{"id":"https://openalex.org/W1983745552","doi":"https://doi.org/10.1016/j.chembiol.2008.03.007","title":"Separate Entrance and Exit Portals for Ligand Traffic in Mycobacterium tuberculosis FabH","display_name":"Separate Entrance and Exit Portals for Ligand Traffic in Mycobacterium tuberculosis FabH","publication_year":2008,"publication_date":"2008-04-01","ids":{"openalex":"https://openalex.org/W1983745552","doi":"https://doi.org/10.1016/j.chembiol.2008.03.007","mag":"1983745552","pmid":"https://pubmed.ncbi.nlm.nih.gov/18420147"},"language":"en","primary_location":{"id":"doi:10.1016/j.chembiol.2008.03.007","doi":"https://doi.org/10.1016/j.chembiol.2008.03.007","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.chembiol.2008.03.007","pdf_url":null,"source":{"id":"https://openalex.org/S85134406","display_name":"Chemistry & Biology","issn_l":"1074-5521","issn":["1074-5521","1879-1301"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemistry & Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://doi.org/10.1016/j.chembiol.2008.03.007","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070219959","display_name":"S. Sachdeva","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126345244","display_name":"Portland State University","ror":"https://ror.org/00yn2fy02","country_code":"US","type":"education","lineage":["https://openalex.org/I126345244"]},{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarbjot Sachdeva","raw_affiliation_strings":["Department of Chemistry, Portland State University, Portland, OR 97207, USA","Department of Medicinal Chemistry, Virginia Commonwealth University, Richmond, VA 23219, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Portland State University, Portland, OR 97207, USA","institution_ids":["https://openalex.org/I126345244"]},{"raw_affiliation_string":"Department of Medicinal Chemistry, Virginia Commonwealth University, Richmond, VA 23219, USA","institution_ids":["https://openalex.org/I184840846"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023001810","display_name":"Faik N. Musayev","orcid":"https://orcid.org/0000-0002-7969-1590","observed_orcids":["https://orcid.org/0000-0002-7969-1590"]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Faik N. Musayev","raw_affiliation_strings":["Department of Medicinal Chemistry, Virginia Commonwealth University, Richmond, VA 23219, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry, Virginia Commonwealth University, Richmond, VA 23219, USA","institution_ids":["https://openalex.org/I184840846"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088249653","display_name":"Mamoun M. Alhamadsheh","orcid":"https://orcid.org/0000-0003-4325-7044","observed_orcids":["https://orcid.org/0000-0003-4325-7044"]},"institutions":[{"id":"https://openalex.org/I126345244","display_name":"Portland State University","ror":"https://ror.org/00yn2fy02","country_code":"US","type":"education","lineage":["https://openalex.org/I126345244"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mamoun M. Alhamadsheh","raw_affiliation_strings":["Department of Chemistry, Portland State University, Portland, OR 97207, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Portland State University, Portland, OR 97207, USA","institution_ids":["https://openalex.org/I126345244"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025444311","display_name":"J.N. Scarsdale","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Neel Scarsdale","raw_affiliation_strings":["Department of Biochemistry, Virginia Commonwealth University, Richmond, VA 23219, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Virginia Commonwealth University, Richmond, VA 23219, USA","institution_ids":["https://openalex.org/I184840846"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021077783","display_name":"H.T. Wright","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H. Tonie Wright","raw_affiliation_strings":["Department of Biochemistry, Virginia Commonwealth University, Richmond, VA 23219, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Virginia Commonwealth University, Richmond, VA 23219, USA","institution_ids":["https://openalex.org/I184840846"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048925702","display_name":"Kevin A. Reynolds","orcid":"https://orcid.org/0000-0003-0270-9809","observed_orcids":["https://orcid.org/0000-0003-0270-9809"]},"institutions":[{"id":"https://openalex.org/I126345244","display_name":"Portland State University","ror":"https://ror.org/00yn2fy02","country_code":"US","type":"education","lineage":["https://openalex.org/I126345244"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Kevin A. Reynolds","raw_affiliation_strings":["Department of Chemistry, Portland State University, Portland, OR 97207, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Portland State University, Portland, OR 97207, USA","institution_ids":["https://openalex.org/I126345244"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5048925702"],"corresponding_institution_ids":["https://openalex.org/I126345244"],"apc_list":null,"apc_paid":null,"fwci":2.5462,"has_fulltext":false,"cited_by_count":39,"citation_normalized_percentile":{"value":0.89396467,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"15","issue":"4","first_page":"402","last_page":"412"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.8895999789237976,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.8895999789237976,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.05469999834895134,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.016300000250339508,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/type-ii-fatty-acid-synthase","display_name":"type II fatty acid synthase","score":0.968999981880188},{"id":"https://openalex.org/keywords/mycolic-acid-biosynthesis","display_name":"mycolic acid biosynthesis","score":0.8339999914169312},{"id":"https://openalex.org/keywords/enzyme-conformational-change","display_name":"enzyme conformational