{"id":"https://openalex.org/W1983989752","doi":"https://doi.org/10.1213/ane.0b013e31826f0637","title":"First Evidence of a Polygenic Susceptibility to Pain in a Pediatric Cohort","display_name":"First Evidence of a Polygenic Susceptibility to Pain in a Pediatric Cohort","publication_year":2012,"publication_date":"2012-12-07","ids":{"openalex":"https://openalex.org/W1983989752","doi":"https://doi.org/10.1213/ane.0b013e31826f0637","mag":"1983989752","pmid":"https://pubmed.ncbi.nlm.nih.gov/23223113"},"language":"en","primary_location":{"id":"doi:10.1213/ane.0b013e31826f0637","doi":"https://doi.org/10.1213/ane.0b013e31826f0637","is_oa":false,"landing_page_url":"https://doi.org/10.1213/ane.0b013e31826f0637","pdf_url":null,"source":{"id":"https://openalex.org/S104698359","display_name":"Anesthesia & Analgesia","issn_l":"0003-2999","issn":["0003-2999","1526-7598"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesia &amp; Analgesia","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://archive-ouverte.unige.ch/unige:35220","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108400676","display_name":"Chantal Mamie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210106256","display_name":"University Hospital of Geneva","ror":"https://ror.org/01m1pv723","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210106256"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Chantal Mamie","raw_affiliation_strings":["Unit of Pediatric Anesthesiology, Division of Anesthesiology, Department of Anesthesiology, Pharmacology and Intensive Care, Geneva University Hospitals, Geneva, Switzerland. chantal.mamie@hcuge.ch","Unit of Pediatric Anesthesiology, Division of Anesthesiology, Department of Anesthesiology, Pharmacology and Intensive Care, Geneva University Hospitals"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unit of Pediatric Anesthesiology, Division of Anesthesiology, Department of Anesthesiology, Pharmacology and Intensive Care, Geneva University Hospitals, Geneva, Switzerland. chantal.mamie@hcuge.ch","institution_ids":["https://openalex.org/I4210106256"]},{"raw_affiliation_string":"Unit of Pediatric Anesthesiology, Division of Anesthesiology, Department of Anesthesiology, Pharmacology and Intensive Care, Geneva University Hospitals","institution_ids":["https://openalex.org/I4210106256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113705050","display_name":"Michela C. Rebsamen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210106256","display_name":"University Hospital of Geneva","ror":"https://ror.org/01m1pv723","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210106256"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Michela C. Rebsamen","raw_affiliation_strings":["Laboratory of Toxicogenetics, Service of Laboratory Medicine, Geneva University Hospitals"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Toxicogenetics, Service of Laboratory Medicine, Geneva University Hospitals","institution_ids":["https://openalex.org/I4210106256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060966201","display_name":"Michael A. Morris","orcid":"https://orcid.org/0000-0002-9660-505X","observed_orcids":["https://orcid.org/0000-0002-9660-505X"]},"institutions":[{"id":"https://openalex.org/I4210106256","display_name":"University Hospital of Geneva","ror":"https://ror.org/01m1pv723","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210106256"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Michael A. Morris","raw_affiliation_strings":["Molecular Diagnostic Laboratory, Service of Genetic Medicine, Geneva University Hospitals","Molecular Diagnostic Laboratory, Service of Genetic Medicine, Geneva University Hospitals; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Diagnostic Laboratory, Service of Genetic Medicine, Geneva University Hospitals","institution_ids":["https://openalex.org/I4210106256"]},{"raw_affiliation_string":"Molecular Diagnostic Laboratory, Service of Genetic Medicine, Geneva University Hospitals; and","institution_ids":["https://openalex.org/I4210106256"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017595492","display_name":"Alfredo Morabia","orcid":"https://orcid.org/0000-0002-1902-0285","observed_orcids":["https://orcid.org/0000-0002-1902-0285"]},"institutions":[{"id":"https://openalex.org/I4210106256","display_name":"University Hospital of Geneva","ror":"https://ror.org/01m1pv723","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210106256"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Alfredo Morabia","raw_affiliation_strings":["Division of Clinical Epidemiology, Department of Community Medicine, Geneva University Hospitals, Geneva, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Clinical Epidemiology, Department of Community Medicine, Geneva University Hospitals, Geneva, Switzerland","institution_ids":["https://openalex.org/I4210106256"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5108400676"],"corresponding_institution_ids":["https://openalex.org/I4210106256"],"apc_list":null,"apc_paid":null,"fwci":5.0489,"has_fulltext":false,"cited_by_count":44,"citation_normalized_percentile":{"value":0.95375345,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"116","issue":"1","first_page":"170","last_page":"177"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11292","display_name":"Pediatric