{"id":"https://openalex.org/W1983644298","doi":"https://doi.org/10.1016/j.intimp.2014.10.006","title":"Anti-neuroinflammatory effect of aurantiamide acetate from the marine fungus Aspergillus sp. SF-5921: Inhibition of NF-\u03baB and MAPK pathways in lipopolysaccharide-induced mouse BV2 microglial cells","display_name":"Anti-neuroinflammatory effect of aurantiamide acetate from the marine fungus Aspergillus sp. SF-5921: Inhibition of NF-\u03baB and MAPK pathways in lipopolysaccharide-induced mouse BV2 microglial cells","publication_year":2014,"publication_date":"2014-10-16","ids":{"openalex":"https://openalex.org/W1983644298","doi":"https://doi.org/10.1016/j.intimp.2014.10.006","mag":"1983644298","pmid":"https://pubmed.ncbi.nlm.nih.gov/25448500"},"language":"en","primary_location":{"id":"doi:10.1016/j.intimp.2014.10.006","doi":"https://doi.org/10.1016/j.intimp.2014.10.006","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.intimp.2014.10.006","pdf_url":null,"source":{"id":"https://openalex.org/S158377717","display_name":"International Immunopharmacology","issn_l":"1567-5769","issn":["1567-5769","1878-1705"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","medline","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Immunopharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5106235682","display_name":"Chi\u2010Su Yoon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I77079311","display_name":"Wonkwang University","ror":"https://ror.org/006776986","country_code":"KR","type":"education","lineage":["https://openalex.org/I77079311"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Chi-Su Yoon","raw_affiliation_strings":["Institute of Pharmaceutical Research and Development, College of Pharmacy, Wonkwang University, Iksan, 570-749, Republic of Korea; Standardized Material Bank for New Botanical Drugs, College of Pharmacy, Wonkwang University, Iksan, 570-749, Republic of Korea","Institute of Pharmaceutical Research and Development, College of Pharmacy, Wonkwang University, Iksan, 570-749, Republic of Korea","Standardized Material Bank for New Botanical Drugs, College of Pharmacy, Wonkwang University, Iksan, 570-749, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pharmaceutical Research and Development, College of Pharmacy, Wonkwang University, Iksan, 570-749, Republic of Korea; Standardized Material Bank for New Botanical Drugs, College of Pharmacy, Wonkwang University, Iksan, 570-749, Republic of Korea","institution_ids":["https://openalex.org/I77079311"]},{"raw_affiliation_string":"Institute of Pharmaceutical Research and Development, College of Pharmacy, Wonkwang University, Iksan, 570-749, Republic of Korea","institution_ids":["https://openalex.org/I77079311"]},{"raw_affiliation_string":"Standardized Material Bank for New Botanical Drugs, College of Pharmacy, Wonkwang University, Iksan, 570-749, Republic of Korea","institution_ids":["https://openalex.org/I77079311"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027332315","display_name":"Dongcheol Kim","orcid":"https://orcid.org/0000-0003-4723-4755","observed_orcids":["https://orcid.org/0000-0003-4723-4755"]},"institutions":[{"id":"https://openalex.org/I77079311","display_name":"Wonkwang University","ror":"https://ror.org/006776986","country_code":"KR","type":"education","lineage":["https://openalex.org/I77079311"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Dong-Cheol Kim","raw_affiliation_strings":["Institute of Pharmaceutical Research and Development, College of Pharmacy, Wonkwang University, Iksan, 570-749, Republic of Korea; Standardized Material Bank for New Botanical Drugs, College of Pharmacy, Wonkwang University, Iksan, 570-749, Republic of Korea","Institute of Pharmaceutical Research and Development, College of Pharmacy, Wonkwang University, Iksan, 570-749, Republic of Korea","Standardized Material Bank for New Botanical Drugs, College of Pharmacy, Wonkwang University, Iksan, 570-749, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pharmaceutical Research and Development, College of Pharmacy, Wonkwang University, Iksan, 570-749, Republic of Korea; Standardized Material Bank for New Botanical Drugs, College of Pharmacy, Wonkwang University, Iksan, 570-749, Republic of Korea","institution_ids":["https://openalex.org/I77079311"]},{"raw_affiliation_string":"Institute of Pharmaceutical Research and Development, College of Pharmacy, Wonkwang University, Iksan, 570-749, Republic of Korea","institution_ids":["https://openalex.org/I77079311"]},{"raw_affiliation_string":"Standardized Material Bank for New Botanical Drugs, College of Pharmacy, Wonkwang University, Iksan, 570-749, Republic of Korea","institution_ids":["https://openalex.org/I77079311"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059247798","display_name":"Dong\u2010Sung Lee","orcid":"https://orcid.org/0000-0002-9234-7567","observed_orcids":["https://orcid.org/0000-0002-9234-7567"]},"institutions":[{"id":"https://openalex.org/I77079311","display_name":"Wonkwang University","ror":"https://ror.org/006776986","country_code":"KR","type":"education","lineage":["https://openalex.org/I77079311"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Dong-Sung Lee","raw_affiliation_strings":["Hanbang Body-Fluid Research Center, Wonkwang University, Iksan, 