change","score":0.7279999852180481},{"id":"https://openalex.org/keywords/product-launch","display_name":"product launch","score":0.578000009059906}],"concepts":[{"id":"https://openalex.org/C2777975735","wikidata":"https://www.wikidata.org/wiki/Q130971","display_name":"Mycobacterium tuberculosis","level":3,"score":0.6345180869102478},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.5862980484962463},{"id":"https://openalex.org/C41183919","wikidata":"https://www.wikidata.org/wiki/Q423026","display_name":"Active site","level":3,"score":0.5791312456130981},{"id":"https://openalex.org/C46371251","wikidata":"https://www.wikidata.org/wiki/Q4886486","display_name":"Cell envelope","level":4,"score":0.4991881847381592},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4515884220600128},{"id":"https://openalex.org/C2778293455","wikidata":"https://www.wikidata.org/wiki/Q414506","display_name":"Mycolic acid","level":4,"score":0.43131494522094727},{"id":"https://openalex.org/C116569031","wikidata":"https://www.wikidata.org/wiki/Q899107","display_name":"Ligand (biochemistry)","level":3,"score":0.4257574677467346},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.42293378710746765},{"id":"https://openalex.org/C2776376580","wikidata":"https://www.wikidata.org/wiki/Q407355","display_name":"Transferase","level":3,"score":0.4205184876918793},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4049513638019562},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.40072622895240784},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.3994119167327881},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.38566315174102783},{"id":"https://openalex.org/C2780374374","wikidata":"https://www.wikidata.org/wiki/Q194309","display_name":"Mycobacterium","level":3,"score":0.375335693359375},{"id":"https://openalex.org/C2781069245","wikidata":"https://www.wikidata.org/wiki/Q12204","display_name":"Tuberculosis","level":2,"score":0.26667869091033936},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.10373029112815857},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000214","descriptor_name":"Acyl Coenzyme A","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D000214","descriptor_name":"Acyl Coenzyme A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003545","descriptor_name":"Cysteine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009169","descriptor_name":"Mycobacterium tuberculosis","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D009171","descriptor_name":"Mycolic Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012997","descriptor_name":"Solvents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015099","descriptor_name":"3-Oxoacyl-(Acyl-Carrier-Protein) Synthase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015099","descriptor_name":"3-Oxoacyl-(Acyl-Carrier-Protein) Synthase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015099","descriptor_name":"3-Oxoacyl-(Acyl-Carrier-Protein) Synthase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020134","descriptor_name":"Catalytic Domain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021241","descriptor_name":"Spectrometry, Mass, Electrospray Ionization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057927","descriptor_name":"Hydrophobic and Hydrophilic Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.chembiol.2008.03.007","doi":"https://doi.org/10.1016/j.chembiol.2008.03.007","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.chembiol.2008.03.007","pdf_url":null,"source":{"id":"https://openalex.org/S85134406","display_name":"Chemistry & Biology","issn_l":"1074-5521","issn":["1074-5521","1879-1301"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemistry & Biology","raw_type":"journal-article"},{"id":"pmid:18420147","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18420147","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemistry & biology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.chembiol.2008.03.007","doi":"https://doi.org/10.1016/j.chembiol.2008.03.007","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.chembiol.2008.03.007","pdf_url":null,"source":{"id":"https://openalex.org/S85134406","display_name":"Chemistry & Biology","issn_l":"1074-5521","issn":["1074-5521","1879-1301"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemistry & Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1900523693","display_name":null,"funder_award_id":"AI52230","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W1546422804","https://openalex.org/W1590673420","https://openalex.org/W1595451534","https://openalex.org/W1870231325","https://openalex.org/W1881865374","https://openalex.org/W1970751856","https://openalex.org/W1977654774","https://openalex.org/W1983965669","https://openalex.org/W1992956214","https://openalex.org/W1995017064","https://openalex.org/W1999590520","https://openalex.org/W2010560652","https://openalex.org/W2013569231","https://openalex.org/W2018236255","https://openalex.org/W2021805040","https://openalex.org/W2023371217","https://openalex.org/W2023928413","https://openalex.org/W2036317207","https://openalex.org/W2036508456","https://openalex.org/W2050974542","https://openalex.org/W2071914197","https://openalex.org/W2080476827","https://openalex.org/W2088334665","https://openalex.org/W2093712250","https://openalex.org/W2095433835","https://openalex.org/W2111874149","https://openalex.org/W2114367386","https://openalex.org/W2116947993","https://openalex.org/W2130007716","https://openalex.org/W2137682340","https://openalex.org/W2140288446","https://openalex.org/W2144081223","https://openalex.org/W2164718888","https://openalex.org/W2164859426"],"related_works":["https://openalex.org/W607264869","https://openalex.org/W2036508456","https://openalex.org/W2038202093","https://openalex.org/W2091852619","https://openalex.org/W1590673420","https://openalex.org/W1595451534","https://openalex.org/W2071914197","https://openalex.org/W3148150814","https://openalex.org/W7116705329","https://openalex.org/W2396497893"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}