{"id":"https://openalex.org/W1983685536","doi":"https://doi.org/10.1097/00041552-199503000-00012","title":"Nitric oxide in the pathogenesis of hypertension","display_name":"Nitric oxide in the pathogenesis of hypertension","publication_year":1995,"publication_date":"1995-03-01","ids":{"openalex":"https://openalex.org/W1983685536","doi":"https://doi.org/10.1097/00041552-199503000-00012","mag":"1983685536","pmid":"https://pubmed.ncbi.nlm.nih.gov/7600050"},"language":"en","primary_location":{"id":"doi:10.1097/00041552-199503000-00012","doi":"https://doi.org/10.1097/00041552-199503000-00012","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00041552-199503000-00012","pdf_url":null,"source":{"id":"https://openalex.org/S185853653","display_name":"Current Opinion in Nephrology & Hypertension","issn_l":"1062-4821","issn":["1062-4821","1080-8221","1473-6543"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Nephrology and Hypertension","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043815002","display_name":"Jean\u2010Fran\u00e7ois Arnal","orcid":"https://orcid.org/0000-0003-2229-6300","observed_orcids":["https://orcid.org/0000-0003-2229-6300"]},"institutions":[{"id":"https://openalex.org/I4405258862","display_name":"Universit\u00e9 de Toulouse","ror":"https://ror.org/01ahyrz84","country_code":"FR","type":"education","lineage":["https://openalex.org/I4405258862"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jean-Francois Arnal","raw_affiliation_strings":["Department of Physiology, School of Medicine, Toulouse, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, School of Medicine, Toulouse, France","institution_ids":["https://openalex.org/I4405258862"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102895409","display_name":"Jean\u2010Baptiste Michel","orcid":"https://orcid.org/0000-0002-1529-2005","observed_orcids":["https://orcid.org/0000-0002-1529-2005","https://orcid.org/0000-0002-7440-6877"]},"institutions":[{"id":"https://openalex.org/I4405258862","display_name":"Universit\u00e9 de Toulouse","ror":"https://ror.org/01ahyrz84","country_code":"FR","type":"education","lineage":["https://openalex.org/I4405258862"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jean-Baptiste Michel","raw_affiliation_strings":["Department of Physiology, School of Medicine, Toulouse, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, School of Medicine, Toulouse, France","institution_ids":["https://openalex.org/I4405258862"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011627807","display_name":"David Glenn Harrison","orcid":"https://orcid.org/0000-0001-9363-6451","observed_orcids":["https://orcid.org/0000-0001-9363-6451"]},"institutions":[{"id":"https://openalex.org/I4405258862","display_name":"Universit\u00e9 de Toulouse","ror":"https://ror.org/01ahyrz84","country_code":"FR","type":"education","lineage":["https://openalex.org/I4405258862"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"David G. Harrison","raw_affiliation_strings":["Department of Physiology, School of Medicine, Toulouse, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, School of Medicine, Toulouse, France","institution_ids":["https://openalex.org/I4405258862"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4405258862"],"apc_list":null,"apc_paid":null,"fwci":1.9431,"has_fulltext":false,"cited_by_count":33,"citation_normalized_percentile":{"value":0.8509887,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"4","issue":"2","first_page":"182","last_page":"188"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10924","display_name":"Cardiovascular Health and Disease Prevention","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":1.0},{"id":"https://openalex.org/keywords/pathogenesis-of-hypertension","display_name":"hypertension pathogenesis","score":0.8799999952316284},{"id":"https://openalex.org/keywords/l-arginine-nitric-oxide-pathway","display_name":"L-arginine-nitric oxide pathway","score":0.968999981880188},{"id":"https://openalex.org/keywords/experimental-hypertension-models","display_name":"experimental hypertension models","score":0.7910000085830688},{"id":"https://openalex.org/keywords/essential-hypertension","display_name":"essential hypertension","score":0.9010000228881836},{"id":"https://openalex.org/keywords/secondary-hypertension","display_name":"secondary hypertension","score":0.9639999866485596},{"id":"https://openalex.org/keywords/endothelial-dysfunction","display_name":"endothelial dysfunction","score":0.6660000085830688}],"concepts":[{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.9396668672561646},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.7301767468452454},{"id":"https://openalex.org/C2777468819","wikidata":"https://www.wikidata.org/wiki/Q173670","display_name":"Arginine","level":3,"score":0.6502915620803833},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5295701026916504},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3039018511772156},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2955159544944763},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1522771716117859},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.049349308013916016}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1097/00041552-199503000-00012","doi":"https://doi.org/10.1097/00041552-199503000-00012","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00041552-199503000-00012","pdf_url":null,"source":{"id":"https://openalex.org/S185853653","display_name":"Current Opinion in Nephrology & Hypertension","issn_l":"1062-4821","issn":["1062-4821","1080-8221","1473-6543"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Nephrology and Hypertension","raw_type":"journal-article"},{"id":"pmid:7600050","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7600050","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current opinion in nephrology and hypertension","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2021165648","https://openalex.org/W2318984587","https://openalex.org/W2024839012","https://openalex.org/W2168038844","https://openalex.org/W2127398792","https://openalex.org/W2408663435","https://openalex.org/W2031614618","https://openalex.org/W2071411920","https://openalex.org/W2040492385","https://openalex.org/W3111535838"],"abstract_inverted_index":{"It":[0],"has":[1],"been":[2],"suspected":[3],"that":[4],"abnormalities":[5,39],"of":[6,15,25,33,40],"the":[7,23,41],"L-arginine-nitric":[8,42],"oxide":[9,27,43],"pathway":[10,44],"could":[11],"underlie":[12],"certain":[13],"forms":[14],"hypertension.":[16],"In":[17],"this":[18],"review,":[19],"we":[20],"will":[21],"consider":[22],"role":[24],"nitric":[26],"in":[28,45,47],"primary":[29],"and":[30,36],"secondary":[31],"models":[32],"experimental":[34],"hypertension":[35,46],"discuss":[37],"potential":[38],"humans.":[48]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}