570-749, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hanbang Body-Fluid Research Center, Wonkwang University, Iksan, 570-749, Republic of Korea","institution_ids":["https://openalex.org/I77079311"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102758496","display_name":"Kyoung-Su Kim","orcid":"https://orcid.org/0009-0001-6248-3111","observed_orcids":["https://orcid.org/0009-0001-6248-3111"]},"institutions":[{"id":"https://openalex.org/I77079311","display_name":"Wonkwang University","ror":"https://ror.org/006776986","country_code":"KR","type":"education","lineage":["https://openalex.org/I77079311"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Kyoung-Su Kim","raw_affiliation_strings":["Institute of Pharmaceutical Research and Development, College of Pharmacy, Wonkwang University, Iksan, 570-749, Republic of Korea; Standardized Material Bank for New Botanical Drugs, College of Pharmacy, Wonkwang University, Iksan, 570-749, Republic of Korea","Institute of Pharmaceutical Research and Development, College of Pharmacy, Wonkwang University, Iksan, 570-749, Republic of Korea","Standardized Material Bank for New Botanical Drugs, College of Pharmacy, Wonkwang University, Iksan, 570-749, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pharmaceutical Research and Development, College of Pharmacy, Wonkwang University, Iksan, 570-749, Republic of Korea; Standardized Material Bank for New Botanical Drugs, College of Pharmacy, Wonkwang University, Iksan, 570-749, Republic of Korea","institution_ids":["https://openalex.org/I77079311"]},{"raw_affiliation_string":"Institute of Pharmaceutical Research and Development, College of Pharmacy, Wonkwang University, Iksan, 570-749, Republic of Korea","institution_ids":["https://openalex.org/I77079311"]},{"raw_affiliation_string":"Standardized Material Bank for New Botanical Drugs, College of Pharmacy, Wonkwang University, Iksan, 570-749, Republic of Korea","institution_ids":["https://openalex.org/I77079311"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084055233","display_name":"Wonmin Ko","orcid":"https://orcid.org/0000-0003-3466-270X","observed_orcids":["https://orcid.org/0000-0003-3466-270X"]},"institutions":[{"id":"https://openalex.org/I77079311","display_name":"Wonkwang University","ror":"https://ror.org/006776986","country_code":"KR","type":"education","lineage":["https://openalex.org/I77079311"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Wonmin Ko","raw_affiliation_strings":["Institute of Pharmaceutical Research and Development, College of Pharmacy, Wonkwang University, Iksan, 570-749, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pharmaceutical Research and Development, College of Pharmacy, Wonkwang University, Iksan, 570-749, Republic of Korea","institution_ids":["https://openalex.org/I77079311"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101777142","display_name":"Jae Hak Sohn","orcid":"https://orcid.org/0000-0001-8026-963X","observed_orcids":["https://orcid.org/0000-0001-8026-963X"]},"institutions":[{"id":"https://openalex.org/I4210123920","display_name":"Silla University","ror":"https://ror.org/02w3gk008","country_code":"KR","type":"education","lineage":["https://openalex.org/I4210123920"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jae Hak Sohn","raw_affiliation_strings":["College of Medical and Life Sciences, Silla University, Busan 617-736, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Medical and Life Sciences, Silla University, Busan 617-736, Republic of Korea","institution_ids":["https://openalex.org/I4210123920"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000436607","display_name":"Joung Han Yim","orcid":"https://orcid.org/0000-0003-4415-1778","observed_orcids":["https://orcid.org/0000-0003-4415-1778"]},"institutions":[{"id":"https://openalex.org/I4210093716","display_name":"Korea Polar Research Institute","ror":"https://ror.org/00n14a494","country_code":"KR","type":"facility","lineage":["https://openalex.org/I133437993","https://openalex.org/I4210093716"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Joung Han Yim","raw_affiliation_strings":["Korea Polar Research Institute, KORDI, 7-50 Songdo-dong, Yeonsu-gu, Incheon 406-840, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Korea Polar Research Institute, KORDI, 7-50 Songdo-dong, Yeonsu-gu, Incheon 406-840, Republic of Korea","institution_ids":["https://openalex.org/I4210093716"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079957929","display_name":"Youn\u2010Chul Kim","orcid":"https://orcid.org/0000-0002-1458-9536","observed_orcids":["https://orcid.org/0000-0002-1458-9536"]},"institutions":[{"id":"https://openalex.org/I77079311","display_name":"Wonkwang University","ror":"https://ror.org/006776986","country_code":"KR","type":"education","lineage":["https://openalex.org/I77079311"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Youn-Chul Kim","raw_affiliation_strings":["Institute of Pharmaceutical Research and Development, College of Pharmacy, Wonkwang University, Iksan, 570-749, Republic of Korea. Electronic address: yckim@wku.ac.kr","Institute of Pharmaceutical Research and Development, College of Pharmacy, Wonkwang University, Iksan, 570-749, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pharmaceutical Research and Development, College of Pharmacy, Wonkwang