{"id":"https://openalex.org/W1983808867","doi":"https://doi.org/10.1074/jbc.m309127200","title":"Altered Fatty Acid Composition of Dopaminergic Neurons Expressing \u03b1-Synuclein and Human Brains with \u03b1-Synucleinopathies","display_name":"Altered Fatty Acid Composition of Dopaminergic Neurons Expressing \u03b1-Synuclein and Human Brains with \u03b1-Synucleinopathies","publication_year":2003,"publication_date":"2003-12-01","ids":{"openalex":"https://openalex.org/W1983808867","doi":"https://doi.org/10.1074/jbc.m309127200","mag":"1983808867","pmid":"https://pubmed.ncbi.nlm.nih.gov/14507911"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m309127200","doi":"https://doi.org/10.1074/jbc.m309127200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m309127200","pdf_url":"http://www.jbc.org/article/S0021925820754979/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.jbc.org/article/S0021925820754979/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009941578","display_name":"Ronit Sharon","orcid":"https://orcid.org/0000-0003-4760-0129","observed_orcids":["https://orcid.org/0000-0003-4760-0129"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ronit Sharon","raw_affiliation_strings":["Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA","Center for Neurologic Diseases, Department of Neurology, Brigham & Women's Hospital, Boston, Massachusetts 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"Center for Neurologic Diseases, Department of Neurology, Brigham & Women's Hospital, Boston, Massachusetts 02115, USA","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077142367","display_name":"Ifat Bar-Joseph","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ifat Bar-Joseph","raw_affiliation_strings":["Center for Neurologic Diseases, Department of Neurology, Boston, Massachusetts 02115"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Neurologic Diseases, Department of Neurology, Boston, Massachusetts 02115","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073058220","display_name":"Gudrun E. Mirick","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gudrun E. Mirick","raw_affiliation_strings":["Center for Experimental, Therapeutic, and Reperfusion Injury, Department of Anaesthesiology, Brigham and Women's Hospital, Boston, Massachusetts 02115"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Experimental, Therapeutic, and Reperfusion Injury, Department of Anaesthesiology, Brigham and Women's Hospital, Boston, Massachusetts 02115","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029525374","display_name":"Charles Nicholas Serhan","orcid":"https://orcid.org/0000-0003-4627-8545","observed_orcids":["https://orcid.org/0000-0003-4627-8545"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charles N. Serhan","raw_affiliation_strings":["Center for Experimental, Therapeutic, and Reperfusion Injury, Department of Anaesthesiology, Brigham and Women's Hospital, Boston, Massachusetts 02115"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Experimental, Therapeutic, and Reperfusion Injury, Department of Anaesthesiology, Brigham and Women's Hospital, Boston, Massachusetts 02115","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087935119","display_name":"Dennis J. Selkoe","orcid":"https://orcid.org/0000-0001-8846-9767","observed_orcids":["https://orcid.org/0000-0001-8846-9767"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Dennis J. Selkoe","raw_affiliation_strings":["Center for Neurologic Diseases, Department of Neurology, Boston, Massachusetts 02115"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Neurologic Diseases, Department of Neurology, Boston, Massachusetts 02115","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5087935119"],"corresponding_institution_ids":[],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":4.0937,"has_fulltext":true,"cited_by_count":187,"citation_normalized_percentile":{"value":0.93485157,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"278","issue":"50","first_page":"49874","last_page":"49881"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13991","display_name":"Nuclear Receptors and Signaling","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alpha-synuclein","display_name":"alpha-synuclein","score":1.0},{"id":"https://openalex.org/keywords/polyunsaturated-fatty-acids","display_name":"polyunsaturated fatty acids","score":0.8830000162124634},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.8569999933242798},{"id":"https://openalex.org/keywords/dementia-with-lewy-bodies","display_name":"dementia with Lewy bodies","score":1.0},{"id":"https://openalex.org/keywords/synucleinopathies","display_name":"synucleinopathies","score":0.9520000219345093},{"id":"https://openalex.org/keywords/dopaminergic-neurons","display_name":"dopaminergic neurons","score":0.8140000104904175},{"id":"https://openalex.org/keywords/alpha-synuclein-oligomerization","display_name":"alpha-synuclein oligomerization","score":0.9229999780654907},{"id":"https://openalex.org/keywords/membrane-fluidity","display_name":"membrane fluidity","score":0.9559999704360962}],"concepts":[{"id":"https://openalex.org/C2777440831","wikidata":"https://www.wikidata.org/wiki/Q2376264","display_name":"Synucleinopathies","level":5,"score":0.9703477621078491},{"id":"https://openalex.org/C137183658","wikidata":"https://www.wikidata.org/wiki/Q461076","display_name":"Dopaminergic","level":3,"score":0.5942447781562805},{"id":"https://openalex.org/C2781449126","wikidata":"https://www.wikidata.org/wiki/Q288591","display_name":"Alpha-synuclein","level":4,"score":0.5824585556983948},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.5380145907402039},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5294351577758789},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.45105209946632385},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3855542540550232},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.3266122043132782},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.223361998796463},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1343020796775818},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.07299655675888062}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001923","descriptor_name":"Brain Chemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003600","descriptor_name":"Cytosol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004298","descriptor_name":"Dopamine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005227","descriptor_name":"Fatty Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005231","descriptor_name":"Fatty Acids, Unsaturated","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008401","descriptor_name":"Gas Chromatography-Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016631","descriptor_name":"Lewy Bodies","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019636","descriptor_name":"Neurodegenerative Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051843","descriptor_name":"Synucleins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051844","descriptor_name":"alpha-Synuclein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1074/jbc.m309127200","doi":"https://doi.org/10.1074/jbc.m309127200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m309127200","pdf_url":"http://www.jbc.org/article/S0021925820754979/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:14507911","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14507911","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.m309127200","doi":"https://doi.org/10.1074/jbc.m309127200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m309127200","pdf_url":"http://www.jbc.org/article/S0021925820754979/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1983808867.pdf","grobid_xml":"https://content.openalex.org/works/W1983808867.grobid-xml"},"referenced_works_count":44,"referenced_works":["https://openalex.org/W570346775","https://openalex.org/W1496790952","https://openalex.org/W1502551601","https://openalex.org/W1559015563","https://openalex.org/W1630502818","https://openalex.org/W1917884859","https://openalex.org/W1982928559","https://openalex.org/W1986084664","https://openalex.org/W1986625112","https://openalex.org/W1996520572","https://openalex.org/W2003511766","https://openalex.org/W2005622137","https://openalex.org/W2009556855","https://openalex.org/W2013826930","https://openalex.org/W2018633688","https://openalex.org/W2032797457","https://openalex.org/W2040706104","https://openalex.org/W2043635206","https://openalex.org/W2052548407","https://openalex.org/W2052583566","https://openalex.org/W2058539931","https://openalex.org/W2066992082","https://openalex.org/W2068602144","https://openalex.org/W2075997185","https://openalex.org/W2076163606","https://openalex.org/W2077044335","https://openalex.org/W2079394877","https://openalex.org/W2079822311","https://openalex.org/W2080739904","https://openalex.org/W2085307219","https://openalex.org/W2108849025","https://openalex.org/W2109558867","https://openalex.org/W2116597539","https://openalex.org/W2117788314","https://openalex.org/W2118518385","https://openalex.org/W2131207606","https://openalex.org/W2132656444","https://openalex.org/W2133451731","https://openalex.org/W2174326934","https://openalex.org/W2186820760","https://openalex.org/W2345591594","https://openalex.org/W2796575992","https://openalex.org/W4236984387","https://openalex.org/W4295994768"],"related_works":["https://openalex.org/W2005622137","https://openalex.org/W2002432816","https://openalex.org/W2809493245","https://openalex.org/W1913024756","https://openalex.org/W1992471237","https://openalex.org/W180737545","https://openalex.org/W2086337422","https://openalex.org/W2052086629","https://openalex.org/W2098943817","https://openalex.org/W2091255227"],"abstract_inverted_index":{"Alpha-synuclein":[0],"(alphaS)":[1],"is":[2],"an":[3],"abundant":[4],"neuronal":[5,52,89,121,182],"protein":[6,45],"that":[7,78,177],"accumulates":[8],"in":[9,12,33,62,70,86,100,113,133,143,160,196],"insoluble":[10,48],"inclusions":[11],"Parkinson's":[13],"disease":[14],"(PD)":[15],"and":[16,38,66,72,102,116,152,195],"the":[17,29,34,94,114,134,144,153,161,188],"related":[18],"disorder,":[19],"dementia":[20],"with":[21,51,170],"Lewy":[22],"bodies":[23],"(DLB).":[24],"A":[25],"central":[26],"question":[27],"about":[28],"role":[30],"of":[31,36,60,96,120,155,163,167,191],"alphaS":[32,61,84,145],"pathogenesis":[35],"PD":[37,71,101],"DLB":[39,73,103],"concerns":[40],"how":[41],"this":[42],"normally":[43,194],"soluble":[44,58,105],"assembles":[46],"into":[47],"aggregates":[49],"associated":[50],"dysfunction.":[53],"We":[54,91],"recently":[55],"detected":[56,112],"highly":[57],"oligomers":[59],"normal":[63],"brain":[64,104],"supernatants":[65,115],"observed":[67],"their":[68],"augmentation":[69],"brains.":[74],"Further,":[75],"we":[76],"found":[77],"polyunsaturated":[79],"fatty":[80],"acids":[81],"(PUFAs)":[82],"enhanced":[83],"oligomerization":[85,189],"intact":[87],"mesencephalic":[88],"cells.":[90],"now":[92],"report":[93],"presence":[95],"elevated":[97],"PUFA":[98,108,131,183],"levels":[99,109,154,184],"fractions.":[106],"Higher":[107],"were":[110,158],"also":[111],"high-speed":[117],"membrane":[118,135,141,150],"fractions":[119],"cells":[122],"over-expressing":[123],"wild-type":[124],"or":[125],"PD-causing":[126],"mutant":[127],"alphaS.":[128,168],"This":[129],"increased":[130,140],"content":[132],"fraction":[136],"was":[137],"accompanied":[138],"by":[139],"fluidity":[142,151],"overexpressing":[146],"neurons.":[147],"In":[148],"accord,":[149],"certain":[156],"PUFAs":[157],"decreased":[159],"brains":[162],"mice":[164],"genetically":[165],"deleted":[166],"Together":[169],"our":[171],"earlier":[172],"observations,":[173],"these":[174],"results":[175],"suggest":[176],"alphaS-PUFA":[178],"interactions":[179],"help":[180],"regulate":[181],"as":[185,187],"well":[186],"state":[190],"alphaS,":[192],"both":[193],"human":[197],"synucleinopathies.":[198]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":12},{"year":2021,"cited_by_count":12},{"year":2020,"cited_by_count":12},{"year":2019,"cited_by_count":11},{"year":2018,"cited_by_count":11},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}