Pain Management Techniques","score":0.7695000171661377,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11292","display_name":"Pediatric Pain Management Techniques","score":0.7695000171661377,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10189","display_name":"Anesthesia and Pain Management","score":0.06790000200271606,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.057999998331069946,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/postoperative-pain","display_name":"postoperative pain","score":0.9570000171661377},{"id":"https://openalex.org/keywords/pediatric-pain","display_name":"pediatric pain","score":0.8019999861717224},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.8059999942779541},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphisms","display_name":"single nucleotide polymorphisms","score":0.859000027179718},{"id":"https://openalex.org/keywords/p-glycoprotein","display_name":"P-glycoprotein","score":0.7760000228881836},{"id":"https://openalex.org/keywords/oprm1","display_name":"OPRM1","score":0.7649999856948853},{"id":"https://openalex.org/keywords/catechol-o-methyltransferase","display_name":"catechol-O-methyltransferase","score":0.8050000071525574},{"id":"https://openalex.org/keywords/ntrk1","display_name":"NTRK1","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cyp2d6","display_name":"CYP2D6","score":0.8289999961853027},{"id":"https://openalex.org/keywords/nociception","display_name":"nociception","score":0.8679999709129333},{"id":"https://openalex.org/keywords/orthopedic-surgery","display_name":"orthopedic surgery","score":0.9269999861717224},{"id":"https://openalex.org/keywords/abdominal-surgery","display_name":"abdominal surgery","score":0.9599999785423279},{"id":"https://openalex.org/keywords/pain-variability","display_name":"pain variability","score":0.6779999732971191}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9623284339904785},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.6358838081359863},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.4692889153957367},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.32565081119537354},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.22741958498954773},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000077208","descriptor_name":"Remifentanil","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000698","descriptor_name":"Analgesia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000701","descriptor_name":"Analgesics, Opioid","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000701","descriptor_name":"Analgesics, Opioid","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000768","descriptor_name":"Anesthesia, General","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008137","descriptor_name":"Longitudinal Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009020","descriptor_name":"Morphine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D009020","descriptor_name":"Morphine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010147","descriptor_name":"Pain Measurement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010149","descriptor_name":"Postoperative Pain","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D010149","descriptor_name":"Postoperative Pain","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D010880","descriptor_name":"Piperidines","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D010880","descriptor_name":"Piperidines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013557","descriptor_name":"Switzerland","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016058","descriptor_name":"Analgesia, Patient-Controlled","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017409","descriptor_name":"Sufentanil","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D017409","descriptor_name":"Sufentanil","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1213/ane.0b013e31826f0637","doi":"https://doi.org/10.1213/ane.0b013e31826f0637","is_oa":false,"landing_page_url":"https://doi.org/10.1213/ane.0b013e31826f0637","pdf_url":null,"source":{"id":"https://openalex.org/S104698359","display_name":"Anesthesia & Analgesia","issn_l":"0003-2999","issn":["0003-2999","1526-7598"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesia &amp; Analgesia","raw_type":"journal-article"},{"id":"pmid:23223113","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23223113","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesia and analgesia","raw_type":"Journal Article"},{"id":"pmh:oai:unige.ch:unige:35220","doi":null,"is_oa":false,"landing_page_url":"https://archive-ouverte.unige.ch/unige:35220","pdf_url":null,"source":{"id":"https://openalex.org/S4306402259","display_name":"Archive ouverte UNIGE (University of Geneva)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114457229","host_organization_name":"University of Geneva","host_organization_lineage":["https://openalex.org/I114457229"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ISSN: 0003-2999","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:unige.ch:aou:unige:35220","doi":null,"is_oa":true,"landing_page_url":"https://archive-ouverte.unige.ch/unige:35220","pdf_url":null,"source":{"id":"https://openalex.org/S4306402259","display_name":"Archive ouverte UNIGE (University of Geneva)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114457229","host_organization_name":"University of Geneva","host_organization_lineage":["https://openalex.org/I114457229"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN: 0003-2999","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:unige.ch:aou:unige:35220","doi":null,"is_oa":true,"landing_page_url":"https://archive-ouverte.unige.ch/unige:35220","pdf_url":null,"source":{"id":"https://openalex.org/S4306402259","display_name":"Archive ouverte UNIGE (University of Geneva)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114457229","host_organization_name":"University of Geneva","host_organization_lineage":["https://openalex.org/I114457229"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN: 0003-2999","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W1518096905","https://openalex.org/W1971361580","https://openalex.org/W1973128804","https://openalex.org/W1978286026","https://openalex.org/W1983877031","https://openalex.org/W1984486655","https://openalex.org/W1988859776","https://openalex.org/W2005886529","https://openalex.org/W2006582768","https://openalex.org/W2014405410","https://openalex.org/W2016124588","https://openalex.org/W2018655119","https://openalex.org/W2019990849","https://openalex.org/W2029226355","https://openalex.org/W2031305766","https://openalex.org/W2043709120","https://openalex.org/W2065775206","https://openalex.org/W2070976511","https://openalex.org/W2080822069","https://openalex.org/W2081577644","https://openalex.org/W2083655489","https://openalex.org/W2088453708","https://openalex.org/W2091853774","https://openalex.org/W2099953867","https://openalex.org/W2123508236","https://openalex.org/W2138984037","https://openalex.org/W2139898757","https://openalex.org/W2141630515","https://openalex.org/W2142884223","https://openalex.org/W2149174813","https://openalex.org/W2150169545","https://openalex.org/W2163636362","https://openalex.org/W2169118158","https://openalex.org/W4240576419"],"related_works":["https://openalex.org/W2290456508","https://openalex.org/W7099300341","https://openalex.org/W7204857554","https://openalex.org/W2911558762","https://openalex.org/W4391363410","https://openalex.org/W2107955043","https://openalex.org/W4388971256","https://openalex.org/W1972634488","https://openalex.org/W4353016741","https://openalex.org/W2469838569"],"abstract_inverted_index":{"BACKGROUND:":[0],"There":[1],"is":[2],"currently":[3],"no":[4],"evidence":[5],"about":[6],"the":[7,71,84,179,255],"genetic":[8,256],"bases":[9],"of":[10,22,64,105,258],"postoperative":[11,87,181],"pain":[12,67,103,233],"variability":[13],"in":[14,51,109,115,120,145],"children.":[15],"METHODS:":[16],"We":[17],"prospectively":[18],"followed":[19],"a":[20,62,94],"cohort":[21,248],"168":[23],"children":[24,37,116,121,146],"after":[25],"orthopedic":[26],"or":[27,199],"abdominal":[28],"surgery,":[29],"who":[30],"were":[31,41,183],"under":[32],"morphine":[33],"patient-controlled":[34],"analgesia.":[35],"The":[36],"and":[38,53,61,78,92,124,141,170,210,216,225,237],"their":[39],"parents":[40],"genotyped":[42],"for":[43,137,166,172,185,188,196,212],"6":[44],"candidate-gene":[45],"polymorphisms":[46,48],"(single-nucleotide":[47],"[SNPs])":[49],"implicated":[50],"nociception":[52],"opiate":[54],"metabolism:":[55],"ABCB1C3435T,":[56],"COMTVal158Met,":[57],"NTRK1His40Tyr,":[58],"OPRMA118G,":[59],"POMCArg236Gln,":[60],"haplotype":[63],"CYP2D6.":[65],"Postoperative":[66],"was":[68,112,142],"assessed":[69],"using":[70],"Faces":[72],"Pain":[73],"Scale":[74],"(FPS),":[75],"at":[76,97,100,190],"rest":[77,191],"during":[79,83,205,218],"mobilization,":[80,98],"11":[81],"times":[82],"first":[85,245],"24":[86,110,180],"hours.":[88],"RESULTS:":[89],"At":[90],"rest,":[91],"to":[93,241,252],"lesser":[95],"extent,":[96],"having":[99],"least":[101],"4":[102],"peaks":[104],"FPS":[106,176],"score":[107],">6":[108],"hours":[111,182],"more":[113,143],"frequent":[114,144],"with":[117,122,147,151,230],"ABCB1_CC":[118],"than":[119,149,187,202,214],"ABCB1_CT":[123],"ABCB1_TT":[125],"(adjusted":[126,153],"risk":[127,154],"ratio":[128,155],"=":[129,156,208,221],"4.5;":[130],"95%":[131,158],"confidence":[132],"interval":[133],"[CI],1.5-13.4;":[134],"corrected":[135,161],"CI":[136],"multiple":[138,173],"comparisons,":[139,174],"0.98-20.55)":[140],"OPRM_GA":[148,186],"those":[150],"OPRM_AA":[152,189],"3.5;":[157],"CI,":[159,162],"1.1-11.2;":[160],"0.70-17.30).":[163],"After":[164],"adjusting":[165],"parental":[167],"mating":[168],"type":[169],"correcting":[171],"mean":[175],"scores":[177],"across":[178],"higher":[184,195],"(P":[192,207,220],"<":[193],"0.0002),":[194],"NTRK1_":[197,200,203],"CT":[198],"TT":[201],"CC":[204],"mobilization":[206,219],"0.002),":[209],"lower":[211],"COMT_GG":[213],"COMT_AA":[215],"COMT_GA,":[217],"0.005).":[222],"CONCLUSIONS:":[223],"ABCB1":[224],"OPRM":[226],"genotypes":[227],"are":[228,239],"associated":[229],"clinically":[231],"meaningful":[232],"variability,":[234],"whereas":[235],"NTRK1":[236],"COMT":[238],"linked":[240],"subclinical":[242],"effects.":[243],"This":[244],"but":[246],"small":[247],"study":[249],"provides":[250],"clues":[251],"further":[253],"explore":[254],"foundations":[257],"pediatric":[259],"pain.":[260]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}