{"id":"https://openalex.org/W1983545384","doi":"https://doi.org/10.4161/onci.28399","title":"The ELR+CXCL chemokines and their receptors CXCR1/CXCR2","display_name":"The ELR+CXCL chemokines and their receptors CXCR1/CXCR2","publication_year":2014,"publication_date":"2014-04-01","ids":{"openalex":"https://openalex.org/W1983545384","doi":"https://doi.org/10.4161/onci.28399","mag":"1983545384","pmid":"https://pubmed.ncbi.nlm.nih.gov/25050209","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4063157"},"language":"en","primary_location":{"id":"doi:10.4161/onci.28399","doi":"https://doi.org/10.4161/onci.28399","is_oa":true,"landing_page_url":"https://doi.org/10.4161/onci.28399","pdf_url":"https://www.tandfonline.com/doi/pdf/10.4161/onci.28399?needAccess=true&role=button","source":{"id":"https://openalex.org/S2497914550","display_name":"OncoImmunology","issn_l":"2162-4011","issn":["2162-4011","2162-402X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315740","host_organization_name":"Landes Bioscience","host_organization_lineage":["https://openalex.org/P4310315740"],"host_organization_lineage_names":["Landes Bioscience"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"OncoImmunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.tandfonline.com/doi/pdf/10.4161/onci.28399?needAccess=true&role=button","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045396112","display_name":"Sandy Giuliano","orcid":"https://orcid.org/0000-0001-7580-0326","observed_orcids":["https://orcid.org/0000-0001-7580-0326"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210119200","display_name":"Institut de Recherche sur le Cancer et le Vieillissement de Nice","ror":"https://ror.org/01td3kv81","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I201841394","https://openalex.org/I4210096427","https://openalex.org/I4210119200"]},{"id":"https://openalex.org/I4387154757","display_name":"Universit\u00e9 Nice Sophia Antipolis","ror":"https://ror.org/02k9vew78","country_code":"FR","type":"education","lineage":["https://openalex.org/I201841394","https://openalex.org/I4387154757"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Sandy Giuliano","raw_affiliation_strings":["University of Nice Sophia Antipolis; UMR CNRS 7284/U INSERM 1081; Nice, France","Nice, France","UMR CNRS 7284/U INSERM 1081","University of Nice Sophia Antipolis"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Nice Sophia Antipolis; UMR CNRS 7284/U INSERM 1081; Nice, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210119200","https://openalex.org/I4387154757"]},{"raw_affiliation_string":"Nice, France","institution_ids":[]},{"raw_affiliation_string":"UMR CNRS 7284/U INSERM 1081","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210119200"]},{"raw_affiliation_string":"University of Nice Sophia Antipolis","institution_ids":["https://openalex.org/I4387154757"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114045760","display_name":"M\u00e9lanie Guyot","orcid":"https://orcid.org/0000-0001-6815-3087","observed_orcids":["https://orcid.org/0000-0001-6815-3087"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210119200","display_name":"Institut de Recherche sur le Cancer et le Vieillissement de Nice","ror":"https://ror.org/01td3kv81","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I201841394","https://openalex.org/I4210096427","https://openalex.org/I4210119200"]},{"id":"https://openalex.org/I4387154757","display_name":"Universit\u00e9 Nice Sophia Antipolis","ror":"https://ror.org/02k9vew78","country_code":"FR","type":"education","lineage":["https://openalex.org/I201841394","https://openalex.org/I4387154757"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"M\u00e9lanie Guyot","raw_affiliation_strings":["University of Nice Sophia Antipolis; UMR CNRS 7284/U INSERM 1081; Nice, France","Nice, France","UMR CNRS 7284/U INSERM 1081","University of Nice Sophia Antipolis"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Nice Sophia Antipolis; UMR CNRS 7284/U INSERM 1081; Nice, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210119200","https://openalex.org/I4387154757"]},{"raw_affiliation_string":"Nice, France","institution_ids":[]},{"raw_affiliation_string":"UMR CNRS 7284/U INSERM 1081","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210119200"]},{"raw_affiliation_string":"University of Nice Sophia Antipolis","institution_ids":["https://openalex.org/I4387154757"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040053100","display_name":"Renaud Gr\u00e9pin","orcid":"https://orcid.org/0009-0005-7178-4521","observed_orcids":["https://orcid.org/0009-0005-7178-4521","https://orcid.org/0000-0002-2942-1074"]},"institutions":[{"id":"https://openalex.org/I4210144557","display_name":"Scientific