{"id":"https://openalex.org/W1983643394","doi":"https://doi.org/10.1016/0005-2736(86)90277-4","title":"Assessment of binding of l-cystine and l-lysine by rat renal brush-border membranes","display_name":"Assessment of binding of l-cystine and l-lysine by rat renal brush-border membranes","publication_year":1986,"publication_date":"1986-12-01","ids":{"openalex":"https://openalex.org/W1983643394","doi":"https://doi.org/10.1016/0005-2736(86)90277-4","mag":"1983643394","pmid":"https://pubmed.ncbi.nlm.nih.gov/3098291"},"language":"en","primary_location":{"id":"doi:10.1016/0005-2736(86)90277-4","doi":"https://doi.org/10.1016/0005-2736(86)90277-4","is_oa":true,"landing_page_url":"https://doi.org/10.1016/0005-2736(86)90277-4","pdf_url":null,"source":{"id":"https://openalex.org/S4210187475","display_name":"Biochimica et Biophysica Acta (BBA) - Biomembranes","issn_l":"0005-2736","issn":["0005-2736","1879-2642"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et Biophysica Acta (BBA) - Biomembranes","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/0005-2736(86)90277-4","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113621071","display_name":"Betty Y.L. Hsu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Betty Y.L. Hsu","raw_affiliation_strings":["Departments of Pediatrics and Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 U.S.A","Division of Biochemical Development and Molecular Diseases, The Joseph Stokes Jr. Research Institute, Children's Hospital of Philadelphia, Philadelphia, PA 19104 U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pediatrics and Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 U.S.A","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Division of Biochemical Development and Molecular Diseases, The Joseph Stokes Jr. Research Institute, Children's Hospital of Philadelphia, Philadelphia, PA 19104 U.S.A","institution_ids":["https://openalex.org/I1335321130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023012956","display_name":"Pamela D. McNamara","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pamela D. McNamara","raw_affiliation_strings":["Departments of Pediatrics and Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 U.S.A","Division of Biochemical Development and Molecular Diseases, The Joseph Stokes Jr. Research Institute, Children's Hospital of Philadelphia, Philadelphia, PA 19104 U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pediatrics and Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 U.S.A","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Division of Biochemical Development and Molecular Diseases, The Joseph Stokes Jr. Research Institute, Children's Hospital of Philadelphia, Philadelphia, PA 19104 U.S.A","institution_ids":["https://openalex.org/I1335321130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109309443","display_name":"Claire T. Rea","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Claire T. Rea","raw_affiliation_strings":["Departments of Pediatrics and Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 U.S.A","Division of Biochemical Development and Molecular Diseases, The Joseph Stokes Jr. Research Institute, Children's Hospital of Philadelphia, Philadelphia, PA 19104 U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pediatrics and Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 U.S.A","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Division of Biochemical Development and Molecular Diseases, The Joseph Stokes Jr. Research Institute, Children's Hospital of Philadelphia, Philadelphia, PA 19104 U.S.A","institution_ids":["https://openalex.org/I1335321130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074778183","display_name":"Susan M. Corcoran","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Susan M. Corcoran","raw_affiliation_strings":["Departments of Pediatrics and Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 U.S.A","Division of Biochemical Development and Molecular Diseases, The Joseph Stokes Jr. Research Institute, Children's Hospital of Philadelphia, Philadelphia, PA 19104 U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pediatrics and Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 U.S.A","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Division of Biochemical Development and Molecular Diseases, The Joseph Stokes Jr. Research Institute, Children's Hospital of Philadelphia, Philadelphia, PA 19104 U.S.A","institution_ids":["https://openalex.org/I1335321130"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113556670","display_name":"Stanton Segal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Stanton Segal","raw_affiliation_strings":["Departments of Pediatrics and Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 U.S.A","Division of Biochemical Development and Molecular Diseases, The Joseph Stokes Jr. Research Institute, Children's Hospital of Philadelphia, Philadelphia, PA 19104 U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pediatrics and Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 U.S.A","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Division of Biochemical Development and Molecular Diseases, The Joseph Stokes Jr. Research Institute, Children's Hospital of Philadelphia, Philadelphia, PA 19104 U.S.A","institution_ids":["https://openalex.org/I1335321130"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5113556670"],"corresponding_institution_ids":["https://openalex.org/I1335321130","https://openalex.org/I79576946"],"apc_list":{"value":3870,"currency":"USD","value_usd":3870},"apc_paid":{"value":3870,"currency":"USD","value_usd":3870},"fwci":0.4069,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.48311093,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"863","issue":"2","first_page":"332","last_page":"336"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cystine","display_name":"cystine","score":0.6700000166893005},{"id":"https://openalex.org/keywords/lysine","display_name":"lysine","score":1.0},{"id":"https://openalex.org/keywords/amino-acid-binding","display_name":"amino acid