{"id":"https://openalex.org/W1983709361","doi":"https://doi.org/10.1006/jmbi.1994.1395","title":"Chloride Masks Effects of Opposing Positive Charges in Hb A and Hb Hinsdale (\u03b2139 Asn \u2192 Lys) that can Modulate Cooperativity as well as Oxygen Affinity","display_name":"Chloride Masks Effects of Opposing Positive Charges in Hb A and Hb Hinsdale (\u03b2139 Asn \u2192 Lys) that can Modulate Cooperativity as well as Oxygen Affinity","publication_year":1994,"publication_date":"1994-06-01","ids":{"openalex":"https://openalex.org/W1983709361","doi":"https://doi.org/10.1006/jmbi.1994.1395","mag":"1983709361","pmid":"https://pubmed.ncbi.nlm.nih.gov/8006968"},"language":"en","primary_location":{"id":"doi:10.1006/jmbi.1994.1395","doi":"https://doi.org/10.1006/jmbi.1994.1395","is_oa":false,"landing_page_url":"https://doi.org/10.1006/jmbi.1994.1395","pdf_url":null,"source":{"id":"https://openalex.org/S46058472","display_name":"Journal of Molecular Biology","issn_l":"0022-2836","issn":["0022-2836","1089-8638"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Molecular Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060269662","display_name":"Celia Bonaventura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Celia Bonaventura","raw_affiliation_strings":["Duke University School of the Environment Marine Laboratory, Beaufort, NC 28516"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke University School of the Environment Marine Laboratory, Beaufort, NC 28516","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103520432","display_name":"Munusamy Arumugam","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289490764","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/042twtr12","country_code":"US","type":"government","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934"]},{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210160401","display_name":"National Center for Infectious Diseases","ror":"https://ror.org/04vmke174","country_code":"US","type":"facility","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934","https://openalex.org/I4210109567","https://openalex.org/I4210121439","https://openalex.org/I4210160401"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Munusamy Arumugam","raw_affiliation_strings":["Department of Cell Biology and Duke University School of the Environment Marine Laboratory Beaufort, NC 28516, U.S.A. and Center for Infectious Diseases, Centers for Disease Control Atlanta, GA 30333, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology and Duke University School of the Environment Marine Laboratory Beaufort, NC 28516, U.S.A. and Center for Infectious Diseases, Centers for Disease Control Atlanta, GA 30333, U.S.A","institution_ids":["https://openalex.org/I1289490764","https://openalex.org/I170897317","https://openalex.org/I4210160401"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002135390","display_name":"Robert E. Cashon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289490764","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/042twtr12","country_code":"US","type":"government","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934"]},{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210160401","display_name":"National Center for Infectious Diseases","ror":"https://ror.org/04vmke174","country_code":"US","type":"facility","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934","https://openalex.org/I4210109567","https://openalex.org/I4210121439","https://openalex.org/I4210160401"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert Cashon","raw_affiliation_strings":["Department of Cell Biology and Duke University School of the Environment Marine Laboratory Beaufort, NC 28516, U.S.A. and Center for Infectious Diseases, Centers for Disease Control Atlanta, GA 30333, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology and Duke University School of the Environment Marine Laboratory Beaufort, NC 28516, U.S.A. and Center for Infectious Diseases, Centers for Disease Control Atlanta, GA 30333, U.S.A","institution_ids":["https://openalex.org/I1289490764","https://openalex.org/I170897317","https://openalex.org/I4210160401"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107412810","display_name":"Joseph Bonaventura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289490764","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/042twtr12","country_code":"US","type":"government","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934"]},{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210160401","display_name":"National Center for Infectious Diseases","ror":"https://ror.org/04vmke174","country_code":"US","type":"facility","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934","https://openalex.org/I4210109567","https://openalex.org/I4210121439","https://openalex.org/I4210160401"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph Bonaventura","raw_affiliation_strings":["Department of Cell Biology and Duke University School of the Environment Marine Laboratory Beaufort, NC 28516, U.S.A. and Center for Infectious Diseases, Centers for Disease Control Atlanta, GA 30333, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology and Duke University School of the Environment Marine Laboratory Beaufort, NC 28516, U.S.A. and Center for Infectious Diseases, Centers for Disease Control Atlanta, GA 30333, U.S.A","institution_ids":["https://openalex.org/I1289490764","https://openalex.org/I170897317","https://openalex.org/I4210160401"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008676192","display_name":"Winston F. Moo-Penn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289490764","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/042twtr12","country_code":"US","type":"government","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934"]},{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210160401","display_name":"National Center for Infectious Diseases","ror":"https://ror.org/04vmke174","country_code":"US","type":"facility","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934","https://openalex.org/I4210109567","https://openalex.org/I4210121439","https://openalex.org/I4210160401"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Winston F. Moo-Penn","raw_affiliation_strings":["Department of Cell Biology and Duke University School of the Environment Marine Laboratory Beaufort, NC 28516, U.S.A. and Center for Infectious Diseases, Centers for Disease Control Atlanta, GA 30333, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology and Duke University School of the Environment Marine Laboratory Beaufort, NC 28516, U.S.A. and Center for Infectious Diseases, Centers for Disease Control Atlanta, GA 