Centre of Monaco","ror":"https://ror.org/04kptf457","country_code":"MC","type":"facility","lineage":["https://openalex.org/I4210144557"]}],"countries":["MC"],"is_corresponding":false,"raw_author_name":"Renaud Gr\u00e9pin","raw_affiliation_strings":["Centre Scientifique de Monaco; Monaco","Centre Scientifique de Monaco","Monaco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre Scientifique de Monaco; Monaco","institution_ids":["https://openalex.org/I4210144557"]},{"raw_affiliation_string":"Centre Scientifique de Monaco","institution_ids":["https://openalex.org/I4210144557"]},{"raw_affiliation_string":"Monaco","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083085617","display_name":"Gilles Pag\u00e8s","orcid":"https://orcid.org/0000-0002-8466-5610","observed_orcids":["https://orcid.org/0000-0002-8466-5610"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210119200","display_name":"Institut de Recherche sur le Cancer et le Vieillissement de Nice","ror":"https://ror.org/01td3kv81","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I201841394","https://openalex.org/I4210096427","https://openalex.org/I4210119200"]},{"id":"https://openalex.org/I4387154757","display_name":"Universit\u00e9 Nice Sophia Antipolis","ror":"https://ror.org/02k9vew78","country_code":"FR","type":"education","lineage":["https://openalex.org/I201841394","https://openalex.org/I4387154757"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Gilles Pag\u00e8s","raw_affiliation_strings":["University of Nice Sophia Antipolis; UMR CNRS 7284/U INSERM 1081; Nice, France","Nice, France","UMR CNRS 7284/U INSERM 1081","University of Nice Sophia Antipolis"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Nice Sophia Antipolis; UMR CNRS 7284/U INSERM 1081; Nice, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210119200","https://openalex.org/I4387154757"]},{"raw_affiliation_string":"Nice, France","institution_ids":[]},{"raw_affiliation_string":"UMR CNRS 7284/U INSERM 1081","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210119200"]},{"raw_affiliation_string":"University of Nice Sophia Antipolis","institution_ids":["https://openalex.org/I4387154757"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5083085617"],"corresponding_institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210119200","https://openalex.org/I4387154757"],"apc_list":{"value":2375,"currency":"GBP","value_usd":2913},"apc_paid":{"value":2375,"currency":"GBP","value_usd":2913},"fwci":0.6553,"has_fulltext":true,"cited_by_count":18,"citation_normalized_percentile":{"value":0.69252024,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"3","issue":"4","first_page":"e28399","last_page":"e28399"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11532","display_name":"Chemokine receptors and signaling","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11532","display_name":"Chemokine receptors and signaling","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10449","display_name":"Renal cell carcinoma treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cxcr1","display_name":"CXCR1","score":0.9160000085830688},{"id":"https://openalex.org/keywords/cxcr2","display_name":"CXCR2","score":1.0},{"id":"https://openalex.org/keywords/renal-cell-carcinoma","display_name":"renal cell carcinoma","score":0.9359999895095825},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.7630000114440918},{"id":"https://openalex.org/keywords/tumor-inflammation","display_name":"tumor inflammation","score":0.9490000009536743},{"id":"https://openalex.org/keywords/tumor-cell-proliferation","display_name":"tumor cell proliferation","score":0.9879999756813049},{"id":"https://openalex.org/keywords/anti-angiogenic-therapy","display_name":"anti-angiogenic therapy","score":0.7739999890327454},{"id":"https://openalex.org/keywords/anti-vegf-therapy","display_name":"anti-VEGF therapy","score":0.7630000114440918},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.8009999990463257}],"concepts":[{"id":"https://openalex.org/C84913492","wikidata":"https://www.wikidata.org/wiki/Q5014892","display_name":"CXC chemokine receptors","level":5,"score":0.8557610511779785},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.7656528949737549},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.6245449185371399},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.589026689529419},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5735911726951599},{"id":"https://openalex.org/C2777025900","wikidata":"https://www.wikidata.org/wiki/Q29725","display_name":"Vascular endothelial growth