University, Iksan, 570-749, Republic of Korea. Electronic address: yckim@wku.ac.kr","institution_ids":["https://openalex.org/I77079311"]},{"raw_affiliation_string":"Institute of Pharmaceutical Research and Development, College of Pharmacy, Wonkwang University, Iksan, 570-749, Republic of Korea","institution_ids":["https://openalex.org/I77079311"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101896684","display_name":"Hyuncheol Oh","orcid":"https://orcid.org/0000-0001-9394-4358","observed_orcids":["https://orcid.org/0000-0001-9394-4358"]},"institutions":[{"id":"https://openalex.org/I77079311","display_name":"Wonkwang University","ror":"https://ror.org/006776986","country_code":"KR","type":"education","lineage":["https://openalex.org/I77079311"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Hyuncheol Oh","raw_affiliation_strings":["Institute of Pharmaceutical Research and Development, College of Pharmacy, Wonkwang University, Iksan, 570-749, Republic of Korea. Electronic address: hoh@wku.ac.kr","Institute of Pharmaceutical Research and Development, College of Pharmacy, Wonkwang University, Iksan, 570-749, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pharmaceutical Research and Development, College of Pharmacy, Wonkwang University, Iksan, 570-749, Republic of Korea. Electronic address: hoh@wku.ac.kr","institution_ids":["https://openalex.org/I77079311"]},{"raw_affiliation_string":"Institute of Pharmaceutical Research and Development, College of Pharmacy, Wonkwang University, Iksan, 570-749, Republic of Korea","institution_ids":["https://openalex.org/I77079311"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5079957929","https://openalex.org/A5101896684"],"corresponding_institution_ids":["https://openalex.org/I77079311"],"apc_list":{"value":3220,"currency":"USD","value_usd":3220},"apc_paid":null,"fwci":2.3207,"has_fulltext":false,"cited_by_count":69,"citation_normalized_percentile":{"value":0.85657791,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"23","issue":"2","first_page":"568","last_page":"574"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.8032000064849854,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.8032000064849854,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.1460999995470047,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11613","display_name":"Phytochemistry and Biological Activities","score":0.00559999980032444,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aurantiamide-acetate","display_name":"aurantiamide acetate","score":1.0},{"id":"https://openalex.org/keywords/marine-fungi","display_name":"marine fungi","score":0.6809999942779541},{"id":"https://openalex.org/keywords/aspergillus","display_name":"Aspergillus","score":0.8859999775886536},{"id":"https://openalex.org/keywords/anti-neuroinflammatory-activity","display_name":"anti-neuroinflammatory activity","score":0.796999990940094},{"id":"https://openalex.org/keywords/microglia","display_name":"microglia","score":0.8410000205039978},{"id":"https://openalex.org/keywords/bv2-cells","display_name":"BV-2 cells","score":0.847000002861023},{"id":"https://openalex.org/keywords/lipopolysaccharide","display_name":"lipopolysaccharide","score":0.9670000076293945},{"id":"https://openalex.org/keywords/nf-kappab-signaling","display_name":"NF-\u03baB signaling","score":0.9160000085830688},{"id":"https://openalex.org/keywords/mapk-signaling","display_name":"MAPK signaling","score":0.7620000243186951},{"id":"https://openalex.org/keywords/jnk","display_name":"JNK","score":0.9359999895095825},{"id":"https://openalex.org/keywords/p38-mapk","display_name":"p38 MAPK","score":0.902999997138977},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.8069999814033508},{"id":"https://openalex.org/keywords/prostaglandin-e2","display_name":"prostaglandin E2","score":0.9710000157356262},{"id":"https://openalex.org/keywords/inducible-nitric-oxide-synthase","display_name":"inducible nitric oxide synthase","score":0.859000027179718},{"id":"https://openalex.org/keywords/cyclooxygenase-2","display_name":"cyclooxygenase-2","score":0.9800000190734863},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.9559999704360962},{"id":"https://openalex.org/keywords/ikappabalpha-phosphorylation","display_name":"I\u03baB\u03b1 phosphorylation","score":0.8270000219345093}],"concepts":[{"id":"https://openalex.org/C51551487","wikidata":"https://www.wikidata.org/wiki/Q2043632","display_name":"p38 mitogen-activated protein kinases","level":4,"score":0.7983050346374512},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.6438864469528198},{"id":"https://openalex.org/C2778754761","wikidata":"https://www.wikidata.org/wiki/Q421804","display_name":"Lipopolysaccharide","level":2,"score":0.58613121509552},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.5811117887496948},{"id":"https://openalex.org/C2777622882","wikidata":"https://www.wikidata.org/wiki/Q417619","display_name":"Nitric oxide