26,38,67,83,98,107,159,165],"require":[23],"frequent":[24],"follow-up":[25],"injections":[27],"which":[28],"place":[29],"a":[30,62,71,110],"tremendous":[31],"burden":[32],"on":[33,162],"both":[34],"healthcare":[36],"system":[37],"patients.":[39],"Consequently,":[40],"there":[41],"remains":[42],"considerable":[43],"interest":[44],"preventing":[46],"or":[47],"slowing":[48],"progression":[50],"AMD":[52,64,76],"requiring":[53],"treatment.":[54],"Epidemiological":[55],"studies":[56,152],"shown":[58],"that":[59,146],"diet":[60],"is":[61,70],"modifiable":[63],"risk":[65],"factor,":[66],"nutrient":[68],"modification":[69],"particularly":[72],"appealing":[73],"due":[77],"to":[78,136],"perceived":[80],"universal":[81],"benefit":[82,101],"relatively":[84],"low":[85],"expense.":[86],"Recently,":[87],"eye":[90],"disease":[91],"study":[92],"part":[93],"two":[94],"(AREDS2)":[95],"was":[96],"concluded":[97],"demonstrated":[99],"further":[100],"with":[102],"addition":[104,121],"lutein":[106],"zeaxanthin":[108],"as":[109],"replacement":[111],"\u03b2-carotene":[114],"previous":[117],"generation":[118],"formulation.":[119],"The":[120],"omega-3":[123],"essential":[124],"fatty":[125],"acids":[126],"did":[127],"not":[128],"show":[129],"an":[130],"added":[131],"benefit.":[132],"This":[133],"review":[134],"aims":[135],"highlight":[137],"some":[138],"evidenced":[141],"based":[142],"body":[143],"knowledge":[145],"has":[147],"accumulated":[149],"from":[150],"recent":[151],"regarding":[153],"use":[155],"nutritional":[157],"supplements":[158],"their":[160],"effect":[161],"AMD,":[163],"cataracts,":[164],"dry":[166],"eyes.":[167]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}