factor","level":3,"score":0.5395618677139282},{"id":"https://openalex.org/C12823836","wikidata":"https://www.wikidata.org/wiki/Q24720618","display_name":"Chemokine receptor","level":4,"score":0.5248434543609619},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.4788525104522705},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4424741566181183},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4209003746509552},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3902066946029663},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.36543968319892883},{"id":"https://openalex.org/C167734588","wikidata":"https://www.wikidata.org/wiki/Q4356503","display_name":"VEGF receptors","level":2,"score":0.2888001799583435},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2040528953075409}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.4161/onci.28399","doi":"https://doi.org/10.4161/onci.28399","is_oa":true,"landing_page_url":"https://doi.org/10.4161/onci.28399","pdf_url":"https://www.tandfonline.com/doi/pdf/10.4161/onci.28399?needAccess=true&role=button","source":{"id":"https://openalex.org/S2497914550","display_name":"OncoImmunology","issn_l":"2162-4011","issn":["2162-4011","2162-402X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315740","host_organization_name":"Landes Bioscience","host_organization_lineage":["https://openalex.org/P4310315740"],"host_organization_lineage_names":["Landes Bioscience"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"OncoImmunology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3354278","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4063157","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4063157","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4063157","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncoimmunology","raw_type":"Text"},{"id":"pmid:25050209","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25050209","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncoimmunology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.4161/onci.28399","doi":"https://doi.org/10.4161/onci.28399","is_oa":true,"landing_page_url":"https://doi.org/10.4161/onci.28399","pdf_url":"https://www.tandfonline.com/doi/pdf/10.4161/onci.28399?needAccess=true&role=button","source":{"id":"https://openalex.org/S2497914550","display_name":"OncoImmunology","issn_l":"2162-4011","issn":["2162-4011","2162-402X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315740","host_organization_name":"Landes Bioscience","host_organization_lineage":["https://openalex.org/P4310315740"],"host_organization_lineage_names":["Landes Bioscience"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"OncoImmunology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320323807","display_name":"Institut National Du Cancer","ror":"https://ror.org/03m8vkq32"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1983545384.pdf","grobid_xml":"https://content.openalex.org/works/W1983545384.grobid-xml"},"referenced_works_count":10,"referenced_works":["https://openalex.org/W1982147571","https://openalex.org/W1989805762","https://openalex.org/W2059527652","https://openalex.org/W2063270450","https://openalex.org/W2079134147","https://openalex.org/W2115342244","https://openalex.org/W2129331774","https://openalex.org/W2135387190","https://openalex.org/W2142112207","https://openalex.org/W2170121153"],"related_works":["https://openalex.org/W2121479816","https://openalex.org/W4242241768","https://openalex.org/W2115342244","https://openalex.org/W4393853106","https://openalex.org/W1495127214","https://openalex.org/W2103766998","https://openalex.org/W2007429429","https://openalex.org/W3105949437","https://openalex.org/W2357007185","https://openalex.org/W2134055933"],"abstract_inverted_index":{"The":[0],"long-term":[1],"efficacy":[2],"of":[3,18],"anti-angiogenesis":[4],"drugs":[5],"targeting":[6],"vascular":[7],"endothelial":[8],"growth":[9,57],"factor":[10],"(VEGF)":[11],"and":[12,33,40,48],"VEGF":[13],"receptors":[14],"in":[15],"the":[16,30],"treatment":[17],"renal":[19],"cell":[20,44],"carcinoma":[21],"(RCC)":[22],"has":[23],"been":[24],"lacking.":[25],"We":[26],"have":[27],"shown":[28],"that":[29],"ELR+CXCL":[31],"cytokines":[32],"their":[34],"(C-X-C)":[35],"chemokine":[36],"receptors,":[37],"namely":[38],"CXCR1":[39],"CXCR2,":[41],"stimulate":[42],"cancer":[43,56],"proliferation,":[45],"tumor":[46],"inflammation,":[47],"angiogenesis.":[49],"Hence,":[50],"this":[51],"essential":[52],"molecular":[53],"nexus":[54],"regulating":[55],"represents":[58],"a":[59],"key":[60],"therapeutic":[61],"target.":[62]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":4},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