binding","score":0.9190000295639038},{"id":"https://openalex.org/keywords/renal-brush-border-membrane","display_name":"renal brush border membrane","score":0.8560000061988831},{"id":"https://openalex.org/keywords/brush-border-membrane-vesicles","display_name":"brush border membrane vesicles","score":0.953000009059906},{"id":"https://openalex.org/keywords/trichloroacetic-acid-precipitation","display_name":"trichloroacetic acid precipitation","score":0.8949999809265137},{"id":"https://openalex.org/keywords/rat-kidney","display_name":"rat kidney","score":0.6779999732971191}],"concepts":[{"id":"https://openalex.org/C2777332483","wikidata":"https://www.wikidata.org/wiki/Q410116","display_name":"Trichloroacetic acid","level":2,"score":0.8816091418266296},{"id":"https://openalex.org/C2776016237","wikidata":"https://www.wikidata.org/wiki/Q178430","display_name":"Lysine","level":3,"score":0.8210082650184631},{"id":"https://openalex.org/C2777608289","wikidata":"https://www.wikidata.org/wiki/Q408626","display_name":"Cystine","level":4,"score":0.8188760280609131},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6666284203529358},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.6180269718170166},{"id":"https://openalex.org/C130316041","wikidata":"https://www.wikidata.org/wiki/Q189206","display_name":"Vesicle","level":3,"score":0.5465410351753235},{"id":"https://openalex.org/C5426402","wikidata":"https://www.wikidata.org/wiki/Q2462753","display_name":"Brush border","level":4,"score":0.488149493932724},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.48797839879989624},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.4386734068393707},{"id":"https://openalex.org/C134121241","wikidata":"https://www.wikidata.org/wiki/Q899301","display_name":"Yield (engineering)","level":2,"score":0.4217618405818939},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.40863990783691406},{"id":"https://openalex.org/C2779201268","wikidata":"https://www.wikidata.org/wiki/Q186474","display_name":"Cysteine","level":3,"score":0.1016852855682373},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.07900696992874146},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.06070798635482788},{"id":"https://openalex.org/C191897082","wikidata":"https://www.wikidata.org/wiki/Q11467","display_name":"Metallurgy","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003553","descriptor_name":"Cystine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008239","descriptor_name":"Lysine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008871","descriptor_name":"Microvilli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009994","descriptor_name":"Osmolar Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011232","descriptor_name":"Chemical Precipitation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014238","descriptor_name":"Trichloroacetic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0005-2736(86)90277-4","doi":"https://doi.org/10.1016/0005-2736(86)90277-4","is_oa":true,"landing_page_url":"https://doi.org/10.1016/0005-2736(86)90277-4","pdf_url":null,"source":{"id":"https://openalex.org/S4210187475","display_name":"Biochimica et Biophysica Acta (BBA) - Biomembranes","issn_l":"0005-2736","issn":["0005-2736","1879-2642"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et Biophysica Acta (BBA) - Biomembranes","raw_type":"journal-article"},{"id":"pmid:3098291","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3098291","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et biophysica acta","raw_type":"Comparative Study"}],"best_oa_location":{"id":"doi:10.1016/0005-2736(86)90277-4","doi":"https://doi.org/10.1016/0005-2736(86)90277-4","is_oa":true,"landing_page_url":"https://doi.org/10.1016/0005-2736(86)90277-4","pdf_url":null,"source":{"id":"https://openalex.org/S4210187475","display_name":"Biochimica et Biophysica Acta (BBA) - Biomembranes","issn_l":"0005-2736","issn":["0005-2736","1879-2642"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et Biophysica Acta (BBA) - Biomembranes","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G7871173828","display_name":"GENETIC METABOLIC DISEASES OF INFANCY AND CHILDHOOD","funder_award_id":"5r01am010894-20","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":10,"referenced_works":["https://openalex.org/W285674794","https://openalex.org/W1521587124","https://openalex.org/W1804060812","https://openalex.org/W2048327266","https://openalex.org/W2073477794","https://openalex.org/W2073748777","https://openalex.org/W2278213307","https://openalex.org/W2312417930","https://openalex.org/W2329564050","https://openalex.org/W6698378874"],"related_works":["https://openalex.org/W2278213307","https://openalex.org/W2220030368","https://openalex.org/W2081965018","https://openalex.org/W2329564050","https://openalex.org/W2093375306","https://openalex.org/W2412582769","https://openalex.org/W1993648191","https://openalex.org/W1982816823","https://openalex.org/W1976802422","https://openalex.org/W2043529922"],"abstract_inverted_index":{"Cystine":[0],"and":[1,44,70,87],"lysine":[2,96],"bind":[3],"to":[4,12,20],"isolated":[5],"rat":[6],"renal":[7],"brush-border":[8],"vesicles.":[9],"Three":[10],"methods":[11,54,92],"determine":[13],"the":[14,21,29,33,63,91],"extent":[15],"of":[16,32,41,93],"amino":[17],"acid":[18,39,65],"binding":[19,74],"membranes":[22],"have":[23],"been":[24],"compared,":[25],"one":[26],"relying":[27],"on":[28],"osmotic":[30,88],"reactivity":[31],"vesicle,":[34],"a":[35,45,68],"second":[36],"by":[37,47],"trichloroacetic":[38,64,99],"precipitation":[40],"membrane-bound":[42],"material":[43],"third":[46],"initial":[48,84],"rate":[49,85],"analysis.":[50],"For":[51,82],"cystine,":[52],"all":[53],"yield":[55],"comparable":[56],"results":[57],"at":[58],"early":[59],"time":[60],"points,":[61],"indicating":[62],"method":[66],"is":[67],"simple":[69],"valuable":[71],"tool":[72],"for":[73],"estimation":[75],"under":[76],"initial-rate":[77,80],"or":[78],"near":[79],"conditions.":[81],"lysine,":[83],"analysis":[86],"perturbation":[89],"are":[90],"choice":[94],"since":[95],"co-precipitates":[97],"with":[98],"acid.":[100]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
