{"id":"https://openalex.org/W1983990055","doi":"https://doi.org/10.1161/01.res.36.6.2","title":"Evidence for a new mineralocorticoid in patients with low-renin essential hypertension.","display_name":"Evidence for a new mineralocorticoid in patients with low-renin essential hypertension.","publication_year":1975,"publication_date":"1975-06-01","ids":{"openalex":"https://openalex.org/W1983990055","doi":"https://doi.org/10.1161/01.res.36.6.2","mag":"1983990055","pmid":"https://pubmed.ncbi.nlm.nih.gov/124232"},"language":"en","primary_location":{"id":"doi:10.1161/01.res.36.6.2","doi":"https://doi.org/10.1161/01.res.36.6.2","is_oa":false,"landing_page_url":"https://doi.org/10.1161/01.res.36.6.2","pdf_url":null,"source":{"id":"https://openalex.org/S10652568","display_name":"Circulation Research","issn_l":"0009-7330","issn":["0009-7330","1524-4571"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042553714","display_name":"Jordan A. Sennett","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J A Sennett","raw_affiliation_strings":["J A Sennett"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"J A Sennett","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049372867","display_name":"Rebecca D. Brown","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R D Brown","raw_affiliation_strings":["R D Brown"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"R D Brown","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038930699","display_name":"Donald P. Island","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D P Island","raw_affiliation_strings":["D P Island"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"D P Island","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046262988","display_name":"L R Yarbro","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L R Yarbro","raw_affiliation_strings":["L R Yarbro"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"L R Yarbro","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109856555","display_name":"Jack Throck Watson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J T Watson","raw_affiliation_strings":["J T Watson"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"J T Watson","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073833679","display_name":"Paul E. Slaton","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P E Slaton","raw_affiliation_strings":["P E Slaton"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"P E Slaton","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031082491","display_name":"John W. Hollifield","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J W Hollifield","raw_affiliation_strings":["J W Hollifield"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"J W Hollifield","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020708932","display_name":"G. W. Liddle","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G W Liddle","raw_affiliation_strings":["G W Liddle"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"G W Liddle","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":10.9432,"has_fulltext":false,"cited_by_count":56,"citation_normalized_percentile":{"value":0.98747848,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":null,"biblio":{"volume":"36","issue":"6","first_page":"2","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11839","display_name":"Hormonal Regulation and Hypertension","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11839","display_name":"Hormonal Regulation and Hypertension","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/low-renin-hypertension","display_name":"low-renin hypertension","score":0.9440000057220459},{"id":"https://openalex.org/keywords/mineralocorticoid-activity","display_name":"mineralocorticoid activity","score":0.8009999990463257},{"id":"https://openalex.org/keywords/aldosterone","display_name":"aldosterone","score":0.718999981880188},{"id":"https://openalex.org/keywords/spironolactone","display_name":"spironolactone","score":0.9110000133514404},{"id":"https://openalex.org/keywords/mineralocorticoid-receptor-antagonists","display_name":"mineralocorticoid receptor antagonists","score":0.7289999723434448}],"concepts":[{"id":"https://openalex.org/C2776069600","wikidata":"https://www.wikidata.org/wiki/Q422519","display_name":"Mineralocorticoid","level":3,"score":0.8363653421401978},{"id":"https://openalex.org/C2776379505","wikidata":"https://www.wikidata.org/wiki/Q422188","display_name":"Spironolactone","level":3,"score":0.8173631429672241},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7661480903625488},{"id":"https://openalex.org/C2777097880","wikidata":"https://www.wikidata.org/wiki/Q988405","display_name":"Essential hypertension","level":3,"score":0.7599032521247864},{"id":"https://openalex.org/C2778525890","wikidata":"https://www.wikidata.org/wiki/Q184564","display_name":"Aldosterone","level":2,"score":0.7194028496742249},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7095822691917419},{"id":"https://openalex.org/C189135053","wikidata":"https://www.wikidata.org/wiki/Q3454531","display_name":"Mineralocorticoid