synthase","level":3,"score":0.5652525424957275},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.5615416765213013},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.5519251823425293},{"id":"https://openalex.org/C2777730290","wikidata":"https://www.wikidata.org/wiki/Q411114","display_name":"NF-\u03baB","level":3,"score":0.5482306480407715},{"id":"https://openalex.org/C87753298","wikidata":"https://www.wikidata.org/wiki/Q17157137","display_name":"Neuroinflammation","level":3,"score":0.4945320785045624},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.48929283022880554},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4836524724960327},{"id":"https://openalex.org/C123298856","wikidata":"https://www.wikidata.org/wiki/Q15317427","display_name":"NFKB1","level":4,"score":0.4761481285095215},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.4548001289367676},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.42995569109916687},{"id":"https://openalex.org/C2779730028","wikidata":"https://www.wikidata.org/wiki/Q15325101","display_name":"I\u03baB\u03b1","level":4,"score":0.42492809891700745},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34894904494285583},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3138032555580139},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.250556617975235},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2056947946548462},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.1923466920852661},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.07849615812301636},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001230","descriptor_name":"Aspergillus","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D001230","descriptor_name":"Aspergillus","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004151","descriptor_name":"Dipeptides","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D004151","descriptor_name":"Dipeptides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D011161","descriptor_name":"Porifera","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015232","descriptor_name":"Dinoprostone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D017628","descriptor_name":"Microglia","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D017628","descriptor_name":"Microglia","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D017628","descriptor_name":"Microglia","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D020935","descriptor_name":"MAP Kinase Signaling System","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D020935","descriptor_name":"MAP Kinase Signaling System","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053583","descriptor_name":"Interleukin-1beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.intimp.2014.10.006","doi":"https://doi.org/10.1016/j.intimp.2014.10.006","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.intimp.2014.10.006","pdf_url":null,"source":{"id":"https://openalex.org/S158377717","display_name":"International Immunopharmacology","issn_l":"1567-5769","issn":["1567-5769","1878-1705"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","medline","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Immunopharmacology","raw_type":"journal-article"},{"id":"pmid:25448500","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25448500","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International immunopharmacology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8940673853","display_name":null,"funder_award_id":"PM13030","funder_id":"https://openalex.org/F4320322011","funder_display_name":"Ministry of Oceans and Fisheries"}],"funders":[{"id":"https://openalex.org/F4320322011","display_name":"Ministry of Oceans and Fisheries","ror":"https://ror.org/00c5s4a53"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W111387551","https://openalex.org/W1534551308","https://openalex.org/W1551721144","https://openalex.org/W1581947086","https://openalex.org/W1753183749","https://openalex.org/W1980609388","https://openalex.org/W1984230217","https://openalex.org/W1991318129","https://openalex.org/W1993031347","https://openalex.org/W2004349171","https://openalex.org/W2013266664","https://openalex.org/W2017736846","https://openalex.org/W2021533801","https://openalex.org/W2024803597","https://openalex.org/W2032553134","https://openalex.org/W2032574998","https://openalex.org/W2034831207","https://openalex.org/W2036091553","https://openalex.org/W2038996946","https://openalex.org/W2039375190","https://openalex.org/W2054333837","https://openalex.org/W2059810913","https://openalex.org/W2059983531","https://openalex.org/W2072074896","https://openalex.org/W2073132923","https://openalex.org/W2074753416","https://openalex.org/W2078415854","https://openalex.org/W2084282266","https://openalex.org/W2084928287","https://openalex.org/W2091695331","https://openalex.org/W2109759840","https://openalex.org/W2118777053","https://openalex.org/W2119958966","https://openalex.org/W2121950202","https://openalex.org/W2124074278","https://openalex.org/W2138992293","https://openalex.org/W2140660632","https://openalex.org/W2144795270","https://openalex.org/W2147921405","https://openalex.org/W2162935886","https://openalex.org/W2464905168"],"related_works":["https://openalex.org/W4225114885","https://openalex.org/W4406327714","https://openalex.org/W2012606189","https://openalex.org/W2770269594","https://openalex.org/W2807116772","https://openalex.org/W7197011764","https://openalex.org/W2020732748","https://openalex.org/W2025621128","https://openalex.org/W2897663713","https://openalex.org/W4380576969"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":11},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}