{"id":"https://openalex.org/W198370807","doi":null,"title":"A prospective clinical trial comparing the treatment of idiopathic membranous nephropathy and nephrotic syndrome with simvastatin and diet, versus diet alone.","display_name":"A prospective clinical trial comparing the treatment of idiopathic membranous nephropathy and nephrotic syndrome with simvastatin and diet, versus diet alone.","publication_year":1996,"publication_date":"1996-10-01","ids":{"openalex":"https://openalex.org/W198370807","mag":"198370807","pmid":"https://pubmed.ncbi.nlm.nih.gov/8905205"},"language":"en","primary_location":{"id":"pmid:8905205","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8905205","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical nephrology","raw_type":"Clinical Trial"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009408665","display_name":"Brian Lindsay Rayner","orcid":"https://orcid.org/0000-0002-0167-9591","observed_orcids":["https://orcid.org/0000-0002-0167-9591"]},"institutions":[{"id":"https://openalex.org/I2802258008","display_name":"Groote Schuur Hospital","ror":"https://ror.org/00c879s84","country_code":"ZA","type":"healthcare","lineage":["https://openalex.org/I1307091933","https://openalex.org/I2802258008"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"B L Rayner","raw_affiliation_strings":["Renal Unit, Groote Schuur Hospital, Cape Town, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Renal Unit, Groote Schuur Hospital, Cape Town, South Africa","institution_ids":["https://openalex.org/I2802258008"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021894365","display_name":"Michael Byrne","orcid":"https://orcid.org/0000-0001-9279-049X","observed_orcids":["https://orcid.org/0000-0001-9279-049X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M J Byrne","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5034975443","display_name":"Richard Nellis van Zyl-Smit","orcid":"https://orcid.org/0000-0002-4115-5362","observed_orcids":["https://orcid.org/0000-0002-4115-5362"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R van Zyl Smit","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.3505,"has_fulltext":false,"cited_by_count":53,"citation_normalized_percentile":{"value":0.78860353,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"46","issue":"4","first_page":"219","last_page":"24"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/idiopathic-membranous-nephropathy","display_name":"idiopathic membranous nephropathy","score":0.996999979019165},{"id":"https://openalex.org/keywords/nephrotic-syndrome","display_name":"nephrotic syndrome","score":0.9990000128746033},{"id":"https://openalex.org/keywords/simvastatin","display_name":"simvastatin","score":1.0},{"id":"https://openalex.org/keywords/statins","display_name":"statins","score":0.9210000038146973},{"id":"https://openalex.org/keywords/cholesterol-lowering-diet","display_name":"cholesterol-lowering diet","score":0.9089999794960022},{"id":"https://openalex.org/keywords/dietary-cholesterol","display_name":"dietary cholesterol","score":0.4860000014305115},{"id":"https://openalex.org/keywords/serum-cholesterol-lowering","display_name":"serum cholesterol lowering","score":0.7360000014305115},{"id":"https://openalex.org/keywords/proteinuria","display_name":"proteinuria","score":0.9610000252723694},{"id":"https://openalex.org/keywords/serum-albumin","display_name":"serum albumin","score":0.8080000281333923},{"id":"https://openalex.org/keywords/renal-function","display_name":"renal function","score":0.7120000123977661},{"id":"https://openalex.org/keywords/ldl-cholesterol","display_name":"LDL cholesterol","score":0.48399999737739563}],"concepts":[{"id":"https://openalex.org/C2776329913","wikidata":"https://www.wikidata.org/wiki/Q670131","display_name":"Simvastatin","level":2,"score":0.8480526804924011},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8302440047264099},{"id":"https://openalex.org/C2778930706","wikidata":"https://www.wikidata.org/wiki/Q504790","display_name":"Nephrotic syndrome","level":2,"score":0.7971279621124268},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7636361122131348},{"id":"https://openalex.org/C2780306776","wikidata":"https://www.wikidata.org/wiki/Q426660","display_name":"Creatinine","level":2,"score":0.7063162326812744},{"id":"https://openalex.org/C2779561371","wikidata":"https://www.wikidata.org/wiki/Q570197","display_name":"Proteinuria","level":3,"score":0.6796786785125732},{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.5826067924499512},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5793434381484985},{"id":"https://openalex.org/C2776125364","wikidata":"https://www.wikidata.org/wiki/Q169219","display_name":"Albumin","level":2,"score":0.5420101881027222},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.48042798042297363},{"id":"https://openalex.org/C2781184683","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Nephropathy","level":3,"score":0.43258368968963623},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4310625493526459},{"id":"https://openalex.org/C77411442","wikidata":"https://www.wikidata.org/wiki/Q181100","display_name":"Urinary