30333, U.S.A","institution_ids":["https://openalex.org/I1289490764","https://openalex.org/I170897317","https://openalex.org/I4210160401"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4730,"currency":"USD","value_usd":4730},"apc_paid":null,"fwci":1.2438,"has_fulltext":false,"cited_by_count":43,"citation_normalized_percentile":{"value":0.78392762,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"239","issue":"4","first_page":"561","last_page":"568"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12094","display_name":"Hemoglobin structure and function","score":0.9779999852180481,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12094","display_name":"Hemoglobin structure and function","score":0.9779999852180481,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.019999999552965164,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12930","display_name":"Biomedical and Chemical Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hemoglobin-variants","display_name":"hemoglobin variants","score":0.6050000190734863},{"id":"https://openalex.org/keywords/chloride-sensitivity","display_name":"chloride sensitivity","score":0.6600000262260437},{"id":"https://openalex.org/keywords/oxygen-affinity","display_name":"oxygen affinity","score":0.7649999856948853},{"id":"https://openalex.org/keywords/cooperativity","display_name":"cooperativity","score":0.8259999752044678},{"id":"https://openalex.org/keywords/beta-globin","display_name":"beta-globin","score":0.4519999921321869},{"id":"https://openalex.org/keywords/cationic-residues","display_name":"cationic residues","score":0.6610000133514404},{"id":"https://openalex.org/keywords/central-cavity","display_name":"central cavity","score":0.6129999756813049},{"id":"https://openalex.org/keywords/allosteric-mechanism","display_name":"allosteric mechanism","score":0.7020000219345093},{"id":"https://openalex.org/keywords/bohr-effect","display_name":"Bohr effect","score":0.8399999737739563},{"id":"https://openalex.org/keywords/oxygen-dissociation-kinetics","display_name":"oxygen dissociation kinetics","score":0.9480000138282776},{"id":"https://openalex.org/keywords/co-binding","display_name":"carbon monoxide binding","score":0.8230000138282776},{"id":"https://openalex.org/keywords/p50","display_name":"P50","score":0.6330000162124634}],"concepts":[{"id":"https://openalex.org/C166014724","wikidata":"https://www.wikidata.org/wiki/Q337217","display_name":"Cooperativity","level":2,"score":0.8676478266716003},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8229424357414246},{"id":"https://openalex.org/C183882617","wikidata":"https://www.wikidata.org/wiki/Q3046749","display_name":"Cationic polymerization","level":2,"score":0.7691243886947632},{"id":"https://openalex.org/C2781014771","wikidata":"https://www.wikidata.org/wiki/Q413961","display_name":"Tris","level":2,"score":0.668631374835968},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.5714629888534546},{"id":"https://openalex.org/C77562769","wikidata":"https://www.wikidata.org/wiki/Q890877","display_name":"Bohr effect","level":4,"score":0.5616419315338135},{"id":"https://openalex.org/C2778917026","wikidata":"https://www.wikidata.org/wiki/Q43041","display_name":"Hemoglobin","level":2,"score":0.513160765171051},{"id":"https://openalex.org/C187250156","wikidata":"https://www.wikidata.org/wiki/Q2902610","display_name":"Cooperative binding","level":3,"score":0.5077765583992004},{"id":"https://openalex.org/C2778695967","wikidata":"https://www.wikidata.org/wiki/Q44791900","display_name":"Chloride","level":2,"score":0.48181524872779846},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.4401966333389282},{"id":"https://openalex.org/C2776816875","wikidata":"https://www.wikidata.org/wiki/Q418359","display_name":"HEPES","level":2,"score":0.43068253993988037},{"id":"https://openalex.org/C155647269","wikidata":"https://www.wikidata.org/wiki/Q243455","display_name":"Medicinal chemistry","level":1,"score":0.4220086336135864},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.40841570496559143},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.3085669279098511},{"id":"https://openalex.org/C127503593","wikidata":"https://www.wikidata.org/wiki/Q7115970","display_name":"Oxygen\u2013haemoglobin dissociation curve","level":3,"score":0.2624516189098358},{"id":"https://openalex.org/C188027245","wikidata":"https://www.wikidata.org/wiki/Q750446","display_name":"Polymer chemistry","level":1,"score":0.19362413883209229},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1349755823612213},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.10797998309135437}],"mesh":[{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002248","descriptor_name":"Carbon Monoxide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002712","descriptor_name":"Chlorides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004227","descriptor_name":"Dithionite","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006441","descriptor_name":"Hemoglobin A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006441","descriptor_name":"Hemoglobin A","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006455","descriptor_name":"Hemoglobins, Abnormal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006455","descriptor_name":"Hemoglobins, Abnormal","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1006/jmbi.1994.1395","doi":"https://doi.org/10.1006/jmbi.1994.1395","is_oa":false,"landing_page_url":"https://doi.org/10.1006/jmbi.1994.1395","pdf_url":null,"source":{"id":"https://openalex.org/S46058472","display_name":"Journal of Molecular Biology","issn_l":"0022-2836","issn":["0022-2836","1089-8638"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Molecular Biology","raw_type":"journal-article"},{"id":"pmid:8006968","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8006968","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of molecular biology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G6521545222","display_name":null,"funder_award_id":"NIEHS ESO-1908","funder_id":"https://openalex.org/F4320332162","funder_display_name":"Centers for Disease Control and Prevention"}],"funders":[{"id":"https://openalex.org/F4320332162","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/042twtr12"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1537210328","https://openalex.org/W1508402003","https://openalex.org/W2167278898","https://openalex.org/W2023724879","https://openalex.org/W1537012945","https://openalex.org/W1589126424","https://openalex.org/W2076949101","https://openalex.org/W2024275147","https://openalex.org/W2004566155","https://openalex.org/W1988211131"],"abstract_inverted_index":null,"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}