receptor","level":3,"score":0.6015464663505554},{"id":"https://openalex.org/C198710026","wikidata":"https://www.wikidata.org/wiki/Q898218","display_name":"Renin\u2013angiotensin system","level":3,"score":0.5778084993362427},{"id":"https://openalex.org/C138976137","wikidata":"https://www.wikidata.org/wiki/Q7201790","display_name":"Plasma renin activity","level":4,"score":0.5593112111091614},{"id":"https://openalex.org/C2780026642","wikidata":"https://www.wikidata.org/wiki/Q40924","display_name":"Urine","level":2,"score":0.5565923452377319},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4818483591079712},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.434762179851532},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.23080512881278992}],"mesh":[{"descriptor_ui":"D000315","descriptor_name":"Adrenalectomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000450","descriptor_name":"Aldosterone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001681","descriptor_name":"Biological Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002849","descriptor_name":"Chromatography, Gas","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003345","descriptor_name":"Corticosterone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003348","descriptor_name":"Cortisone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003687","descriptor_name":"Dehydroepiandrosterone","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D003687","descriptor_name":"Dehydroepiandrosterone","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D003687","descriptor_name":"Dehydroepiandrosterone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003900","descriptor_name":"Desoxycorticosterone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006914","descriptor_name":"Hydroxysteroids","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D006914","descriptor_name":"Hydroxysteroids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011863","descriptor_name":"Radioimmunoassay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012083","descriptor_name":"Renin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D013058","descriptor_name":"Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1161/01.res.36.6.2","doi":"https://doi.org/10.1161/01.res.36.6.2","is_oa":false,"landing_page_url":"https://doi.org/10.1161/01.res.36.6.2","pdf_url":null,"source":{"id":"https://openalex.org/S10652568","display_name":"Circulation Research","issn_l":"0009-7330","issn":["0009-7330","1524-4571"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation Research","raw_type":"journal-article"},{"id":"pmid:124232","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/124232","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2001169709","https://openalex.org/W2061030938","https://openalex.org/W283969148","https://openalex.org/W2016668290","https://openalex.org/W7118066269","https://openalex.org/W2040793821","https://openalex.org/W2408581592","https://openalex.org/W2097590236","https://openalex.org/W4245593769","https://openalex.org/W1965458074"],"abstract_inverted_index":{"Patients":[0],"with":[1,9,41,151],"low-renin":[2,22,42,152],"essential":[3,23,43,153],"hypertension":[4,24,44],"have":[5,97],"certain":[6],"features":[7],"consistent":[8],"excessive":[10],"mineralocorticoid":[11,28,48,78,99,110,129],"activity.":[12],"Because":[13],"known":[14,67],"mineralocorticoids":[15,68],"are":[16],"normal":[17],"in":[18,31,50,69,105,123,141,149],"the":[19,32,66,70,76,106,114,118,124,142],"majority":[20],"of":[21,34,103,112],"patients,":[25],"an":[26],"unknown":[27],"was":[29,80,94,136,144],"sought":[30],"urine":[33,115,143],"such":[35,58],"patients.":[36],"Urine":[37],"extracts":[38,116],"from":[39],"patients":[40,150],"were":[45,121],"assayed":[46],"for":[47,64,75,134],"activity":[49,59,79],"adrenalectomized":[51],"rats":[52],"and":[53,82,117,138],"found":[54,95,145],"to":[55,96,146],"contain":[56],"more":[57],"than":[60],"could":[61],"be":[62,147],"accounted":[63],"by":[65,85,126],"extracts.":[71],"The":[72,109],"factor":[73],"responsible":[74],"unexplained":[77],"purfied":[81],"then":[83],"identified":[84],"mass":[86],"spectral":[87],"analysis":[88],"as":[89],"16beta-hydroxydehydroepiandrosterone":[90],"(16beta-OH-DHEA).":[91],"Synthetic":[92],"16beta-OH-DHEA":[93,135],"a":[98,128],"potency":[100],"one-fortieth":[101],"that":[102],"aldosterone":[104],"rat":[107,125],"bioassay.":[108],"effects":[111],"both":[113],"synthetic":[119],"steroid":[120],"blocked":[122],"spironolactone,":[127],"antagonist.":[130],"A":[131],"specific":[132],"assay":[133],"developed,":[137],"its":[139],"level":[140],"elevated":[148],"hypertension.":[154]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}