system","level":2,"score":0.4107092022895813},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.34711015224456787},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.2053358554840088},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.06417351961135864}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000924","descriptor_name":"Anticholesteremic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002784","descriptor_name":"Cholesterol","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D002791","descriptor_name":"Cholesterol, Dietary","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D003131","descriptor_name":"Combined Modality Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008148","descriptor_name":"Lovastatin","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D008148","descriptor_name":"Lovastatin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D009404","descriptor_name":"Nephrotic Syndrome","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D009404","descriptor_name":"Nephrotic Syndrome","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012709","descriptor_name":"Serum Albumin","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015433","descriptor_name":"Glomerulonephritis, Membranous","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015433","descriptor_name":"Glomerulonephritis, Membranous","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D019161","descriptor_name":"Hydroxymethylglutaryl-CoA Reductase Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019821","descriptor_name":"Simvastatin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:8905205","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8905205","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical nephrology","raw_type":"Clinical Trial"},{"id":"mag:198370807","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8905205","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2065535290","https://openalex.org/W2042173532","https://openalex.org/W2226932327","https://openalex.org/W2402831054","https://openalex.org/W2051081770","https://openalex.org/W129892455","https://openalex.org/W2063238387","https://openalex.org/W2116986363","https://openalex.org/W2381530372","https://openalex.org/W1989200854"],"abstract_inverted_index":{"Of":[0],"17":[1],"patients":[2],"with":[3,16,73],"idiopathic":[4],"membranous":[5],"nephropathy":[6],"(IMN)":[7],"and":[8,22,26,35,53,104,113,121,130,145,155,164,175,178,201],"nephrotic":[9,197],"syndrome,":[10],"9":[11],"were":[12],"allocated":[13],"to":[14,28,126,160],"treatment":[15,34,103],"simvastatin":[17],"(an":[18],"HMG":[19],"CoA-reductase":[20],"inhibitor)":[21],"low":[23],"cholesterol":[24,194],"diet,":[25],"8":[27],"diet":[29],"alone.":[30],"At":[31,82],"entry,":[32],"the":[33,64,79,83,86,88,102,136,140,183,189,196,209],"control":[36,80,105,184],"groups":[37,106],"did":[38],"not":[39],"differ":[40],"in":[41,63,78,90,101,135,173,182,195,208,213],"mean":[42,57,109,141],"serum":[43,51,193,203],"creatinines,":[44],"chromium-labelled":[45,91],"EDTA":[46,92],"clearances,":[47],"urinary":[48,146,179],"protein/creatinine":[49,147,180],"ratios,":[50],"albumins,":[52],"lipid":[54],"profiles.":[55],"The":[56,108],"follow":[58],"up":[59],"period":[60],"(+/-":[61,69,75,110,119,123,128,132,142,152,157,162,166],"SEM)":[62,111,143],"treated":[65,137],"group":[66],"was":[67,94,170],"19.3":[68],"4.4)":[70],"months":[71,77],"compared":[72],"16.6":[74],"5.9)":[76],"group.":[81,185],"end":[84],"of":[85,211],"trial":[87],"fall":[89],"clearances":[93],"similar":[95],"(-1.27":[96],"versus":[97],"-1.28":[98],"mls/min/months/1.73":[99],"m2)":[100],"respectively.":[107,168],"total":[112,174],"LDL-cholesterol":[114],"had":[115],"gone":[116],"from":[117,150],"10.5":[118],"0.94)":[120],"8.02":[122],"1)":[124],"mmol/l":[125],"5.2":[127],"0.49)":[129],"3.47":[131],"0.44)":[133],"respectively":[134],"patients.":[138],"Additionally":[139],"albumin":[144,177,204],"ratio":[148,181],"went":[149],"25.6":[151],"2.4)":[153],"gm/l":[154],"0.52":[156],"0.09)":[158],"gm/mmol":[159],"45.5":[161],"2.8)":[163],"0.13":[165],"0.04)":[167],"There":[169],"little":[171],"change":[172],"LDL-cholesterol;":[176],"This":[186],"study":[187],"supports":[188],"observation":[190],"that":[191],"lowering":[192],"syndrome":[198],"reduces":[199],"proteinuria":[200],"increases":[202],"levels.":[205],"No":[206],"difference":[207],"rate":[210],"decline":[212],"renal":[214],"function":[215],"could":[216],"be":[217],"demonstrated.":[218]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}